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Clinicopathological characteristics of clinical early gastric cancer in the upper-third stomach

World Journal of Gastroenterology 2015年第45期21卷 12851-12856页

作者： daisuke Ichikawa Shuhei Komatsu Toshiyuki Kosuga Hirotaka Konishi Kazuma Okamoto Atsushi Shiozaki Hitoshi Fujiwara Eigo Otsuji Division of Digestive Surgery Department of Surgery Kyoto Prefectural University of Medicine

AIM: To elucidate the clinicopathological characteristics of clinically early gastric cancer in the upper-third stomach and to clarify treatment ***: A total of 683 patients with clinical early gastric cancer were enrolled in this retrospective study, 128 of whom had gastric cancer in the upper-third stomach(U group). All patients underwent a double contrast barium examination, endoscopy, and computed tomography(CT), and were diagnosed preoperatively based on the findings obtained. The clinicopathological features of these patients were compared with those of patients with gastric cancer in the middle- and lower-third stomach(ML group). We also compared clinicopathological factors between accurate-diagnosis and under-diagnosis groups in order to identify factors affecting the accuracy of a preoperative diagnosis of tumor ***: Patients in the U group were older(P = 0.029), had a higher ratio of males to females(P = 0.015), and had more histologically differentiated tumors(P = 0.007) than patients in the ML group. A clinical under-diagnosis occurred in 57 out of 683 patients(8.3%), and was more frequent in the U group than in the ML group(16.4% vs 6.3%, P < 0.0001). Therefore, the rates of lymph node metastasis and lymphatic invasion were slightly higher in the U group than in the ML group(P = 0.071 and 0.082, respectively). An under-diagnosis was more frequent in histologically undifferentiated tumors(P = 0.094) and in those larger than 4 cm(P = 0.024). The medianfollow-up period after surgery was 56 mo(range, 1-186 mo). Overall, survival and disease-specific survival rates were significantly lower in the U group than in the ML group(P = 0.016 and 0.020, respectively). However, limited operation-related cancer recurrence was not detected in the U group in the present ***: Clinical early gastric cancer in the upper-third stomach has distinguishable characteristics that increase the risk of a clinical under-diagnosis, especially i

关键词： Upper-third stomach Diagnosis Gastric cancer

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Effects of docosahexaenoic acid or arachidonic acid supplementation on the behavior of cardiomyocytes derived from human pluripotent stem cells

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BIOCELL 2023年第5期47卷 1095-1106页

作者： MIZUNA YANO KOTA HIROI TETSUYA YUASA KENJI INOUE OSAMU YAMAMOTO TAKAO NAKAMURA daisuke SATO ZHONGGANG FENG Graduate School of Science and Engineering Yamagata UniversityYonezawa9928510Japan Faculty of Health Sciences Japan Healthcare UniversitySapporo0620053Japan

Background:Human heart changes its energetic substrates from lactate and glucose to fatty acids during the neonatal *** the lack of fatty acids in media for the culture of cardiomyocytes derived from human pluripotent stem cells(hiPS-CM),researchers have supplemented mixtures of fatty acids to hiPS-CM and reported the enhancement in the maturation of *** our previous studies,we separately supplemented two polyunsaturated fatty acids(PUFAs),docosahexaenoic acid(DHA)or arachidonic acid(AA),to rat fetal cardiomyocytes and found that the supplementations upregulated the expressions of mRNAs for cardiomyocyte differentiation,fatty acid metabolism,and cellular *** enhancement in cellular contractility was attributed to the improvement in intercellular connection rather than a direct enhancement of the contractile ***:This study reports the successive results of the effects of DHA or AA supplementation on *** addition to the contractile force and mRNA measurements used in the previous study,we further investigated the effect of different cellular aggregations on the contractile force output by means of finite element analysis,measured glucose and fatty acids metabolites,and assessed cTNT and MLC2v expressions through immunofluorecsence ***:It showed that the sole supplementation of albumin-conjugated DHA or AA can be taken up by hiPS-CM without other uptake-enhancing factors,and the supplementations may activate the CD36_ERRγmetabolic *** or AA supplementation increased the cellular contractile ratio on collagen gels and AA supplementation stimulated hiPS-CM aggregation to form cellular *** enhancement effect on the hiPS-CM contractile force was modest since the increase in contractile force was not *** supplementation was more effective than DHA supplementation because it significantly upregulated mRNA expressions of P300 and ***,finite element analysis showed that the formati

关键词： Human iPS cells Cardiomyocytes Polyunsaturated fatty acid mRNA expression Contractility Fatty acid metabolism

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Brachiocephalic to left brachial vein thrombotic vasculitis accompanying mediastinal pancreatic fistula:A case report

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World Journal of Clinical Cases 2022年第32期10卷 11882-11888页

作者： Reiji Kokubo daisuke Yunaiyama Yu Tajima Natsumi Kugai Mitsuru Okubo Kazuhiro Saito Takayoshi Tsuchiya Takao Itoi Department of Radiology Tokyo Medical UniversityTokyo 160-0023Japan Department of Gastroenterology and Hepatology Tokyo Medical UniversityTokyo 160-0023Japan

BACKGROUND Pancreatitis is a severe inflammatory pancreatic disease commonly due to bile duct stones or excessive alcohol usage,with clinical manifestations of abdominal pain,nausea,fever,and fluid *** persons with less symptomatic pancreatitis are quite ***,we report a case of a patient with an undetermined onset of pancreatitis mimicking left arm cellulitis due to thrombotic vasculitis of the brachiocephalic *** SUMMARY A 50-year-old woman visited our hospital for tenderness in the left arm over several recent *** was diagnosed with cellulitis on the left arm due to left elbow *** antibiotics administration did not improve symptoms and laboratory data worsened;thus,chest and abdominal computed tomography(CT)was *** demonstrated pancreatitis with pseudocyst around the pancreas extending to the *** vasculitis of the brachiocephalic to left brachial vein was observed,which could be the cause of left elbow pain.A pancreatic fistula was found in the head of the pancreas by endoscopic retrograde cholangiopancreatography,so a pancreatic cyst drainage tube via the duodenum was placed in the *** content culture was positive for Escherichia coli *** symptoms,imaging findings,and inflammatory reactions resolved gradually after starting therapeutic *** mediastinal pancreatic pseudocysts shrunk,and the venous thrombi remained but *** The case of a patient with pancreatitis with an undetermined onset that mimics left arm cellulitis is *** vein thrombosis should be kept in mind when treating patients with severe inflammatory disease.

关键词： Pancreatic fistula Thrombotic vasculitis Pancreatitis Computed tomography Case report

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Effectiveness of a Telenursing System on Side Effects of Chemotherapy by a Crossover Trial

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Open Journal of Nursing 2022年第12期12卷 817-830页

作者： daisuke Sato Makoto Shimoyama Faculty of Medical Sciences Division of Nursing University of Fukui Fukui Japan School of Nursing Miyagi University Miyagi Japan

Background: This crossover trial aimed to examine the efficacy of the Tele-nursing Symptom Management System for Chemotherapy in Outpatient Treatment (T-SCOT) in reducing the side effects in patients undergoing out-patient chemotherapy. Methods: Using a tablet computer, participants were asked to provide information on various items, including fever, nausea, hair loss, fatigue, and vital signs. Both the participants and researchers automati-cally monitored time-dependent changes in symptoms, and the researchers proposed concrete measures to reduce patients’ complications. The primary endpoint was the M. D. Anderson Symptom Inventory (MDASI-J) score. The secondary endpoint, Quality of Life (QOL) was evaluated using the Quality of Life Questionnaire for Cancer Patients Treated with Anticancer Drugs (QOL- ACD). Results: This study included 20 patients who met all the inclusion cri-teria, 14 of whom agreed to participate in the study. There was no significant difference between the MDASI-J and QOL-ACD pre- and post-comparison of the primary and secondary evaluations in the intervention group. The control group had significantly higher scores 3 months after the intervention for symptom intensity (p = 0.04) and symptom-induced disruption to life (p = 0.03), and the symptoms worsened. The QOL-ACD had significantly lower scores for activity (p = 0.03), overall QOL (p = 0.04), and total QOL score (p = 0.02), resulting in a lower quality of life. Conclusions: Participants used the Internet to obtain information on treatments and side effects and changed their behavior in daily life. It is speculated that the Information and Commu-nications Technology (ICT) literacy in older adults has improved, and they are benefiting from digital utilization.

关键词： Telenursing Outpatient Chemotherapy Symptoms Complications Prevention

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Effectiveness of a Telenursing System to Prevent the Exacerbation of Symptoms in Patients with Cancer Undergoing Outpatient Chemotherapy

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Open Journal of Nursing 2021年第6期11卷 466-476页

作者： daisuke Sato Makoto Shimoyama Faculty of Health Sciences Komatsu University Ishikawa Japan Faculty of Nursing Miyagi University Miyagi Japan

During outpatient chemotherapy, adverse events occurring at home must be carefully monitored. We have developed a tele-nursing system that can store physical information such as blood pressure and pulse measured by cancer patients in the cloud by using Bluetooth, which is wireless communication technology, and collect information from remote locations. The tele-nursing system name is T-SCOT. The purpose of this study is to conduct a randomized controlled trial to investigate the efficacy of T-SCOT intervention. Participants are those who receive T-SCOT intervention plus Care as usual as the intervention group, and those who receive only Care as usual as the control group. T-SCOT includes the following five steps: 1) Answer questions related to side effects of chemotherapy [10 items];2) Measure blood pressure, pulse, body temperature, and SPO2. The measured data is automatically saved in the cloud via Bluetooth;3) Watch a video of coping behavior for side effects;4) The data entered by the patient is visualized as a line graph;5) Utilize the videophone function with researchers if you have any problems or troubles. Utilization of ICT in telenursing makes it possible to visualize patient’s physical information and contributes to the reduction of medical expenses.

关键词： Telenursing Outpatient Chemotherapy Symptoms Complications Prevention

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Indium chloride bone marrow scintigraphy for hepatic myelolipoma: A case report

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World Journal of Clinical Cases 2023年第18期11卷 4377-4383页

作者： Akio Sato Kazuhiro Saito Koichiro Abe Katsutoshi Sugimoto Toshitaka Nagao Aoi Sukeda daisuke Yunaiyama Department of Radiology Tokyo Medical University HospitalShinjuku-ku 160-0023TokyoJapan Department of Gastroenterology and Hepatology Tokyo Medical University HospitalShinjuku-ku 160-0023TokyoJapan Department of Anatomic Pathology Tokyo Medical University HospitalShinjuku-ku 160-0023TokyoJapan

BACKGROUND As hepatic myelolipoma is rarely encountered,its radiological diagnosis using ultrasonography(US),computed tomography(CT),and magnetic resonance imaging(MRI)is *** myelolipoma is similar to fat-contained hepatic lesions seen in hepatocellular carcinoma and ***,further development of techniques to diagnose hepatic myelolipoma is *** SUMMARY A 44-year-old obese man was found to have a hepatic lesion during his medical *** lesion was 50 mm×57 mm in size and was detected in segment 8(S8)of the liver by *** patient was diagnosed with hepatic lesion 20 years ago,but it was left *** patient had no symptoms,liver dysfunction,hepatitis virus antibody,or tumor marker *** CT showed a welldefined lesion in S8 of the *** central and peripheral areas of the lesion primarily exhibited fat density and hypodensity,*** revealed a capsule-like *** was performed to address the probability of hepatocellular *** lesion was pathologically confirmed as a *** marrow scintigraphy performed using 111InCl3 revealed accumulation of the radiopharmaceutical in the soft tissue component,except in the fat-dominant part of the tumor,as well as in the surrounding liver parenchyma due to the presence of reticuloendothelial cells in the *** This is the first report on the diagnosis of hepatic myelolipoma using 111InCl3 *** effectiveness of bone marrow scintigraphy for diagnosing hepatic myelolipoma might be *** radiopharmaceuticals accumulate in both hematopoietic and reticuloendothelial cells,the accumulation of radiopharmaceuticals in the lesion is obscure.

关键词： Liver 111InCl3 Myelolipoma Magnetic resonance imaging Benign tumor Case report

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Decomposition of dynamic transcriptomic responses during effector-triggered immunity reveals conserved responses in two distinct plant cell populations

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Plant Communications 2024年第8期5卷 1-17页

作者： Xiaotong Liu daisuke Igarashi Rachel A.Hillmer Thomas Stoddard You Lu Kenichi Tsuda Chad L.Myers Fumiaki Katagiri Department of Plant and Microbial Biology University of Minnesota-Twin CitiesSt PaulMN 55108USA Department of Computer Science and Engineering University of Minnesota-Twin CitiesMinneapolisMN 55455USA Bioinformatics and Computational Biology Graduate Program University of Minnesota-Twin CitiesMinneapolisMN 55455USA Institute for Innovation Ajinomoto Co.Inc.KawasakiJapan State Key Laboratory of Agricultural Microbiology Hubei Hongshan LaboratoryHubei Key Lab of Plant PathologyCollege of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Present address:225 S 6th St MinneapolisMN 55402USA Present address:Biotalys Inc.2520 Meridian Parkway Suite 480DurhamNC 27713USA Present address:Life Sciences Institute and Department of Cell and Developmental Biology University of Michigan Medical SchoolAnn ArborMI 48109USA

Rapid plant immune responses in the appropriate cells are needed for effective defense against *** transcriptome analysis is often used to describe overall immune responses,collection of transcriptome data with sufficient resolution in both space and time is *** reanalyzed public Arabidopsis time-course transcriptome data obtained after low-dose inoculation with a Pseudomonas syringae strain expressing the effector AvrRpt2,which induces effector-triggered immunity in ***-peak time-course patterns are prevalent among thousands of upregulated *** implemented a multicompartment modeling approach to decompose the double-peak pattern into two single-peak patterns for each *** decomposed peaks reveal an“echoing”pattern:the peak times of the first and second peaks correlate well across most upregulated *** demonstrated that the two peaks likely represent responses of two distinct cell populations that respond either cell autonomously or indirectly to ***,the peak decomposition has extracted spatial information from the time-course *** echoing pattern also indicates a conserved transcriptome response with different initiation times between the two cell populations despite different elicitor types.A gene set highly overlapping with the conserved gene set is also upregulated with similar kinetics during pattern-triggered *** of a WRKY network via different entry-point WRKYs can explain the similar but not identical transcriptome responses elicited by different elicitor *** discuss potential benefits of the properties of the WRKY activation network as an immune signaling network in light of pressure from rapidly evolving pathogens.

关键词： Arabidopsis Pseudomonas syringae plant immune response multi-compartment model WRKY transcription factors resilient immune signaling network

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Successful embolization of an intrahepatic portosystemic shunt using balloon-occluded retrograde transvenous obliteration:A case report

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World Journal of Clinical Cases 2022年第6期10卷 2023-2029页

作者： Hidemasa Saito Satoru Murata Fumie Sugihara Tatsuo Ueda daisuke Yasui Izumi Miki Hiromitsu Hayashi Shin-Ichiro Kumita Department of Radiology Nippon Medical SchoolTokyo 113-8602Japan Center for Interventional Radiology Teikyo University Chiba Medical CenterChiba 299-0011Japan

BACKGROUND A congenital intrahepatic portosystemic shunt(IPSVS)is a rare vascular abnormality that is characterized by an anomalous intrahepatic venous tract that connects the intrahepatic portal vein with the hepatic venous *** encephalopathy is an indication for IPSVS embolization,which is technically challenging because rapid blood flow through shunts can induce the migration of embolization material to systemic *** case report discusses the efficacy of percutaneous balloon-occluded retrograde transvenous obliteration for treating patients with *** SUMMARY A 75-year-old woman presented with a six-month history of repeated hepatic encephalopathy due to an IPSVS without liver *** successfully embolized the IPSVS using percutaneous balloon-occluded retrograde transvenous obliteration with interlocking detachable *** the procedure,the patient exhibited no symptoms of hepatic encephalopathy for 14 *** Balloon-occluded retrograde transvenous obliteration with detachable coils can be effective for the endovascular treatment of an IPSVS.

关键词： Hepatic veins Portal vein Hepatic encephalopathy Endovascular procedures Embolization Therapeutic Case report

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Benefits and risks of erythrocyte-stimulating agents

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World Journal of Clinical Urology 2014年第3期3卷 258-263页

作者： daisuke Katagiri Fumihiko Hinoshita Division of Nephrology and Endocrinology The University of TokyoTokyo 162-8655 Japan Department of Nephrology National Center for Global Health and MedicineTokyo 162-8655 Japan

Chronic kidney disease(CKD)is a common and serious clinical *** in patients with advanced CKD,frequently called renal anemia,causes disabling fatigue and diminishes patients’quality of *** and excess transfusions or iron supplementation are potentially *** it remains unclear whether the main factor in the development of renal anemia is the failure of erythropoietin(EPO)production in the kidney or a dysfunction in oxygen sensing exogenous EPO administration is considered a rational *** advent of recombinant human erythropoietin(r Hu-EPO)products has dramatically changed the therapeutic strategy for renal *** rH u-EPO therapy has improved patients’quality of life and decreased the need for blood transfusions,some potential adverse effects have been reported till *** brief review discusses the treatment of renal anemia with regard to the following:(1)historical background;(2)effectiveness of r Hu-EPO;(3)some topics regarding the treatment of anemia,including EPO resistance,hemoglobin(Hb)cycling,and adequate Hb levels;(4)major adverse effects of rH u-EPO,including hypertension,thrombotic complications,and pure red cell aplasia;and(5)future problems to be resolved.

关键词： Chronic kidney disease Erythrocyte-stimulating agents Renal anemia Erythropoietin Pure red cell aplasia

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630-nm red InGaN micro-light-emitting diodes(<20μm×20μm)exceeding 1 mW/mm~2 for full-color micro-displays

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Photonics Research 2021年第9期9卷 1796-1802页

作者： ZHE ZHUANG daisuke IIDA MARTIN VELAZQUEZ-RIZO KAZUHIRO OHKAWA Computer Electrical and Mathematical Sciences and Engineering(CEMSE)DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia

We demonstrated 10×10 arrays of In Ga N 17μm×17μm micro-light-emitting diodes(μLEDs)with a peak wavelength from 662 to 630 nm at 10–50 A∕cm^(2).The on-wafer external quantum efficiency reached 0.18%at 50 A∕cm^(2).The output power density of the redμLEDs was obtained as 1.76 m W∕mm^(2),which was estimated to be higher than that of 20μm×20μm Al In Ga P redμLEDs(~630 nm).Finally,we demonstrate that In Ga N red/green/blueμLEDs could exhibit a wide color gamut covering 81.3%and 79.1%of the Rec.2020 color space in CIE 1931 and 1976 diagrams,respectively.

关键词： diodes emitting arrays

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