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Nanomaterial‑Based Repurposing of Macrophage Metabolism and Its Applications

Nano-Micro Letters 2024年第11期16卷 494-528页

作者： Tingting Meng danfeng he Zhuolei Han Rong Shi Yuhan Wang Bibo Ren Cheng Zhang Zhengwei Mao Gaoxing Luo Jun Den Institute of Burn Research Southwest HospitalState Key Laboratory of Trauma and Chemical PoisoningArmy Medical UniversityChongqing 400038People’s Republic of China Department of Breast Surgery Gansu Provincial HospitalLanzhouGansu 730030People’s Republic of China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Macrophage immunotherapy represents an emerging therapeutic approach aimed at modulating the immune response to alleviate disease ***(NMs)have been engineered to monitor macrophage metabolism,enabling the evaluation of disease progression and the replication of intricate physiological signal *** achieve this either directly or by delivering regulatory signals,thereby mapping phenotype to effector functions through metabolic repurposing to customize macrophage fate for ***,a comprehensive summary regarding NM-mediated macrophage visualization and coordinated metabolic rewiring to maintain phenotypic equilibrium is currently *** review aims to address this gap by outlining recent advancements in NM-based metabolic *** initially explore the relationship between metabolism,polarization,and disease,before delving into recent NM innovations that visualize macrophage activity to elucidate disease onset and fine-tune its fate through metabolic remodeling for macrophage-centered ***,we discuss the prospects and challenges of NM-mediated metabolic immunotherapy,aiming to accelerate clinical *** anticipate that this review will serve as a valuable reference for researchers seeking to leverage novel metabolic intervention-matched immunomodulators in macrophages or other fields of immune engineering.

关键词： Immunomodulatory nanomaterial Macrophage polarization Macrophage metabolic reprogramming Immune engineering

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Correction:Nanomaterial-Based Repurposing of Macrophage Metabolism and Its Applications

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Nano-Micro Letters 2024年第12期16卷 357-357页

作者： Tingting Meng danfeng he Zhuolei Han Rong Shi Yuhan Wang Bibo Ren Cheng Zhang Zhengwei Mao Gaoxing Luo Jun Deng Institute of Burn Research Southwest HospitalState Key Laboratory of Trauma and Chemical PoisoningArmy Medical UniversityChongqing 400038People’s Republic of China Department of Breast Surgery Gansu Provincial HospitalLanzhouGansu 730030People’s Republic of China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Following publication of the original article[1],the authors reported an error in the last author’s name,it was mistakenly written as“Jun Den”.The correct author’s name“Jun Deng”has been updated in this Correction.

关键词： mistake correct Correction

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离心管石墨消解-原子荧光光谱法测定土壤中总砷和总汞

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化学分析计量 2024年第8期33卷 74-78页

作者：袁野何丹风易姗姗南充农产品质量监测检验中心四川南充637000 南充市嘉陵区农业农村局四川南充637000

对现有国标方法(GB/T 22105.1—2008《土壤质量总汞、总砷、总铅的测定原子荧光法第1部分:土壤中总汞的测定》和GB/T 22105.2—2008《土壤质量总汞、总砷、总铅的测定原子荧光法第2部分:土壤中总砷的测定》)测量土壤中总砷和总汞的方法... 详细信息

对现有国标方法(GB/T 22105.1—2008《土壤质量总汞、总砷、总铅的测定原子荧光法第1部分:土壤中总汞的测定》和GB/T 22105.2—2008《土壤质量总汞、总砷、总铅的测定原子荧光法第2部分:土壤中总砷的测定》)测量土壤中总砷和总汞的方法进行改进,建立离心管石墨消解-原子荧光光谱法测定土壤中总砷和总汞含量。称取国家一级土壤标准物质GBW 07428、GBW 07408样品于离心管中,采用王水消解,测定土壤中总砷和总汞含量。砷和汞的质量浓度在一定范围内与荧光强度具有良好的线性关系,线性相关系数均大于0.999,检出限分别为0.057、0.0043 mg/kg。测定结果的相对标准偏差为2.48%~3.82%(n=8),砷、汞的加标回收率分别为94.0%~101.4%、98.6%~103.5%。该方法检出限、精密度、准确度均能满足土壤检测的要求,样品无需过滤或放置澄清,能更好地满足日渐增加的土壤分析工作。

关键词：土壤王水方法改进原子荧光光谱法总砷总汞

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二维金属偶氮盐框架用于高效二氧化碳光还原

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Science China Materials 2024年第8期67卷 2637-2644页

作者：谷建霞王龄欣韩旭贺敬婷由思琦董曼单国刚何丹凤周付江孙春义苏忠民 Department of Chemistry Xinzhou Normal UniversityXinzhou 034000China College of Science Qiongtai Normal UniversityHaikou 571100China National&Local United Engineering Laboratory for Power Batteries Key Laboratory of Polyoxometalate Science of Ministry of EducationDepartment of ChemistryNortheast Normal UniversityChangchun 130024China School of Chemical and Environmental Engineering Changchun University of Science and TechnologyChangchun 130022China

由可见光驱动的将CO_(2)转化为高附加值燃料是一种清洁可再生的技术,有助于控制全球变暖和应对能源短缺.近年来,二维的金属偶氮盐框架(2D MAFs)因其特定的电子传输路径、高度暴露的表面活性位点及可调节的吸光能力,在CO_(2)光还原研究... 详细信息

由可见光驱动的将CO_(2)转化为高附加值燃料是一种清洁可再生的技术,有助于控制全球变暖和应对能源短缺.近年来,二维的金属偶氮盐框架(2D MAFs)因其特定的电子传输路径、高度暴露的表面活性位点及可调节的吸光能力,在CO_(2)光还原研究中备受关注.然而,对其在该领域的研究仍处于初级阶段.本文设计了一种新型二维MAFs(compound 1),通过四-(4-四唑基苯基)乙烯(H;4;TTPE)与钴的自组装实现了对CO_(2)的光还原.作为对比,通过类似的合成过程构建了具有三维结构的compound 2.非均相光催化实验结果显示,2D compound 1的光还原性能明显优于3D compound 2,在相同条件下,其CO产率高达11.56 mmol g^(-1)h^(-1),是compound 2(1.94 mmol g^(-1)h^(-1))的6倍.这一性能优势源于compound 1独特的二维结构,其不仅具有有利于CO_(2)还原的能级,还能在整个CO_(2)光还原过程中促进电子-空穴高效分离.本工作为设计适用于高效CO_(2)光还原的2D MAFs光催化剂指引了方向.

关键词：光还原表面活性位能源短缺二维结构二氧化碳三维结构传输路径全球变暖

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Construction of heparin-based hydrogel incorporated with Cu_(5.4)O ultrasmall nanozymes for wound healing and inflammation inhibition

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Bioactive Materials 2021年第10期6卷 3109-3124页

作者： Yuan Peng danfeng he Xin Ge Yifei Lu Yuanhao Chai Yixin Zhang Zhengwei Mao Gaoxing Luo Jun Deng Yan Zhang Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai JiaoTong University School of Medicine639 Zhi Zao Ju RoadShanghai200011China Institute of Burn Research Southwest HospitalState Key Lab of TraumaBurn and Combined InjuryChongqing Key Laboratory for Disease ProteomicsThird Military Medical University(Army Medical University)Chongqing400038China Department of Gastroenterology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing400010China McKelvey School of Engineering Washington University in Saint LouisOne Brookings Drive Saint LouisMO63130USA MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China

Excessive production of inflammatory chemokines and reactive oxygen species(ROS)can cause a feedback cycle of inflammation response that has a negative effect on cutaneous wound *** use of wound-dressing materials that simultaneously absorb chemokines and scavenge ROS constitutes a novel‘weeding and uprooting’treatment strategy for inflammatory *** the present study,a composite hydrogel comprising an amine-functionalized star-shaped polyethylene glycol(starPEG)and heparin for chemokine sequestration as well as Cu_(5.4)O ultrasmall nanozymes for ROS scavenging(Cu_(5.4)O@hep-PEG)was *** material effectively adsorbs the inflammatory chemokines monocyte chemoattractant protein-1 and interleukin-8,decreasing the migratory activity of macrophages and ***,it scavenges the ROS in wound fluids to mitigate oxidative stress,and the sustained release of Cu_(5.4)O promotes *** acute wounds and impaired-healing wounds(diabetic wounds),Cu_(5.4)O@hep-PEG hydrogels outperform the standard-of-care product Promogram®in terms of inflammation reduction,increased epidermis regeneration,vascularization,and wound closure.

关键词： Inflammatory chemokines Reactive oxygen species Nanozymes Hydrogels Wound healing

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DNA methylation in poultry:a review

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Journal of Animal Science and Biotechnology 2024年第2期15卷 509-518页

作者： Xing Ju Zhijun Wang danfeng Cai Semiu Folaniyi Bello Qinghua Nie State Key Laboratory for Conservation and Utilization of Subtropical Agro‑Bioresources Lingnan Guangdong Laboratory of AgricultureCollege of Animal ScienceSouth China Agricultural UniversityGuangzhouGuangdong 510642China Guangdong Provincial Key Lab of Agro‑Animal Genomics and Molecular Breeding and Key Lab of Chicken Genetics Breeding and ReproductionMinistry of AgricultureGuangzhouGuangdong 510642China College of Animal Science and Technology Zhejiang Agriculture and Forestry University666 Wusu RoadLin’an 311300China

As an important epigenetic modification,DNA methylation is involved in many biological processes such as animal cell differentiation,embryonic development,genomic imprinting and sex chromosome *** DNA methylation sequencing becomes more sophisticated,it becomes possible to use it to solve more zoological *** paper reviews the characteristics of DNA methylation,with emphasis on the research and application of DNA methylation in poultry.

关键词： CpG islands Differentially methylated genes Differentially methylated regions DNA methylation Poultry

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Recent advances of on-demand dissolution of hydrogel dressings

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Burns & Trauma 2018年第4期6卷 242-254页

作者： Hao Lu Long Yuan Xunzhou Yu Chengzhou Wu danfeng he Jun Deng Department of Dermatology Chongqing Traditional Chinese Medicine HospitalChongqing 400021China Institute of Burn Research South-West HospitalState Key Lab of TraumaBurn and Combined InjuryThird Military Medical University(Army Medical University)Gaotanyan Road No.30Shapingba DistrictChongqing 400038China Department of Breast Surgery Southwest HospitalThird Military Medical University(Army Medial University)Chongqing 400038China Department of Respiratory Wuxi Country People’s HospitalChongqing 405800China

Wound management is a major global challenge and a big financial burden to the healthcare system due to the rapid growth of chronic diseases including the diabetes, obesity, and aging population. Modern solutions to wound management include hydrogels that dissolve on demand, and the development of such hydrogels is of keen research interest. The formation and subsequent on-demand dissolution of hydrogels is of keen interest to scientists and clinicians. These hydrogels have excellent properties such as tissue adhesion, swelling, and water absorption. In addition, these hydrogels have a distinctive capacity to form in situ and dissolve on-demand via physical or chemical reactions. Some of these hydrogels have been successfully used as a dressing to reduce bleeding in hepatic and aortal models, and the hydrogels remove easily afterwards. However, there is an extremely wide array of different ways to synthesize these hydrogels. Therefore, we summarize here the recent advances of hydrogels that dissolve on demand, covering both chemical cross-linking cases and physical cross-linking cases. We believe that continuous exploration of dissolution strategies will uncover new mechanisms of dissolution and extend the range of applications for hydrogel dressings.

关键词： Wound management Wound dressing On-demand dissolution Hydrogel

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Fabrication and characterization of multi-scale coated boron powders with improved combustion performance:A brief review

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Defence Technology（防务技术） 2024年第1期31卷 27-40页

作者： Rui Liu danfeng Yang Kunyu Xiong Ying-Lei Wang Qi-Long Yan Science and Technology on Combustion Internal Flow and Thermo-structure LaboratoryNorthwestern Polytechnical UniversityXi'an710072China Xi'an Modern Chemistry Research Institute Xi'an710065China

Boron has high mass and volume calorific values,but it is difficult to ignite and has low combustion *** literature review summarizes the strategies that are used to solve the above-mentioned problems,which include coatings of boron by using fluoride compounds,energetic composites,metal fuels,and metal *** techniques include recrystallization,dual-solvent,phase transfer,electrospinning,*** one of the effective coating agents,the fluorine compounds can react with the oxide shell of boron *** comparison,the energetic composites can effectively improve the flame temperature of boron powder and enhance the evaporation efficiency of oxide film as a condensed *** and metal oxides would react with boron powder to form metal borides with a lower ignition point,which could reduce its ignition temperature.

关键词： Boron powder coating Structure and morphology Condensed phase thermal reaction Ignition and combustion

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Asymmetric side-chain engineering of organic semiconductor for ultrasensitive gas sensing

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Chinese Chemical Letters 2024年第3期35卷 428-433页

作者： Xiaoying Ma Xiaojuan Dai Lanyi Xiang Jiajun Chang danfeng Zhi Haozhen Zhao Zhenjie Ni Ye Zou Xike Gao Fengjiao Zhang School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China Laboratory of Organic Solids Institute of ChemistryChinese Academy of SciencesBeijing 100190China Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China Binzhou Institute of Technology Binzhou 256606China

Molecular structure of organic semiconductor plays a critical role in determining the performance and functionality of organic electronic devices,by optimizing the electrical,optical and physicochemical *** alkyl chains are fundamental units in tailering the solubility and assemblability,among which the asymmetric properties have been reported as key element for controlling the packing motifs and intrinsic charge ***,we expanded the scope of molecular asymmetry dependent sensing features based on a new series of naphthalene diimides(NDI)-based derivatives substituted with a same branching alkyl chain but various linear-shaped alkyl chains(Cn-).A clear molecular stacking change,from head-to-head bilayer to head-to-tail monolayer packing model,is observed based on the features of anisotropic molecular interactions with the change in the chain *** importantly,a unique LUMO level shift of 0.17 eV is validated for NDI-PhC4,providing a record sensitivity up to 150%to 0.01 ppb ammonia,due to the desired molecular reactivity and device amplification *** results indicate that asymmetric side-chain engineering opens a route for breath healthcare.

关键词： Organic thin film transistor Asymmetric side chain Gas sensing Molecular stacking Energy level manipulating

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Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

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Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing Qiu Mengting Yang danfeng Gong Haiying Liang Tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

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