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第十届全国免疫学学术大会

作者： GANG LI Alissa L Moss Thomas A Medsger Jr Robyn T Domsic Mary R Lucas dana E Ivanco Robert Lafyatis Donna b Stolz Patrizia Fuschiotti Children's Hospital of Soochow University Department of Immunology University of Pittsburgh School of Medicine Department of Medicine Division of Rheumatology and Clinical Immunology University of Pittsburgh School of Medicine Rheumatology Section Boston University School of Medicine Department of Cell biology University of Pittsburgh School of Medicine

Objective:Loss of CD28 expression by CD8+T cells occurs with age and during chronic inflammatory ***8+CD28-T cells are a heterogeneous cell subpopulation ranging from immunosuppressive to effector *** showed previously that Interleukin(IL)-13-producing CD8+T cells are implicated in the pathogenesis of systemic sclerosis(SSc).Here we analyzed the role of CD8+CD28-T cells in SSc pathogenesis in an age-and disease-controlled cohort of ***:Flow cytometry was employed to determine cell surface phenotype,cytokine production and cytotoxicity function of peripheral blood CD8+CD28-T cells from patients and *** and apoptosis properties of CD8+T-cell subsets were measured by CFSE and Annexin V *** and immunohistochemistry were used to assess expression of cytokine and markers of cytotoxicity by CD8+T cells in the affected skin of ***:We found that the proportion of CD8+CD28-T cells is increased in patients with SSc independently of patient age and correlates with the extent of skin *** CD8+CD28-T cells are found in the effector and effector/memory subsets,secrete IL-13,and are ***,they exhibit normal levels of proliferation and susceptibility to ***,IL-13-producing CD8+T cells that express markers of cytotoxicity are found in the sclerotic skin of ***:We provide new insight into the pathogenesis of SSc by identifying a pathogenic CD8+T-cell subset characterized by profibrotic IL-13 overproduction and direct cellular *** novel molecular targets may open avenues for future therapeutic intervention.

关键词： scleroderm CD8+CD28-T cells perforin granzyme b IL-13

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科学猜猜看?

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少年科普世界 2019年第9期 15-15,39页

作者： dana·Q(文/图) 不详

这是什么?这些红色的像小灯泡一样的东西是什么呢?快来猜猜吧!A.这是植物的果子;b.这是黏菌;C.这是圣诞树上的彩灯。

关键词：科学小灯泡圣诞树

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美国农作物育种与农村发展

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中国种业 2012年第8期 18-21页

作者：何艳琴 Keith E Woeste Sterling b blanche Karen A Moldenhaver C dana Nelson 全国农业技术推广服务中心北京100125

农作物育种家为美国农业和经济发展做出了巨大贡献。他们通过提高农业生产效益,改善了农民的经济条件,推动了农村社区的结构调整和发展。自第二次世界大战以来,通过鼓励农业产业化生产模式和补贴政策有力地促进了农业发展和农村生活水... 详细信息

农作物育种家为美国农业和经济发展做出了巨大贡献。他们通过提高农业生产效益,改善了农民的经济条件,推动了农村社区的结构调整和发展。自第二次世界大战以来,通过鼓励农业产业化生产模式和补贴政策有力地促进了农业发展和农村生活水平的提高。育种家为农业开发新技术,提供适宜的品种,其主要贡献在于培育适应环境变化和机械化收割、运输的高产作物新品种。随着社会、技术和经济的不断变化,农业生产经营模式不断演化,农村人口不断向外转移。与此同时,多种社会、经济因素促使本土膳食主义、社区农业等新型食品系统模式产生。可持续发展指数反映了大型零售商希望消费者与食品生产之间关系更透明的愿望。这些因素,连同美国对农村生活质量的关注,为育种家解决新的客户需要、开发符合其价值观的技术以及以新的方式服务传统客户提供了机遇。

关键词：农作物育种美国农业农村发展第二次世界大战经济发展农业生产效益生产经营模式农村社区

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Temporal trends in inflammatory bowel disease publications over a 19-years period

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World Journal of Gastroenterology 2014年第44期20卷 16745-16749页

作者： Yael Weintraub Francis b Mimouni Shlomi Cohen Pediatric Gastroenterology and Nutrition Unit "Dana-Dwek" Children’s Hospital Tel Aviv Medical Center Sackler Faculty of Medicine Tel Aviv University Department of Pediatrics "Dana-Dwek" Children’s Hospital Tel Aviv Medical Center and Sackler Faculty of Medicine Tel Aviv University Division of Neonatology Shaare Zedek Medical Center

AIM: To determine whether temporal changes occurred in the pediatric vs adult inflammatory bowel disease(IbD), both in terms of number and type of yearly published ***:We aimed to evaluate all Pub Med-registered articles related to the field of IbD from January1,1993 and until December 31,*** searched for articles using the key words"inflammatory bowel disease"or"Crohn’s disease"or"ulcerative colitis"or"undetermined colitis",using the age filters of"child"or"adult".We repeated the search according to the total number per year of articles per type of article,for each year of the specified *** studied randomized controlled trials,clinical trials,case reports,meta-analyses,letters to the editor,reviews,systematic reviews,practice guidelines,and ***:We identified 44645 articles over the *** were 8687 pediatric-tagged articles vs 19750 adult-tagged *** 16208 articles were unaccounted and not assigned a"pediatric"or"adult"tag by Pub *** was an approximately3-fold significant increase in all articles recorded both in pediatric and adult *** significant increase was true for nearly every category of article but the number of clinical trials,meta-analysis,and randomized controlled trials increased proportionally more than the number of"lower quality"articles such as editorials or letters to the *** few guidelines were published every ***:There is a yearly linear increase in publications related to ***,there are more and more clinical trials and higher quality articles.

关键词： Inflammatory bowel disease Crohn's dis-ease Ulcerative colitis Randomized clinical trial Meta-analysis

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The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases

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Cellular & Molecular Immunology 2011年第2期8卷 110-120页

作者： Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina bartova Daniel Sanchez Petra Fundova dana borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda Institute of Microbiology Academy of Sciences of the Czech Republicv.v.i.PragueCzech Republic Institute of Dental Research General Faculty Hospital and 1st Faculty of MedicineCharles UniversityPragueCzech Republic Ear Nose and Throat DepartmentCentral Military HospitalPragueCzech Republic Institute of Experimental Medicine Academy of Science of the Czech RepublicPragueCzech Republic Institute of Clinical and Experimental Medicine PragueCzech Republic

Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the *** methods are an indispensable tool for studying the consequences of bacterial *** used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these *** this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)***,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared *** induction of tolerance to allergen bet v1 was not influenced by the presence or absence of *** of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment.

关键词： allergy hygiene hypothesis intestinal permeability leaky gut probiotics

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Human development Diane E. Papalia, Sally Wendkos Olds, Ruth Duskin Feldman ; in consultation with dana Gross. 9th ed.

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2004年

作者： Diane E. Papalia Sally Wendkos Olds Ruth Duskin Feldman in consultation with dana Gross.

Accompanied by student CD-ROM.

ISBN: (数字)0072820306

ISBN: (纸本)9780072820300

Accompanied by student CD-ROM.

关键词： Developmental psychology.

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Extreme events as ecosystems drivers： Ecological consequences of anomalous Southern Hemisphere weather patterns during the 2001/2002 austral spring-summer

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Advances in Polar Science 2018年第3期29卷 190-204页

作者： dana M. bERGSTROM Eric J. WOEHLER Andrew R. KLEKOCIUK Michael J. POOK Robert A. MASSOM Australian Antarctic Division Department of the Environment and Energy 203 Channel Highway Kingston Tasmania 7050 Australia School of Zoology Private Bag 55 University of Tasmania Hobart Tasmania 7001 Australia Antarctic Climate and Ecosystems Cooperative Research Centre Private Bag 80 University of Tasmania Hobart Tasmania 7001 Australia CSIRO Oceans and Atmosphere Hobart Tasmania 7001 Australia

The frequency and severity of extreme events associated with global change are both forecast to increase with a concomitant increase expected in perturbations and disruptions of fundamental processes at ecosystem, community and population scales, with potentially catastrophic consequences. Extreme events should thus be viewed as ecosystem drivers, rather than as short term deviations from a perceived ＇norm＇. To illustrate this, we examined the impacts associated with the extraordinary weather pattern of the austral spring/summer of 2001/2002, and find that patterns of ocean-atmosphere interactions appear linked to a suite of extreme events in Antarctica and more widely across the Southern Hemisphere. In the Antarctic, the extreme events appear related to particular ecological impacts, including the substantial reduction in breeding success of Ade1ie penguins at sites in the Antarctic Peninsula as well as for Adelie penguin and snow petrel colonies in East Antarctica, and the creation of new benthic habitats associated with the disintegration of the Larsen b Ice Shelf. Other major impacts occurred in marine and terrestrial ecosystems at temperate and tropical latitudes. The suite of impacts demonstrates that ecological consequences of extreme events are manifested at fundamental levels in ecosystem processes and produce long-term, persistent effects relative to the short-term durations of the events. Changes in the rates of primary productivity, species mortality, community structure and inter-specific interactions, and changes in trophodynamics were observed as a consequence of the conditions during the 2001/2002 summer. Lasting potential consequences include reaching or exceeding tipping points, trophic cascades and regime shifts.

关键词： Antarctica atmospheric pressure anomalies ecosystem processes and drivers tipping points trophiccascades regime shifts

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The Role of T Lymphocytes in bone Remodeling

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Open Journal of Orthopedics 2023年第4期13卷 131-146页

作者： Jaymes L. Fuller Renee E. Samuel Jason J. Abraham Dina Gad dana M. Padilla Jessica A. Cottrell Department of biological Sciences Seton Hall University South Orange USA

bone remodeling is a tightly regulated resorption and formation of bone matrix for physiological processes or to maintain bone function. bone remodeling involves the synchronized differentiation and activity of bone-related cell types including bone matrix-depositing osteoblasts, bone matrix-resorbing osteoclasts, collagen/extracellular matrix-producing chondrocytes, and the progenitors of these cell types. T and b cells are adaptive immune cells that can influence bone remodeling by directly regulating the function of bone-related cells under normal and pathophysiological conditions. The specific mechanisms through which T cells control remodeling are not well defined. Here, we review the impact and influence of T cells and their products on the differentiation and function of bone cells during bone remodeling. Synthesizing new connections and highlighting potential mechanisms may promote additional avenues of study to elucidate the full role that immune cells play in regulating bone homeostasis.

关键词： Osteoimmunology bone Homeostasis Fracture T Cells b Cells Osteoblasts Osteoclasts Chondrocytes

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LED光质对决明芽苗菜光合色素和营养品质的影响

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河南师范大学学报（自然科学版） 2017年第2期45卷 60-64,70页

作者：王静姜静王丹王茹丹李汇阳李景原河南师范大学生命科学学院河南新乡453007 河南师范大学河南省绿色药材生物技术工程实验室河南新乡453007

以决明(Cassia tora L.)幼苗为材料,采用半导体发光二极管光源(LED)精确调制白光(W)、红光(R)、蓝光(b)、绿光(G),对决明(***)芽苗进行2 h的辐照处理,探究对决明(***)芽苗菜光合色素、可溶性糖、可溶性蛋白、总酚、类黄酮及花青素含量... 详细信息

以决明(Cassia tora L.)幼苗为材料,采用半导体发光二极管光源(LED)精确调制白光(W)、红光(R)、蓝光(b)、绿光(G),对决明(***)芽苗进行2 h的辐照处理,探究对决明(***)芽苗菜光合色素、可溶性糖、可溶性蛋白、总酚、类黄酮及花青素含量的影响.结果表明:以室内自然光处理(D)为对照,各光质都显著提高决明(***)芽苗菜中叶绿素及类胡萝卜素的含量,绿光处理叶绿素a含量增加了31.73%,白光处理叶绿素b以及叶绿素总含量、类胡萝卜素含量分别增加了50.20%、33.62%、52.71%;红光处理可溶性糖含量增加了57.04%;蓝光、白光和红光处理可溶性蛋白含量分别增加了69.33%、51.74%、40.58%;几种光质处理后总酚和类黄酮含量都明显高于对照组,但不同光质间差异不明显;蓝光处理花青素含量最高,增加了32.89%.生产中可通过增加LED照射提高决明(***)芽苗菜的营养品质.

关键词： LED光质决明芽苗菜光合色素营养品质

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Novel biomarkers of Contrast-Induced Kidney Injury after Endovascular Procedures: An Interventional Cardiologists Notion

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World Journal of Cardiovascular Diseases 2019年第12期9卷 942-957页

作者： Anton Khilchuk dana Abdulkarim Sergei Vlasenko Sergei Abugov Sergei Scherbak Vitalii Popov Dmitrii Vorobyovskii Maksim Agarkov Andrei Sarana Evgenii Karmazanashvili Department of Interventional Radiology City Hospital No. 40 Saint-Petersburg Russia Medical Faculty Saint-Petersburg State University Saint-Petersburg Russia Endovascular and Arrhythmology Department Russian National Research Center of Surgery Named after Academician B.V. Petrovsky Moscow Russia Department of Interventional Radiology Gusev Central Regional Hospital Gusev Yekaterinburg Russia Department of Interventional Radiology City Hospital No. 26 Saint-Petersburg Russia

Modern achievements of interventional cardiology in treatment of coronary heart disease (CHD) have significantly increased frequency of interventions and volume of contrast media (CM). Contrast-induced acute kidney injury (CIAKI) associated with CM administration is determined by 26.5 μmol/l increase in serum creatinine (SCr) within 48 - 72 hours or >?1.5-fold SCr increase versus its known or estimated level in the previous 7 days. Without effective disease management, prevention with early CIAKI risk stratification and cessation of nephrotoxic medications taken by patients are important. Given significant complexity in existing CIAKI treatment, modern therapeutic options are limited only to adequate renal injury prevention. The problem’s significance and diagnostic limitations associated with SCr definition require search for clinically and diagnostically significant AKI biomarkers. In terms of coronarography and percutaneous coronary interventions, several studies have been conducted on clinical and diagnostic significance of some biomarkers. This article characterizes and discloses prospective practical use of neutrophil gelatinase-associated lipocalin (NGAL), liver-type fatty acid binding protein (L-FAbP), kidney injury molecule-1 (KIM-1), cystatin C (CysC) and interleukins-6,8,18 (IL-6,8,18) in interventional cardiology.

关键词： Percutaneous Coronary Intervention Acute Kidney Injury Coronary Artery Disease

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