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Advantage of populous countries in the trends of innovation efficiency

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Chinese Physics B 2022年第6期31卷 65-73页

作者： dan-dan hu Xue-Jin Fang Xiao-Pu Han 2 1Alibaba Research Center for Complexity SciencesHangzhou Normal UniversityHangzhou 311121China Institute of Information Economy and Alibaba Business School Hangzhou Normal UniversityHangzhou 311121China

A flurry of studies indicates that population size has a positive effect on innovation,however,cross-country empirical evidence remains *** this paper,we add to the literature by investigating the relationship between population size and innovation efficiency at the country level through constructing three relative indexes based on the datasets of patent applications and Research and Development(R&D)*** from previous studies based on absolute innovation indicators,the relative indexes can reflect the core innovation efficiency of economies by excluding the impact from the difference of economic development level,with a view putting all economies into a comparable standard *** all of the three relative indexes,their long-term trends show significant correlations with population size,and the economy with a larger population usually has better and stable performance on the trends of innovation *** addition,we find that there is a critical population size,over which the economy would be more likely to have a spontaneous improvement on innovation *** study provides direct evidence in supporting the population size advantage on the trends of innovation efficiency at the economy level and provides new insight to understand the rapid development of innovation in a few populous countries.

关键词： innovation efficiency population size the relative indexes

Impact of stage-specific limb function exercises guided by a selfmanagement education model on arteriovenous fistula maturation status

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World Journal of Clinical Cases 2024年第14期12卷 2316-2323页

作者： Yi Li Li-Jun huang Jian-Wen Hou dan-dan hu Department of Nursing The People's Hospital of Jianyang CityJianyang 641400Sichuan ProvinceChina Department of Nephrology The People's Hospital of Jianyang CityJianyang 641400Sichuan ProvinceChina Department of Head and Neck Surgery Zhejiang Cancer HospitalHangzhou 310000Zhejiang ProvinceChina School of Nursing Shangqiu Institute of TechnologyShangqiu 476005Henan ProvinceChina

BACKGROUND The exercise of limb function is the most economical and safe method to promote the maturation of arteriovenous fistula(AVF).However,due to the lack of a uni-fied exercise standard in China,many patients have insufficient awareness of the importance of AVF,leading to poor effectiveness of limb function *** self-management education model can effectively promote patients to take pro-active health-related *** study focuses on the characteristics of patients during the peri-AVF period and conducts a phased limb function exercise under the guidance of the self-management education model to observe changes in fac-tors such as the maturity of *** To assess the impact of stage-specific limb function exercises,directed by a self-management education model,on the maturation status of *** This study is a randomized controlled trial involving 74 patients with forearm AVFs from the Nephrology Department of a tertiary hospital in Sichuan Province,*** were randomly divided into an observation group and a control group using a random number table *** observation group underwent tailored stage-specific limb func-tion exercises,informed by a self-management education model which took into account the unique features of AVF at various stages,in conjunction with routine ***,the control group was given standard limb function exercises along with routine *** assessment involves the maturity of AVFs post-intervention,post-operative complications,and the self-management level of the fistula in both groups *** were conducted using SPSS version *** data were represented by frequency and percentage and subjected to chi-square test *** data adhering to a normal distribution were presented as mean±*** independent samples t-test was utilized for inter-group comparisons,while the paired t-test was used for intra-group *** measurement data not fitting a normal distr

关键词： Self-management Education model Stage-specific Limb function exercises Arteriovenous fistula Maturation status

Toll Like Receptor-2 is required for itch sensation by potentiating TRPV1

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Toll Like Receptor-2 is required for itch sensation by poten...

中国神经科学学会第十二届全国学术会议

作者： dan-dan hu Dong Bai Ling Zhang Department of Neurobiology Tongji University School of Medicine

Objective Toll-like receptors（TLRs） are well known for its roles in triggering innate immune responses. Recent study demonstrated that TLR3, TLR4 and TLR7, are expressed by a subset of primary sensory neurons, and play an important role in itch sensation. TLR2 is a member of TLRs family and demonstrated involving in neuropathic pain. However, whether TLR2 regulates itch sensation remains unclear. Method behavior and immunostaining test were measured in TLR2 knock out mice and its control mice. Result In this study, we found that TLR2 was involved both in histamine and nohistamine dependent acute itch and AEW-induced chronic itch. Furthermore, TLR2 agonist, increased itch but not pain behavior in dose dependent manner in mice cheek model. Finally, TLR2 mediated itch sensation through activating TRPV1 but not TRPA1. Conclusion TLR2 mediates itch by potentiating TRPV1.

关键词： itch Pain TLR2 TRPV1 TRPA1

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西藏豌豆资源蛋白质含量及遗传多样性分析

植物遗传资源学报 2018年第2期19卷 252-262页

作者：侯维海王建林旦巴胡单西藏农牧学院/高原作物分子育种实验室林芝860000

为探究西藏高原豌豆资源遗传多样性,分析种子蛋白质含量与生态地理环境间的关系。本研究搜集整理了54份来自西藏不同生态地理环境条件下的豌豆材料。利用SDS-PAGE对54份豌豆种子水溶性和盐溶性蛋白进行遗传多样性分析,测定种子蛋白质含... 详细信息

为探究西藏高原豌豆资源遗传多样性,分析种子蛋白质含量与生态地理环境间的关系。本研究搜集整理了54份来自西藏不同生态地理环境条件下的豌豆材料。利用SDS-PAGE对54份豌豆种子水溶性和盐溶性蛋白进行遗传多样性分析,测定种子蛋白质含量,分析地理生态因子(经度、纬度、海拔)与总蛋白含量间的关系。结果表明,54份豌豆材料种子总蛋白含量为17.58%~28.67%,其中水溶性蛋白占86.12%~91.40%,盐溶性蛋占4.76%~8.29%。相关分析表明,西藏豌豆种子总蛋白含量与经度呈显著正相关,与纬度呈正相关,而与海拔高度呈负相关。54份豌豆种子水溶性和盐溶性蛋白SDSPAGE分别检测出蛋白谱带1588条和699条,其中水溶性蛋白分出迁移率不同的谱带类型43种,基因多样性指数为0~0.50,相对分子量在24.71~149.54 Ku之间,且其谱带多集中于24.87~50.41 Ku低相对分子量区和56.34~88.08 Ku高相对分子量区;盐溶性蛋白分离出迁移率不同的谱带类型24条,基因多样性指数0~0.50,相对分子量在24.85~91.24 Ku之间。基于蛋白的谱带的聚类分析将54份豌豆资源可划分为7个类群,遗传相似系数变异范围为0.60~0.91;根据海拔高度将54份豌豆资源划分为4个地理类群,各类群蛋白谱带的基因多样性指数分别为0.23、0.18、0.35和0.31,Shannon's信息指数分别为0.33、0.41、0.52和0.46。西藏豌豆资源遗传变异较丰富,表现出随着海拔高度增加,遗传变异呈增大趋势。同时种子贮藏蛋白含量与经度呈显著正相关,而与纬度和海拔高度相关性不大。

关键词：豌豆蛋白质含量 SDS-PAGE 西藏

A Comprehensive,Prospective and Clinical Investigation of the Neurological Involvement in Children Infected with Enterovirus 71

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A Comprehensive,Prospective and Clinical Investigation of th...

阿莫西林/克拉维酸钾干混悬剂有关物质测定方法的比较研究

中华医学会急诊医学分会第17次全国急诊医学学术年会

作者： peiqing Li sida Yang wei Li Wenying Lai Wencheng Ma Jia-ming Lu Yan Hong Yu-ting Liang dan-dan hu Yuan-yuan Gao Yi Zhou Jun Shen Hongsheng Liu Yan-ling Chen Guangzhou women and children's medical center Dongguan Taiping People's Hospital Zhongshan People's Hospital

EV71 has been found the most significant neurotropic enterovirus after *** study is prospective,and of the clinical observation of totally 288 confirmed EV71-infected cases with neurologic complications from January to October 2012 in 3 *** observation index consists of more than 80 terms of neurological symptoms and ***

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中国抗生素杂志 2016年第11期41卷 848-852页

作者：沈丹丹吴群胡幸刘映倩姜学美张涛重庆市食品药品检验检测研究院重庆401121 重庆市药物过程与质量控制工程技术研究中心重庆401121 福安药业集团重庆礼邦药物开发有限公司重庆401121

目的比较不同标准中阿莫西林/克拉维酸钾干混悬剂有关物质的测定方法。方法采用2015年版《中国药典》(以下简称Ch P 2015)、2014版《英国药典》(以下简称BP2014)、同品种进口注册标准(JX20040226)所收载的阿莫西林/克拉维酸钾干混悬剂... 详细信息

目的比较不同标准中阿莫西林/克拉维酸钾干混悬剂有关物质的测定方法。方法采用2015年版《中国药典》(以下简称Ch P 2015)、2014版《英国药典》(以下简称BP2014)、同品种进口注册标准(JX20040226)所收载的阿莫西林/克拉维酸钾干混悬剂质量标准中有关物质的方法,分别测定其有关物质,对色谱行为、已知杂质系统适用性、有关物质测定结果等进行比较。结果阿莫西林/克拉维酸钾干混悬剂有关物质的测定方法存在较大差异,BP2014中有关物质的色谱条件对阿莫西林/克拉维酸钾杂质的分离效能更好。结论建议在以后的标准制定中利用系统适用性中各杂质的色谱信息,参照BP2014色谱条件,提高本品有关物质的测定方法。

关键词：阿莫西林/克拉维酸钾干混悬剂有关物质系统适用性中国药典英国药典进口注册标准

Generalized Lanchester warfare model characterized by information asymmetry effect

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Journal of Systems Engineering and Electronics 2017年第2期28卷 315-321页

作者： Weiwen hu dan Mei Yongkai Liu College of Science Naval University of Engineering Wuhan 430033 China

Combined with the fact that information asymmetry between two belligerent parties is very common in information-based warfare, the bidirectional influence of asymmetric information on both sides is analyzed. A new damage coefficient is formed based on the analysis, and a generalized Lanchester warfare model characterized by information asymmetry effect is built. According to the staggered transformation of information asymmetric degree resulting from the changing tactic of both sides by turns, a method for approximate solution of the model is presented by translating the information asymmetric degree as a ladder function, and both examples of the solving model and further discussion about the solution are given. The results indicate that the model can serve as a reference to analyze and forecast the course of war quantitatively. © 2017 Beijing Institute of Aerospace Information.

关键词： Electronics industry Engineering Industrial engineering

Dual Extended Kalman Filter for Combined Estimation of Vehicle State and Road Friction

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Chinese Journal of Mechanical Engineering 2013年第2期26卷 313-324页

作者： ZONG Changfu hu dan ZHENG Hongyu State Key Laboratory of Automotive Simulation and Control Jilin University

Vehicle state and tire-road adhesion are of great use and importance to vehicle active safety control systems. However, it is always not easy to obtain the information with high accuracy and low expense. Recently, many estimation methods have been put forward to solve such problems, in which Kalman filter becomes one of the most popular techniques. Nevertheless, the use of complicated model always leads to poor real-time estimation while the role of road friction coefficient is often ignored. For the purpose of enhancing the real time performance of the algorithm and pursuing precise estimation of vehicle states, a model-based estimator is proposed to conduct combined estimation of vehicle states and road friction coefficients. The estimator is designed based on a three-DOF vehicle model coupled with the Highway Safety Research Institute（HSRI） tire model; the dual extended Kalman filter （DEKF） technique is employed, which can be regarded as two extended Kalman filters operating and communicating simultaneously. Effectiveness of the estimation is firstly examined by comparing the outputs of the estimator with the responses of the vehicle model in CarSim under three typical road adhesion conditions（high-friction, low-friction, and joint-friction）. On this basis, driving simulator experiments are carried out to further investigate the practical application of the estimator. Numerical results from CarSim and driving simulator both demonstrate that the estimator designed is capable of estimating the vehicle states and road friction coefficient with reasonable accuracy. The DEKF-based estimator proposed provides the essential information for the vehicle active control system with low expense and decent precision, and offers the possibility of real car application in future.

关键词： vehicle state road friction coefficient estimation dual extended Kalman filter (DEKF)

Estimation of vehicle states and tire-road friction using parallel extended Kalman filtering

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第6期12卷 446-452页

作者： Chang-fu ZONG Pan SONG dan hu State Key Laboratory of Automotive Simulation and Control Jilin University Changchun 130025 China

A model-based estimator design and implementation is described in this paper to undertake combined estimation of vehicle states and tire-road friction *** estimator is designed based on a vehicle model with three degrees of freedom(3-DOF) and the dual extended Kalman filter(DEKF) technique is *** of the estimation is examined and validated by comparing the outputs of the estimator with the responses of the vehicle model in CarSim in three typical road adhesion conditions(high-friction,low-friction,and joint-friction roads).Simulation results demonstrate that the DEKF estimator algorithm designed is able to obtain vehicle states(e.g.,yaw rate and roll angle) as well as road friction coefficients with reasonable accuracy.

关键词： Vehicle dynamics State estimation and system identification Active safety and passive safety