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第十届全国免疫学学术大会

作者： GANG lI Alissa l Moss Thomas A Medsger Jr Robyn T Domsic Mary R lucas dana E Ivanco Robert lafyatis Donna B Stolz Patrizia Fuschiotti Children's Hospital of Soochow University Department of Immunology University of Pittsburgh School of Medicine Department of Medicine Division of Rheumatology and Clinical Immunology University of Pittsburgh School of Medicine Rheumatology Section Boston University School of Medicine Department of Cell Biology University of Pittsburgh School of Medicine

Objective:loss of CD28 expression by CD8+T cells occurs with age and during chronic inflammatory ***8+CD28-T cells are a heterogeneous cell subpopulation ranging from immunosuppressive to effector *** showed previously that Interleukin(Il)-13-producing CD8+T cells are implicated in the pathogenesis of systemic sclerosis(SSc).Here we analyzed the role of CD8+CD28-T cells in SSc pathogenesis in an age-and disease-controlled cohort of ***:Flow cytometry was employed to determine cell surface phenotype,cytokine production and cytotoxicity function of peripheral blood CD8+CD28-T cells from patients and *** and apoptosis properties of CD8+T-cell subsets were measured by CFSE and Annexin V *** and immunohistochemistry were used to assess expression of cytokine and markers of cytotoxicity by CD8+T cells in the affected skin of ***:We found that the proportion of CD8+CD28-T cells is increased in patients with SSc independently of patient age and correlates with the extent of skin *** CD8+CD28-T cells are found in the effector and effector/memory subsets,secrete Il-13,and are ***,they exhibit normal levels of proliferation and susceptibility to ***,Il-13-producing CD8+T cells that express markers of cytotoxicity are found in the sclerotic skin of ***:We provide new insight into the pathogenesis of SSc by identifying a pathogenic CD8+T-cell subset characterized by profibrotic Il-13 overproduction and direct cellular *** novel molecular targets may open avenues for future therapeutic intervention.

关键词： scleroderm CD8+CD28-T cells perforin granzyme B Il-13

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Correlation of Ceruloplasmin with Biomarkers of Cardiac Remodelling and Myofibrosis in Patients with Acute Decompensated Heart Failure Referred to a Tertiary Nurse lead Heart Failure Clinic

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Open Journal of Nursing 2015年第11期5卷 971-975页

作者： Filip Malek Dagmar Vondrakova Oxana Komendova dana Ríhova Jana Vranova lenka Sedlackova Tana Andreasova Petr Neuzil Department of Cardiology Na Homolce HospitalPragueCzech Republic Third School of Medicine Charles UniversityPragueCzech Republic Department of Clinical Biochemistry Haematology and ImmunologyNa Homolce HospitalPragueCzech Republic

Background: Ceruloplasmin is an acute phase protein with plasma copper binding properties, and is a potent extracellular antioxidative enzyme. Inflammation and oxidative stress might explain the role of ceruloplasmin in the pathophysiology of heart failure. Study objective: The objective is to assess the correlation of ceruloplasmin levels with biomarkers of cardiac remodelling and myofibrosis in patients with acute decompensated heart failure. Patients and methods: Blood samples were taken and serum levels of soluble ST2, galectin-3, NT-proBNP and ceruloplasmin were analysed in 31 consecutive patients with systolic HF referred to tertiary care nurse lead heart failure clinic with acute decompensated CHF requiring i.v. diuretics. The mean patients’ age was 68 years, mean left ventricular ejection fraction (lV EF) was 29%, 66% patients had ischemic aetilogy of CHF and 33% had atrial fibrillation. Results: The mean ceruloplasmin level was 0.243 g/l, mean galectin-3 level was 1.26 ng/ml, mean sST2 level was 38.15 ng/ml, and mean NT-proBNP was 1927 pg/ml. The ceruloplasmin level correlated with NT-proBNP (r = 0.58, p levels correlated significantly with NT-proBNP (r = 0.66, p loplasmin level did not correlate with galectin-3 concentration. Conclusion: The ceruloplasmin level correlates with the biomarkers of cardiac remodelling (NT-proBNP, sST2), but not with the biomarker of myofibrosis (galectin-3). This finding supports the hypothesis of inflammatory response in acute decompensated heart failure.

关键词： Acute Decompensated Heart Failure Ceruloplasmin NT-proBNP sST2 Galectin-3

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Novel Biomarkers of Contrast-Induced Kidney Injury after Endovascular Procedures: An Interventional Cardiologists Notion

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World Journal of Cardiovascular Diseases 2019年第12期9卷 942-957页

作者： Anton Khilchuk dana Abdulkarim Sergei Vlasenko Sergei Abugov Sergei Scherbak Vitalii Popov Dmitrii Vorobyovskii Maksim Agarkov Andrei Sarana Evgenii Karmazanashvili Department of Interventional Radiology City Hospital No. 40 Saint-Petersburg Russia Medical Faculty Saint-Petersburg State University Saint-Petersburg Russia Endovascular and Arrhythmology Department Russian National Research Center of Surgery Named after Academician B.V. Petrovsky Moscow Russia Department of Interventional Radiology Gusev Central Regional Hospital Gusev Yekaterinburg Russia Department of Interventional Radiology City Hospital No. 26 Saint-Petersburg Russia

Modern achievements of interventional cardiology in treatment of coronary heart disease (CHD) have significantly increased frequency of interventions and volume of contrast media (CM). Contrast-induced acute kidney injury (CIAKI) associated with CM administration is determined by 26.5 μmol/l increase in serum creatinine (SCr) within 48 - 72 hours or >?1.5-fold SCr increase versus its known or estimated level in the previous 7 days. Without effective disease management, prevention with early CIAKI risk stratification and cessation of nephrotoxic medications taken by patients are important. Given significant complexity in existing CIAKI treatment, modern therapeutic options are limited only to adequate renal injury prevention. The problem’s significance and diagnostic limitations associated with SCr definition require search for clinically and diagnostically significant AKI biomarkers. In terms of coronarography and percutaneous coronary interventions, several studies have been conducted on clinical and diagnostic significance of some biomarkers. This article characterizes and discloses prospective practical use of neutrophil gelatinase-associated lipocalin (NGAl), liver-type fatty acid binding protein (l-FABP), kidney injury molecule-1 (KIM-1), cystatin C (CysC) and interleukins-6,8,18 (Il-6,8,18) in interventional cardiology.

关键词： Percutaneous Coronary Intervention Acute Kidney Injury Coronary Artery Disease

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STAT3在SAMe抑制HepG2细胞VEGF表达中的作用

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上海交通大学学报（医学版） 2006年第6期26卷 576-580页

作者：邱伟华 Bingsen Zhou dana Darwish Peiguo G.Chu Frank luh 陈皓杨卫平李宏为 Yun Yen 上海交通大学医学院瑞金医院器官移植中心 Department of Medical Oncology & Therapeutic Research Department of Pathology City of Hope National Medical CenterDuarteCA91010USA

目的研究肝癌细胞(HepG2)和正常胎肝细胞(Cl-48)血管内皮生长因子(VEGF)和信号转导与转录激活因子3(STAT3)的表达状态,以及S-腺苷甲硫氨酸(SAM e)对其的干预作用,为HepG2和Cl-48的不同调控途径提供功能性依据。方法在对数生长期的Cl-48... 详细信息

目的研究肝癌细胞(HepG2)和正常胎肝细胞(Cl-48)血管内皮生长因子(VEGF)和信号转导与转录激活因子3(STAT3)的表达状态,以及S-腺苷甲硫氨酸(SAM e)对其的干预作用,为HepG2和Cl-48的不同调控途径提供功能性依据。方法在对数生长期的Cl-48和HepG2细胞中加入不同浓度的SAM e(0、0.5、1.0 mmol/l)作用72 h,分别采用Northern印迹法、实时荧光定量PCR、W estern印迹法以及[3H]胸腺嘧啶脱氧核苷掺入法(3H-Tdr)和细胞克隆形成法,观察VEGF和STAT3表达的变化趋势,分析DNA合成及细胞生长能力的变化。结果SAM e作用前(SAM e 0 mmol/l),HepG2和Cl-48均呈现VEGF和STAT3高表达状态。SAM e作用后:HepG2的VEGF和STAT3表达明显降低,并呈现剂量-效应关系,DNA合成和细胞生长能力明显受限;Cl-48的STAT3表达虽然受到抑制,但VEGF的高表达状态无明显降低趋势,且DNA合成和细胞生长能力无显著变化。结论虽然HepG2和Cl-48均呈现VEGF和STAT3的高表达,但二者具有不同的调控途径;SAM e通过抑制STAT3的组成性活化而降低VEGF的高表达状态,可能是SAM e的肝脏保护机制之一。

关键词：血管内皮生长因子信号转导与转录激活因子3 S-苷甲硫氨酸肝细胞性肝癌

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An examination of the population dynamics of syngnathid fishes within Tampa Bay,Florida,USA

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Current Zoology 2010年第1期56卷 118-133页

作者： Heather D.MASONJONES Emily ROSE lori Benson McRAE Danielle l.DIXSON Biology Department University of Tampa Biology Department Texas A & M University School of Marine and Tropical Biology James Cook University

Seagrass ecosystems worldwide have been declining, leading to a decrease in associated fish populations, especially those with low mobility such as syngnathids （pipefish and seahorses）. This two-year pilot study investigated seasonal patterns in density, growth, site fidelity, and population dynamics of Tampa Bay （Fl） syngnathid fishes at a site adjacent to two marinas under construction. Using a modified mark-recapture technique, fish were collected periodically from three closely located sites that varied in seagrass species （Thalassia spp., Syringodium spp., and mixed-grass sites） and their distance from open water, but had consistent physical/chemical environmental characteristics. Fish were marked, photographed for body size and gender measurements, and released the same day at the capture site. Of the 5695 individuals surveyed, 49 individuals were recaptured, indicating a large, flexible population. Population density peaks were observed in July of both years, with low densities in late winter and late summer. Spatially, syngnathid densities were highest closest to the mouth of the bay and lowest near the shoreline. Seven species of syngnathid fishes were observed, and species-specific patterns of seagrass use emerged during the study. However, only two species, Syngnathus scovelli and Hippoeampus zosterae, were observed at high frequencies. For these two species, body size decreased across the study period, but while S. scovelli＇s population density decreased, H. zosterae＇s increased. Across six of the seven species, population size declined over the course of this preliminary study; however, seasonal shifts were impossible to distinguish from potential anthropogenic effects of construction [Current Zoology 56 （1）： 118-133, 2010].

关键词： Syngnathids Habitat-use Seahorse Pipefish Population density Mark-recapture

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2016年

作者： (美)达纳·盖恩斯·罗宾逊(dana Gaines Robinson)[等]

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Phenotypic Characterization and Prevalence of Carbapenemase-Producing Acinetobacter baumanii Isolates in Four Health Facilities in Cameroon

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Open Journal of Medical Microbiology 2023年第3期13卷 234-249页

作者： Cécile Ingrid Djuikoue Benhamed Nadjia Paule dana Djouela Djoulako Celianthe Guegang Cedric Seugnou Nana Hélène Valérie Same Njanjo Yemina Grace Kombeu Christiane Kiyang Possi Rodrigue Kamga Wouambo Gandhi Ndieffouo Fosso Merimé Joel Tchinda Talokou Bianca Tchounga Chimi Olivier Pomte Agbor Michael Benjamin D. Thumamo Pokam Nicolas Antoine-Moussiaux Department of Public Health Faculty of Health Sciences of the Université des Montagnes Bangangté Cameroon American Society for Microbiology Bangangte Cameroon Université des Sciences et de la Technologie d’Oran Mohamed Boudiaf Oran Algeria Faculty of Medicine Sorbonne Université Paris France Estuary Academic and Strategic Institute (IUEs/INSAM) Douala Cameroon Faculty of Medicine and Pharmaceutic Sciences University of Douala Douala Cameroon Division of Hepatology Department of Medicine II Leipzig University Medical Center University of Leipzig Leipzig Germany Centre Hospitalier Dominicain St Martin de Porres Yaounde Cameroon Department of Medical laboratory Science Faculty of Health Sciences University of Buea Buea Cameroon Faculty of Veterinary Medicine University of Liège Liège Belgium

Background and Objective: Nowadays, the clinical utility of carbapenems is threatened by the emergence of resistant bacteria, favored by its increasing use. According to the WHO, Acinetobacter baumannii: nosocomial infection agent, tops the list of priority antibiotic-resistant pathogens, considered to be the riskiest for humans. This study sought to determine the prevalence of carbapenemase-producing Acinetobacter baumannii strains in four health facilities in the Center and littoral regions of Cameroon and the associated risk factors. Materials and Method: An analytical cross-sectional study was conducted over a six-month period from January to June 2022. All suspicious A. baumanii isolates obtained from pathological samples at the bacteriology laboratory of the different health facilities were systematically collected and re-identified. Re-identification and antimicrobial susceptibility Testing (AST) were performed using the VITEK 2 System and the Kirby-Bauer method according to the guidelines of the Clinical and laboratory Standards Institute (ClSI). Detection and phenotypic characterization of carbapenemases was performed according to adequate standard procedures. Results: A total of 168/226 clinical isolates of Acinetobacter baumannii were confirmed after re-identification, among which 52.69% derived from male patients, 55.09% from participants aged between 10 - 39 years old, and 46.71% from pus samples. A very high resistance rates to all families of antibiotics was noted, except to colistin (10.2%). 40.12% of these isolates produced carbapenemase, represented by 62.69% of class B and 37.31% of class A. Carbapenemase production was observed only at HMR1, Centre region and at laquintinie hospital, littoral region with 53.33% and 50% respectively, even if there is no significant difference (P = 0.81). In addition, frequent hospitalisation was significantly associated to the production of carbapenemase among A. baumanii (Adjusted-OR = 16.53, P-value 0.0001). Con

关键词： Acinetobacter baumannii Resistance Carbapenemases Health Facilities

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Assemblage-based biomonitoring of freshwater ecosystem health via multimetric indices:A critical review and suggestions for improving their applicability

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Water Biology and Security 2022年第3期1卷 28-42页

作者： Robert l.Vadas Jr. Robert M.Hughes Yeon Jae Bae Min Jeong Baek Orestes Carlos Bello Gonzáles Marcos Callisto Débora ReisdeCarvalho Kai Chen Maria T.Ferreira Pablo Fierro Jon S.Harding dana M.Infante C.J.Kleynhans Diego R.Macedo Isabela Martins Norman Mercado Silva Nabor Moya Susan J.Nichols Paulo S.Pompeu Renata Ruaro Deborah R.O.Silva R.Jan Stevenson Bianca de Freitas Terra Christa Thirion Douglas Ticiani lizhu Wang Chris O.Yoder 2909 Boulevard Rd SEOlympiaWA98501-3971USA Amnis Opes Institute 2895 SE GlennCorvallisOR97333USA Department of Fisheries Wildlife&Conservation SciencesOregon State UniversityCorvallisOR97331USA Division of Environmental Science&Ecological Engineering Korea University145 Anam-roSeongbuk-guSeoul02841South Korea National Institute of Biological Resources Ministry of Environment42 Hwangyeong-roSeo-guIncheon22689South Korea Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de Morelos1001Col.ChamilpaC.P62209CuernavacaMorelosMexico Departamento de Genética Ecologia e EvoluçaoInstituto de Ciências BiologicaUniversidade Federal de Minas GeraisAvenida Ant^onio Carlos 6627CEP31270-901Belo HorizonteMGBrazil Departamento de Ecologia e Conservaçao Universidade Federal de Lavras37200-900LavrasMGBrazil State Key laboratory of Marine Resource Utiliization in South China Sea Hainan UniversityHaikou570228China Forest Research Centre&Associate laboratory TERRA University of LisbonTapada da Ajuda1349-017LisbonPortugal Instituto de Ciencias Marinas y limnologicas Universidad Austral de ChileValdiviaChile School of Biological Sciences University of CanterburyPrivate Bag 4800Christchurch8140New Zealand Department of Fisheries&Wildlife Michigan State University1405 South Harrison Road#318East LansingMI48823USA Department of Water Affairs and Forestry(retired) 8th Avenue 771Wonderboom South0084PretoriaSouth Africa Departamento de Geografia Instituto de GeociênciasUniversidade Federal de Minas GeraisAvenida Antônio Carlos 6627CEP31270-901Belo HorizonteMGBrazil Instituto Guaicuy 109 Rua BrasopolisBelo HorizonteMG31150-170Brazil Centro de Investigación en Biodiversidad y Conservación Universidad Autónoma del Estado de MorelosAvenida Universidad 1001Col.ChamilpaC.P.62209CuernavacaMorelosMexico Instituto Experimental de Biología Universidad San Francisco Xavier de ChuquisacaSucreBolivia Centre for Applied Water Science Un

Freshwater biota are more comprehensive and direct indicators of biological impacts,and more meaningful to the public than water quality or physical habitat *** biotic data and the multiple biological indicators developed from them offer a much richer array of data for assessing the impacts of pollution controls than a limited set of physical or chemical *** recent decades,assemblage-based assessments by ecologists,environmental scientists,and water quality agencies have been employed globally for determining the condition of,and threats to,freshwater ecosystems.A key step in this advance has been the development of multimetric indices(MMIs)or indices of biotic integrity(IBIs)based on quantitative assessments of algae,macrophyte,macroinvertebrate,fish or riparian bird *** Europe,where biological assemblages are mandated for assessing freshwater ecosystem health,many indices are ***,the proliferation of MMIs globally has not always occurred through the application of rigorous study designs and monitoring protocols,nor have they always effectively incorporated functional metrics,stressor assessments,and statistical ***,in this review,we discuss eleven major concerns with the development and application(including logistical limitations)of multimetric indicators based on freshwater biota to encourage more rigorous and widely applicable(transferable)MMI use and ***,our concerns focus on reference conditions;sampling effort,methods,and season;trophic guild definition;metric comprehensiveness,options,screening and scoring;and MMI *** could also benefit from increased attention to ecological mechanisms and metric development,to further improve our understanding of anthropogenic impacts as well as rehabilitation effects on freshwater ecosystems *** closer attention to study designs,ecological mechanisms and metric development should further improve our understa

关键词： IBI MMI Fish Macroinvertebrates Algae Streams Rivers lakes Wetlands Biological monitoring

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lED光质对决明芽苗菜光合色素和营养品质的影响

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河南师范大学学报（自然科学版） 2017年第2期45卷 60-64,70页

作者：王静姜静王丹王茹丹李汇阳李景原河南师范大学生命科学学院河南新乡453007 河南师范大学河南省绿色药材生物技术工程实验室河南新乡453007

以决明(Cassia tora l.)幼苗为材料,采用半导体发光二极管光源(lED)精确调制白光(W)、红光(R)、蓝光(B)、绿光(G),对决明(***)芽苗进行2 h的辐照处理,探究对决明(***)芽苗菜光合色素、可溶性糖、可溶性蛋白、总酚、类黄酮及花青素含量... 详细信息

以决明(Cassia tora l.)幼苗为材料,采用半导体发光二极管光源(lED)精确调制白光(W)、红光(R)、蓝光(B)、绿光(G),对决明(***)芽苗进行2 h的辐照处理,探究对决明(***)芽苗菜光合色素、可溶性糖、可溶性蛋白、总酚、类黄酮及花青素含量的影响.结果表明:以室内自然光处理(D)为对照,各光质都显著提高决明(***)芽苗菜中叶绿素及类胡萝卜素的含量,绿光处理叶绿素a含量增加了31.73%,白光处理叶绿素b以及叶绿素总含量、类胡萝卜素含量分别增加了50.20%、33.62%、52.71%;红光处理可溶性糖含量增加了57.04%;蓝光、白光和红光处理可溶性蛋白含量分别增加了69.33%、51.74%、40.58%;几种光质处理后总酚和类黄酮含量都明显高于对照组,但不同光质间差异不明显;蓝光处理花青素含量最高,增加了32.89%.生产中可通过增加lED照射提高决明(***)芽苗菜的营养品质.

关键词： lED光质决明芽苗菜光合色素营养品质

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有机氯杀虫剂与子宫内膜异位症的风险:来自一个以人群为基础的病例对照研究结果

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环境与职业医学 2014年第4期31卷 287-287页

作者： Kristen Upson Anneclaire J.De Roos Mary lou Thompson Sheela Sathyanarayana Delia Scholes dana Boyd Barr Victoria l.Holt

摘要：[背景]子宫内膜异位症是一种雌激素依赖性疾病。具有激素特性的持久性环境化学物，例如有机氯杀虫剂（OCPs），可能会影响子宫内膜异位症的风险。[目的]探讨子宫内膜异位症的风险与环境OCPs暴露之间的相关性。[方法]数据来自妇女... 详细信息

摘要：[背景]子宫内膜异位症是一种雌激素依赖性疾病。具有激素特性的持久性环境化学物，例如有机氯杀虫剂（OCPs），可能会影响子宫内膜异位症的风险。[目的]探讨子宫内膜异位症的风险与环境OCPs暴露之间的相关性。[方法]数据来自妇女子宫内膜异位症风险（WREN）研究，这是一项以人群为基础的子宫内膜异位症的病例一对照研究，参加者为华盛顿州西部一个大型医疗保健系统中18～49岁的女性。

关键词：子宫内膜异位症病例对照研究有机氯杀虫剂风险人群雌激素依赖性疾病环境化学物医疗保健系统

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