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World Journal of Hepatology 2024年第2期16卷 286-293页

作者： Yoshiki Morihisa Hobyung Chung Shuichiro Towatari daisuke Yamashita Tetsuro Inokuma Department of Gastroenterology and Hepatology Kobe City Medical Center General HospitalKobe 650-0047HyogoJapan Department of Pathology Kobe City Medical Center General HospitalKobe 650-0047HyogoJapan

BACKGROUND Chronic hepatitis C virus(HCV)infection is a major global health concern that leads to liver fibrosis,cirrhosis,and *** containing direct-acting antivirals(DAAs)have become the mainstay of HCV treatment,achieving a high sustained virological response(SVR)with minimal adverse *** SUMMARY A 74-year-old woman with chronic HCV infection was treated with the DAAs ledipasvir,and sofosbuvir for 12 wk and achieved ***-four weeks after treatment completion,the liver enzyme and serum IgG levels increased,and antinuclear antibody became positive without HCV viremia,suggesting the development of autoimmune hepatitis(AIH).After liver biopsy indicated AIH,a definite AIH diagnosis was made and prednisolone was *** treatment was effective,and the liver enzyme and serum IgG levels ***,multiple strictures of the intrahepatic and extrahepatic bile ducts with dilatation of the peripheral bile ducts appeared on magnetic resonance cholangiopancreatography after 3 years of achieving SVR,which were consistent with primary sclerosing *** The potential risk of developing autoimmune liver diseases after DAA treatment should be considered.

关键词： Liver Hepatitis C virus Autoimmune hepatitis Primary sclerosing cholangitis Immune system Case report

Hyperacute experimental model of rat lung transplantation using a coronary shunt cannula

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World Journal of Transplantation 2024年第2期14卷 155-161页

作者： Munehisa Takata Yusuke Tanaka daisuke Saito Shuhei Yoshida Isao Matsumoto Department of Thoracic Surgery Kanazawa UniversityKanazawa 920-8641IshikawaJapan

BACKGROUND Lung transplantation is a well-established treatment of end-stage lung disease.A rodent model is an inexpensive way to collect biological data from a living model after lung ***,mastering the surgical technique takes time owing to the small organ *** To conduct rat lung transplantation using a shunt cannula(SC)or modified cannula(MC)and assess their *** Rat lung transplantation was performed in 11 animals in the SC group and 12 in the MC *** devised a method of rat lung transplantation using a coronary SC for coronary artery bypass surgery as an anastomosis of pulmonary arteri-ovenous vessels and *** same surgeon performed all surgical proce-dures in the donor and recipient rats without using a magnifying *** success rate of lung transplantation,operating time,and PaO2 values were com-pared after 2-h reperfusion after *** Ten and 12 lungs were successfully transplanted in the SC and MC groups,*** the SC group,one animal had cardiac arrest within 1 h after reperfusion owing to bleeding during pulmonary vein *** opera-ting time for the removal of the heart-lung block from the donor and preparation of the left lung graft was 26.8±2.3 and 25.7±1.3 min in the SC and MC groups,respectively(P=0.21).The time required for left lung transplantation in the recipients was 37.5±2.8 min and 35.9±1.4 min in the SC and MC groups,respectively(P=0.12).PaO2 values at 2 h after reperfusion were 456.2±25.5 and INTRODUCTION Lung transplantation is a well-established treatment of end-stage lung *** immune and non-immune mech-anisms in lung transplantation are highly complex,and post-transplant complications such as infections and primary and chronic lung allograft dysfunction must be reduced to improve ***,there is a need for immunological and pathophysiological analyses using animal lung transplantation *** rat lung transplantation model was f

关键词： Lung transplantation Rat Shunt cannula Modified cannula Reperfusion

Stand-Up Assistive Devices Allowing Patients to Perform Voluntary Movements within the Safety Movement Tolerance

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Journal of Artificial Intelligence and Technology 2022年第4期2卷 164-173页

作者： daisuke Chugo Satoshi Muramatsu Sho Yokota Jinhua She Hiroshi Hashimoto Kwansei Gakuin University Japan Tokai University Japan Tokyo University Japan Advanced Institute of Industrial Technology Japan

This paper proposes a novel standing assistance robot,which realizes voluntary movements of the patient within a safety motion *** the previous studies,conventional assistive robots did not require patients to use their own physical strength to stand,which led to decreased strength in the *** general assistive robots helped patients by using a fixed motion reference pathway in spite of their original intention,and as a result,these robots failed to use the physical strength of the ***,this study proposes a novel method for assisting the patient to stand up safely while using their physical abilities,by determining the range of movements that can be safely performed from the patient’s physical condition and allowing the patient to move freely within this *** standing motion is a set of different movements:inclining the trunk forward,lifting the trunk,and extending the *** this study,the range of movements in which the patient can safely stand in each movement is determined in terms of body stability and the muscle output that the patient can ***,this study proposes a robot control method that allows movements based on the patient’s free will if the patient’s posture is within the safety tolerance,and it corrects the movements when the patient’s posture is estimated to fall outside of *** proposed idea is implemented in our new prototype,and its effectiveness is verified by experimental results with elderly subjects who live in the nursing care house.

关键词： standing assistance assistive robot safety tolerance musculoskeletal simulation

Relationship between office workers’staying and workstation attributes in a non-territorial office using ultra wide band sensor network

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Frontiers of Structural and Civil Engineering 2010年第4期4卷 438-449页

作者： Xinnan ZHANG Takashi IZATO Junzo MUNENOTO daisuke MATSUSHITA Tetsu YOSHIDA Department of Architecture Kyoto UniversityKyoto 615-8540Japan Architecture&Engineering Division TAISEI CorporationTokyo 163-0606Japan Department of Architecture Okayama University of ScienceOkayama 700-0005Japan Department of Architecture Faculty of EngineeringKyoto UniversityKyoto 615-8540Japan

This paper investigates the staying and moving characteristics of office workers in a non-territorial office using an ultra wide band(UWB)impulse radio sensor *** differences between office workers’staying and moving are clarified according to the individual workstation type that they *** study determines the characteristics of each type of *** clarifying office workers’preference for staying and moving with regard to individual workstation types and office worker post,the reasons why office workers in different posts tended to select different types of workstations were ***,leaders tended to select workstations at the“inner meeting corner side”most frequently,as they had a greater need to stay in other *** contrast,ordinary staff needed to visit office workers in other areas less often,and as such,they tended to select individual workstations at the“middle meeting corner side.”Barring this,they tended to select individual workstations at the“middle corridor side”or“outer-meeting corner side.”Temporary staff members had little need to visit or stay at other places so they tended to select individual workstations at the“window side,”which is seldom visited or stayed at by other office workers and they could be disturbed less often from their solo work.

关键词： workplace non-territorial office staying behavior ultra wide band(UWB) sensor network

Classification of Plant Endogenous States Using Machine Learning-Derived Agricultural Indices

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Plant Phenomics 2023年第3期5卷 474-483页

作者： Sally Shuxian Koh Kapil Dev Javier Jingheng Tan Valerie Xinhui Teo Shuyan Zhang Dinish U.S. Malini Olivo daisuke Urano Temasek Life Sciences Laboratory National University of SingaporeSingaporeSingapore Department of Biological Sciences National University of SingaporeSingaporeSingapore Translational Biophotonics Laboratory Institute of Bioengineering and BioimagingAgency for ScienceTechnology and Research(A*STAR)SingaporeSingapore Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore

Leaf color patterns vary depending on leaf age,pathogen infection,and environmental and nutritional stresses;thus,they are widely used to diagnose plant health statuses in agricultural *** visible-near infrared-shortwave infrared(VIS-NIR-SWIR)sensor measures the leaf color pattern from a wide spectral range with high spectral ***,spectral information has only been employed to understand general plant health statuses(e.g.,vegetation index)or phytopigment contents,rather than pinpointing defects of specific metabolic or signaling pathways in ***,we report feature engineering and machine learning methods that utilize VIS-NIR-SWIR leaf reflectance for robust plant health diagnostics,pinpointing physiological alterations associated with the stress hormone,abscisic acid(ABA).Leaf reflectance spectra of wild-type,ABA2-overexpression,and deficient plants were collected under watered and drought ***-and ABA-associated normalized reflectance indices(NRIs)were screened from all possible pairs of wavelength *** associated NRIs showed only a partial overlap with those related to ABA deficiency,but more NRIs were associated with drought due to additional spectral changes within the NIR wavelength *** support vector machine classifiers built with 20 NRIs predicted treatment or genotype groups with an accuracy greater than those with conventional vegetation *** selected NRIs were independent from leaf water content and chlorophyll content,2 well-characterized physiological changes under *** screening of NRIs,streamlined with the development of simple classifiers,serves as the most efficient means of detecting reflectance bands that are highly relevant to characteristics of interest.

关键词： drought reflectance indices

Quantitative Trait Loci Mapping for Leaf Length and Leaf Width in Rice ***64 Derived Lines

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Journal of Integrative Plant Biology 2010年第6期52卷 578-584页

作者： Muhammad Farooq Analiza G.Tagle Rizza E.Santos Leodegario A.Ebron daisuke Fujita Nobuya Kobayashi International Rice Research Institute(IRRI) Department of Agronomy University of Agriculture Faisalabad

The present study was conducted to identify quantitative trait loci （QTLs） for leaf size traits in IR64 introgression lines （INLs）. For this purpose, selected F2 populations derived from crosses between recurrent parent IR64 and its derived INLs, unique for leaf length and leaf width, were used to confirm QTLs. A total of eight QTLs, mapped on three chromosomes, were identified for the four leaf size traits in six F2 populations. A QTL for leaf length, qLLnpt-1, in HKL69 was identified around simple sequence repeat （SSR） marker RM3709 on chromosome 1. Two QTLs for flag leaf length, qFLLnpt-2 and qFLLnpt-4, in HFG39 were indentified on chromosomes 2 and 4, respectively. For flag leaf width, a QTL, qFLWnpt-4, in HFG39 was identified around RM17483 on chromosome 4. While another QTL for flag leaf width, qFLWnpt-1, in HFG27 was identified around RM3252 on chromosome 1. A QTL for leaf width, qLWnpt-2, in HKL75 was identified around RM7451 on chromosome 2. For leaf width, two QTLs, qLWnpt-4a, qLWnpt-4b, in HKL48 and HKL99 were identified around RM7208 and RM6909, respectively on chromosome 4. Results from this study suggest the possibilities to use marker-assisted selection and pyramiding these QTLs to improve rice water productivity.

关键词： QTLs Quantitative Trait Loci Mapping for Leaf Length and Leaf Width in Rice cv.IR64 Derived Lines IR

Improvement on the Effectiveness of Marine Stock Enhancement in the Artificial Reef Area by a New Cage-Based Release Technique

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Journal of Ocean University of China 2021年第4期20卷 992-998页

作者： ZHANG Junbo HE Yufeng GUO Zhixing JI Shuheng ZHANG Shuo TANG Yanli SHENG Huaxiang WAN Rong KITAZAWA daisuke College of Marine Sciences Shanghai Ocean UniversityShanghai 201306China College of Economics and Management Shanghai Ocean UniversityShanghai 201306China Marine Hazard Mitigation Service Ministry of Natural ResourcesBeijing 100194China College of Fisheries Ocean University of ChinaQingdao 266003China National Engineering Research Center for Oceanic Fisheries Shanghai Ocean UniversityShanghai 201306China Institute of Industrial Science the University of Tokyo5-1-5 KashiwanohaKashiwa-shiChiba 277-8574Japan

The release technique,affecting the survival rate of fish species released for stock enhancement,plays a vital role in the effectiveness of the *** order to improve the probability of released fish settling down to bottom,a new cage-based release technique was designed and tested via a water tank with artificial reef *** coral reef fish species,Sebastes schlegelii and Paralichthys olivaceus were assessed using this *** behavior and distribution in water tank were recorded and compared with the traditional release release *** showed that in the case of cage-based release technique:1)when the release process is just finished,the distribution index(DI)of juveniles *** and *** were 97.8%and 98.9%at reef area,40%and 71.1%at release point,respectively,which was higher than those using two alternative techniques;2)its impact duration was less than that in the other two conditions,where the DI within 4 hours was higher after releasing,especially for *** findings indicated that the new cage-based technique could release the fish into the specified location,and has a potential to mitigate the stress reaction of fish caused by releasing process.

关键词： release technique cage-based device distribution patterns distribution index stock enhancement

Generation of insulin-producing β-like cells from human iPS cells in a defined and completely xeno-free culture system

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Journal of Molecular Cell Biology 2014年第5期8卷 394-408页

作者： Hussain Md. Shahjalal Nobuaki Shiraki daisuke Sakano Kazuhide Kikawa Soichiro Ogaki Hideo Baba Kazuhiko Kume Shoen Kume Department of Stem Cell Biology Institute of Molecular Embryology and Genetics Kumamoto University Honjo 2-2-1 Chuo-Ku Kumamoto 860-0811 Japan Global-Center of Excellence (6-COE) Kumamoto University Honjo 2-2-1 Chuo-ku Kumamoto 860-0811 Japan Department of Pediatrics Graduate School of Medical Sciences Kumamoto University Honjo 1-1-1 Chuo-Ku Kumamoto 860-8556 Japan Department of Gastroenterological Surgery Graduate School of Medical Sciences Kumamoto University Honjo 1-1-1 Chuo-Ku Kumamoto 860-8556 Japan Department of Neuropharmacology Graduate School of Pharmaceutical Sciences Nagoya City University 3-1 Tanabe Street Mizuho Nagoya 467-8603 Japan Program for Leading Graduate Schools 'HIGO (Health Life Science Interdisciplinary and Glocal Oriented) Program ' Kumamoto University Honjo 2-2-1 Chuo-ku Kumamoto 860-0811 Japan

Human induced pluripotent stem （hiPS） cells are considered a potential source for the generation of insulin-producing pancreatic β-ceUs because of their differentiation capacity. In this study, we have developed a five-step xeno-free culture system to efficiently dif- ferentiate hiPS cells into insulin-producing cells in vitro. We found that a high NOGGIN concentration is crucial for specifically inducing the differentiation first into pancreatic and duodenal homeobox-1 （PDX1）-positive pancreatic progenitors and then into neurogenin 3 （NGN3）-expressing pancreatic endocrine progenitors, while suppressing the differentiation into hepatic or intestinal cells. We also found that a combination of 3-isobutyl-l-methylxanthine （IBMX）, exendin-4, and nicotinamide was important for the differentiation into insulin single-positive cells that expressed various pancreatic β-cell markers. Most notably, the differentiated cells contained en- dogenous C-peptide pools that were released in response to various insulin secretagogues and high levels of glucose. Therefore, our results demonstrate the feasibility of generating hiPS-derived pancreatic β-ceUs under xeno-free conditions and highlight their poten- tial to treat patients with type I diabetes.

关键词： diabetes pancreas ceil therapy hiPS ceils xeno-free differentiation β-cells

Zinc-Based Metal-Organic Frameworks for High-Performance Supercapacitor Electrodes:Mechanism Underlying Pore Generation

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Energy & Environmental Materials 2023年第2期6卷 100-112页

作者： Shigeyuki Umezawa Takashi Douura Koji Yoshikawa daisuke Tanaka Vlad Stolojan S.Ravi P.Silva Mika Yoneda Kazuma Gotoh Yasuhiko Hayashi Seiwa Electric Mfg.Co.Ltd. Kyoto 610-0192Japan Graduate School of Natural Science and Technology Okayama UniversityOkayama 700-8350Japan School of Science and Technology Kwansei Gakuin UniversityHyogo 669-1337Japan JST PRESTO2-1 GakuenHyogo 669-1337Japan Advanced Technology Institute University of SurreyGuilfordSurreyGU27XHUK

Heat treatment of metal-organic frameworks(MOFs)has provided a wide variety of functional carbons coordinated with metal *** this study,two kinds of zinc-based MOF(ZMOF),C_(16)H_(10)O_(4)Zn(ZMOF1)and C_(8)H_(4)O_(4)Zn(ZMOF2),were ***1 and ZMOF2 were carbonized at 1000℃,forming CZMOF1 and CZMOF2,*** specific surface area(S_(BET))of CZMOF2 was~2700 m^(2)g^(−1),much higher than that of CZMOF1(~1300 m^(2)g^(−1)).A supercapacitor electrode based on CZMOF2 achieved specific capacitances of 360,278,and 221 F g^(−1)at 50,250,and 1000 mA g^(−1)in an aqueous electrolyte(H2SO_(4)),respectively,the highest values reported to date for ZMOF-derived electrodes under identical *** practical applicability of the CZMOF-based supercapacitor was verified in non-aqueous *** initial capacitance retention was 78%after 100000 charge/discharge cycles at 10 A g^(−1).Crucially,the high capacitance of CZMOF2 arises from pore generation during *** 1000℃,pore generation is dominated by the Zn/C ratio of ZMOFs,as carbon atoms reduce the zinc oxides formed during *** 1000℃,a high O/C ratio becomes essential for pore generation because the oxygen functional groups are *** findings will provide insightful information for other metal-based MOFderived multifunctional carbons.

关键词： metal-organic frameworks pore generation porous carbons supercapacitor zinc oxides

Troponin T from the Japanese Pearl Oyster <i>Pinctada fucata</i>: Molecular Cloning, Tissue Distribution, Gene Structure, and Interaction Analysis with Tropomyosin

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American Journal of Molecular Biology 2020年第1期10卷 61-73页

作者： daisuke Funabara Yoshinori Urakawa daisuke Ishikawa Satoshi Kanoh Graduate School of Bioresources Mie University Tsu Japan

Troponin (Tn) is composed of three subunits (TnI, TnC and TnT) that bind Ca2+ and regulate striated muscle contraction in vertebrates. TnT’s function has been extensively described in vertebrates, but its role has been obscure in molluscan muscles. Our previous work indicated that the TnC and TnI subunits work in adductor phasic muscle, but not in catch muscle. Here, we have characterized TnT from the Japanese bivalve pearl oyster Pinctada fucata to start to explain the function of Tn in molluscan muscle contraction. We determined the primary structure of the full-length TnT protein from the P. fucata adductor muscle (Pifuc-TnT), and found that it is composed of 316 amino acid residues with a predicted molecular mass of 37.4 kDa. Multiple sequence alignment showed that Pifuc-TnT has an extension of >60 residues at the C-terminus that are not present in vertebrate TnTs, including known TnTs from other mollusks. Pifuc-TnT gene structure predictions using Splign alignment of the cDNA generated in this study and genome sequences indicated that Pifuc-TnT consists of 13 exons. Start and stop codons are located in exons 2 and 12, respectively. Quantitative real-time PCR revealed that the Pifuc-TnT gene was predominantly expressed in adductor phasic muscle, weakly in adductor catch muscle, slightly in gill, and not at all in mantle and foot. These findings suggest that TnT plays a regulatory role in adductor phasic muscle contraction, but not in catch contraction. Isothermal titration calorimetry revealed that unlike vertebrate TnTs, Pifuc-TnT does not interact with P. fucata tropomyosin-1 nor with tropomyosin-2. These findings in P. fucata imply that Tn functions differently in molluscan muscle than it does in vertebrates.

关键词： Adductor Muscle Catch Contraction Pinctada fucata Troponin T Tropomyosin