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Study on the diagnostic criteria of syndrome of dampness obstruction in idiopathic membranous nephropathy based on expert consensus

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Journal of Traditional Chinese Medicine 2025年第1期45卷 167-175页

作者： wang dan HUANG Xiaoyan LI Ping HONG Xiaofan ZHANG Yumin wang Rongrong BAO Kun LIANG Xing Nephrology Department Qianxinan Autonomous Prefecture Hospital of Traditional Chinese Medicine Nephrology Department Guangdong Provincial Hospital of Chinese Medicine Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Disease the Second Affiliated Hospital of Guangzhou University of Chinese Medicine State Key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese Medicine State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research

OBJECTIVE: To reach consensus on the diagnostic criteria of syndrome of dampness obstruction in idiopathic membranous nephropathy(IMN) patients by literature research and expert investigation(interviews and a Delphi method). METHODS: Our study was consistent with T/CACM 1336-2020. We searched the monographs and references published in the past 40 years(1983-2022), and established the diagnostic criteria pool of waterdampness syndrome and dampness-turbidity syndrome in Traditional Chinese Medicine(TCM) based on literature by using frequency statistics and correlation analysis. Expert investigation(interview method and two rounds of Delphi method) was used to form the diagnostic criteria of water-dampness syndrome and dampnessturbidity syndrome of idiopathic membranous nephropathy. Clinical diagnostic test research was carried out, and compared with “Diagnostic Criteria for dampness syndrome”(T/CACM 1454-2023) to evaluate the authenticity, reliability and clinical application value of the standard. RESULTS: A total of 122 relevant guides, standards, monographs and documents were included through searching books and Chinese databases. Four experts were interviewed and two rounds of delphi method(75 experts nationwide) were carried out. The experts' opinions are relatively concentrated and the differences are small. Based on the weight of each index, the diagnostic criteria indexes of water-dampness syndrome and dampness-turbidity syndrome were selected. After discussion by the core group members, the diagnostic model of "necessary symptoms and optional symptoms" was established, and the final diagnostic criteria of waterdampness syndrome and dampness-turbidity syndrome were established. One hundred and ninety-one inpatients and outpatients of Guangdong Provincial Hospital of Chinese Medicine from January 2021 to February 2023 were included in Diagnostic test study. There was no statistical difference in gender, age and course of disease(P > 0.05). The sensitivity and s

关键词： combination of disease and syndrome diagnostic tests, routine glomerulonephritis, membranous syndrome diagnostic criteria syndrome of dampness obstruction

PAMPHLET:PAM Prediction HomoLogous-Enhancement Toolkit for precise PAM prediction in CRISPR-Cas systems

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Journal of Genetics and Genomics 2025年第2期52卷 258-268页

作者： Chen Qi Xuechun Shen Baitao Li Chuan Liu Lei Huang Hongxia Lan Donglong Chen Yuan Jiang dan wang Guangdong Provincial Key Laboratory of Interdisciplinary Research and Application for Data Science BNU-HKBU United International CollegeZhuhaiGuangdong 519087China School of Biology and Biological Engineering South China University of TechnologyGuangzhouGuangdong 510006China BGI Research HangzhouZhejiang 310030China BGI Research ShenzhenGuangdong 518083China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Laboratory of Integrative Biomedicine Department of BiologyFaculty of ScienceUniversity of CopenhagenCopenhagenDenmark Qingdao-Europe Advanced Institute for Life Sciences BGI ResearchQingdaoShandong 266555China School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China STOmics Americas Ltd. 2904 Orchard PkwySan Jose CA 95134USA

CRISPR-Cas technology has revolutionized our ability to understand and engineer organisms,evolving from a singular Cas9 model to a diverse CRISPR toolbox.A critical bottleneck in developing new Cas proteins is identifying protospacer adjacent motif(PAM)*** to the limitations of experimental methods,bioinformatics approaches have become ***,existing PAM prediction programs are limited by the small number of spacers in CRISPR-Cas systems,resulting in low *** address this,we develop PAMPHLET,a pipeline that uses homology searches to identify additional spacers,significantly increasing the number of spacers up to *** is validated on 20 CRISPR-Cas systems and successfully predicts PAM sequences for 18 *** predictions are further validated using the DocMF platform,which characterizes protein-DNA recognition patterns via next-generation *** high consistency between PAMPHLET predictions and DocMF results for Cas proteins demonstrates the potential of PAMPHLET to enhance PAM sequence prediction accuracy,expedite the discovery process,and accelerate the development of CRISPR tools.

关键词： CRISPR-Cas Protospacer adjacentmotif Genome editing PAM prediction Computational framework

铸牢中华民族共同体意识的多元内涵、基本原则与实践路径

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新疆大学学报(哲学社会科学版) 2025年第1期53卷 11-19页

作者：王茹俊王丹大连海事大学马克思主义学院辽宁大连116026

中华民族是一个命运与共的共同体,共同的意识指引着各民族的团结奋进大业。铸牢中华民族共同体意识是一项系统工程,应当置于“五位一体”总体布局内进行阐发,科学把握政治认同、经济繁荣、文化自信、社会互嵌、生态和谐等多元核心内涵,... 详细信息

中华民族是一个命运与共的共同体,共同的意识指引着各民族的团结奋进大业。铸牢中华民族共同体意识是一项系统工程,应当置于“五位一体”总体布局内进行阐发,科学把握政治认同、经济繁荣、文化自信、社会互嵌、生态和谐等多元核心内涵,充分彰显其现实的正当性与科学性。当前,需要站稳科学的行动立场,严格坚守核心原则、主体原则、精神原则与目标原则,不断为铸牢中华民族共同体意识注入磅礴动力。此外,铸牢中华民族共同体意识离不开各族人民的实践参与,通过落实制度引领、法治建设、传播塑造、教育熔铸等科学路径,在有形策略与无形方式的统一中完成铸牢任务。

关键词：中华民族共同体意识新时代民族工作

SiEPFs enhance water use efficiency and drought tolerance by regulating stomatal density in foxtail millet(Setaria italica)

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Journal of Integrative Agriculture 2025年第2期24卷 786-789页

作者： Jianhong Hao Xueting Kang Lingqian Zhang Jiajing Zhang Huashuang Wu Zidong Li dan wang Min Su Shuqi Dong Xiaorui Li Lulu Gao Guanghui Yang Xiaoqian Chu Xiangyang Yuan Jiagang wang Hou Ji Laboratory in Shanxi Province/College of Agriculture Shanxi Agricultural University State Key Laboratory of Sustainable Dryland Agriculture (in preparation) Shanxi Agricultural University

Highlights The water use efficiency of the drought-resistant variety MT3 was found to be correlated with stomatal *** enhance water use efficiency and drought tolerance by regulating stomatal density in foxtail ***(D)causedbyglobalwarmingisseverely affecting crop growth and agricultural production (Gupta etal. 2020).Stomata provide an important window for photosynthesis and water transpiration, and stomatal densityiscloselyrelatedtothedroughtresponse(Herrmann and Torii 2021).Foxtail millet (Setaria italica)isan important drought tolerant crop that plays an important role in ensuring food and nutritional security(Muthamilarasan and Prasad 2017).Unlike in other crops, the drought-resistance mechanism of foxtail millet is not fully understood, with only SiDPY1, SiYTH1, and SiMYBS3 currently identified and characterized (Liu et al.2023; Luo et al. 2023; Zhao et al. 2023).Therefore, the drought resistance mechanism remains unclear.

关键词： tolerance drought density water efficiency enhance foxtail italica millet regulating

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省域高等教育分类发展的竞合逻辑与实践路径

高校教育管理 2025年第1期19卷 74-83页

作者：王丹吴立保南京信息工程大学高等教育研究所江苏南京210044 淮北师范大学教育学院安徽淮北235000

实现高等教育分类发展是建设教育强国的先决条件,省域高等教育分类发展对教育强国建设负有主体责任。本研究依托竞合理论,针对省域高等教育分类标准固化、合作联动不足和分类目标建设失衡、合作理念和行动不足等问题,提出竞合视角下省... 详细信息

实现高等教育分类发展是建设教育强国的先决条件,省域高等教育分类发展对教育强国建设负有主体责任。本研究依托竞合理论,针对省域高等教育分类标准固化、合作联动不足和分类目标建设失衡、合作理念和行动不足等问题,提出竞合视角下省域高等教育分类发展的实践路径,通过构建省域高等教育分类多主体竞合生态关系,建立互涉共生的省域高校分类发展主体,形成互补嵌入的结构化竞合和评价机制,分类引领确立互为目标的价值旨归以突破传统分类发展中的路径依赖和组织惯习影响,为建设中国特色、世界一流的高等教育贡献力量。

关键词：省域高等教育分类发展竞合理论生态关系实践路径

RIS辅助多MEC服务器的联合任务卸载和资源分配策略

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计算机应用研究 2025年第2期42卷 566-574页

作者：王丹赵静王嘉程重庆邮电大学通信与信息工程学院重庆400065

针对传统集中式计算无法有效应对海量设备产生的庞大数据,且移动边缘计算(MEC)服务器资源受限容易引起资源拥塞以及复杂的通信环境导致用户任务卸载传输受阻甚至中断的问题,提出了一种可重构智能表面(RIS)辅助多MEC服务器的联合任务卸... 详细信息

针对传统集中式计算无法有效应对海量设备产生的庞大数据,且移动边缘计算(MEC)服务器资源受限容易引起资源拥塞以及复杂的通信环境导致用户任务卸载传输受阻甚至中断的问题,提出了一种可重构智能表面(RIS)辅助多MEC服务器的联合任务卸载和资源分配方法。由于最大化系统卸载效用问题是一个混合整数非线性规划问题,难以直接求解,于是整体求解过程采用交替优化法,进行迭代求解。通过联合优化RIS处相移矩阵、MEC服务器端中央处理器(central processing unit,CPU)的计算资源、卸载用户和MEC服务器的关联决策以及用户端上行传输功率,最大化系统卸载效用。具体地,通过最佳相位规划,拟凸优化技术以及凸优化技术分别求解RIS最佳相移、用户发射功率分配以及MEC服务器计算资源分配决策,并设计了一种改进的启发式算法求解用户与MEC服务器的关联决策。仿真结果表明,将RIS和改进的启发式算法结合的方法较传统求解方法中的启发式算法相比,系统的平均卸载效用提升了约22.89%,并且方法比基准方案中采用基于局部搜索的经典求解方法的卸载效用提升了约14.02%。因此,该方法有益于提高用户的通信服务质量。

关键词：移动边缘计算可重构智能表面任务卸载资源分配启发式算法

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TOE拓展框架下城市基础设施韧性组态路径研究

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中国安全生产科学技术 2025年第2期21卷 208-216页

作者：王丹邬凡辽宁工程技术大学工商管理学院辽宁葫芦岛125105

为辨析在可持续发展目标下复杂城市环境影响城市基础设施韧性的复杂因果机制,基于“技术-组织-环境”框架和整体图的经验象限,构建包含多重复杂因素的TOE-E拓展框架,结合模糊集定性比较分析和必要条件分析方法,识别L省14个地级市的城市... 详细信息

为辨析在可持续发展目标下复杂城市环境影响城市基础设施韧性的复杂因果机制,基于“技术-组织-环境”框架和整体图的经验象限,构建包含多重复杂因素的TOE-E拓展框架,结合模糊集定性比较分析和必要条件分析方法,识别L省14个地级市的城市基础设施韧性组态路径。研究结果表明:教育水平是构成期望城市基础设施韧性的唯一必要条件;期望和非期望城市基础设施韧性结果对应的组态路径各4条;潜在替代或互补关系是构成不同路径中条件组合间替代关系的原因。研究结果可为城市基础设施韧性组态路径识别与分析提供参考。

关键词：城市基础设施韧性 TOE拓展框架 fsQCA方法 NCA方法潜在替代关系

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电动汽车接入的综合能源系统鲁棒优化调度

华中科技大学学报(自然科学版) 2025年第1期53卷 56-62页

作者：杨志淳谷博操燕春王丹国网湖北省电力有限公司电力科学研究院华中科技大学电气与电子工程学院国网湖北省电力有限公司黄冈供电公司

提出一种计及电动汽车接入的多不确定性下园区综合能源系统多阶段鲁棒优化调度模型．首先考虑了源荷出力不确定性及系统运行场景概率分布不确定性因素，将模型构建为两阶段四层鲁棒优化模型，其中系统运行场景概率分布优化阶段采用分布... 详细信息

提出一种计及电动汽车接入的多不确定性下园区综合能源系统多阶段鲁棒优化调度模型．首先考虑了源荷出力不确定性及系统运行场景概率分布不确定性因素，将模型构建为两阶段四层鲁棒优化模型，其中系统运行场景概率分布优化阶段采用分布鲁棒优化方法．然后，将优化模型构建为Stackelberg博弈问题，通过Karush-KuhnTucker条件将博弈模型转化为单层优化问题进行求解．最后，采用一种迭代算法将构建的多阶段鲁棒优化模型迭代求解．算例结果表明：提出的多阶段鲁棒优化调度模型提升了系统运行的经济性与鲁棒性．

关键词：园区综合能源系统电动汽车多重不确定性鲁棒优化 Stackelberg博弈

circT P63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway

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Science China Life Sciences 2025年

作者： dan wang Sicheng Zuo Junshang Ge Hongke Qu Jie Wu Na Yi Lei Shi Yumin wang Yongzhen Mo Chunmei Fan Yi He Pan Chen Ming Zhou Bo Xiang Wei Xiong Wenjia Guo Zhaoyang Zeng Can Guo NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research Institute and School of Basic Medicine Sciences Central South University Furong Laboratory Cancer Research Institute Affiliated Cancer Hospital of Xinjiang Medical University Xinjiang Key Laboratory of Translational Biomedical Engineering

Circular RNAs(circRNAs) play pivotal roles in the development and progression of various diseases, including malignant tumors. However,the biological functions and the underlying mechanisms of many circRNAs remain elusive. In this study, we identified a novel circRNA,circTP63-N, generated through the splicing of exons 2–4 of the TP63 gene in nasopharyngeal carcinoma(NPC). circTP63-N was found to be downregulated in clinical samples of NPC. Both in vitro and in vivo experiments unequivocally demonstrated that circTP63-N inhibits the proliferation and metastasis of NPC cells. Further investigations revealed that circTP63-N interacted with the HSP90AB1 protein, leading to the recruitment of LATS/YAP1 proteins. This, in turn, induced phosphorylation and ubiquitination-dependent degradation of YAP1, resulting in reduced nuclear translocation of YAP1 and inhibition of the transcriptional activation of downstream oncogenic genes, including INHBA, MMP3, and CCNE2. Our findings highlight the identification of circTP63-N, a novel circRNA encoded by an important tumor-relevant gene TP63 and elucidate its molecular mechanism as a tumor suppressor in NPC. These insights offer novel potential molecular markers and therapeutic targets for the clinical diagnosis and treatment of NPC.

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