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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第8期18卷 723-724页

作者： Shigeki matsubara Hironori TAKAHASHI daisuke matsubara Yosuke BABA Department of Obstetrics and Gynecology Jichi Medical University329-0498 Tochigi Japan Department of Pediatrics Jichi Medical University 329-0498Tochigi Japan

Uterine artery pseudoaneurysm （UAP）, an im-portant disorder causing postpartum hemorrhage, hasbeen considered to occur after ＂traumatic delivery＂such as cesarean section （CS）. Our recent study （Babaet al., 2016... 详细信息

关键词：浙江大学学报英文版

Paradoxical brain embolism followed by percutaneous atrial septal closure： Stroke in a patient＇s thirties highlighting some issues surrounding brain stroke in an emergency setting

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World Journal of Emergency Medicine 2017年第4期8卷 308-309页

作者： daisuke matsubara Koichi Kataoka Teppei matsubara Takaomi Minami Takanori Yamagata Department of Pediatrics Jichi Medical University Tochigi Japan Department of Clinical Neurophysiology Neurological Institute Graduate School of Medical Sciences Kyushu UniversityFukuoka Japan

Brain stroke in patients younger than 40 deprivessociety of its work force. Paradoxical brain embolism（PBE） is sometimes responsible. PBE should never beoverlooked in emergency settings because its recurrencemay be ... 详细信息

关键词： Brain stroke patients younger PBE

Current perspectives of viral

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World Journal of Gastroenterology 2024年第18期30卷 2402-2417页

作者： daisuke Usuda Yuki Kaneoka Rikuo Ono Masashi Kato Yuto Sugawara Runa Shimizu Tomotari Inami Eri Nakajima Shiho Tsuge Riki Sakurai Kenji Kawai Shun matsubara Risa Tanaka Makoto Suzuki Shintaro Shimozawa Yuta Hotchi Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima 177-8521TokyoJapan Department of Sports Medicine Faculty of MedicineJuntendo UniversityBunkyo 113-8421TokyoJapan

Viral hepatitis represents a major danger to public health,and is a globally leading cause of *** five liver-specific viruses:Hepatitis A virus,hepatitis B virus,hepatitis C virus,hepatitis D virus,and hepatitis E virus,each have their own unique epidemiology,structural biology,transmission,endemic patterns,risk of liver complications,and response to antiviral *** remain few options for treatment,in spite of the increasing prevalence of viral-hepatitiscaused liver ***,chronic viral hepatitis is a leading worldwide cause of both liver-related morbidity and mortality,even though effective treatments are available that could reduce or prevent most patients’*** 2016,the World Health Organization released its plan to eliminate viral hepatitis as a public health threat by the year 2030,along with a discussion of current gaps and prospects for both regional and global eradication of viral ***,treatment is sufficiently able to prevent the disease from reaching advanced ***,future therapies must be extremely safe,and should ideally limit the period of treatment necessary.A better understanding of pathogenesis will prove beneficial in the development of potential treatment strategies targeting infections by viral *** review aims to summarize the current state of knowledge on each type of viral hepatitis,together with major innovations.

关键词： Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus Current perspectives

Formation mechanism of extension fractures induced by excavation of a gallery in soft sedimentary rock,Horonobe area,Northern Japan

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Geoscience Frontiers 2013年第1期4卷 105-111页

作者： Tetsuya Tokiwa Kimikazu Tsusaka Makoto matsubara Taiki Ishikawa daisuke Ogawa Horonobe Underground Research Unit Japan Atomic Energy AgencyHokkaido 098-3224Japan Geoscience Research Laboratory Kanagawa 242-0014Japan Mitsubishi Materials Techno Corporation Tokyo 102-8205Japan

This paper focuses on the formation mechanism of fractures induced by excavation of a gallery in soft sedimentary rocks in the Horonobe area of Japan. Detailed fracture mapping of the gallery indicates that the fractures consist of both pre-existing shear fractures and excavation damaged zone （EDZ） fractures. EDZ fractures correspond to weak planes associated with bedding planes or transgranular cracks. The EDZ fractures terminate against pre-existing shear fractures. Therefore, even for excavations in soft sedimentary rocks, formation of the EDZ fractures are controlled by pre-existing fractures and earlier weak planes.

关键词： Fracture Excavation damaged zone (EDZ)Weak plane Soft rock Excavation

Destruction energy index(DEI)of vitamin E blended UHMWPE for artificial joints

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Biosurface and Biotribology 2019年第1期5卷 24-27页

作者： Naoya Hatano Masaya Higaki Youhei Otsu Tatsuya Otsu Shinji Mikami Mitsuhiro Matsumoto daisuke Kono Atsushi matsubara Naohide Tomita Mechanical Engineering and Science Kyoto UniversityKyotoJapan Micro Engineering Kyoto UniversityKyotoJapan

Destruction resistance such as start-up wear resistance characteristics of vitamin E(dl-α-tocopherol)blended ultrahigh molecular weight polyethylene(UHMWPE)were evaluated using the destruction energy index(DEI).The DEI is used to evaluate wear-like destruction,by minimising the effects of viscosity at the sliding interface,and is estimated using newly designed friction *** this experiment,silicone oils of different viscosities were used to determine micro displacement up to a start-up point,and the DEI of the UHMWPE was changed from 17.48 to 1.84μJ by adding vitamin *** results suggest that the blending with vitamin E reduces destruction of UHMWPE at start-up friction in silicone oils.

关键词： vitamin struction friction

Monitoring salivary amylase activity is useful for providing timely analgesia under sedation

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World Journal of Gastrointestinal Endoscopy 2014年第6期6卷 240-247页

作者： Masaya Uesato Yoshihiro Nabeya Takashi Akai Masahito Inoue Yoshiyuki Watanabe daisuke Horibe Hiroshi Kawahira Hideki Hayashi Hisahiro matsubara Department of Frontier Surgery Chiba University Graduate School of Medicine Division of Gastroenterological Surgery Chiba Cancer Center Department of Endoscopic Diagnostics and Therapeutics Chiba University Hospital Research Center for Frontier Medical Engineering Chiba University

AIM:To detect the criteria and cause of elevated salivary amylase activity(sAMY)in patients undergoing endoscopic submucosal dissection(ESD)under ***:A total of 41 patients with early gastric cancer removed via ESD under deep sedation(DS)were *** perioperative sAMY,which was shown as sympathetic excitements(SE),was *** time at which a patient exhibited a relatively increased rate of sAMY compared with the preoperative baseline level(IR,%)≥100%(twice the actual value)was assumed as the moment when the patient received *** the 41 patients,we focused on 14 patients who exhibited an IR≥100% at any time that was associated with sAMY elevation during ESD(H-group)and examined whether any particular endoscopic procedures can cause SE by simultaneously monitoring the sAMY *** a patient demonstrated an elevated sAMY level above twice the baseline level,the endoscopic procedure was immediately *** the impossible case of discontinuance,analgesic medicines were *** study was performed ***:A total of 26 episodes of sAMY eruption were considered moments of SE in the *** baseline level of sAMY significantly increased in association with an IR of>100% at 5 min,with a significant difference(IR immediately before elevation/IR at elevation of sAMY=8.72±173/958±1391%,P<0.001).However,effective intervention decreased the elevated sAMY level immediately within only 5 min,with a significant difference(IR at sAMY elevation/immediately after intervention=958±1391/476±1031,P<0.001).The bispectral indices,systolic blood pressure and pulse rates,which were measured at the same time,remained stable throughout the *** endoscopic insertion or over insufflation was performed during 22 of the 26 *** of the gastric wall tension and/or the administration of analgesic medication resulted in the immediate recovery of the elevated sAMY level,independent of body ***:By detecting tw

关键词： Salivary amylase activity Endoscopic submucosal dissection Analgesia Anesthesia Sedation Sympathetic excitement Gastric wall tension

Hemorrhagic shock due to submucosal esophageal hematoma along with mallory-weiss syndrome:A case report

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World Journal of Clinical Cases 2022年第27期10卷 9911-9920页

作者： Jiro Oba daisuke Usuda Shiho Tsuge Riki Sakurai Kenji Kawai Shun matsubara Risa Tanaka Makoto Suzuki Hayabusa Takano Shintaro Shimozawa Yuta Hotchi Kenki Usami Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima-ku 177-8521TokyoJapan Faculty of Medicine Juntendo UniversityBunkyo-ku 113-8421TokyoJapan

BACKGROUND Esophageal submucosal hematoma is a rare *** the exact etiology remains uncertain,vessel fragility with external factors is believed to have led to submucosal bleeding and hematoma formation;the vessel was ruptured by a sudden increase in pressure due to nausea,and the hematoma was enlarged by antiplatelet or anticoagulant *** conditions are rare,with a better *** present the first known case of submucosal esophageal hematoma-subsequent hemorrhagic shock due to Mallory-Weiss *** SUMMARY A 73-year-old female underwent endovascular treatment for an unruptured cerebral *** patient received aspirin and clopidogrel before surgery and heparin during surgery,and was well during the *** hours after returning to the ICU,she complained of chest discomfort,vomited 500 m L of fresh blood,and entered hemorrhagic *** submucosal hematoma with Mallory-Weiss syndrome was diagnosed through an endoscopic examination and computed *** addition to a massive fluid and erythrocyte transfusion,we performed a temporary compression for hemostasis with a Sengstaken-Blakemore(S-B)***,she became hemodynamically *** postoperative day 1,we performed an upper gastrointestinal endoscopy and confirmed no expansion of the hematoma nor any recurring bleeding;therefore,we removed the S-B tube and clipped the gastric mucosal laceration at the esophagogastric *** started oral intake on postoperative day *** patient made steady progress,and was discharged on postoperative day *** We present the first known case of submucosal esophageal hematoma subsequent hemorrhagic shock due to Mallory-Weiss syndrome.

关键词： Esophageal submucosal hematoma Hemorrhagic shock Mallory-Weiss syndrome Antithrombotic therapy Anticoagulant therapy Case report

Amebic liver abscess by Entamoeba histolytica

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World Journal of Clinical Cases 2022年第36期10卷 13157-13166页

作者： daisuke Usuda Shiho Tsuge Riki Sakurai Kenji Kawai Shun matsubara Risa Tanaka Makoto Suzuki Hayabusa Takano Shintaro Shimozawa Yuta Hotchi Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima 177-8521TokyoJapan Department of Sports Medicine Faculty of MedicineJuntendo UniversityBunkyo 113-8421TokyoJapan

Amebic liver abscesses(ALAs)are the most commonly encountered extraintestinal manifestation of human invasive amebiasis,which results from Entamoeba histolytica(***)spreading *** can be complicated by liver abscess in 9%of cases,and ALAs led to almost 50000 fatalities worldwide in *** there have been fewer and fewer cases in the past several years,ALAs remain an important public health problem in endemic *** causes both amebic colitis and liver abscess by breaching the host’s innate defenses and invading the intestinal *** often enter the circulatory system,where they are filtered in the liver and produce abscesses,and develop into severe invasive diseases such as *** clinical presentation can appear to be colitis,including upper-right abdominal pain accompanied by a fever in ALA *** diagnosis requires nonspecific liver imaging as well as detecting *** antibodies;however,these antibodies cannot be used to distinguish between a previous infection and an acute ***,diagnostics primarily aim to use PCR or enzyme-linked immunosorbent assay to detect *** can be treated medically,and percutaneous catheter drainage is only necessary in approximately 15%of *** indicated treatment is to administer an amebicidal drug(such as tinidazole or metronidazole)and paromomycin or other luminal cysticidal agent for clinical *** is good with almost universal *** which diagnostic methods are most efficacious will necessitate further analysis of similar clinical cases.

关键词： Amebic liver abscess Entamoeba histolytica Polymerase chain reaction Enzyme-linked immunosorbent assay Percutaneous catheter drainage Amebicidal drug

High doses of dextromethorphan induced shock and convulsions in a 19-year-old female:A case report

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World Journal of Clinical Cases 2023年第16期11卷 3870-3876页

作者： Shintaro Shimozawa daisuke Usuda Toru Sasaki Shiho Tsuge Riki Sakurai Kenji Kawai Shun matsubara Risa Tanaka Makoto Suzuki Yuta Hotchi Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Suguru Asako Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima-city 177-8521TokyoJapan Clinical Training Center Juntendo University Nerima HospitalNerima-city 177-8521TokyoJapan Department of Sports Medicine Faculty of MedicineJuntendo UniversityBunkyo-city 113-8421TokyoJapan

BACKGROUND Dextromethorphan is a prevalent antitussive agent that can be easily obtained as an over-the-counter *** has been a growing number of reported cases of toxicity in recent ***,there are numerous instances of mild symptoms,with only a limited number of reports of severe cases necessitating intensive *** presented the case of a female who ingested 111 tablets of dextromethorphan,leading to shock and convulsions and requiring intensive care that ultimately saved her *** SUMMARY A 19-year-old female was admitted to our hospital via ambulance,having overdosed on 111 tablets of dextromethorphan(15 mg)obtained through an online importer in a suicide *** patient had a history of drug abuse and multiple self-inflicted *** the time of admission,she exhibited symptoms of shock and altered ***,upon arrival at the hospital,the patient experienced recurrent generalized clonic convulsions and status epilepticus,necessitating tracheal *** convulsions were determined to have been caused by decreased cerebral perfusion pressure secondary to shock,and noradrenaline was administered as a *** lavage and activated charcoal were also administered after *** systemic management in the intensive care unit,the patient’s condition stabilized,and the need for vasopressors *** patient regained consciousness and was *** patient was subsequently transferred to a psychiatric facility,as suicidal ideation *** We report the first case of shock caused by an overdose of dextromethorphan.

关键词： Dextromethorphan Drug overdose Shock Symptom Treatment Case report

Penile and scrotal strangulation by stainless steel rings in an human immunodeficiency virus positive man: A case report

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世界临床病例杂志 2023年第24期11卷 5811-5816页

作者： daisuke Usuda Nobuyoshi Kaminishi Masashi Kato Yuto Sugawara Runa Shimizu Tomotari Inami Shiho Tsuge Riki Sakurai Kenji Kawai Shun matsubara Risa Tanaka Makoto Suzuki Shintaro Shimozawa Yuta Hotchi Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima 177-8521TokyoJapan Clinical Training Center Juntendo University Nerima HospitalNerima 177-8521TokyoJapan Sports Medicine Juntendo UniversityBunkyo 113-8421TokyoJapan

BACKGROUND Penoscrotal constriction devices are either used as autoerotic stimuli or to increase sexual pleasure or performance by maintaining an erection for a longer period,and a variety of metallic and non-metallic objects are *** the other hand,penile strangulation is a rare urologic emergency that requires prompt evaluation and intervention to prevent long-term *** goal of treating penile incarceration is to remove the foreign object as soon as *** the other hand,removal can be very challenging,and often requires resourcefulness and a multidisciplinary *** SUMMARY A 47-year-old man who has sex with men was transferred to our hospital for persistent phallodynia and scrotal pain,accompanying swelling due to strangulation by stainless steel *** medical history included acquired immunodeficiency *** day prior,he had put three stainless steel rings on his penis and scrotum before sexual *** sexual intercourse,he was unable to remove them,due to swelling of his penis and *** swelling persisted,and he felt pain in the affected area the next day,then he was transferred to our hospital by *** emergency department found that his penis and scrotum were markedly engorged and *** established a diagnosis of penile and scrotal strangulation by stainless steel *** unsuccessfully attempted to cut the rings using a cutter,then requested a rescue team via emergency medical *** cut through each ring in two places,using an electric-powered angle grinder,and successfully removed all of the ***,he was discharged and went *** We report the first case of penile and scrotal strangulation by stainless steel rings in an human immunodeficiency virus positive person.

关键词： Penile strangulation Stainless steel ring Human immunodeficiency virus Urologic emergency Management Case report