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MP-3 microperimeter in early primary open angle glaucoma with a new pattern

International Journal of Ophthalmology(English edition) 2024年第5期17卷 861-868页

作者： Shuang Liang Li-Tao Wang Xiao-Li liu Jia-Liang Duan dan-yan liu Department of Ophthalmology of the Second Hospital of Hebei Medical University Shijiazhuang 050000Hebei ProvinceChina Department of Ophthalmology Shijiazhuang People’s HospitalShijiazhuang 050000Hebei ProvinceChina

AIM:To investigate macular microperimetry in patients with early primary open angle glaucoma(POAG)using a new custom-made pattern,and analyze the characteristics of macular ***:This case-control study included 38 patients with POAG,who were divided into pre-perimetric glaucoma(18 eyes of 18 patients),early-stage(20 eyes of 20 patients),and control(20 eyes of 20 patients)*** subjects underwent standard 24-2 humphrey visual field *** MP-3 microperimeter with a new custom-made pattern(28 testing points distributed in four quadrants,covering the central 10°of the retina)was used to evaluate macular *** cell complex(GCC)thicknesses were examined using an RS-3000 Advance OCT *** features of structure and function were analysed per ***:The pre-perimetric glaucoma group had significantly lower inferior hemifield macular sensitivity compared to controls(P<0.05).The early-stage POAG group had significantly lower average,inferior hemifield,inferonasal,and inferotemporal mean sensitivities compared to the pre-perimetric glaucoma group(P<0.05),and lower macular sensitivity in all sectors compared to controls(P<0.05).Regarding GCC thickness,all sectors in the early-stage POAG group became thinner compared to those in controls(P<0.05);whereas all sectors in the early-stage POAG group,except the superonasal quadrant,became thinner compared to those in the pre-perimetric glaucoma group(P<0.05).Macular sensitivity and GCC thickness were significantly associated in each *** inferotemporal quadrant had the highest correlation coefficients(0.840).The structure-function relationship for the inferonasal and inferotemporal sectors was stronger compared to the corresponding superior ***:Microperimetry reveals variations in macular sensitivity in patients with early glaucoma earlier than conventional perimetry,particularly in pre-perimetric glaucoma cases in which it might be undetectable by conventional me

关键词： early primary open angle glaucoma macular sensitivity microperimetry optical coherence tomography ganglion cell complex

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Cutaneous metastases of pancreatic carcinoma to the labia majora: A case report and review of literature

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World Journal of Gastrointestinal Oncology 2020年第11期12卷 1372-1380页

作者： Ying Shi Shan-Shan Li dan-yan liu yan Yu Department of Dermatology First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Dermatology and Venereology First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Radiology First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND Cutaneous metastases originating from pancreatic cancer are relatively rare. The most common reported site of metastasis is the umbilicus, and this manifestation is known as the Sister Mary Joseph's nodule. Non-umbilical cutaneous metastases are far less common, with only a few cases reported in the literature. Our case is the first case report, to our knowledge, on metastasis involving the labia majora and flat *** SUMMARY A 49-year-old Chinese female patient presented with a number of red, swollen papules on the vulva for 2 mo. Histological examination of the labia majora lesion revealed metastatic adenocarcinoma. The serum levels of tumor biomarkers CA199, CA242, and CA125 were significantly elevated. B-mode ultrasoundguided needle biopsy of the pancreas demonstrated moderately and poorly differentiated adenocarcinoma. The patient finally declined treatment for financial reasons and died 3 mo *** Metastatic cutaneous lesions could indicate pancreatic cancer. Serum levels of tumor biomarkers may aid in diagnosing metastatic pancreatic adenocarcinoma.

关键词： Pancreatic cancer Cutaneous Metastasis Non-umbilical Biomarker Case report

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Micro-sized nanoaggregates:Spray-drying-assisted fabrication and applications

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Particuology 2024年第2期85卷 22-48页

作者： dan-Lei yang Rong-Kun liu yan Wei Qian Sun Jie-Xin Wang School of Life Sciences and Chemical Engineering Jiangsu Second Normal UniversityNanjing210013China State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing100029China Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology School of Chemistry and Chemical EngineeringGuangxi UniversityNanning530004China

The applications of nanoparticles suffer from their extremely small size and intrinsic trend of *** nanoparticles to form micro-sized nanoaggregates(MNAs)with increased size,ordered structure,as well as controllable size,shape,and morphology is a crucial step in various fields of science and technology to maintain the unique characteristics of nanoparticles while obtaining greatly enhanced or new performance at the *** structure of MNAs prominently affects their functionality,which is determined by the arrangement of nanoparticles and the interaction between primary *** methods have been proposed to prepare the MNAs,in which spray-drying technology stands out considering the feasibility,scalability for industry,cost,and *** assembly of nanoparticles through spray-drying under tunable process parameters yields diverse physical properties and structural arrangements of nanoparticles of the MNAs,they therefore exhibit enormous potential in a wide range of application *** review presents the construction and applications of spray-dried *** factors that influence the size,morphology,and structure of the MNAs are discussed in *** addition,the outstanding application performance resulting from the tightly packed nanoparticles in regular-shaped MNAs obtained by the spray-drying process is illustrated.

关键词： Spray-drying Micro-sized nanoaggregates Applications

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Cloning, expression and chitin-binding activity of two peritrophin-like protein genes in the common cutworm, Spodoptera fitura

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Insect Science 2014年第4期21卷 449-458页

作者： Wei-Jun Chen Li-Xia Huang dan Hu Li-yan liu Jun Gu Li-Hua Huang Qi-Li Feng Guangdong Provincial Key Laboratory of Biotechnology for Plant Development School of Life Sciences South China Normal UniversityGuangzhou China

Insect midgut secretes a semi-permeable peritrophic membrane （PM）, which plays important roles in protecting the midgut and helping with food digestion. The lep- idopteran larvae produce type 1 PM, which is degraded when insects develop into the metamorphic stages. However, the underlying mechanism is unclear. In the present study, two peritrophin-like proteins （peritrophin-57 and 37） were identified from the midgut expression sequence tag library and transcriptome of the common cutworm, Spodoptera litura. The temporal and spatial expression patterns and responses to the induction of 20- hydroxyecdysone （20E） and starvation were examined by real-time quantitative polymerase chain reaction according to their common sequence region. The chitin-binding activity was also studied using a competitor, calcofluor. The open reading frames are 1 554 and 1 020 bp, respectively. They shared four highly conserved peritrophin-A domains and were ex- pressed only in the midgut rather than in the other tissues, including fat body, epidermis, Malpighian tube and hemolymph. Their transcriptional expression could only be detected at the larval stages rather than in eggs, prepupae, pupae and adults. The purified protein of peritrophin-37 bound to chitin in a dose-dependent manner. These results indicate that the two proteins are peritrophins, the structural components of PM. In addition, the messenger RNA levels of the two peritrophins were significantly down-regulated by 20E injection, whereas feeding/starvation had no effect on the expression. These findings suggest that the increase of20E titer may be an important factor which controls the degradation of PM during metamorphosis.

关键词： metamorphosis peritrophic membrane peritrophin starvation 20-hydroxyecdysone

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Optical performance of toric intraocular lenses in the presence of decentration

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 730-735页

作者： Bin Zhang Jin-Xue Ma dan-yan liu Ying-Hua Du Cong-Rong Guo Yue-Xian Cui Department of Ophthalmology the Second Hospital of Hebei Medical University

· AIM: To evaluate the optical performance of toric intraocular lenses(IOLs) after decentration and with different pupil diameters, but with the IOL astigmatic axis aligned.· METHODS: Optical performances of toric T5 and SN60 AT spherical IOLs after decentration were tested on a theoretical pseudophakic model eye based on the Hwey-Lan Liou schematic eye using the Zemax ray-tracing program. Changes in optical performance were analyzed in model eyes with 3-mm, 4-mm, and 5-mm pupil diameters and decentered from 0.25 mm to 0.75 mm with an interval of 5° at the meridian direction from0° to 90°. The ratio of the modulation transfer function(MTF) between a decentered and a centered IOL(MTFDecentration/MTFCentration) was calculated to analyze the decrease in optical performance.· RESULTS: Optical performance of the toric IOL remained unchanged when IOLs were decentered in any meridian direction. The MTFs of the two IOLs decreased,whereas optical performance remained equivalent after decentration. The MTFDecentration/MTFCentrationratios of the IOLs at a decentration from 0.25 mm to 0.75 mm were comparable in the toric and SN60 AT IOLs. After decentration, MTF decreased further, with the MTF of the toric IOL being slightly lower than that of the SN60 AT IOL. Imaging qualities of the two IOLs decreased when the pupil diameter and the degree of decentration increased, but the decrease was similar in the toric and spherical IOLs.· CONCLUSION: Toric IOLs were comparable to spherical IOLs in terms of tolerance to decentration at the correct axial position.

关键词： lens artificial astigmatism cornea decentration model

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Microphase Separation of Semiflexible Ring Diblock Copolymers

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Chinese Journal of Polymer Science 2024年第2期42卷 267-276,I0011页

作者： dan-yan Qin Sheng-Da Zhao Zhi-Xin liu Jing Zhang Xing-Hua Zhang School of Physical Science and Engineering Beijing Jiaotong UniversityBeijing100044China

Aiming at the difficult problem of solving the conformation statistics of complex polymers, this study presents a novel and concise conformation statistics theoretical approach based on Monte Carlo and Neural Network method. This method offers a new research idea for investigating the conformation statistics of complex polymers, characterized by its simplicity and practicality. It can be applied to more complex topological structure, more higher degree of freedom polymer systems with higher dimensions, theory research on dynamic self-consistent field theory and polymer field theory, as well as the analysis of scattering experimental data. The conformation statistics of complex polymers determine the structure and response properties of the system. Using the new method proposed in this study, taking the semiflexible ring diblock copolymer as an example, Monte Carlo simulation is used to sample this ring conformation to construct the dataset of polymer. The structure factor describing conformation statistics are expressed as continuous functions of structure parameters by neural network supervised learning. This is the innovation of this work. As an application, the structure factors represented by neural networks were introduced into the random phase approximation theory to study the microphase separation of semiflexible ring diblock copolymers. The influence of the ring's topological properties on the phase transition behavior was pointed out.

关键词： Ring copolymer Diblock copolymers Semiflexible The order-disorder transition

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Construction of an engineered Escherichia coli for effective synthesis of 2'-fucosyllactose via the salvage pathway

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Synthetic and Systems Biotechnology 2024年第1期9卷 108-114页

作者： Shanquan Liang Zi He dan liu Shaoqing yang Qiaojuan yan Zhengqiang Jiang College of Food Science and Nutritional Engineering China Agricultural UniversityBeijing100083China Food Laboratory of Zhongyuan Luohe462300HenanChina College of Engineering China Agricultural UniversityBeijing100083China

2'-Fucosyllactose(2'-FL)is one of the important functional oligosaccharides in breast *** far,few attempts on biosynthesis of 2'-FL by the salvage pathway have been ***,the salvage pathway enzyme genes were introduced into the *** BL21star(DE3)for synthesis of 2'-*** 2'-FL titer increased from 1.56 to 2.13 g/L by deleting several endogenous genes on competitive ***α-1,2-fucosyltransferase(WbgL)was selected,and improved the 2'-FL titer to 2.88 g/***,the expression level of pathway enzyme genes was tuned through optimizing the plasmid copy ***,the spatial distribution of WbgL was enhanced by fusing with the MinD *** optimizing the fermentation conditions,the 2'-FL titer reached to 7.13 g/*** final strain produced 59.22 g/L of 2'-FL with 95%molar conversion rate of lactose and 92% molar conversion rate of fucose in a 5 L *** findings will contribute to construct a highly efficient microbial cell factory to produce 2'-FL or other HMOs.

关键词： 2'-fucosyllactose Human milk oligosaccharides Escherichia coli Fed-batch fermentation Salvage pathway

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An experimental and theoretical study on photoluminescence of Ce^(3+)-doped ZnS quantum dots and their application in Aspergillus oryzae

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Journal of Rare Earths 2024年第6期42卷 1020-1028,I0001页

作者： yan Lei Guangzhi Zhang Yitong Yao Gaiqin Zhu Zhong Chen Jiangrong dan Hua liu Shuwang Duo School of Materials and Mechanical and Electrical EngineeringJiangxi Science and Technology Normal University Nanchang330013China

ZnS and ZnS:3.125%Ce^(3+)(ZSC)quantum dots(QDs)were synthesized by a low-temperature solid-phase *** crystal structure,photoluminescence(PL)properties of ZSC QDs,and their effects on the growth and kojic acid production of Aspergillus oryzae(***)were *** is found that both QDs have a cubic blend structure with the average particle size ranging of 2.75-6.14 ***^(3+)doping not only increases the band gap of ZnS QDs from 3.43 to 3.48 eV,but also increases the PL intensity by about 2.23 times,which is due to the fact that the electron carrier concentration is improved,and then the rate of radiative recombination is *** integral emission intensity,biomass,extracellular proteins yield,and kojic acid production of *** cultured with ZSC(ZnS)QDs are about 4.31(3.23),1.61(1.20),1.12(1.09),and 2.99(1.68)times higher than that of medium without QDs,respectively.

关键词： Zns Quantum dots Doping First-principles calculations Aspergllus oryzae Rare earths

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Two different autorefractors for vision screening in children and adolescents

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 331-338页

作者： Xiao-Jun Chen Lin-Jie liu Bing Sun dan-dan Jiang Shu-Shu Zuo yan-Hui Wang Chun-Hua Zhang yan-yan Chen School of Optometry and Ophthalmology Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To compare the consistency of two autorefractors(Tianle RM-9000 and Topcon KR-800)for school-age myopia children,and to provide a basis for largescale data analysis and ***:The refractive error in 909 subjects(age 4–18y)were measured using both autorefractors without *** data were analyzed using Fourier decomposition and the correlation coefficients,intraclass correlation coefficients(ICC),and Bland-Altman limits of agreement(LoA)for each parameter were ***:There was a strong correlation between the spherical equivalent(SE),sphere diopter(DS),and cylinder diopter(DC)readings of the Tianle RM-9000 and those of the Topcon KR-800,with correlation coefficient values of 0.98,0.98 and 0.83 and ICC values of 0.99,0.99 and 0.93,***,the correlation coefficients and ICC values of J0 and J45 were unreliable(R=-0.004,-0.034;both ICC<0.10).Bland-Altman analysis revealed that SE,DS,and DC measured by the Tianle RM-9000 were significantly biased toward myopia compared with the Topcon KR-800,and the mean differences were-0.072,-0.026,-0.091 D,respectively(all P<0.01).The minimum absolute value of the difference within the 95%LoA for SE,DS,and DC was 0.63 D,0.50 D,0.62 D,respectively;all these values were in the clinically acceptable *** J0 and J45,the mean differences were close to zero(P=0.43,0.84);however,the 95%LoA were relatively wide(J0 SD:0.53;95%CI:-1.00,1.10;J45 SD:0.52;95%CI:-1.00,1.00).CONCLUSION:The two autorefractors are consistent with each other,as the differences in SE,DS,and DC were within the clinically acceptable *** can compare the data measured by either device in different studies and use the two devices in the same study to generate a dataset that can be analyzed ***,the J0 and J45 vectors are unreliable and should not be used to assess astigmatism.

关键词： refractive error autorefractors school-age myopia children

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Double-confined nanoheterostructure Sb/Sb_(2)S_(3)@Ti_(3)C_(2)T_(x)@C toward ultra-stable Li-/Na-ion batteries

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Rare Metals 2024年第5期43卷 2067-2079页

作者： dan Wang Qun Ma Huan He Zhi-Yuan Wang Run-Guo Zheng Hong-Yu Sun yan-Guo liu Chun-Li liu School of Materials Science and Engineering Northeastern UniversityShenyang110819China School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao 066004China Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province Qinhuangdao 066004China Department of Physics and Oxide Research Center Hankuk University of Foreign StudiesYongin 17035Korea

Antimony-based materials with high capacities and moderate potentials are promising anodes for lithium-/-sodium-ion ***,their tremendous volume expansion and inferior conductivity lead to poor structural stability and sluggish reaction ***,a doubleconfined nanoheterostructure Sb/Sb_(2)S_(3)@Ti_(3)C_(2)T_(x)@C has been fabricated through a solvothermal method followed by low-temperature heat *** dual protection of“MXene”and“carbon”can better accommodate the volume expansion of Sb/Sb_(2)S_(3).The strong covalent bond(Ti-S,Ti-O-Sb,C-O-Sb)can firmly integrate Sb-based material with Ti_(3)C_(2)T_(x)and carbon,which significantly improves the structure *** addition,the carbon layer can restrain the oxidation of MXenes,and the nano-Sb/Sb_(2)S_(3)can facilitate electron/ion transport and suppress the restacking of *** heterogeneous interface between Sb and Sb_(2)S_(3)can further promote interfacial charge *** MXene-Sb/Sb_(2)S_(3)@C-1 with the optimal Sb content shows high specific capacities,comparable rate properties and ultra-stable cycling performances(250 m Ah·g^(-1)after 2500 cycles at 1 A·g^(-1)for sodium-ion batteries).Ex situ X-ray diffractometer(XRD)test reveals the storage mechanism including the conversion and alloying process of MXene-Sb/Sb_(2)S_(3)@*** voltammetry(CV)test results demonstrate that the pseudocapacitance behavior is dominant in MXene-Sb/Sb_(2)S_(3)@C-1,especially at large *** design paves the way for exploring high-performance alloy-based/conversion-type anode for energy storage devices.

关键词： Sb/Sb_(2)S_(3) MXene Carbon Anode Lithium-ion batteries Sodium-ion batteries

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