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Third generation biosensor based on myoglobin-TiO_2/MWCNTs modified glassy carbon electrode

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Chinese Chemical Letters 2008年第8期19卷 965-968页

作者： Lei Zhang dan Bi tian Jun Jie Zhu College of Science Nanjing University of Technology Nanjing 210009 China Laboratory of Analytical Chemistry for Life Science Department of Chemistry Nanjing University Nanjing 210093 China

TiO2 nanoparticles were homogeneously coated on multi-walled carbon nanotubes by hydrothermal deposition, this nanocomposite may be a promising material for myoglobin immobilization in view of its high biocompatibility and large surface. The glassy carbon electrode modified with Mb-TiO2/MWCNTs films exhibited a pair of weU defined, stable and nearly reversible cycle voltammetric peaks. The electron transfer between Mb and electrode surface, Ks of 3.08 s^-1, was greatly facilitated in the TiO2/ MWCNTs film. The electrocatalytic reductions of hydrogen peroxide were studied, the apparent Michaelis-Menten constant is calculated to be 83.10 μmol/L, which shows a large catalytic activity of Mb in the TiO2/MWCNTs film to H2O2.

关键词： Myoglobin Multi-walled carbon nanotubes TiO2 Electrocatalysis Electrochemistry

Chemical constituents and pharmacological effects of Lonicerae japonicae

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Asian Journal of Traditional Medicines 2024年第1期19卷 34-45页

作者： Yunpeng Yang dan tian Yibo Wang Yi’an Shi Yuntian Xing Yu Chen School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China Shenyang Hoper Group Co. LtdShenyang 110122China National Health Commission Key Laboratory of Parasitic Disease Control and Prevention Jiangsu Provincial Key Laboratory on Parasite and Vector Control TechnologyJiangsu Provincial Medical Key LaboratoryJiangsu Institute of Parasitic DiseasesWuxi 214064China

Lonicera japonica,also known as honeysuckle,is an evergreen shrub in the family of *** consulting Sciencedirect databases and Web of Science databases,79 related articles were found,of which 22 were related to chemical composition and pharmacological *** articles show that *** has a wide range of pharmacological activities,including antiviral,anti-tumor,and antioxidant *** activities have important applications in the pharmaceutical,food,and fragrance *** review focuses on the chemical composition and pharmacological effects of ***,which is of great significance to the development of new drugs and therapeutic methods.

关键词： Lonicerae japonicae chemical composition pharmacological activity

Quantitative microstructure and fatigue life of B319 casting alloys

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Rare Metals 2017年第10期36卷 780-791页

作者： Yue Shen Xiao-Shan Liu Guo-Qiu He dan-dan tian Qi-Gui Wang Shi-Quan Lv School of Materials Science and Engineering Tongji University Shanghai 201804 China Shanghai Key Laboratory for R&D and Application of Metallic Functional Materials Shanghai 201804 China Mat Technol Global Powertrain Engn Gen Motors Co Pontiac MI 48340 USA

In this study, the microstructure of B319 casting alloys and effects of five different casting conditions on microstructure were studied. Multi-scale microstructure was quantified in terms of secondary dendrite arm spacing （SDAS）, and Si particle size and aspect ratio. The effects of SDAS, Si aspect ratio and size on fatigue life were analyzed. The results indicate that the size and aspect ratio of Si particles are a function of SDAS which is dependent on cooling rate during solidification. The fatigue life decreases with SDAS increasing as SDAS is smaller than 30 pm while it increases with SDAS increasing as SDAS is larger than 60 ~tm. In addition, the fatigue life decreases with Si aspect ratio and size increasing at the same SDAS. Moreover, SDAS and Si particles have also influence on fatigue fracture, such as the area of cracks propagation region and the roughness of fatigue fracture. The cracks propagation area is smaller, and the fatigue fracture is similar to tensile fracture with larger SDAS. Besides, the longitudinal section of fatigue fracture is rougher with large SDAS and elongated Si particles.

关键词： B319 aluminum alloy Microstructure SDAS Si aspect ratio Si size Fatigue life

A selective voltammetric detection for dopamine using poly(gallic acid) film modified electrode

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Chinese Chemical Letters 2010年第3期21卷 349-352页

作者： Song, Wei Chen, Yu Xu, Juan tian, dan Bi Nanjing Univ Technol Coll Sci Nanjing 210009 Peoples R China

The electrochemistry behavior of dopamine was investigated by cyclic voltammetry and differential pulse voltammetry at a poly (gallic acid) film modified glassy carbon *** electrons and two protons participated in the diffusion-controlled electrocatalytic oxidation of dopamine with a diffusion coefficient of 2.186×10^(-5) cm^2/*** interference of ascorbic acid with the determination of dopamine could be efficiently *** work provided a simple approach to selectively and sensitively de...

关键词： Dopamine Ascorbic acid Gallic acid Electropolymerization Modified electrode

超声剪切波弹性成像结合血浆NRG4水平评估慢性乙型肝炎肝纤维化程度的价值

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肝脏 2024年第7期29卷 825-829页

作者：刘艳午田丹宋晶晶雅安市人民医院四川625000

目的探究超声剪切波弹性成像(SWE)联合血浆神经调节蛋白4(NRG4)水平评估慢性乙型肝炎(CHB)肝纤维化程度的价值。方法2020年6月—2022年6月雅安市人民医院接诊的CHB肝纤维化患者116例,均进行肝脏穿刺病理活检,采用超声SWE检测肝脏杨氏模... 详细信息

目的探究超声剪切波弹性成像(SWE)联合血浆神经调节蛋白4(NRG4)水平评估慢性乙型肝炎(CHB)肝纤维化程度的价值。方法2020年6月—2022年6月雅安市人民医院接诊的CHB肝纤维化患者116例,均进行肝脏穿刺病理活检,采用超声SWE检测肝脏杨氏模量值,Elisa法检测血浆NRG4水平。分析肝脏杨氏模量值及血浆NRG4水平与肝纤维化程度的相关性。绘制受试者工作特征曲线(ROC),并采用曲线下面积(AUC)评估杨氏模量值联合血浆NRG4水平对CHB肝纤维化程度的诊断效能。结果116例CHB肝纤维化患者中F1期33例(28.4%)、F2期38例(32.8%)、F3期26例(22.4%)、F4期19例(16.4%)。F1期、F2期、F3期、F4期患者的杨氏模量值分别为[(5.2±1.3)kPa、(6.3±1.2)kPa、(8.7±1.4)kPa、(11.9±1.6)kPa,P<0.05];F1期、F2期、F3期、F4期患者的血浆NRG4水平分别为(6.7±1.2)、(4.9±1.0)、(3.3±0.9)、(1.9±0.5)pg/mL(P<0.05)。Spearman相关性分析结果显示,杨氏模量值与肝纤维化程度呈正相关(r=0.673,P<0.05);血浆NRG4水平与肝纤维化程度呈负相关(r=-0.702,P<0.05)。ROC分析结果显示,杨氏模量值对CHB肝纤维化患者F1期、F2期、F3期及F4期诊断的AUC分别为0.85(95%CI:0.75~0.94)、0.83(95%CI:0.75~0.92)、0.86(95%CI:0.76~0.95)、0.92(95%CI:0.82~1.00)。血浆NRG4水平对CHB肝纤维化患者F1期、F2期、F3期及F4期诊断的AUC分别为0.86(95%CI:0.76~0.95)、0.82(95%CI:0.74~0.91)、0.88(95%CI:0.80~0.97)、0.92(95%CI:0.82~1.00)。杨氏模量值联合血浆NRG4水平对CHB肝纤维化患者F1期、F2期、F3期及F4期诊断的AUC分别为0.92(95%CI:0.84~0.99)、0.92(95%CI:0.85~0.98)、0.94(95%CI:0.88~1.00)、0.97(95%CI:0.91~1.00),杨氏模量值联合血浆NRG4诊断肝纤维化不同分期的AUC高于二者单一诊断(P<0.05)。结论杨氏模量值和血浆NRG4水平对CHB肝纤维化程度的诊断效果良好,且联合诊断价值更高。

关键词：慢性乙型肝炎肝纤维化分期剪切波弹性成像杨氏模量值神经调节蛋白4

营养风险评估与综合护理在消化系统疾病患者中的应用价值分析

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罕少疾病杂志 2024年第4期31卷 128-130页

作者：田丹丹王亚培牟玉秀吕宁郑州大学第一附属医院消化内科河南郑州450052

目的探究营养风险评估与综合护理在消化系统疾病患者中的应用价值。方法选取2020年~2022年于本院接受治疗的消化系统疾病患者108例,所有病人均接受营养风险评估,按护理方案进行分组,采用常规护理方案的62例病人为对照组,采用综合护理方... 详细信息

目的探究营养风险评估与综合护理在消化系统疾病患者中的应用价值。方法选取2020年~2022年于本院接受治疗的消化系统疾病患者108例,所有病人均接受营养风险评估,按护理方案进行分组,采用常规护理方案的62例病人为对照组,采用综合护理方案的46例病人为观察组。比较两组的康复指标、营养状况、营养风险评分、焦虑抑郁情况以及护理满意度。结果两组干预前各指标差异比较均无统计学意义(P>0.05)。干预后,相较于对照组,观察组住院时间、卧床时间、排气时间、排便时间、NRS2002、SAS、SDS评分均显著降低(P<0.05);ALB、PA、TP水平、护理满意度均显著升高(P<0.05)。结论营养风险评估与综合护理应用于消化系统疾病患者的临床护理中,可明显改善患者的康复指标和营养状况,有效降低营养风险,缓解焦虑抑郁情绪,同时具有较高的护理满意度,值得临床推广应用。

关键词：营养风险评估综合护理消化系统疾病应用价值

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Needleless Electrospinning:Reciprocation ***

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Fluid Dynamics & Materials Processing 2021年第6期17卷 1015-1019页

作者： Xiaoxia Li Manyu Qian dan tian Jihuan He School of Textile Garment and Design Changshu Institute of TechnologySuzhouChina National Engineering Laboratory for Modern Silk College of Textile and Clothing EngineeringSoochow UniversitySuzhouChina School of Science Xi’an University of Architecture and TechnologyXi’anChina

Needleless electrospinning is a versatile method to produce *** particular,the rotary version of this technique has enjoyed widespread use because there is no need to clean the *** rotation speed is limited by the potential deviation of the jet due to the centrifugal *** limitations are due to the fast volatilization of the solvent from the opened spinning *** order to overcome these drawbacks,here a novel reciprocating system based on a moving spinning-plate is *** spinning process is implemented in a half-closed system with the spinning-plate immersed in the solution *** the immersed spinning-plate moves up from the solution tank,multiple jets are ejected from the droplets on the tips of the spinning-plate under the effect of an electric field *** morphology of the obtained nanofibers has been analyzed by scanning electron *** results indicated that the obtained fibers are uniform in structures and small in *** issues of needle clogging and intense solvent evaporation can be mitigated using this alternate approach.

关键词： Needleless electrospinning reciprocation spinning-plate nanofibers

基于罗汉果治疗糖尿病肾病机制的网络药理学和分子对接分析

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吉林大学学报（医学版） 2024年第1期50卷 161-167页

作者：于洋田丹倪东贺张铎北华大学附属医院医学影像中心吉林吉林132011

目的:利用网络药理学分析罗汉果对糖尿病肾病(DN)的改善作用,阐明其可能的相关机制。方法:采用中药系统药理学数据库和分析平台(TCMSP)确定罗汉果中的有效成分及其作用靶点。通过DisGeNET数据库和GeneCards数据库筛选DN靶基因。将罗汉果... 详细信息

目的:利用网络药理学分析罗汉果对糖尿病肾病(DN)的改善作用,阐明其可能的相关机制。方法:采用中药系统药理学数据库和分析平台(TCMSP)确定罗汉果中的有效成分及其作用靶点。通过DisGeNET数据库和GeneCards数据库筛选DN靶基因。将罗汉果与DN靶点进行对比,获取罗汉果对DN的关键靶点。通过STRING数据库和Cytoscape软件构建蛋白-蛋白互作(PPI)网络图,通过Cytoscape软件进行基因本体论(GO)功能富集分析和京都基因与基因组百科全书(KEGG)信号通路富集分析。采用分子对接技术预测DN核心靶点与罗汉果主要活性成分的结合能力。结果:采用TCMSP数据库结合选入标准共筛选出罗汉果5种活性成分(ZINC03860434、Perlolyrine、beta-sitosterol、Kaempferol和Flazin)及丝氨酸/苏氨酸蛋白激酶1 (AKT1)、转录因子RELA、c-Jun氨基末端激酶(JUN)和肿瘤坏死因子(TNF)为代表的85个靶点,其中kaempferol所含靶点最多。筛选出的85个靶点中与DN相关的靶点有34个。GO功能富集分析主要涉及氧化应激、炎症及凋亡调控和细胞信号传导等生物学过程(BP)。KEGG信号通路富集分析涉及晚期糖基化终产物(AGE)-AGE受体(AGE-RAGE)信号通路、 TNF信号通路和C型凝集素受体信号通路等。罗汉果主要活性成分与DN靶点蛋白分子对接分析,5种活性成分分子对接结合能均在-8.00~-5.00 kJ·mol^(-1)之间。结论:Kaempferol是罗汉果中对DN治疗最有效的活性成分,其作用机制主要与抑制炎症有关。

关键词：罗汉果糖尿病肾病网络药理学炎症因子蛋白-蛋白互作网络

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Syntheses,structures,luminescent and magnetic properties of two coordination polymers based on a flexible multidentate carboxylate ligand

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Chinese Chemical Letters 2015年第5期26卷 499-503页

作者： dan tian Xiao-Jing Liu Rong-Ying Chen Ying-Hui Zhang Department of Chemistry and TKL of Metal-and Molecule-Based Material Chemistry Key Laboratory of Advanced Energy Materials Chemistry(MOE)and Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Nankai University

Two coordination polymers, {[Cu3（tci）2（DMAc）3].6DMAc-2H2O}n （1[） and {[Cu3（tci）2（tpt）2（H2O）2]- 2DMAc-2H2O}n （2）（H3tci = tris（2-carboxyethyl）isocyanurate, tpt = 2,4,6-tris（4-pyridyl）-l,3,5-triazine, DMAc = N,N-dimethylacetamide）, have been constructed under solvothermal conditions. Both polymers were structurally characterized by single crystal X-ray diffraction, elemental analyses, IR spectra, thermogravimetric （TG） analyses and powder X-ray diffraction （RXPD）. 1 shows a （3,4）-connected 2D layer structure comprising Cu2（CO2）4 paddle-wheel units, which are further bridged by C-H.--O interactions to give a 3D supramolecular network. The introduction oftpt produces different framework for 2 that comprises a dinuclear and a mononuclear Cu（II） building units, which are further bridged together by tci3- and tpt ligands to give a 4-connected 2D topological net. Adjacent 2D layers are packed together via C-H...O interactions and π...π stacking interactions to form a 3D supramolecular structure. In addition, the luminescent properties and the solid-state UV-vis spectra of I and 2 were explored. Furthermore, antiferromagnetic exchange interactions were unveiled in the Cu2（COO）4 units of 1. ~ 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

关键词： Coordination polymers X-ray crystallography Copper Magnetic properties Luminescence