检索结果-南通市图书馆

转移癌脊髓压迫症的单次剂量和多次剂量放射治疗比较:功能性疗效研究(英文)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Chinese-German Journal of Clinical Oncology 2011年第9期10卷 535-540页

作者： Mohammad Abu-hegazy Hanan A.Wahba Department of Neurology Faculty of MedicineMansoura UniversityMansouraEgypt Department of Clinical Oncology and Nuclear Medicine Faculty of MedicineMansoura UniversityMansouraEgypt

Objective:The optimal treatment of patients with metastatic spinal cord compression(MSCC) is still being *** randomized trial was planned to compare the functional outcome and its related prognostic factors,toxicity and in-field recurrence of the three schedules of ***:Two hundred and eighty five patients enrolled in the study of which 95 received 1 × 8 Gy,100 received 10 x 3 Gy and 90 received the radiation treatment of 20 × 2 *** was performed with 6-10 Mv linear accelerators or cobalt-60 units by single posterior field or parallel opposed fields according to depth of irradiation *** with dexamethasone was started from the first day of clinico-radiologic diagnosis till 4-5 days after the end of radiotherapy(RT) then tapered off during 10 *** prognostic factors were evaluated with respect to functional ***:All groups were balanced for patient's characteristics and potential prognostic *** statistically significant difference was observed between the 3 groups as regard functional outcome and toxicity while single fraction was associated with higher in-field recurrences(22.8%) with statistically significant difference between the 3 groups(P = 0.01).Functional outcome was significantly better with younger age(≤ 60 y),Eastern Cooperative Oncology Group performance status(ECOG-PS) of 1-2,involved vertebra of 1-2,favorable tumor type,absence of visceral or other bone metastasis,decreased time of developing motor deficit before radiotherapy,long interval between cancer diagnosis to metastatic spinal cord compression,and normal ambulatory ***:The three schedules provided similar functional ***-radiation dose was associated with higher in-field *** minimize treatment time and costs,the dose of 1 × 8 Gy is recommended for patients with poor predicated survival and 10 × 3 Gy for other patients.

关键词：放射治疗转移性脊髓单组分辐射剂量治疗时间直线加速器发展中国家

PNPLA3 and TNF-α G238A Genetic Polymorphisms in Egyptian Patients with Different Grades of Severity of NAFLD

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Open Journal of Gastroenterology 2016年第3期6卷 53-64页

作者： Mona A. hegazy Rasha M. Abdel Samie Ahmed Ezzat Nagwa Ramadan Laila A. Rashed Abeer M. elsayed Internal Medicine Department Cairo University Cairo Egypt Medical Biochemistry Department Cairo University Cairo Egypt Pathology Department National Cancer Institute Cairo University Cairo Egypt

Introduction: There is growing evidence that genetic and environmental factors play an important role in the development and progression of non-alcoholic fatty liver disease (NAFLD). We investigated the association of single nucleotide polymorphism (SNP) rs738409 in PNPLA3 gene and TNF-α G238A polymorphism with the development and severity of NAFLD in an overweight and obese Egyptian population. Material and Methods: 100 overweight and obese patients with NAFLD and 30 control subjects were enrolled. All NAFLD patients underwent a confirmatory biopsy. Laboratory investigations included fasting plasma glucose, kidney and liver function tests, liver enzymes, lipid profile and hepatitis markers. Abdominal ultrasound was performed and all subjects were genotyped for (rs738409) PNPLA3 and (rs361525) TNF-α gene polymorphisms using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Results: The homozygous GG genotype of the PNPLA3 was most frequent among patients with NASH (26%) as compared to borderline NASH (20.5%) and simple steatosis (20%). Higher serum levels of transaminases were observed in NAFLD patients and controls who were carriers of the G allele of rs738409, but this was not statistically significant. Regarding the TNF-α G238A SNP;the frequency of the A allele was significantly higher in NAFLD patients (20%) compared to controls (5%) (p value = 0.006). The highest TNF G allele frequency was observed in the NASH group (88%) and this was statistically significant (p value = 0.009). Conclusion: Our study confirmed the association of the PNPLA3 (rs738409) and TNF-α promoter region G238A polymorphisms with susceptibility to NAFLD and its progression.

关键词： NAFLD PNPLA3 TNF-α Polymorphism NASH

Determination of the Potency of Extracted, Purified and Formulated Insulin from the Pancreatic Organs of the Sudanese Beef Cattle

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pharmacology & Pharmacy 2013年第6期4卷 467-472页

作者： Abdella Emam Abdella Baragob Waleed Hassan AlMalki Imran Shahid Ragia Mahmood hegazy Khojali Salwa Muhammed Samia Abdella Department of Pharmacology and Toxicology College of Pharmacy Umm Al Qura University Makkah KSA Department of Pharmacology and Toxicology College of Pharmacy Umm Al Qura University Makkah KSA Veterinary Research Institute Khartoum Sudan.

The treatment of type 1 diabetes is mainly dependent on insulin therapy and current formulated insulin formulations are used for its control all over the world. The presented study was designed to evaluate the potency of extracted, purified and formulated insulin from the pancreatic organs of the Sudanese beef cattle. Twenty healthy rabbits were used to conduct the study following subcutaneous administration of the sample insulin, to determine the hypoglycemic effect and to analyze the potency of the testing insulin by the hypoglycemic seizure method, blood sugar method and glucose enzymatic colorimetric test (GOD-PAP) respectively. The potency of the injected insulin samples was estimated by comparing the variation in blood glucose levels produced in the treated animals with that produced by a standard insulin preparation under the suitable conditions of the blood sugar method. The results revealed that the potency of the testing beef insulin samples was slightly higher (i.e., 2.2 USP units/ml, 9%) compared to the standard and assumed potency of the prepared insulin preparations (i.e., 1-2 USP units/ml) which indicated that the solvents and diluents used to prepare the assay dilution might be of higher potency and must be diluted to such an extent that the testing insulin potency must be compatible with the standard dilutions. Furthermore, to determine the choice of an assay to analyze the potency of insulin preparations, not only the accuracy of the result but also the purpose for which the test is to be used and the time limit must be taken into consideration.

关键词： Blood Sugar Method Glucose Oxidase Method Hypoglycemic Effect Insulin Potency

Totally Endoscopic (Thoracoscopic and Laparoscopic) Radical Esophagectomy with Gastric Tube Reconstruction through a Small Neck Incision: An Early Experience with Thirty Egyptian Patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surgical Science 2014年第5期5卷 214-223页

作者： Adel Denewer Adel Fathi Ahmed Setit Mohamed hegazy Ashraf Khater Osama Hussein Sameh Roshdy Fayez Shahatto Fathy Denewer Department of Surgical Oncology Oncology Center (OCMU) Faculty of Medicine Mansoura University Mansoura Egypt

Background: Minimally invasive esophagectomy nowadays is replacing the classic open technique. Additional studies are needed to confirm its safety and efficacy. Methods: thirty patients with esophageal carcinoma were enrolled in this study. Patients were evaluated preoperatively and they underwent thoracoscopic and laparoscopic procedures for assessment of resectability. Resectablepatients underwent radical esophagectomy with gastric tube reconstruction through a four-cm neck incision. Results: 17 patients were operable and 13 patients were inoperable. The mean operative time for the whole procedure was 5.97 ± 1.66 hours. The mean blood loss was 250 ± 138.07 cc. The mean overall hospital stay was 17.47 ± 5.49 daysdays. Common postoperative complications included pneumonia (13.3%) pleural effusion (6.7%), cervical anastomotic leakage (10%), and wound infection (13.3%). One patient died in the early postoperative period. Conclusions: we conclude that totallyendoscopic (thoracoscopic and laparoscopic) esophagectomy is feasible and relatively safe technique. Beside its efficacy as an assessment tool, total esophagectomy and lymphadenectomy could be performed in the same time.

关键词： Thoracoscopic Laparoscopic Radical Esophagectomy Gastric Reconstruction Esophagus Cancer

The Effectiveness of Intraoperative Frozen Section Analysis of Safety Margins in Breast Conserving Surgery and the Role of Surgeon in Decreasing the Rate of Positive Margins

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surgical Science 2017年第12期8卷 499-509页

作者： Omar Farouk Ahmed Senbel Mosab Shetiwy Essam Attia Ahmed Abdallah Osama el-Damshety Ashraf Khater Sameh Roshdy Amr Abouzid Amr Hossam Islam H. Metwally Omar Hamdy Amir M. Zaid Mahmoud Abdelaziz Mohamed elmetwally Adel Fathi Emad-eldeen Hamed Khaled Abdel Wahab Wagdi el-Kashef Mohamed Hafez Khaled Zalata Mohamed hegazy Adel Denewer Surgical Oncology Department Oncology Center Faculty of Medicine Mansoura University Mansoura Egypt Pathology Department Faculty of Medicine Mansoura University Mansoura Egypt

Introduction: Nowadays the more accepted surgical option for treating early breast cancer is breast conserving surgery. The main challenge in this type of surgery is to get free safety margins without need of second surgical operation, so many breast surgeons have started to depend on intraoperative frozen sections to ensure free safety margins. Aim of work: To assess our policy that we prefer to depend on intraoperative frozen section analysis to get free safety margin in breast conserving surgery from the 1st surgery, and its oncologic outcome. Patients and Methods: This is a retrospective study conducted in Oncology Center—Mansoura University (OCMU), where the data of 219 patients with breast cancer, who were managed by breast conserving surgery with intraoperative frozen section analysis of the safety margins, was analyzed. Results: The intraoperative frozen section analysis of safety margin was negative from the start in 183 (83.6%) patients, while it was positive in 36 patients (16.4%). Intraoperative decision of margin re-excision was applied for 29 patients (13.2%) in order to reach negative margin, modified radical mastectomy was offered for 4 patients (1.8%), while nipple sparing mastectomy with immediate breast reconstruction using latissimus dorsi flap was offered for 3 patients (1.4%). The postoperative paraffin results were typical with intraoperative frozen section analysis results in 216 patients (98.6%) and different results were obtained in only 3 patients (1.4%) who were managed by modified radical mastectomy in a second operation. Only 4 patients had local recurrence (1.8%) during the period of follow-up duration which was ranged from 1 to 86 months with mean ± SD (22.3 ± 14.1). Conclusion: The intraoperative frozen section analysis of safety margins in breast conserving surgery has very high-rate typical results with the paraffin section analysis and it is very helpful in decreasing the rate of second surgical operation in cases of infiltrated m

关键词： Breast Conserving Surgery Intraoperative Frozen Section Analysis Safety Margins Breast

Evaluation of Surgical Outcome after Resection of Pancreatic Tumors, Our Experience in Mansoura Oncology Center, a Middle-Volume Center in Egypt

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2012年第5期3卷 477-481页

作者： Nazem Shams Mahmoud Mosbah Mohammad hegazy Osama Hussein Omar Farouk Sameh Roshdy Mohamed Tarek Hafez Ashraf Khater Khaled Abdel Wahab Oncology Center Mansoura University Mansoura Egypt

Background: Pancreatic cancer is the fourth most common cause of cancer related deaths in the world. Surgical resection remains the only potentially curative treatment for adenocarcinoma of the pancreas;only 10% - 20% of patients are candidate for standard pancreatic resection. Objective: To evaluate perioperative mortality, morbidity and survival for patients underwent PD in middle-volume center. Patients and Methods: Sixty patients with pancreatic tumors were enrolled in this study for different surgical procedure according to type of tumors. Results: No early postoperative complications were observed in 60% of patients, whereas 40% of patients developed one or more complication, the median survival for this group was 12.3 months with standard deviation 3.8 months.

关键词： Pancreatic Cancer Whipple Complication Survival

Peristaltic Transport of Magnetohydrodynamic Carreau Nanofluid with Heat and Mass Transfer inside Asymmetric Channel

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Computational Mathematics 2017年第1期7卷 1-20页

作者： Nabil T. M. eldabe Osama M. Abo-Seida Adel A. S. Abo-Seliem A. A. elShekhipy Nada hegazy Mathematics Department Faculty of Education Ain Shams University Cairo Egypt Faculty of Computers and Information Kafrelsheikh University Kafrelsheikh Egypt Mathematics Department Faculty of Science Kafrelsheikh University Kafrelsheikh Egypt Mathematics Department Faculty of Science Minia University El-Minia Egypt Mathematics Department Faculty of science Imam Abdulrahman Bin Faisal University Al-Dammam KSA

In this work, the peristaltic motion of a nano non-Newtonian fluid which obeys Carreau model through a porous medium inside an asymmetric channel is investigated. The hall current effects with Joule heating and viscous dissipation are considered. The problem is modulated mathematically by a set of nonlinear partial differential equations which describe the conservation of mass, momentum, energy and concentration of nanoparticles. The non-dimensional form of these equations is simplified under the assumption of long wavelength and low Reynolds number, and then resulting equations of coupled nonlinear differential equations are tackled numerically with appropriate boundary conditions. Graphical results are presented for dimensionless velocity, temperature, concentration and pressure gradient in order to illustrate the variations of various parameters of this problem on these obtained solutions.

关键词： Peristaltic Motion MHD Carreau Nanofluid Asymmetric Channel Porous Medium Heat and Mass Transfer

Role of Urokinase-Type Plasminogen Activator Receptors as an Early Detector for Treatment Outcome in Adult Acute Myeloid Leukemia in Egyptian Patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2015年第11期6卷 963-970页

作者： Hanan R. Nassar Eman Z. Kandeel Laila A. E. hegazy Amany M. Helal Tarek Darwish Soad A. eltokhy Medical Oncology NCI Cairo Egypt Clinical Pathology NCI Cairo Egypt Clinical Pathology Faculty of Medicine Cairo University Cairo Egypt

Background: The urokinase-type plasminogen activator system which consists of a proteinase (the urokinase-type plasminogen activator, uPA), a receptor (the urokinase-type plasminogen activator receptor uPAR or CD87) and inhibitors (PAI1) is enriched in several types of tumors and involved in proteolysis, cell migration and invasion. High expression of uPA and uPAR is associated with an increased relapse rate and shorter survival in breast cancer and colorectal carcinomas. Aims: This study shed light on the expression of uPAR in adult acute myeloid leukemia (AML) and its prognostic relevance. Methods: Peripheral blood and bone marrow samples are obtained from 54 newly diagnosed AML adult patients, 20 healthy controls stained with anti CD87 and estimated on flow cytometry. Results: CD87 expression was heterogeneous in different FAB subtypes of AML with high expression in monocytic leukemia (M4/M5) (P value 0.001). High expression of CD87 was associated with shorter survival and poor response to therapy (P = 0.028, 0.002 respectively). The most discriminating cut off value of CD87 expression was 20%, patients with less than 20% expression had 4.6 times better treatment outcome than those with more than or equal to 20%. On the multivariate analysis, CD87 was the most significant single variable that affect treatment outcome compared to total leucocytic count, hemoglobin level, platelets count, cytogenetic and FLT expression. Summary/Conclusion: High CD87 expression is an independent prognostic parameter associated with poor response and shorter overall survival in adult AML patients.

关键词： AML Plasminogen Survival uPAR CD87

Characterization and Antitumor Activity of Chitosan/Poly （Vinyl Alcohol） Blend Doped with Gold and Silver Nanoparticles in Treatment of Prostatic Cancer Model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmacy and Pharmacology 2018年第7期6卷 659-673页

作者： A. Abaza E. A. hegazy Ghada. A. Mahmoud B. elsheikh Nuclear and Radiological Regulatory Authority (ENRRA) Cairo11762 Egypt National Center for Radiation Research and Technology (NCRRT) Atomic Energy Authority Cairo 11787 Egypt Faculty of Science Al-Azhar University Nasr City Cairo 11371 Egypt