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Association between fundamental motor skills and physical activity in the early years:A systematic review and meta-analysis

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Journal of Sport and Health Science 2020年第6期9卷 542-552页

作者： dan jones Alison Innerd Emma L.Giles Liane B.Azevedo School of Health and Life Sciences Teesside UniversityMiddlesbrough TS13BXUK

Background:Physical activity(PA)in the early years is associated with a range of positive health *** motor skill(FMS)competence is associated with PA and is theorized to be driven by PA in the early years and vice versa in mid to late ***,to date,no studies have meta-analyzed the association between PA and FMS in the early ***:Six electronic databases were searched for articles published up to April ***-sectional and longitudinal studies were included if they targeted children(ages 3-6 year)as the population of the study and assessed the association between objectively measured PA and *** FMS,total physical activity(TPA),and moderate-to-vigorous physical activity(MVPA)data were meta-analyzed using a random effects ***:We identified 24,815 titles and *** total,19 studies met the inclusion criteria,including 14 cross-sectional and 4 longitudinal studies,as well as 1 study with cross-sectional and longitudinal *** was a significant but small positive association between FMS and MVPA(r=0.20,95%confidence interval(CI):0.13-0.26)and TPA(r=0.20,95%CI:0.12-0.28).Findings from longitudinal studies revealed that PA drives FMS in early *** was explored in 1 study,which found that perceived motor competence did not mediate the association between FMS and ***:Using a meta-analysis,this study is the first to show a positive association between FMS,MVPA,and TPA in the early years of childhood,suggesting that the association begins at an early *** evidence from longitudinal studies supports the theory that PA drives FMS in the early years of *** evidence is needed from large studies to track PA and FMS until mid to late childhood and to explore the mediators of this association.

关键词： Early years Fundamental motor skills Physical activity

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Recent advances in the diagnostic evaluation of pancreatic cystic lesions

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World Journal of Gastroenterology 2022年第6期28卷 624-634页

作者： Devarshi R Ardeshna Troy Cao Brandon Rodgers Chidiebere Onongaya dan jones Wei Chen Eugene J Koay Somashekar G Krishna Department of Internal Medicine Ohio State University Wexner Medical CenterColumbusOH 43210United States College of Medicine Ohio State UniversityColumbusOH 43210United States James Molecular Laboratory Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Pathology Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of GI Radiation Oncology The University of Texas MD AndersonHoustonTX77030United States Division of Gastroenterology Department of Internal MedicineOhio State University Wexner Medical CenterColumbusOH 43210United States

Pancreatic cystic lesions(PCLs)are becoming more prevalent due to more frequent abdominal imaging and the increasing age of the general *** has become crucial to identify these PCLs and subsequently risk stratify them to guide *** the high morbidity associated with pancreatic surgery,only those PCLs at high risk for malignancy should undergo such ***,current diagnostic testing is suboptimal at accurately diagnosing and risk stratifying ***,research has focused on developing new techniques for differentiating mucinous from non-mucinous PCLs and identifying high risk lesions for *** sectional imaging radiomics can potentially improve the predictive accuracy of primary risk stratification of PCLs at the time of detection to guide invasive *** cyst fluid glucose has reemerged as a potential biomarker,cyst fluid molecular markers have improved accuracy for identifying specific types of *** ultrasound guided approaches such as confocal laser endomicroscopy and through the needle microforceps biopsy have shown a good correlation with histopathological findings and are evolving techniques for identifying and risk stratifying *** most of these recent diagnostics are only practiced at selective tertiary care centers,they hold a promise that management of PCLs will only get better in the future.

关键词： Pancreatic cystic lesion Intraductal papillary mucinous neoplasms Mucinous cystic neoplasm Microforceps biopsy Radiomics Confocal laser endomicroscopy

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空王冠

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作者： (英)丹·琼斯(dan jones)

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圣殿骑士团

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作者： (英)丹·琼斯(dan jones)

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血夏

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作者： (英)丹·琼斯(dan jones)

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生物标记物对分子靶向治疗的影响

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中国处方药 2009年第3期8卷 62-63页

作者： dan jones 梁伟

鉴于KRAS基因突变对抗EGFR分子靶向药物治疗疗效的影响,ASCO发布了相关的治疗指南,建议在给予抗EGFR药物治疗前必须先检测KRAS基因的突变状况。但是这一研究结果是基于回顾性研究的分析,而药品监管机构对于回顾性研究的结果却表现的比... 详细信息

鉴于KRAS基因突变对抗EGFR分子靶向药物治疗疗效的影响,ASCO发布了相关的治疗指南,建议在给予抗EGFR药物治疗前必须先检测KRAS基因的突变状况。但是这一研究结果是基于回顾性研究的分析,而药品监管机构对于回顾性研究的结果却表现的比较慎重,很难据此做出修改分子靶向药品说明书的决定。制药企业未来在开发分子靶向药物时应该将这些因素考虑在内。

关键词：分子靶向药物生物标记物 RAS基因突变抗EGFR药物药品监管机构药品说明书治疗疗效治疗指南

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