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面向供应链分销的多维空间Pareto边界自动谈判模型研究

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管理工程学报 2024年第3期38卷 227-239页

作者：曹慕昆杨荇贻党圣洁厦门大学管理学院福建厦门361005

随着电子商务的快速发展,自动谈判逐渐成为提升供应链系统效率的一种手段。为了优化多方参与的供应链分销谈判应用,本文将多边多属性谈判问题转化为多目标优化模型,采用改进的非支配遗传算法NSGA-Ⅲ计算多维空间的Pareto边界;然后,设计... 详细信息

随着电子商务的快速发展,自动谈判逐渐成为提升供应链系统效率的一种手段。为了优化多方参与的供应链分销谈判应用,本文将多边多属性谈判问题转化为多目标优化模型,采用改进的非支配遗传算法NSGA-Ⅲ计算多维空间的Pareto边界;然后,设计多线程谈判模型,将参与多方谈判的买卖各方拆解为多个双边谈判线程,分别在多维Pareto边界上进行谈判;进而,采用动态时间依赖策略(DTD),使Agent根据对方报价在Pareto边界上动态调整让步策略,快速达成协议。为验证模型的有效性,本文进行了大量模拟自动谈判实验。实验结果表明,所提出的改进算法和谈判流程优于领域最新研究成果,能有效提升多边多属性谈判效率,有助于多方达成共赢局面。

关键词：供应链分销多边多属性谈判遗传算法 Pareto边界 Agent

Amalgamated gold-nanoalloys with enhanced catalytic activity for the detection of mercury ions(Hg^2+)in seawater samples

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Nano Research 2020年第4期13卷 989-998页

作者： Natasha Logan Claire McVey Christopher Elliott cuong cao Institute for Global Food Security School of Biological SciencesQueens University Belfast19 Chlorine GardensBelfastBT95DLUK Material and Advanced Technologies for Healthcare Queens University Belfast18-30 Malone RoadBelfastBT95BNUK

Mercury(Hg)is extremely toxic,and continues to cause major threats to aquatic life,human health and the ***^2+mainly derives from seawater as a product of atmospheric deposition,therefore there is great demand for sensing approaches that can detect Hg^2+in seawater ***,we demonstrate that the peroxidase-mimicking activity of gold nanoparticles(AuNPs)or so-called nanozymes,can be exploited for the detection of Hg^2+ions in various water *** a high electrolyte environment,the catalytic activity for the oxidation of 3,3’,5,5’-tetramethylbenzidine(TMB)was significantly diminished due to poor stability of the *** activity was reduced by-73.7%when the NaCl concentration was higher than 1.168%,which is much lower than that of seawater(-3.5%),thus presenting its unsuitability for detecting Hg^2+in harsh water *** overcome this limitation,AuNPs were first functionalized with oligo-ethylene glycol(OEG),of which their colloidal form presented high stability in NaCl concentrations up to 20%and across a wide range of pHs from ***,the catalytic activity of OEG-AuNPs for the oxidation of TMB was strongly suppressed by the coating,but enhanced upon formation of Au-Hg *** novel finding underlies a straightforward,sensitive,and highly selective detection platform for Hg^2+in water *** approach could detect the exposure limit level for Hg^2+in drinking water(i.e.,2 ppb for tap and bottled water)as set by the United States Environmental Protection Agency(EPA)and the World Health Organization(WHO).When Hg^2+was spiked into a 3.5%saline solution and a coastal seawater certified reference material(CRM),the detection limits were found to be 10 ancM 3 ppb,respectively,which exceed the Hg^2+concentrations commonly found within seawater(-60-80 ppb).The whole procedure takes less than 45 min to conduct,providing a highly innovative,rapid and low-cost approach for detecting Hg^2+in complex water matrices.

关键词： gold nanoparticles nanozyme peroxidase-like mercury detection w ater samples seawater

可变形纳米囊载体——传递体在透皮制剂中的研究进展

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医药导报 2024年第8期43卷 1302-1308页

作者：李梓茜陈潇曹德英党云洁河北医科大学药剂学教研室石家庄050017

透皮制剂可以有效避免首过效应,且具有良好的临床用药依从性。传递体(TF)作为一种新型的可变形类脂囊泡,具有较好的皮肤渗透效率和包封率,可在体内维持稳定的血药浓度而发挥药效,是极具开发前景的新型透皮吸收制剂。该文总结了目前TF的... 详细信息

透皮制剂可以有效避免首过效应,且具有良好的临床用药依从性。传递体(TF)作为一种新型的可变形类脂囊泡,具有较好的皮肤渗透效率和包封率,可在体内维持稳定的血药浓度而发挥药效,是极具开发前景的新型透皮吸收制剂。该文总结了目前TF的研究现状,包括制备工艺、评价指标及其临床应用现状,并对其研究前景予以展望。

关键词：经皮给药传递体类脂质囊泡

Gold Nanozymes:From Concept to Biomedical Applications

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Nano-Micro Letters 2021年第1期13卷 138-173页

作者： Javier Lou‑Franco Bhaskar Das Christopher Elliott cuong cao Institute for Global Food Security School of Biological SciencesQueen’s University of Belfast19 Chlorine GardensBelfast BT95DLUK Present Address:Department of Biotechnology and Medical Engineering National Institute of Technology RourkelaRourkelaIndia

In recent years,gold nanoparticles have demonstrated excellent enzyme-mimicking activities which resemble those of peroxidase,oxidase,catalase,superoxide dismutase or ***,merged with their ease of synthesis,tunability,biocompatibility and low cost,makes them excellent candidates when compared with biological enzymes for applications in biomedicine or biochemical ***,over 200 research papers have been systematically reviewed to present the recent progress on the fundamentals of gold nanozymes and their potential *** review reveals that the morphology and surface chemistry of the nanoparticles play an important role in their catalytic properties,as well as external parameters such as pH or ***,real applications often require specific biorecognition elements to be immobilized onto the nanozymes,leading to unexpected positive or negative effects on their ***,rational design of efficient nanozymes remains a challenge of paramount *** implementation paths have already been explored,including the application of peroxidase-like nanozymes for the development of clinical diagnostics or the regulation of oxidative stress within cells via their catalase and superoxide dismutase *** review also indicates that it is essential to understand how external parameters may boost or inhibit each of these activities,as more than one of them could ***,further toxicity studies are required to ensure the applicability of gold nanozymes in *** challenges and future prospects of gold nanozymes are discussed in this review,whose significance can be anticipated in a diverse range of fields beyond biomedicine,such as food safety,environmental analyses or the chemical industry.

关键词： Gold nanoparticles Catalysis Nanozymes Diagnosis Nanomedicine

基于壳聚糖的抗菌可注射自愈性水凝胶的制备及其生物相容性研究

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中国海洋大学学报（自然科学版） 2024年第3期54卷 60-69页

作者：曹亚婵刘晓坤党奇峰刘成圣中国海洋大学海洋生命学院山东青岛266003 青岛海洋生物医药研究院山东青岛266075

为了解决传统水凝胶作为敷料或支架在生物体内应用时所表现出的抑菌活性低、生物相溶性差和机械性能差等问题,本文以氧化普鲁兰多糖(OP)为交联剂,分别同硫醇化季铵盐壳聚糖(NAC-QCS)和己二酸二酰肼(ADH)发生动态化学反应,首次制备出一... 详细信息

为了解决传统水凝胶作为敷料或支架在生物体内应用时所表现出的抑菌活性低、生物相溶性差和机械性能差等问题,本文以氧化普鲁兰多糖(OP)为交联剂,分别同硫醇化季铵盐壳聚糖(NAC-QCS)和己二酸二酰肼(ADH)发生动态化学反应,首次制备出一种可注射的自愈性抗菌的水凝胶——NQC-OP-ADH水凝胶,并对水凝胶的物理化学性质、抑菌活性和生物相容性进行研究。实验表明:NQC-OP-ADH对Escherichia coli和Staphlococcu aureus均表现出较高的抑菌活性,抑菌率分别为84%和99%;溶血率小于2%,具有良好的血液相容性;对培养24、48和72 h的L929细胞显示出较低的细胞毒性;在NQC-OP-ADH水凝胶表面和内部的培养至第5天的L929细胞仍具有良好的生长状态,特别是表面培养过程中有较多细胞迁移到NQC-OP-ADH水凝胶内部,表明NQC-OP-ADH水凝胶具有良好的细胞相容性。成胶后的NQC-OP-ADH可顺利通过注射器,无堵塞现象发生,且具有良好的自愈能力。

关键词：硫醇化季铵盐壳聚糖普鲁兰多糖自愈性水凝胶抑菌活性细胞相容性

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减量化、再利用、再循环:黄土高原独立式窑居住区绿色更新策略研究

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建筑学报 2024年第2期 50-55页

作者：曹晓腾雷振东党雨田田虎高雅西安建筑科技大学建筑学院西安710055 绿色建筑全国重点实验室西安710055

针对黄土高原独立式窑居住区人口老龄化与生活设施配置错位、闲置化与生产设施落地困难矛盾、荒废化与人居生态系统恶化并存的问题,基于“减量化、再利用、再循环”原则,提出住区生活功能、生产功能修补和人居生态系统修复策略,为黄土... 详细信息

针对黄土高原独立式窑居住区人口老龄化与生活设施配置错位、闲置化与生产设施落地困难矛盾、荒废化与人居生态系统恶化并存的问题,基于“减量化、再利用、再循环”原则,提出住区生活功能、生产功能修补和人居生态系统修复策略,为黄土高原独立式窑居住区的绿色更新提供借鉴。

关键词：黄土高原独立式窑居住区绿色更新策略减量化再利用再循环

细胞力学作用对MDCK细胞系微组织形态发生的影响

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中国组织工程研究 2024年第31期28卷 5003-5009页

作者：曹煜吴当欧阳明星邓林红常州大学医学与健康工程学院生物医学工程与健康科学研究院常州大学药学院生物与食品工程学院

背景：体内组织器官的发生是一个精确而自主调控的过程，生物力学因素在该宏观尺度上的功能是值得探索的基础科学问题。目的：探讨细胞力学作用对3D Madin-Darby犬肾(MDCK)上皮微组织形态发生的影响。方法：利用荧光共振能量转移技术观... 详细信息

背景：体内组织器官的发生是一个精确而自主调控的过程，生物力学因素在该宏观尺度上的功能是值得探索的基础科学问题。目的：探讨细胞力学作用对3D Madin-Darby犬肾(MDCK)上皮微组织形态发生的影响。方法：利用荧光共振能量转移技术观测MDCK上皮微组织的形成，检验不同的细胞力学信号和胞外基质环境对微组织发生的影响以及相应的ERK活性变化。结果与结论：(1)抑制ERK信号通路对MDCK上皮微组织的生长有抑制作用；(2)抑制细胞收缩力信号如ROCK通路和肌球蛋白MyosinⅡ活性，ERK活性降低，微组织变小；(3)选择性地抑制质膜和内质网上的钙离子通道导致ERK活性和微组织生长受到抑制；(4)通过抑制细胞膜上力学敏感受体Piezo离子通道或整合素信号，分别导致微组织变小或不能有效生成组织形态；(5)不同的细胞外基质组分影响微组织的形态发生，Matrigel胶中添加Ⅰ型胶原使微组织从微球形向长体形转变；(6)该研究结果初步显示细胞和细胞外基质环境中的机械力学信号在MDCK上皮微组织发生中具有重要作用，并提供了部分的分子机制理解。

关键词： ERK激酶 MDCK微组织荧光共振能量转移细胞力学细胞外基质

All-optical control of exciton flow in a colloidal quantum well complex

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Light(Science & Applications) 2020年第1期9卷 1749-1756页

作者： Junhong Yu Manoj Sharma Ashma Sharma Savas Delikanli Hilmi Volkan Demir cuong dang LUMINOUS Centre of Excellence for Semiconductor Lighting and DisplaysSchool of Electrical and Electronic EngineeringThe Photonics Institute(TPI)Nanyang Technological University50 Nanyang Avenue639798 SingaporeSingapore Department of Electrical and Electronics Engineering and Department of Physics UNAM-Institute of Materials Science and NanotechnologyBilkent UniversityBilkent06800 AnkaraTurkey School of Physical and Mathematical Sciences Division of Physics and Applied PhysicsNanyang Technological University639798 SingaporeSingapore CINTRA UMI CNRS/NTU/THALES 3288 Research Techno Plaza50 Nanyang DriveBorder X BlockLevel 6637553 SingaporeSingapore

Excitonics,an alternative to romising for processing information since semiconductor electronics is rapidly approaching the end of Moore’s ***,the development of excitonic devices,where exciton flow is controlled,is mainly focused on electric-field modulation or exciton polaritons in high-Q ***,we show an alloptical strategy to manipulate the exciton flow in a binary colloidal quantum well complex through mediation of the Förster resonance energy transfer(FRET)by stimulated *** the spontaneous emission regime,FRET naturally occurs between a donor and an *** contrast,upon stronger excitation,the ultrafast consumption of excitons by stimulated emission effectively engineers the excitonic flow from the donors to the ***,the acceptors’stimulated emission significantly accelerates the exciton flow,while the donors’stimulated emission almost stops this *** this basis,a FRET-coupled rate equation model is derived to understand the controllable exciton flow using the density of the excited donors and the unexcited *** results will provide an effective alloptical route for realizing excitonic devices under room temperature operation.

关键词： process flow quantum

The Stable Carbon Isotopic Compositions of n-Alkanes in Sediments of the Bohai and North Yellow Seas: Implications for Sources of Sedimentary Organic Matter

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Journal of Ocean University of China 2021年第2期20卷 340-348页

作者： dang Tianxiang cao Yunyun XING Lei Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of ChinaQingdao 266100China Laboratory for Marine Ecology and Environmental Science Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China

Stable carbon isotopic compositions of n-alkanes in surface sediments of the Bohai and North Yellow Seas were investigated to elucidate sources of sedimentary organic matter in these seas. The long-chain n-alkanes in surface sediments are predominantly long-chain C27, C29, and C31 types, with obvious odd carbon predominance. The δ13 C values of long-chain n-C27, n-C29, and n-C31 alkanes are-30.8% ± 0.5‰,-31.9% ± 0.6‰, and-32.1% ± 1.0‰, respectively, within the range of n-alkanes of C3 terrestrial higher plants. This suggests that sedimentary n-alkanes are derived mainly from terrestrial higher plants. Compound-specific carbon isotopic analysis of long-chain n-alkanes indicates that C3 terrestrial higher plants predominate(64%–79%), with angiosperms being the main contributors. The n-alkane δ13 C values indicate that mid-chain n-alkanes in sediments are derived mainly from aquatic emergent macrophytes, with significant petroleum pollution and bacterial degradation sources for short-chain n-alkanes.

关键词： biomarker carbon isotopes n-alkanes Bohai Sea North Yellow Sea