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Performance of three rapid diagnostic tests for the detection of Cryptosporidium *** Giardia duodenalis in children with severe acute malnutrition and diarrhoea

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Infectious Diseases of Poverty 2019年第6期8卷 76-83页

作者： joseph Bitilinyu-Bangoh Wieger Voskuijl johnstone Thitiri Sandra Meriting Nienke Verhaar Laura Mwalekwa daisy B.de jong Merlin van Loenen Petra F.Mens james A.Berkley Robert H.j.Bandsma Henk D.F.H.Schallig Academ ic Medical Centre Department of Medical MicrobiologyParasitology UnitAmsterdam University Medical CentresMeibergdreef 91105AZAmsterdamThe Netherlands Queen Elizabeth Central Hospital BlantyreMalawi College of Medicine Department of Paediatrics and Child HealthUniversity of MalawiBlantyreMalawi Global Child Health Group Emma Children's HospitalAmsterdam University Medical CentresAmsterdamThe Netherlands The Childhood Acute Illness and Nutrition Network(CHAIN) NairobiKenya KEMRIA/Vellcome Trust Research Programme KilifiKenya Translational Medicine Program Hospital for Sick ChildrenTorontoCanada

Background:There is significant need for accurate diagnostic tools for Cryptosporidium *** Qiordia duodenalis infections in resource limited countries where diarrhoeal disease caused by these parasites is often *** present study assessed the diagnostic performance of three commercially available rapid diagnostic tests(RDTs)based on faecal-antigen detection for Cryptosporidium ***/or *** infections in stool samples of children admitted with severe acute malnutrition(SAM)and *** established multiplex PCR was used as reference ***:Stool samples from children with SAM and diarrhoea enrolled in a randomized controlled trial(registered at ***/ct2/show/NCT02246296)in Malawi(n=175)and Kenya(n=120)between December 2014 and December 2015 were analysed by a multiplex PCR for the presence of Cryptosporidium sppv *** or Entomoebo histolytica parasite ***-positive samples were species typed using restriction fragment length polymorphism analysis.A sub-sample of the stool specimens(n=236)was used for testing with three different *** accuracy of the tests under evaluation was assessed using the results of PCR as reference standard using MedCalc *** Chi-square test and Fisher's exact test were used to determine(significant)difference between the number of cryptosporidiosis or giardiasis cases found by PCR in Malawi and *** overall diagnostic accuracy of each RDT was calculated by plotting a receiver operating characteristic(ROC)curve for each test and to determine the area under the curve(AUC)using SPSS8 ***:Prevalence of Cryptosporidium *** PCR was 20.0 and 21.7%in Malawi and Kenya respectively,mostly *** prevalence was 23.4 and 5.8%in Malawi and Kenya respectively.E histolytica was not detected by *** testing followed the same pattern of *** sensitivities ranged for cryptosporidiosis from 42.9 to 76.9%and for ***

关键词： Diagnosis Cryptosporidium Giordio Rapid diagnostic test Severe acute malnutrition

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虚拟会议一定是明确的——如何定义新型会议活动的战略价值

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中国会展 2012年第6期 48-50页

作者： jenise Fryatt Rosa Garriga Ruud janssen Richard john Samuel j. Smith

过去会议人士使用虚拟会议只是一次性的，今天，他们要把虚拟会议技术融入策略性管理中，成为其中的一部分。根据MPI基金会和全球战略会议管理公司Maxvantage最近进行的调查结果显示，部分公司每年安排了上百场的虚拟会议。这份研究结... 详细信息

过去会议人士使用虚拟会议只是一次性的，今天，他们要把虚拟会议技术融入策略性管理中，成为其中的一部分。根据MPI基金会和全球战略会议管理公司Maxvantage最近进行的调查结果显示，部分公司每年安排了上百场的虚拟会议。这份研究结果通过网上问卷调查和定性访谈的方式得出，展示出业内专家对于虚拟会议定义的一致性，但是其在各个会议的表现形式上各有不同。虚拟会议能帮助主办方节省成本，强化信息传递，而定义不清、缺乏知识基础和迎接专业技术的勇气是虚拟技术发展的诸多阻碍。需要强调的一点是，“虚拟会议”的内容一定是明确的。

关键词：虚拟会议活动定义价值网上问卷调查管理公司技术发展策略性管理

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Stroke：急性缺血性卒中血管内再通治疗工作流程新进展

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中国卒中杂志 2019年第12期14卷 1249-1250页

作者：杨中华 janssen P M VENEMA E DIPPELD W j 首都医科大学附属北京天坛医院神经病学中心脑血管病中心神经重症医学科不详

对于行血管内治疗的急性缺血性卒中患者,提供最佳的诊断过程和快速的血管内治疗需要急救医疗服务(emergency medical service,EMS)人员、急诊科医师、卒中医师、神经介入医师和麻醉医师的密切合作。2019年Stroke杂志新发表的一项系统性... 详细信息

对于行血管内治疗的急性缺血性卒中患者,提供最佳的诊断过程和快速的血管内治疗需要急救医疗服务(emergency medical service,EMS)人员、急诊科医师、卒中医师、神经介入医师和麻醉医师的密切合作。2019年Stroke杂志新发表的一项系统性回顾和荟萃分析探讨了对于急性缺血性卒中患者救治,特定的工作流程改进对快速行血管内治疗的效果。这些具体的工作流程改进内容如下.

关键词：急性缺血性卒中急救医疗服务血管内治疗荟萃分析中医师流程改进麻醉医师急诊科医师

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早产儿的心血管自主调节:阿托品的作用

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世界核心医学期刊文摘（儿科学分册） 2005年第7期1卷 49-50页

作者： Andriessen P. janssen B.j.A. Berendsen R.C.M. 虎小毅 Dr.M'axima Medical Center Neonatal Intensive Care Unit P.O.Box 7777 Veldhoven 5500 MB Netherlands

To study cardiovascular autonomic control, we assessed the effect of atropine on heart rate (HR) and blood pressure (BP)-variability in 12 preterm infants (range 26-32 wk) before intubation for respiratory *** power analysis of R-R interval and systolic BP (SBP) series were estimated in a low-frequency (LF; 0.04-0.15 Hz) and high-frequency (HF; 0.4-1.5Hz) band and evaluated for a 10-min period before and a 10-min period after atropine sulfate (0.01 mg/kg).Baroreceptor reflex (BR) functioning was estimated using transfer function analysis at LF (coherence, gain, and phase).Atropine resulted in a significant 12%increase in steady-state HR (p < 0.01) and unchanged *** R-R interval series, the total spectral power decreased 6-fold (p < 0.01), which was predominantly due to a reduction in the LF band (16-fold; p < 0.01).In contrast, we observed a significant increase (25%; p < 0.05) in total spectral power of SBP series partly as a result of an increase in HF *** LF power of SBP series was not *** median LF transfer gain (BR sensitivity) between SBP and R-R interval decreased from 4.2 to 1.4 ms/mm Hg (p < 0.01) after *** LF phase relationship (BP leads R-R interval fluctuations by ～4 s) was not changed after *** conclusion, even in preterm infants in distress, atropine modulates HR and BP variability, suggesting that BR-mediated parasympathetic control of heart rate is of significance for cardiovascular control at that age.

关键词：自主调节低频带心率控制函数分析能量分析呼吸窘迫压力感受器高频能量高频带低频能量

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Biological function and distribution of human interleukin-12 receptor β chain

Biological function and distribution of human interleukin-12...

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作者： Rajeev R,Warrier daisy M,Carvajal Anne O,Chua Lisa j,Minetti Richard Chizzonite Patrica K,A,Monginiz Alvin S,Stern Ueli Gubler David H．Presky Maurice K．Gately Department of Inflammation/Autoimmune Diseases Hoffmann-La Roche Inc. NutleyUSA Department of Rheumatology and Moleculae Medicine Hospital for Joint DiseasesNew YorkUSA Department of Inflammation/Autoimmune Diseases Hoffmann-La Roche Inc.NutleyUSA

We previously described the cloning of a cDNA encoding an interleukin-12 receptor (IL-12R) subunit, designated β,that bound IL-12 with low affinity when expressed in COS cells. We now report that a pair of monoclonal antibodies (mAb),2B10 and 2.4E6,directed against different epitopes on the IL-12Rβ chain, when used in combination,strongly inhibited IL-12-induced proliferation of activated T cells, IL-12-induced secretion of interferon-γby resting peripheral

关键词： Interleukin-12 Interleukin-12 receptor Interleukin-12 receptor β chain

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Next generation MHC multimer technology for detection of antigen-specific T cells

Next generation MHC multimer technology for detection of ant...

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第十二届全国免疫学学术大会

作者： Garstka Malgorzata Luimstra jolien j Roex Marthe Cj Redeker Anke janssen George MC Van Veelen Peter A Arens Ramon Falkenburg Frederik jH Neefjes jacques Ovaa Huib Xi'an jiaotong University Second Affiliated Hospital Department of Chemical Immunology Leiden University Medical Center Department of Hematology Leiden University Medical Center Department of Immunohematology and Blood Transfusion Leiden University Medical Center Center for Proteomics and Metabolomics Leiden University Medical Center

Peptide ligand presentation by MHC class I molecules is a key element of immunodominance in antiviral and antitumor immune *** multimers are oligomeric forms of MHC-peptide monomers,generally tagged with a fluorochrom... 详细信息

关键词： MHC multimers cytotoxic T cells immunodiagnostics

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慢性乙型肝炎患者肝炎突发是由宿主因素还是病毒因素诱发:在聚乙二醇干扰素-α2b治疗期间对治疗应答的关系

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世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 36-37页

作者： Flink H.j Sprengers D Hansen B.E. H.L.A. janssen 李翔 Department of Gastroenterology and Hepatology Erasmus Medical Centre Dr. Molewaterplein 40 3015 GD Rotterdam NetherlandsDr.

Background and aims: Flares are a well known phenomenon during antiviral treatment for chronic hepatitis B. Little is known about the effect of flares on response. We investigated the timing and characteristics of flares, in relation to treatment response (hepatitis B e antigen loss). Patients: A total of 266 patients, participating in a global randomised controlled study, were assigned to 52wee ks of 100 μg pegylated (Peg)-interferon a-2b weekly, combined with either dai ly lamivudine 100 mg or placebo. Results: Sixty seven patients (25%) exhibited 75 flares, with 38 (51%) flares in the combination therapy and 37 (49%) in the monotherapy groups. Overall, 30%of patients with and 38%of patients without a flare responded to therapy (p = 0.25). In 24 patients (36%) the flare was foll owed by a decrease in hepatitis B virus (HBV) DNA (host induced flare). In 25 (3 8%) patients the flare was preceded by an increase in HBV DNA (virus induced fl are). In 17 (26%) patients the flare did not meet one of these criteria (indete rminate flare). Of patients with host induced flare, 58%responded whereas only 20%of patientswith virus induced flares responded (p = 0.008). Hepatitis B surf ace antigen loss (n = 8) was exclusively seen in patients experiencing a host in duced flare. Multivariate logistic analysis showed that host induced flares was an independent predictor of response (p = 0.043). Conclusion: Flares are not mor e common in responders than in non-responders to Peginterferon α-2b therapy. Virus induced flares, which occur after an increase in HBV DNA level, and most p robably are indicative for increased expression of viral antigens, did not lead to treatment response. In contrast, host induced flares which were followed by a HBV DNA decrease were highly associated with treatment response.

关键词：治疗应答乙型肝炎干扰素-α 宿主因素 DNA 安慰剂高度相关性多变量拷贝数

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Advances in newly developing therapy for chronic hepatitis C virus infection

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Frontiers of Medicine 2014年第2期8卷 166-174页

作者： Paul j. Pockros Division of Gastro/Hepatology Scripps Clinic 10666 N Torrey Pines Road N203 La Jolla CA 92067 USA

Chronic hepatitis C virus （HCV） infection afflicts a reported 170 million people worldwide and is often complicated by cirrhosis and hepatocellular carcinoma. Morbidity and mortality are decreased with the successful treatment of chronic HCV infection. Increased understanding of the HCV has allowed further development of new direct-acting antiviral （DAA） agents against the HCV and has also allowed the development of IFN-free oral treatment regimens. In late 2013 the first nucleotide polymerase inhibitor regimen with RBV alone for genotypes 2/3 and in combination with a 12-week regimen of PEG-IFN ＋ RBV for genotypes 1, 4 was approved for use in the US. A number of promising new DAA regimens which are IFN-free are in phase 3 development and the first will likely be approved for use in the US in 2014. The currently approved regimens are discussed in detail and currently available data on future regimens are reviewed herein.

关键词： direct-acting antiviral (DAA) nucleotide polymerase inhibitors protease inhibitors

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卷帘式彩色LCoS显示器的对比度改善

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现代显示 2004年第4期 17-21页

作者： j.A.Shimizu P.janssen S.Yakovenko D.Anderson 柳玉华徐康兴 Philips Research USA Philips LCoS Microdisplay Systems USA 北京牡丹电子集团公司

卷帘式彩色LCoS(硅上液晶)显示必须展现其快速和高对比度两项特性。这些要求推动了成像核心的液晶和光学系统的设计选择。我们发现,输入方向必须沿着入射偏振方向,且须选择一种补偿性的45TN0效应。高对比度需要对界面反射提出严格的要... 详细信息

卷帘式彩色LCoS(硅上液晶)显示必须展现其快速和高对比度两项特性。这些要求推动了成像核心的液晶和光学系统的设计选择。我们发现,输入方向必须沿着入射偏振方向,且须选择一种补偿性的45TN0效应。高对比度需要对界面反射提出严格的要求。线栅PBS能实现高的对比度且能简化系统结构。在关注上述问题的同时,我们曾报告过,在视屏上的时序对比度为8001。采用90TN0效应,其对比度可以更高,但会有一些光效损失。采用这种效应所测时序对比度为20001。

关键词：硅上液晶对比度投影

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鼠RanBp17条件性基因打靶载体的构建及同源重组阳性克隆的筛选

鼠RanBp17条件性基因打靶载体的构建及同源重组阳性克隆的筛选

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湖北省暨武汉市生物化学与分子生物学学会第八届第十七次学术年会

作者：过健俐 Martina Dorotee jWG janssen 华中科技大学同济医学院生物化学与分子生物学系

RanBp17基因是由 j W G janssen 研究小组在克隆两例儿童 ALL 人血样 DNA 染色体重组断裂点 t(5:14)(q34,q11)处基因的过程中发现并克隆的新基因。该基因定位于5q34,含有 28个外显子。Northern blot 结果显示它主要在睾丸和胰腺组织中...

RanBp17基因是由 j W G janssen 研究小组在克隆两例儿童 ALL 人血样 DNA 染色体重组断裂点 t(5:14)(q34,q11)处基因的过程中发现并克隆的新基因。该基因定位于5q34,含有 28个外显子。Northern blot 结果显示它主要在睾丸和胰腺组织中有高表达。初步研究表明其

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