检索结果-南通市图书馆

中国肿瘤 1995年第7期4卷 25-27页

作者：方福德左瑾丁濂王燕云高惠兰张敏磊杨俊保 W．d．Henner 中国医学科学院基础医学研究所北京100005 美国哈佛大学dana-Farber癌症研究所

维普期刊数据库

Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion

在线全文

学校读者我要写书评

暂无评论

Copy number variation detection in whole-genome sequencing d...

Sci Rep:科学家阐明线粒体的程序性细胞死亡过程

第五届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会高通量时代的生物信息学与系统生物学

作者：席瑞斌 Angela G Hadjipanayis Lovelace J.Luquette Tae-Min Kim Eunjung Lee Jianhua Zhang Mark d.Johnson donna M.Muzny david A.Wheeler Richard A.Gibbs Raju Kucherlapati Peter J.Park Center for Biomedical Informatics Harvard Medical SchoolBostonMassachusetts 02115USA division of Genetics Brigham andWomen's HospitalBostonMA 02115 The Belfer Institute for Applied Cancer Science Dana-Farber Cancer InstituteBostonMA 02115 department of Neurological Surgery Brigham and Women Hospital and Harvard Medical SchoolBostonMassachusetts 02115 Genome Sequencing Center Baylor College of MedicineHoustonTX division of Genetics Brigham and Women's HospitalBostonMA 02115 department of Genetics Harvard Medical SchoolBostonMA 02115 Children's Hospital Informatics Program BostonMassachusetts 02115USA

dNA copy number variations(CNVs) play an important role in the pathogenesis and progression of cancer and confer susceptibility to a variety of human *** this study, we developed an algorithm to detect CNVs from whole-genome sequencing data and applied it to a newly sequenced glioblastoma genome with a matched *** read-depth algorithm,called BIC-seq,can accurately and efficiently identify CNVs via minimizing the Bayesian information criterion(BIC).Using BIC-seq,we identified hundreds of CNVs as small as 40 bp in the cancer genome sequenced at 10X coverage,while we could only detect large CNVs(>15 Kb) in the array CGH profiles for the same *** percent(14/16) of the small variants tested(110 bp to 14 Kb) were experimentally validated by quantitative PCR,demonstrating high sensitivity and true positive rate of the *** also extended the algorithm to detect recurrent CNVs in multiple samples as well as deriving error bars for breakpoints using a Gibbs sampling approach.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

现代生物医学进展 2016年第35期16卷 I0004-I0004页

作者： Ted d. Pham Phi Q. Pham Jinfeng Li Anthony G. Letai douglas C. Wallace Peter J. Burke department of Biomedical Engineering University of California Irvine CA USA department of Chemical Engineering and Materials Science University of California Irvine CA USA department of Chemical Engineering and Materials Science University of California Irvine CA USA dana-Farber Cancer Institute Harvard University Boston MA USA Center for Mitochondrial and Epigenomic Medicine Children’s Hospital of Philadelphia and Department of Pathology and Laboratory Medicine University of Pennsylvania Philadelphia PA USA department of Biomedical Engineering University of California Irvine CA USA department of Chemical Engineering and Materials Science University of California Irvine CA USA department of Electrical Engineering and Computer Science University of California Irvine CA USA

日前。发表在Scientific Reports杂志上的一篇研究报告中，来自加利福尼亚大学等机构的研究人员通过利用一种由石墨烯组成的新型传感器深入解析了线粒体的程序性细胞死亡过程，该研究或为驱动癌细胞自我毁灭提供了新的线索。研究者通过... 详细信息

日前。发表在Scientific Reports杂志上的一篇研究报告中，来自加利福尼亚大学等机构的研究人员通过利用一种由石墨烯组成的新型传感器深入解析了线粒体的程序性细胞死亡过程，该研究或为驱动癌细胞自我毁灭提供了新的线索。研究者通过研究开发了一种监测线粒体改变的电子学方法，该方法能够指示出细胞进行自我毁灭的开始阶段，我们机体每个细胞中都有数百个、甚至数千个线粒体。每个线粒体都有着内膜和外膜结构；作为细胞的能量工厂，线粒体会对细胞中的碳水化合物和脂肪进行代谢产能以便细胞利用并且储存。但同时线粒体还有第二个角色，那就是调节细胞的生死通路。

关键词：死亡过程癌细胞线粒体程序性 Sci 科学家 Rep 加利福尼亚大学

Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2022年第3期7卷 856-868页

作者： Qi Zhang Bridget Riley-Gillis Lina Han Yanan Jia Alessia Lodi Haijiao Zhang Saravanan Ganesan Rongqing Pan Sergej N.Konoplev Shannon R.Sweeney Jeremy A.Ryan Yulia Jitkova Kenneth dunner Jr Shaun E.Grosskurth Priyanka Vijay Sujana Ghosh Charles Lu Wencai Ma Stephen Kurtz Vivian R.Ruvolo Helen Ma Connie CWeng Cassandra LRamage Natalia Baran Ce Shi Tianyu Cai Richard Eric davis Venkata L.Battula Yingchang Mi Jing Wang Courtney d.diNardo Michael Andreeff Jeffery W.Tyner Aaron Schimmer Anthony Letai Rose Ann Padua Carlos E.Bueso-Ramos Stefano Tiziani Joel Leverson Relja Popovic Marina Konopleva department of Leukemia The University of Texas MD Anderson Cancer CenterHoustonTXUSA AbbVie Inc. North ChicagoILUSA Institute of Hematology Chinese Academy of Medical Sciences&Peking Union Medical CollegeTianjinChina department of Nutritional Sciences Department of PediatricsDepartment of OncologyDell Medical SchoolThe University of Texas at AustinAustinTX 78712USA department of Cell Developmental&Cancer BiologyDivision of Hematology&Medical OncologyKnight Cancer InstituteOregon Health&Science UniversityPortlandORUSA Universite de Paris Institut de la Recherche Saint-Louis(IRSL)Inserm Unit 1131ParisFrance dana-Farber Cancer Institute BostonMAUSA department of Hematopathology The University of Texas MD Anderson Cancer CenterHoustonTXUSA Princess Margaret Cancer Center TorontoONCanada High Resolution Electron Microscopy Facility The University of Texas MD Anderson Cancer CenterHoustonTXUSA department of Bioinformatics&Computational Biology The University of Texas MD Anderson Cancer CenterHoustonTXUSA department of Hematology The First Hospital Affiliated Harbin Medical UniversityHarbinChina department of Lymphoma&Myeloma Research The University of Texas MD Anderson Cancer CenterHoustonTXUSA

despite high initial response rates,acute myeloid leukemia(AML)treated with the BCL-2-selective inhibitor venetoclax(VEN)alone or in combinations commonly acquires *** performed gene/protein expression,metabolomic and methylation analyses of isogenic AML cell lines sensitive or resistant to VEN,and identified the activation of RAS/MAPK pathway,leading to increased stability and higher levels of MCL-1 protein,as a major acquired mechanism of VEN resistance.

关键词： acute myeloid acquired

Mutation-Specific Antibodies for the detection of EGFR Mutations in Non-Small-Cell Lung Cancer

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mutation-Specific Antibodies for the Detection of EGFR Mutat...

内镜下全层折叠术治疗胃食管反流病:北美地区的术后12个月随访的开放试验

第六届全国免疫学学术大会

作者： Susan Kane Elisa Benedettini Cynthia Reeves Gregory Innocenti Randy Wetzel Katherine Crosby Alison Becker Michelle Ferrante Gabriel Cheung Lucian R.Chirieac Lynette M.Sholl Herbert Haack Bradley Smith Roberto d.Polakiewicz Massimo Loda Michael J.Comb Cell Signaling Technology Inc.3 Trask LaneDanversMA 01923 department of Medical Oncology and Center for Molecular Oncologic Pathology Dana-Farber Cancer InstituteBrigham & Women’s HospitalBostonMassachusetts 02115USA

Activating mutations within the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) are found in approximately 10-20% of non-small cell lung cancer (NSCLC) patients and are associated with response t...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（胃肠病学分册） 2005年第9期1卷 28-28页

作者： Pleskow d. Rothstein R. Lo S. A. Lembo 赵天智 Beth Israel deaconess Medical Center Dana 501 330 Brookline Ave. Boston MA 02215 United States Dr.

Background: The aim of this study was to assess the intermediate-term (12-month) safety and efficacy of endoscopic full-thickness plication in patients with symptomatic GERd. Methods: Sixty-four patients with chronic heartburn that required maintenance antisecretory therapy received a single, endoscopically placed, full-thickness plication in the gastric cardia 1 cm distal to the gastroesophageal junction. At baseline and 12 months after plication, patients completed the GERd Health Related Quality of Life questionnaire, Gastrointestinal Symptom Rating Scale, and SF-36 Health Survey, as well as a medication use diary. Ambulatory 24-hour pH monitoring and esophageal manometry were obtained at baseline and 3 months after plication. At 6 months after plication, the 24-hour pH study was repeated. Results: Of the 57 patients who completed the 12-month follow-up, 40 (70%) were no longer taking a proton pump inhibitor. Median GERd Health Related Quality of Life scores were improved compared with baseline while taking medication (19.0 vs. 5.0; p d while not taking medication (13.0 vs. 5.0; p dure, an improvement in distal esophageal acid exposure was demonstrated in 40 of 51 patients (80%), with a decrease of 39%in the median percentage of time the pH was less than 4 (p d in 30%of patients. All procedure-related adverse events occurred acutely, as previously reported, and no new adverse event was observed during extended follow-up. Conclusions: Full-thickness plication at the gastroesophageal junction is an effective endoscopic procedure for treatment of patients with symptoms caused by GERd. It reduces reflux symptoms and antisecretory medication use over at least a 1-year period.

关键词：折叠术开放试验胃食管反流食管测压连接部反流症状质量调查表胃肠症状等级量表灼热感

维普期刊数据库

一种对活化的RAS P21特异性的单克隆抗体

在线全文

学校读者我要写书评

暂无评论

细胞与分子免疫学杂志 1987年第1期 101-101页

作者： W.P.Carney,P.Hamer,d.Petic,H.Wolfe.M.Lefbvre,M.Lefbvre,G.Cooper,H.Rabin,E.I.dupont de Nemours,黄其全 Biomedical Products department N. Billerica MA and the department of Pathology Tufts New England Medical Center and dana Farber Cancer Institute. Boston MA Biomedical Products department N. Billerica MA and the department of Pathology Tufts New England Medical Center and dana Farber Cancer Institute. Boston MA Biomedical Products department N. Billerica MA and the department of Pathology Tufts New England Medical Center and dana Farber Cancer Institute. Boston MA Biomedical Products department N. Billerica MA and the department of Pathology Tufts New England Medical Center and dana Farber Cancer Institute. Boston MA Biomedical Products department N. Billerica MA and the department of Pathology Tufts New England Medical Center and dana Farber Cancer Institute. Boston MA Biomedical Products department N. Billerica MA and the department of Pathology Tufts New England Medical Center and dana Farber Cancer Institute. Boston MA Biomedical Products department N. Billerica MA and the department of Pathology Tufts New England Medical Center and dana Farber Cancer Institute. Boston MA Biomedical Products department N. Billerica MA and the department of Pathology Tufts New England Medical Center and dana Farber Cancer Institute. Boston MA

曾在10～20％的人肿瘤中检出活化的Ras转录基因,其所编码的蛋白质(P21)在12、13及61位上的氨基酸被置换。由于在人膀胱癌T24和结肠癌SW480中发现的P21与正常的P21同源特异性结构上不同,本文探讨了制备特异的与T24和SW480中活化的P211(2... 详细信息

曾在10～20％的人肿瘤中检出活化的Ras转录基因,其所编码的蛋白质(P21)在12、13及61位上的氨基酸被置换。由于在人膀胱癌T24和结肠癌SW480中发现的P21与正常的P21同源特异性结构上不同,本文探讨了制备特异的与T24和SW480中活化的P211(2位为颉氨酸)反应的单克隆抗体的可能性。一种命名为dWP的单克隆抗体可与一种人工合成的十二肽(其

关键词：单克隆抗体 RAS P21 特异性

Correction: Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2022年第5期7卷 1860-1860页

作者： Qi Zhang Bridget Riley-Gillis Lina Han Yannan Jia Alessia Lodi Haijiao Zhang Saravanan Ganesan Rongqing Pan Sergej N.Konoplev Shannon R.Sweeney Jeremy A.Ryan Yulia Jitkova Kenneth dunner Jr Shaun E.Grosskurth Priyanka Vijay Sujana Ghosh Charles Lu Wencai Ma Stephen Kurtz Vivian R.Ruvolo Helen Ma Connie C.Weng Cassandra L.Ramage Natalia Baran Ce Shi Tianyu Cai Richard Eric davis Venkata L.Battula Yingchang Mi Jing Wang Courtney d.diNardo Michael Andreeff Jeffery W.Tyner Aaron Schimmer Anthony Letai Rose Ann Padua Carlos E.Bueso-Ramos Stefano Tiziani Joel Leverson Relja Popovic Marina Konopleva department of Leukemia The University of Texas MD Anderson Cancer Center Houston TX USA Institute of Hematology Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China department of Hematology The First Hospital Affiliated Harbin Medical University Harbin China AbbVie Inc. North Chicago IL USA department of Nutritional Sciences Department of Pediatrics Department of Oncology Dell Medical School The University of Texas at Austin Austin TX 78712 USA department of Cell Developmental & Cancer Biology Division of Hematology & Medical Oncology Knight Cancer Institute Oregon Health & Science University Portland OR USA Université de Paris Institut de la Recherche Saint-Louis (IRSL) Inserm Unit 1131 Paris France dana-Farber Cancer Institute Boston MA USA department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA Princess Margaret Cancer Center Toronto ON Canada High Resolution Electron Microscopy Facility The University of Texas MD Anderson Cancer Center Houston TX USA department of Bioinformatics & Computational Biology The University of Texas MD Anderson Cancer Center Houston TX USA department of Lymphoma & Myeloma Research The University of Texas MD Anderson Cancer Center Houston TX USA

Correction to:Signal Transduction and Targeted Therapy(2022)7:1–13,https://***/10.1038/s41392-021-00870-3 In the original version of this article,given name of 4th author Yannan Jia was incorrectly published as Yanan *** original article has been *** Access This article is licensed under a Creative Commons Attribution 4.0 International License,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source.

关键词： myeloid Therapy resistance

急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议（英文）

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华神经外科疾病研究杂志 2017年第6期16卷 529-529页

作者： Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke d Burns AS Chiba K dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS Toronto Western Hospital University Health Network University of Toronto University College Cork University of Maryland University of Wisconsin University of Kansas Medical Center The University of Kansas University of Utah Toronto Rehabilitation Institute University Health Network National defense Medical College Spectrum Research Inc University of California at Los Angeles Christopher & dana Reeve Foundation Ontario Neurotrauma Foundation University of Cambridge Medical College of Wisconsin University of British Columbia Thomas Jefferson University Hospital University of Sydney Nagoya University Keio University The University of Kansas Ottawa Hospital Research Institute Thomas Jefferson University Li Ka Shing Knowledge Institute St. Michael's Hospital Sunnybrook Health Sciences Centre

The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic *** review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline development Group(GdG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI *** on GRAdE(Grading of Recommendation,Assessment,development and Evaluation),a strong recommendation is worded as " we recommend," whereas a weaker recommendation is indicated by "we suggest." Results Based on the limited available evidence and the clinical expertise of the GdG,our recommendations were:(1) "We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making"(quality of evidence,very low) and(2) "We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome "(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI.

关键词：神经外科疾病医学研究患者

维普期刊数据库

单中心244例浆液性卵巢癌病人肝受累方式及预后的重要性研究

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2017年第2期 210-210页

作者： A.C.O'Neill B.Somarouthu S.H.Tirumani M.Braschi-Amirfarzan A.d.Van den Abbeele N.H.Ramaiya 蒋宇吴兰 department of Imaging Dana -Farber Cancer Institute

摘要目的评估浆液性卵巢癌肝受累的发生率、方式及对预后的重要性。材料与方法该回顾性研究获伦理委员会批准,并免除知情同意书。共纳入经病理证实为浆液性卵巢

关键词：浆液性卵巢癌受侵中位数个月肝实质腹膜转移预后病人