检索结果-南通市图书馆

Multidisciplinary and multiscale nanoscience research roadmap based on large scientific facilities

Science China Chemistry 2024年第8期67卷 2497-2523页

作者： yuan Zeng Shuhan Zhang yuecong Guo Yalin Cong Xu Ding Peihua li yunxiang lin Wenzhi Ren Hui Su Weigang Sun liuxin Xu Guikai Zhang Shihua Chen yu Chen Weiren Cheng Shengqi Chu Yong Guan Jinru Han Jie lin Hengjie liu Zheyi liu Pan Luo Fanchun Meng Sicong Qiao Zongyin Song Ying Wang Zhao Wu Chenyu Yang Meng Yang Shirui Yang Zi Yin Zhibin Yin Pengjun Zhang Hongyu Zhang Pingping Zheng Jia Zhou Wanlin Zhou Pengfei An He Cheng Chunhai Fan Xingjiu Huang Yong Lei lina li Mu li Qinghua liu Shuming Peng li Song Zhihu Sun Yangchao Tian Fangjun Wang lihua Wang liming Wang Shiqiang Wei Aiguo Wu Chunlei Xiao Xueming Yang Panchao Yin Jing Zhang Mingxin Zhang Yaling Wang Chunying Chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety New Cornerstone Science LaboratoryNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China Institute of Solid State Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationCAS Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China College of Chemistry and Chemical Engineering Hunan Normal UniversityChangsha 410081China State Key Laboratory of Luminescent Materials and Devices South China Advanced Institute for Soft Matter Science and TechnologySouth China University of TechnologyGuangzhou 510640China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China CAS Key Laboratory of Separation Sciences for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Institute of Advanced Science Facilities Shenzhen 518107China State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Acade

With the advancement of modern science and technology, large scientific facilities are increasingly oriented toward demand and application, and can be used for basic research as well as serving multiple disciplines. Developing large scientific facilities and related analytical technologies enhances understanding of large scientific facilities and popularizes their application in research across multiple disciplines. The combination of light or neutron sources from large scientific facilities and advanced analytical technologies can be achieved for materials structure information, dynamics study of chemical reactions, high dissociation of biomolecules, 3D visualization of energy materials or biological samples, etc. We first introduce the progress of domestic large scientific facilities of synchrotron radiation(SR) and free electron lasers(FELs) with different wavelengths and neutron *** further discuss the comparison between Chinese and typical foreign facilities in X-ray radiation from X-ray tubes, synchrotrons, X-ray FELs, and neutron sources based on physical parameters of light and neutron sources. In addition, we focus on the technological progress and perspectives combined with advanced X-ray radiation and neutron sources of large scientific facilities in China, especially in the nanoscience fields of energy catalysis and biological science. We hope that this roadmap will provide references on technology and methods to experimental users, as well as prospects for future development of technologies based on large research infrastructure facilities. Comprehensive studies and guidelines for basic research to practical application in various disciplines can be made with the assistance of large scientific facilities.

关键词： large scientific facilities synchrotron radiation FEL light sources neutron sources spectroscopic analysis methods X-ray imaging techniques structural information chemical dynamics

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ultrahigh-brightness 50 MeV electron beam generation from laser wakefield acceleration in a weakly nonlinear regime

引用

Matter and Radiation at Extremes 2024年第3期9卷 4-10页

作者： Zhongtao Xiang Changhai yu Zhiyong Qin Xuhui Jiao Jiahui Cheng Qiaoxuan Zhou Gatie Axi Jianghua Jie Ya Huang Jintan Cai Jiansheng liu Department of Physics Shanghai Normal UniversityShanghai 200234China

We propose an efficient scheme to produce ultrahigh-brightness tens of MeV electron beams by designing a density-tailored plasma to induce a wakefield in the weakly nonlinear regime with a moderate laser energy of 120 *** this scheme,the second bucket of the wakefield can have a much lower phase velocity at the steep plasma density down-ramp than the first bucket and can be exploited to implement longitudinal electron injection at a lower laser intensity,leading to the generation of bright electron beams with ultralow emittance together with low energy ***-dimensional particle-in-cell simulations are carried out and demonstrate that high-quality electron beams with a peak energy of 50 MeV,ultralow emittance of28 nm rad,energy spread of 1%,charge of 4.4 pC,and short duration less than 5 fs can be obtained within a 1-mm-long tailored plasma density,resulting in an ultrahigh six-dimensional brightness B6D,n of2×1017 A/m2/0.1%.By changing the density parameters,tunable bright electron beams with peak energies ranging from 5 to 70 MeV,a small emittance of B0.1 mm mrad,and a low energy spread at a few-percent level can be *** bright MeV-class electron beams have a variety of potential applications,for example,as ultrafast electron probes for diffraction and imaging,in laboratory astrophysics,in coherent radiation source generation,and as injectors for GeV particle accelerators.

关键词： weakly nonlinear acceleration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

舒眠胶囊治疗失眠有效性和安全性的系统评价与Meta分析

引用

中国中药杂志 2024年第1期49卷 268-278页

作者：单心觉康丹陈哲张诗语刘春香天津中医药大学第一附属医院国家中医针灸临床研究中心天津300381 天津中医药大学循证医学中心天津301617 东北师范大学吉林长春130024

系统评价舒眠胶囊治疗失眠的有效性和安全性。检索数据库中舒眠胶囊治疗失眠的随机对照试验(RCT),采用RevMan 5.4软件对纳入研究进行Meta分析。最终纳入23篇RCTs,样本量2621例。Meta分析结果显示,舒眠胶囊治疗失眠(RR=1.07,95%CI[1.03,1... 详细信息

系统评价舒眠胶囊治疗失眠的有效性和安全性。检索数据库中舒眠胶囊治疗失眠的随机对照试验(RCT),采用RevMan 5.4软件对纳入研究进行Meta分析。最终纳入23篇RCTs,样本量2621例。Meta分析结果显示,舒眠胶囊治疗失眠(RR=1.07,95%CI[1.03,1.10],P=0.0002)与失眠伴抑郁(RR=1.13,95%CI[1.02,1.25],P=0.02)患者临床总有效率均具有优势。舒眠胶囊改善失眠(MD=-0.75,95%CI[-1.33,-0.17],P=0.01)和失眠伴抑郁(MD=-2.51,95%CI[-2.96,-2.06],Plity index,PSQI)评分均具有优势。舒眠胶囊单用(RR=0.33,95%CI[0.24,0.46],P<0.00001)或舒眠胶囊+常规西药(RR=0.71,95%CI[0.54,0.95],P=0.02)治疗失眠与单纯常规西药比较均可降低不良事件发生率。另外,舒眠胶囊改善失眠伴抑郁患者汉密尔顿抑郁量表(Hamilton depression scale,HAMD)评分具有优势(P<0.0001),可降低失眠患者血清中5-羟色胺(5-HT)、促甲状腺激素(TSH)、三碘甲状腺原氨酸(T3)、甲状腺素(T4)水平(P<0.05)。证据质量评价多为中、低级质量。结果表明,舒眠胶囊治疗失眠具有较好的有效性和安全性,且可改善症状评分,可能与降低血清中5-HT、TSH、T3、T4水平有关。鉴于研究证据质量,临床实践中应综合判定后再考虑应用。

关键词：舒眠胶囊失眠系统评价 Meta分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

G6P[1]型牛轮状病毒的分离培养及鉴定

引用

中国人兽共患病学报 2024年第2期40卷 134-139页

作者：王铭月张锦华章青孔翔羽王宏孙晓曼李丹地庞立丽段招军甘肃中医药大学公共卫生学院兰州730000 传染病溯源预警与智能决策全国重点实验室国家卫生健康委员会医学病毒和病毒病重点实验室中国疾病预防控制中心病毒病预防控制所北京102206

目的从轮状病毒阳性的牛粪便标本中,分离出一株G6P[1]型牛轮状病毒(Bovine Rotavirus,BRV),对其进行培养和鉴定。方法用PBS溶液重悬粪便标本并离心,将其上清过滤除菌和胰酶处理后,利用MA104细胞进行分离培养;通过逆转录-聚合酶链式反应(... 详细信息

目的从轮状病毒阳性的牛粪便标本中,分离出一株G6P[1]型牛轮状病毒(Bovine Rotavirus,BRV),对其进行培养和鉴定。方法用PBS溶液重悬粪便标本并离心,将其上清过滤除菌和胰酶处理后,利用MA104细胞进行分离培养;通过逆转录-聚合酶链式反应(Reverse Transcription-polymerase Chain Reaction,RT-PCR)对样本VP4和VP7基因进行扩增和测序,与GenBank上的参考序列进行同源性分析,构建进化树,分析确定其G/P基因分型。通过聚丙烯酰胺凝胶电泳法(Polyacrylamine Gel Electrophoresis,PAGE)、噬斑实验和电镜(Transmission Electron Microscope,TEM)等技术对分离到的病毒进行鉴定和纯化。绘制病毒生长动力学曲线。结果分离培养了1株BRV毒株,将其命名BLL。VP7和VP4基因测序结果显示此毒株为G6P[1]型轮状病毒。PAGE胶结果显示分离株电泳型为长型,条带呈现A组轮状病毒排列电泳图谱;通过噬斑实验将毒株进行了纯化。电镜检测到典型的轮状病毒颗粒。病毒生长动力学曲线可发现病毒在感染后6 h已经开始复制。结论本研究成功分离到G6P[1]型牛型轮状病毒,为研究G6P[1]型轮状病毒的病原学特征提供实验基础和技术参考。

关键词：轮状病毒 G6P 分离噬斑实验纯化序列分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tungsten separation behavior on preparation of high-purity cerium by combined vacuum gravity sedimentation-directional solidification

引用

Journal of Rare Earths 2024年第6期42卷 1182-1186,I0007页

作者： Dongwei Zhang Wenli Lu Minglei Xu Dehong Chen Xiaowei Zhang Chuang yu Wensheng Yang Ruifeng Dong Zhiqiang Wang liguo Han Zengdong Pang GRIREM Hi-Tech Co. Ltd.Langfang065201China National Engineering Research Center for Rare Earth China GRINM Group Co.Ltd.Beijing100088China GRIREM Advanced Materials Co. Ltd.Beijing100088China

In light of the difficult removal of harmful impurity tungsten(W)in Ce metal,in this paper a combined vacuum gravity sedimentation-directional solidification method was innovatively designed and the W separation behavior was *** reducing the electron beam power instantly and gradually at reduction rates of 1,3 and 5 kW/min,it is found that W is enriched at the bottom of ingots as the melt *** enrichment effect is much better than that of single purification method and the enrichment degree increases as the beam reduction rate decreases,attributed to the k0(W)>1 andρ(W)>ρ(Ce).Overall,the minimum content of W impurity can decrease from 630 to 0.1 ppm at the top of the ingot,and the purity of Ce increases from 99.932 wt%to 99.995 wt%by this combined ***,this paper provides a new method for the removal of high density and low evaporation coefficient impurities in low vapor pressure rare earth metals.

关键词： Cerium Electron beam melting Directional solidification Gravity sedimentation Rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Middle Devonian ostracods from Jiwozhai patch reef(Dushan,Guizhou Province,South China):Biostratigraphic and palaeoecological implication

引用

Journal of Palaeogeography 2024年第3期13卷 581-593页

作者： Jun-Jun Song Jia-yuan Huang Wen Guo Kun liang yu-Cong Sun Zhi-Hong Wang Wen-Kun Qie State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008Jiangsu ProvinceChina Hubei Key Laboratory of Paleontology and Geological Environment Evolution Wuhan Center of China Geological SurveyWuhan 430205Hubei ProvinceChina University of Chinese Academy of Sciences NanjingNanjing 211135Jiangsu ProvinceChina

The Middle Devonian ostracods from the Jiwozhai patch reef in Dushan, Guizhou Province, South China were described for the first time in this study. Twenty-nine species belonging to 20 genera were identified and figured, including a new species named Wangshangkia jiwozhaiensis sp. nov. The ostracod fauna in the Jiwozhai patch reef represents a Givetian age. The ostracod assemblage belongs to the smooth-podocopid association, which is also ecologically equivalent to the Eifelian Mega-Assemblage Ⅲ. This association is indicative of shallow open-marine environments. The Jiwozhai patch reef fauna is primarily comprised of suspension feeders, including filter-feeding ostracods, corals, brachiopods and bryozoans. Ostracods from the Jiwozhai patch reef were compared to the ostracod faunas from Laurentia-Baltica at generic level, which reveals limited faunal exchanges between South China and Laurentia-Baltica during the Middle Devonian.

关键词： Ostracods Givetian Jiwozhai patch reef Dushan Palaeoecology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Covalent organic frameworks/carbon nanotubes composite with cobalt(II)pyrimidine sites for bifunctional oxygen electrocatalysis

引用

Nano Materials Science 2024年第4期6卷 419-427页

作者： Zhuangzhuang Wu lijuan Feng Zhe Lu Xinxin yu yuzhen Zhao Junming Luo Shaolei Wang Xinlong Tian Qi Chen State Key Laboratory of Marine Resource Utilization in South China Sea School of Marine Science and Engineering Hainan University Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education School of Chemistry Northeast Normal University School of Bioengineering Zhuhai Campus of Zunyi Medical University

With characteristics and advantages of functional composite materials, they are commendably adopted in numerous fields especially in oxygen electrocatalysis, which is due to the significant synergies between various components. Herein, a novel bifunctional oxygen electrocatalyst（Co-CNT@COF-Pyr） has been synthesized through in-situ growth of covalent organic frameworks（COFs） layers on the outer surface of highly conductive carbon nanotubes（CNTs） followed by coordination with Co（II）. For electrocatalytic OER, Co-CNT@COF-Pyr reveals a low overpotential（438 mV） in alkaline electrolyte（1.0 M aqueous solution of KOH） with a current density of 10 mA cm-2, which is comparable to most discovered COF-based catalysts. For electrocatalytic ORR, CoCNT@COF-Pyr exhibits a low H2O2yield range（9.0 %–10.1 %） and a reaction pathway close to 4e-（n =3.82–3.80） in alkaline electrolyte（0.1 M aqueous solution of KOH） within the test potential range of 0.1–0.6 V ***, which is superior to most reported COF-based catalysts. Hence, this research could not only offer an innovative insight into the construction of composites, but also facilitate the practical application of renewable fuel cells, closed water cycle, and rechargeable metal-air batteries.

关键词： Oxygen electrocatalysis Covalent organic frameworks Carbon nanotubes Composite materials

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Low-density lipoprotein receptor-related protein 2(LRP2)is required for lipid export in the midgut of the migratory locust,Locusta migratoria

引用

Journal of Integrative Agriculture 2024年第5期23卷 1618-1633页

作者： Yiyan Zhao Weimin liu Xiaoming Zhao Zhitao yu Hongfang Guo Yang Yang Hans Merzendorfer Kun Yan Zhu Jianzhen Zhang Research Institute of Applied Biology Shanxi Key Laboratory of Nucleic Acid BiopesticidesShanxi UniversityTaiyuan 030006China College of life Science Shanxi UniversityTaiyuan 030006China Interfaculty Institute of Cell Biology University of TubingenTubingen 72076Germany Institute of Biology University of SiegenSiegen 57076Germany Department of Entomology Kansas State UniversityManhattanKS 66506USA

Low-density lipoprotein receptor-related protein 2(LRP2)is a multifunctional endocytic receptor expressed in epithelial *** mammals,it acts as an endocytic receptor that mediates the cellular uptake of cholesterol-containing apolipoproteins to maintain lipid ***,little is known about the role of LRP2 in lipid homeostasis in *** the present study,we investigated the function of LRP2 in the migratory locust Locusta migratoria(LmLRP2).The mRNA of LmLRP2 is widely distributed in various tissues,including integument,wing pads,foregut,midgut,hindgut,Malpighian tubules and fat body,and the amounts of LmLRP2 transcripts decreased gradually in the early stages and then increased in the late stages before ecdysis during the nymphal developmental *** immunohistochemistry revealed that the LmLRP2 protein is mainly located in cellular membranes of the midgut and *** RNAi to silence LmLRP2 caused molting defects in nymphs(more than 60%),and the neutral lipid was found to accumulate in the midgut and surface of the integument,but not in the fat body,of dsLmLRP2-treated *** results of a lipidomics analysis showed that the main components of lipids(diglyceride and triglyceride)were significantly increased in the midgut,but decreased in the fat body and ***,the content of total triglyceride was significantly increased in the midgut,but markedly decreased in the fat body and hemolymph in dsLmLRP2-injected *** results indicate that LmLRP2 is located in the cellular membranes of midgut cells,and is required for lipid export from the midgut to the hemolymphand fat body in locusts.

关键词： Locusta migratoria low-density lipoprotein receptor-related protein 2 midgut lipids transport RNAi

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

妊娠早期蜕膜甲状腺激素受体信号异常对蜕膜化进程的影响及其与流产发生的关联

引用

安徽医科大学学报 2024年第6期59卷 1076-1081页

作者：翟沐鑫李萱余涛赵丽于震杨媛媛安徽医科大学第一附属医院妇产科合肥230032 国家卫生健康委配子及生殖道异常研究重点实验室合肥230032 生殖健康与遗传安徽省重点实验室合肥230032

目的评估自然流产患者蜕膜血管生成情况,并探讨自然流产患者蜕膜中甲状腺激素受体信号的表达改变。方法收集行人流术的孕妇蜕膜。以自然流产患者作为实验组,以社会因素行人流术的健康孕妇作为对照组,收集两组人群蜕膜组织。采用Western ... 详细信息

目的评估自然流产患者蜕膜血管生成情况,并探讨自然流产患者蜕膜中甲状腺激素受体信号的表达改变。方法收集行人流术的孕妇蜕膜。以自然流产患者作为实验组,以社会因素行人流术的健康孕妇作为对照组,收集两组人群蜕膜组织。采用Western blot方法,检测蜕膜组织中甲状腺激素受体-α(THR-α)和THR-β的核转位情况,同时使用免疫组化法定位蜕膜组织中THR-α和THR-β的分布。Western blot测定蜕膜组织中Ⅱ型脱碘酶(DIO2)的蛋白表达水平,免疫荧光法定位DIO2在蜕膜组织分布并测定荧光强度。使用免疫组化,以CD34作为内皮标志物测定蜕膜血管密度。Western blot检测血管内皮生长因子受体(VEGFR-1)的蛋白表达水平。结果对照组与流产组在年龄、妊娠天数、TSH、T3、T4等基本资料中,差异均无统计学意义。Western blot结果提示THR-α和THR-β蛋白核转位置下降,同时蜕膜组织免疫组化染色结果表明自然流产患者蜕膜甲状腺激素受体核转位减少(P<0.05)。Western blot结果表明流产组DIO2蛋白表达较对照组下降,提示自然流产孕妇蜕膜中,甲状腺激素代谢受到影响;免疫荧光实验结果显示流产组DIO2的荧光强度较对照组减弱(P<0.05)。免疫组化法CD34标记蜕膜小血管的结果显示,在流产组中,CD34^(+)血管数量下降,差异有统计学差异(P<0.05)。Western blot结果提示流产组和对照组中VEGFR-1无明显变化,差异无统计学意义。结论蜕膜局部甲状腺激素受体信号异常可能导致蜕膜血管生成减少,从而参与自然流产的发生。

关键词：流产蜕膜化甲状腺激素受体

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

人参皂苷Rg_(1)通过IRE1-JNK-CHOP通路抑制自噬改善OGD/R诱导的PC12细胞损伤

引用

中国中药杂志 2024年第10期49卷 2745-2753页

作者：李雨晴魏梁丽袁雨琪杨子腾汪宁蔡标汪光云安徽中医药大学中西医结合学院安徽合肥230012 安徽中医药大学药学院安徽合肥230012

探讨人参皂苷Rg_(1)(ginsenoside Rg_(1),GRg_(1))对氧糖剥夺/复氧(oxygen and glucose deprivation/reoxygenation,OGD/R)损伤大鼠嗜铬细胞瘤(rat adrenal pheochromocytoma,PC12)细胞的保护作用及其作用机制是否与调控肌醇需求酶1(inositol-requiring enzyme 1,IRE1)-c-Jun氨基末端激酶(c-Jun N-terminal kinase,JNK)-C/EBP同源蛋白(C/EBP homologous protein,CHOP)信号通路有关。在PC12细胞中建立OGD/R模型,将PC12细胞随机分组为对照组、模型组、OGD/R+GRg_(1)(0.1、1、10μmol·L^(-1))组,OGD/R+GRg_(1)+雷帕霉素(rapamycin,自噬激动剂)组、OGD/R+GRg_(1)+3-甲基腺嘌呤(3-methyladenine,3-MA,自噬抑制剂)组、OGD/R+GRg_(1)+衣霉素(tunicamycin,内质网应激激动剂)组、OGD/R+GRg_(1)+4-苯基丁酸(4-phenylbutyric acid,4-PBA,内质网应激抑制剂)组、OGD/R+GRg_(1)+3,5-二溴水杨醛(3,5-dibromosalicylaldehyde,DBSA,IRE1抑制剂)组。除对照组外,其他组都进行OGD/R处理,即氧糖剥夺6 h再复氧6 h。MTT法检测细胞活力,Hoechst 33342染色检测细胞凋亡情况,MDC法检测细胞自噬体的荧光强度。Western blot检测自噬相关蛋白Beclin1、LC3-Ⅱ、p62和通路相关蛋白IRE1、p-IRE1、JNK、p-JNK、葡萄糖调节蛋白78(glucose-regulated protein 78,GRP78)、CHOP的表达情况。结果显示,与模型组相比,0.1、1、10μmol·L^(-1)GRg_(1)剂量依赖性地提高了PC12细胞的活力,降低了自噬蛋白Beclin1、LC3-Ⅱ和通路相关蛋白p-IRE1、p-JNK、GRP78、CHOP表达,降低了细胞凋亡率和MDC荧光强度,同时也增加了p62蛋白表达。而分别干预自噬和内质网应激后,与OGD/R+GRg_(1)(10μmol·L^(-1))组相比,OGD/R+GRg_(1)+rapamycin组和OGD/R+GRg_(1)+tunicamycin组细胞凋亡率和MDC荧光强度增加,自噬蛋白Beclin1、LC3-Ⅱ和通路相关蛋白p-IRE1、p-JNK、GRP78、CHOP表达增加,细胞相对存活率和p62蛋白表达降低。3-MA、4-PBA和DBSA则发挥了相反作用。综上所述,GRg_(1)可能通过IRE1-JNK-CHOP通路抑制自噬而改善OGD/R诱导PC12细胞的损伤。

关键词：人参皂苷Rg_(1)(GRg_(1)) 氧糖剥夺/复氧(OGD/R) 内质网应激自噬 IRE1-JNK-CHOP

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：