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Longitudinal changes in cardiac function in the very elderly: the Jerusalem longitudinal cohort study

Journal of Geriatric Cardiology 2019年第11期16卷 800-805页

作者： David Leibowitz Irit Stessman-Lande Hend Sliman Jeremy M Jacobs Jochanan Stessman dan gilon Jerusalem Institute of Aging Research Hadassah-Hebrew University Medical CenterMount-ScopusJerusalemIsrael Coronary Care Unit Hadassah–Hebrew University Medical CenterMount-ScopusJerusalemIsrael Department of Geriatrics and Rehabilitation Hadassah-Hebrew University Medical CenterMount-ScopusJerusalemIsrael

Background People over the age of 85 are a rapidly growing age group with a high incidence of congestive heart failure(CHF),in particular heart failure with preserved ejection fraction(HFp EF).The diagnosis of CHF is challenging and longitudinal data assessing cardiac structure and function are necessary to distinguish physiologic from pathologic cardiac *** objective of the study was to determine longitudinal changes in cardiac struture and function from ages 85 to 94 years using home *** Subjects were recruited from the Jerusalem Longitudinal Cohort *** three members of the initial cohort(32 F,31 M)who underwent home echocardiography at age 85 were the subjects of the current study and underwent repeat home 2-D and Doppler echocardiographic assessment at age *** There were no significant longitudinal changes in left ventricular mass index(LVMI),however LV end-diastolic volume significantly decreased from 113.4±30 to 103.6±35.5 m L(P<0.02).Ejection fraction(EF)remained stable,however longitudinal systolic function significantly decreased with age from 7.9±1.8 to 6.6±1.4 cm/s2(P<0.0001).Diastolic function as assessed by increased E:e’(11.2±3.4 to 16±7.5,P<0.0001)and increased left atrial volume index(34.1±11.3 to 42.4±13.7 m L/m^2,P<0.0001)was reduced with *** This study demonstrated preserved EF with decreased longitudinal systolic function and diastolic function without significant change in LV *** in LV function in the very elderly may be independent of changes in LV geometry.

关键词： Echocardiography The elderly Ventricular function

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