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Insulinoma presenting with postprandial hypoglycemia and a low body mass index:A case report

World Journal of Clinical Cases 2020年第18期8卷 4169-4176页

作者： dana prídavková Matej Samoš Roman Kyčina Katarína Adamicová Michal Kalman Margita Belicová Marián Mokáň Clinic of Internal Medicine Ⅰ Comenius University in BratislavaJessenius Faculty of Medicine in MartinMartin 03601Slovakia Clinic of Surgery and Transplant Center Comenius University in BratislavaJessenius Faculty of Medicine in MartinMartin 03601Slovakia Department of Pathological Anatomy Comenius University in BratislavaJessenius Faculty of Medicine in MartinMartin 03601Slovakia

BACKGROUND Insulinomas are the most common type of functioning endocrine neoplasms of the pancreas presenting hypoglycemic *** characteristically develop symptoms while fasting,but some patients have reported symptoms only in the postprandial *** and prolonged hypoglycemic episodes can reduce the awareness of adrenergic symptoms,and patients may have amnesia,which delays *** SUMMARY We describe a case of a 24-year-old underweight patient who showed hypoglycemic symptoms for almost 6 *** patients with insulinoma characteristically develop symptoms while fasting,this young man had hypoglycemic symptoms up to one hour postprandially,especially after highsugar meals and after physical *** fasting tests and imaging methods performed at local hospitals were evaluated as negative for abnormal ***,brown adipose tissue exhibited increased metabolic activity,and some muscle groups had histological changes as indicated by positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro-D-glucose integrated with computed *** deficiency was also histologically *** patient’s symptoms progressed over the years and occurred more frequently,i.e.,several times a month,and the patient had reduced awareness of adrenergic *** follow-up fasting test was positive,and the imaging results showed a tumor in the head of the *** patient underwent laparotomy with enucleation of the *** Weight gain and fasting hypoglycemia are not necessarily characteristics of *** prolonged cases,adrenergic symptoms can be suppressed.

关键词： Brown adipose tissue Glycogen deficit Hypoglycemia Insulinoma Underweight Case report

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Assemblage-based biomonitoring of freshwater ecosystem health via multimetric indices:A critical review and suggestions for improving their applicability

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Water Biology and Security 2022年第3期1卷 28-42页

作者： Robert L.Vadas Jr. Robert M.Hughes Yeon Jae Bae Min Jeong Baek Orestes Carlos Bello Gonzáles Marcos Callisto Débora ReisdeCarvalho Kai Chen Maria T.Ferreira Pablo Fierro Jon S.Harding dana M.Infante C.J.Kleynhans Diego R.Macedo Isabela Martins Norman Mercado Silva Nabor Moya Susan J.Nichols Paulo S.Pompeu Renata Ruaro Deborah R.O.Silva R.Jan Stevenson Bianca de Freitas Terra Christa Thirion Douglas Ticiani Lizhu Wang Chris O.Yoder 2909 Boulevard Rd SEOlympiaWA98501-3971USA Amnis Opes Institute 2895 SE GlennCorvallisOR97333USA Department of Fisheries Wildlife&Conservation SciencesOregon State UniversityCorvallisOR97331USA Division of Environmental Science&Ecological Engineering Korea University145 Anam-roSeongbuk-guSeoul02841South Korea National Institute of Biological Resources Ministry of Environment42 Hwangyeong-roSeo-guIncheon22689South Korea Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de Morelos1001Col.ChamilpaC.P62209CuernavacaMorelosMexico Departamento de Genética Ecologia e EvoluçaoInstituto de Ciências BiologicaUniversidade Federal de Minas GeraisAvenida Ant^onio Carlos 6627CEP31270-901Belo HorizonteMGBrazil Departamento de Ecologia e Conservaçao Universidade Federal de Lavras37200-900LavrasMGBrazil State Key Laboratory of Marine Resource Utiliization in South China Sea Hainan UniversityHaikou570228China Forest Research Centre&Associate Laboratory TERRA University of LisbonTapada da Ajuda1349-017LisbonPortugal Instituto de Ciencias Marinas y Limnologicas Universidad Austral de ChileValdiviaChile School of Biological Sciences University of CanterburyPrivate Bag 4800Christchurch8140New Zealand Department of Fisheries&Wildlife Michigan State University1405 South Harrison Road#318East LansingMI48823USA Department of Water Affairs and Forestry(retired) 8th Avenue 771Wonderboom South0084PretoriaSouth Africa Departamento de Geografia Instituto de GeociênciasUniversidade Federal de Minas GeraisAvenida Antônio Carlos 6627CEP31270-901Belo HorizonteMGBrazil Instituto Guaicuy 109 Rua BrasopolisBelo HorizonteMG31150-170Brazil Centro de Investigación en Biodiversidad y Conservación Universidad Autónoma del Estado de MorelosAvenida Universidad 1001Col.ChamilpaC.P.62209CuernavacaMorelosMexico Instituto Experimental de Biología Universidad San Francisco Xavier de ChuquisacaSucreBolivia Centre for Applied Water Science Un

Freshwater biota are more comprehensive and direct indicators of biological impacts,and more meaningful to the public than water quality or physical habitat *** biotic data and the multiple biological indicators developed from them offer a much richer array of data for assessing the impacts of pollution controls than a limited set of physical or chemical *** recent decades,assemblage-based assessments by ecologists,environmental scientists,and water quality agencies have been employed globally for determining the condition of,and threats to,freshwater ecosystems.A key step in this advance has been the development of multimetric indices(MMIs)or indices of biotic integrity(IBIs)based on quantitative assessments of algae,macrophyte,macroinvertebrate,fish or riparian bird *** Europe,where biological assemblages are mandated for assessing freshwater ecosystem health,many indices are ***,the proliferation of MMIs globally has not always occurred through the application of rigorous study designs and monitoring protocols,nor have they always effectively incorporated functional metrics,stressor assessments,and statistical ***,in this review,we discuss eleven major concerns with the development and application(including logistical limitations)of multimetric indicators based on freshwater biota to encourage more rigorous and widely applicable(transferable)MMI use and ***,our concerns focus on reference conditions;sampling effort,methods,and season;trophic guild definition;metric comprehensiveness,options,screening and scoring;and MMI *** could also benefit from increased attention to ecological mechanisms and metric development,to further improve our understanding of anthropogenic impacts as well as rehabilitation effects on freshwater ecosystems *** closer attention to study designs,ecological mechanisms and metric development should further improve our understa

关键词： IBI MMI Fish Macroinvertebrates Algae Streams Rivers Lakes Wetlands Biological monitoring

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西达本胺预处理后化疗的高危难治淋巴系统恶性肿瘤16例

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白血病．淋巴瘤 2018年第12期27卷 750-753页

作者：黄顺桦孟凡义俞亚琴姚达娜钟清秀陈虹羽王晓果广东省东莞康华医院血液病中心 523000

目的探讨继西达本胺预处理后化疗的高危、难治淋巴系统恶性肿瘤患者的治疗效果方法对东莞康华医院血液病中心2015年1月至2017年6月采用西达本胺联合化疗治疗继西达本胺预处理3 d后化疗的高危、难治淋巴系统恶性肿瘤16例患者的疗效及不... 详细信息

目的探讨继西达本胺预处理后化疗的高危、难治淋巴系统恶性肿瘤患者的治疗效果方法对东莞康华医院血液病中心2015年1月至2017年6月采用西达本胺联合化疗治疗继西达本胺预处理3 d后化疗的高危、难治淋巴系统恶性肿瘤16例患者的疗效及不良反应进行分析:结果16例患者中,男性6例,女性10例,中位年龄49.5岁(23 ~ 88岁),既往系统化疗中位疗程4个(0?22个)14例入组该方案诱导化疗患者中,完全缓解(CR )7例,部分缓解(pr )7例.14例患者均获得临床疗效,总有效率(ORR)为100% 2例缓解后进入本方案巩固治疗的患者持续CR随访至2017年12月,中位随访时间为13个月(2~24个月).患者总生存(OS )9例,死亡7例,无进展生存(PFS)9例.继西达本胺预处理后化疗的不良反应常见有胃肠道反应,程度轻且可控.结论继西达本胺预处理后化疗有望提高高危、难治淋巴系统恶性肿瘤患者的治疗效果,改善疾病预后.

关键词：淋巴瘤药物疗法,联合西达本胺高危难治

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