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RANKL deletion in periodontal ligament and bone lining cells blocks orthodontic tooth movement

International Journal of Oral Science 2018年第1期10卷 27-35页

作者： Chia-Ying Yang Hyeran Helen Jeon Ahmed Alshabab Yu Jin Lee Chun-Hsi Chung dana T. Graves Department of Orthodontics School of Dental Medicine University of Pennsylvania Philadelphia PA USA Department of Pedodontics School of Dental Medicine University of Pennsylvania Philadelphia PA USA

The bone remodeling process in response to orthodontic forces requires the activity of osteoclasts to allow teeth to move in the direction of the force applied. Receptor activator of nuclear factor-κB ligand(RANKL) is essential for this process although its cellular source in response to orthodontic forces has not been determined. Orthodontic tooth movement is considered to be an aseptic inflammatory process that is stimulated by leukocytes including T and B lymphocytes which are presumed to stimulate bone resorption. We determined whether periodontal ligament and bone lining cells were an essential source of RANKL by tamoxifen induced deletion of RANKL in which Cre recombinase was driven by a 3.2 kb reporter element of the Col1α1 gene in experimental mice(Col1α***+.RANKLf/f) and compared results with littermate controls(Col1α***-.RANKLf/f). By examination of Col1α***+.ROSA26 reporter mice we showed tissue specificity of tamoxifen induced Cre recombinase predominantly in the periodontal ligament and bone lining cells. Surprisingly we found that most of the orthodontic tooth movement and formation of osteoclasts was blocked in the experimental mice, which also had a reduced periodontal ligament space. Thus, we demonstrate for the first time that RANKL produced by periodontal ligament and bone lining cells provide the major driving force for tooth movement and osteoclastogenesis in response to orthodontic forces.

关键词： DEPENDENT UP-REGULATION OSTEOCLAST DIFFERENTIATION ALKALINE-PHOSPHATASE MECHANICAL VIBRATION PDL FIBROBLASTS GENE-TRANSFER B-CELLS EXPRESSION TISSUE COMPRESSION

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ExaHDF5: Delivering Efficient Parallel I/O on Exascale Computing Systems

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Journal of Computer Science & Technology 2020年第1期35卷 145-160页

作者： Suren Byna M.Scot Breitenfeld Bin Dong Quincey Koziol Elena Pourmal dana Robinson Jerome Soumagne Houjun Tang Venkatram Vishwanath Richard Warren Lawrence Berkeley National Laboratory BerkeleyCA 94597U.S.A The HDF Group ChampaignIL 61820U.S.A Argonne National Laboratory LemontIL 60439U.S.A

Scientific applications at exascale generate and analyze massive amounts of data.A critical requirement of these applications is the capability to access and manage this data efficiently on exascale *** I/O,the key technology enables moving data between compute nodes and storage,faces monumental challenges from new applications,memory,and storage architectures considered in the designs of exascale *** the storage hierarchy is expanding to include node-local persistent memory,burst buffers,etc.,as well as disk-based storage,data movement among these layers must be *** I/O libraries of the future should be capable of handling file sizes of many terabytes and *** this paper,we describe new capabilities we have developed in Hierarchical Data Format version 5(HDF5),the most popular parallel I/O library for scientific ***5 is one of the most used libraries at the leadership computing facilities for performing parallel I/O on existing HPC *** state-of-the-art features we describe include:Virtual Object Layer(VOL),Data Elevator,asynchronous I/O,full-featured single-writer and multiple-reader(Full SWMR),and parallel *** this paper,we introduce these features,their implementations,and the performance and feature benefits to applications and other libraries.

关键词： parallel I/O Hierarchical Data Format version 5(HDF5) I/O performance virtual object layer HDF5 optimizations

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Comparison of success rate and intraocular pressure spikes between selective laser trabeculoplasty and micropulse laser trabeculoplasty in African American and Hispanic patients

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 75-80页

作者： Alexander Z Robin Palwasha Syar dana Darwish Catherine Thomas NMPfahler Agni Kakouri Thomas Patrianakos Michael Giovingo Department of Ophthalmology John H.StrogerJr.Hospital of Cook CountyChicagoIL 60612USA Rosalind Franklin University of Medicine and Science North ChicagoIL 60064USA Department of Ophthalmology and Visual Science University of Illinois at ChicagoChicagoIL 60612USA Department of General Surgery University of Texas at HoustonHoustonTX 77030USA

AIM:To examine the efficacy and safety of micropulse laser trabeculoplasty(MLT)versus selective laser trabeculoplasty(SLT)in a large cohort of primarily African American and Hispanic ***:A single center retrospective comparative cohort review conducted at Cook County Health facilities that included patients with a diagnosis of open angle glaucoma or ocular hypertension who received an SLT or MLT procedure between January 2017 and May ***:Totally 131 eyes of 99 patients were *** 77 eyes received SLT and 54 received *** out of 77 eyes in the SLT group(9.1%)and 1 out of 54 eyes in the MLT group(1.9%)had an IOP spike(defined as>5 mm Hg)at either 1h or 1wk after procedure(P=0.05,Chisquared test with Haldane-Anscombe correction).The procedure failure rate at one year was 50%for SLT and 48%for MLT(P=0.31).CONCLUSION:MLT has a significantly lower incidence of pressure spikes and a similar treatment failure rate at 1-year post-procedure,demonstrating that it is a reasonable alternative compared to SLT.

关键词： selective laser trabeculoplasty micropulse laser trabeculoplasty glaucoma open angle glaucoma ocular hypertension

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The Relevance of CARICOM＇s Existence to the Virgin Islands in the Context of Globalization

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Chinese Business Review 2011年第12期10卷 1148-1155页

作者： dana Lewis-Ambrose H. Lavity Stoutt Community College Paraquita Bay Tortola the Virgin Islands

The purpose of this study was to consider the relevance of CARICOM＇s existence to the Virgin Islands （BVI）. Its relevance becomes more significant to the BVI and the Caribbean, by extension, when the globalization phenomenon is applied; a phenomenon that has been in existence for centuries. Overall, the study concluded that even though the BVI remains only an associate member of CARICOM and not of CSME, it still has an interest in the progress of the regional grouping and its trade initiatives. Over the years, CARICOM has been struggling with its identity as a unified grouping. Nonetheless, it was found that in an effort to combat the trade liberalization process, the grouping must find that inner connection to advance its agenda on the global stage. Accordingly, it has been suggested that CARICOM begin to focus on its strengths and opportunities in order for economic development across the region to occur. It has also been recommended that more serious considerations be taken towards the development of a comprehensive regional market for the trading of goods and services, that is, the Caribbean Single Market and Economy （CSME）. To substantiate its findings, the paper used the qualitative research approach, combined with a situation （SWOT） analysis.

关键词： CARICOM qualitative research method SWOT analysis the Virgin Islands

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Ru/C催化剂上香豆素加氢制八氢香豆素（英文）

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催化学报 2015年第7期36卷 957-960页

作者： dana Bílková Petr Jansa Iva Paterová Libor erveny DepartmentofOrganicTechnology InstituteofChemicalTechnologyPragueTechnickd516628Praha6CzechRepublic AromaPrahaa.s. Zidovice6441183HrobceCzechRepublic

The production of octahydrocoumarin,which can serve as a replacement for toxic coumarin,was investigated using 5% Ru on active carbon(Ru/C) as the catalyst for the hydrogenation of coumarin. The hydrogenation was studied by optimizing the reaction conditions(pressure,solvent and coumarin concentration). The activity and selectivity of the Ru/C catalyst were compared for different solvents. The mechanism of coumarin hydrogenation was deduced. The formation of side products was explained. The optimal hydrogenation reaction conditions were: 130 °C,10 MPa,60 wt% coumarin in methanol,and 0.5 wt%(based on coumarin) of Ru/C catalyst. At the complete conversion of coumarin,the selectivity to the desired product was 90%.

关键词：钌/碳催化剂加氢反应条件香豆素 RU 活性炭副产物氢化转化率

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