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The Compatibility of Groups Used to Protect Phenolic Functionality during Oxone-Mediated Oxidative Esterification

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Green and Sustainable Chemistry 2022年第4期12卷 83-90页

作者： Tomoko Mineno Yuki Suzuki Tomoya Nobuta daiki takano Hisao Kansui Laboratory of Medicinal Chemistry Faculty of Pharmacy Takasaki University of Health and Welfare Takasaki Japan Laboratory of Molecular Design Chemistry Faculty of Pharmacy Takasaki University of Health and Welfare Takasaki Japan Laboratory of Organic Chemistry Faculty of Pharmaceutical Sciences Sojo University Kumamoto Japan

Protecting groups often play an essential role in organic synthesis, particularly for multi-step synthesis or natural product total synthesis. Various protecting groups areavailable to mask the vulnerable functionality;phenolic hydroxy groups are noteworthy examples, but their stability differs when protected. Herein, the compatibility of protective phenolic functionality was investigated with the implementation of indium (III) triflate-catalyzed oxidative esterification using Oxone in methanol. A wide range of protective moieties was selected and subjected to Oxone-mediated oxidative esterification. For example, sulfonates were found to be sufficiently stable and inert whereas acetals were susceptible to reaction conditions. The details of this investigation are provided.

关键词： Compatibility Protecting Groups Phenolic Functionality Oxone Oxidative Esterification

Recent trends in bone metastasis treatments:A historical comparison using the new Katagiri score system

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World Journal of Clinical Cases 2024年第15期12卷 2499-2505页

作者： Kenji Matsuda Kazuhiro Shimazu Hanae Shinozaki Koji Fukuda Taichi Yoshida daiki Taguchi Kyoko Nomura Hiroyuki Shibata Department of Clinical Oncology Akita University Graduate School of MedicineAkita 010-8543Japan Department of Environmental Health Science and Public Health Akita University Graduate School of MedicineAkita 010-8543Japan Department of Comprehensive Cancer Control Akita University Graduate School of MedicineAkita 010-8543Japan

BACKGROUND Bone metastasis has various negative *** of daily living(ADL)and quality of life(QOL)can be significantly decreased,survival may be impacted,and medical expenses may *** is estimated that at least 5%cancer patients might be suffering from bone *** 2016,we published the Comprehensive Guidelines for the Diagnosis and Treatment of Bone *** then,the therapeutic outcomes for patients have gradually *** life expectancy is a major determinant of surgical intervention,the strategy should be modified if the prolongation of survival is to be *** To monitor how bone metastasis treatment has changed before and after launch of our guidelines for bone *** For advanced cancer patients with bone metastasis who visited the Department of Clinical Oncology at Akita University hospital between 2012 and 2023,parameters including the site and number of bone metastases,laboratory data,and survival time,were extracted from electronic medical records and the Katagiri score was *** association with survival was determined for each *** Data from 136 patients were *** 1-year survival rate for the poor prognosis group with a higher Katagiri score was 20.0%in this study,which was 6%and an apparent improvement from 2014 when the scoring system was *** factors significantly affecting survival included five or more bone metastases than less(P=0.0080),and treatment with chemotherapy(P<0.001),bone modifying agents(P=0.0175)and immune checkpoint inhibitors(P=0.0128).In recent years,advances in various treatment methods have extended the survival period for patients with advanced *** is necessary not only to simply extend survival time,but also to maintain ADL and improve *** Various therapeutic interventions including surgical approach for bone metastasis,which is a disorder of locomotor organs,are increasingly *** and scoring system for p

关键词： Bone metastasis New Katagiri scoring system Prognosis Immune check point inhibitors Survival

日本学校撤并的多主体决策参与研究——基于理性选择制度主义视角

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比较教育研究 2024年第2期46卷 74-82,102页

作者：三好大树高益民北京师范大学国际与比较教育研究院北京100875

基础教育阶段的学校撤并是许多国家存在的共同现象。学校撤并涉及各方利益,不同主体对相关决策的参与方式和参与程度极大地影响着学校撤并的效果。日本有过强行推动学校撤并引起官民严重冲突的历史,这为研究学校撤并的多主体决策参与问... 详细信息

基础教育阶段的学校撤并是许多国家存在的共同现象。学校撤并涉及各方利益,不同主体对相关决策的参与方式和参与程度极大地影响着学校撤并的效果。日本有过强行推动学校撤并引起官民严重冲突的历史,这为研究学校撤并的多主体决策参与问题提供了重要的样本。基于理性选择制度主义的视角分析日本学校撤并的决策过程,发现各行动者的偏好差异和利益冲突、权力分配的不均衡以及决策监管机制的缺失等导致决策效率较低、家长和社区居民对决策的公平参与缺乏保障、决策的程序化和形式化明显、政策适应存在较多不确定性因素等问题。尽管存在上述问题且经历了不少挫折,但日本的学校撤并决策还是逐渐从政府独断走向了政府主导下的民主协商。

关键词：学校撤并教育政策决策参与理性选择制度主义

Hochschild cohomology ring modulo nilpotence of a one point extension of a quiver algebra defined by two cycles and a quantum-like relation

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Frontiers of Mathematics in China 2016年第4期11卷 1003-1015页

作者： daiki OBARA Department of Mathematics Tokyo University of Science Shinjuku-ku Tokyo Japan

We consider a one point extension algebra B of a quiver algebra Aq over a field k defined by two cycles and a quantum-like relation depending on a nonzero element q in k. We determine the Hochschild cohomology ring of B modulo nilpotence and show that if q is a root of unity, then B is a counterexample to Snashall-Solberg＇s conjecture.

关键词： Hochschild cohomology, quantum-like relation one point extension

The Compatibility of Groups Used to Protect Phenolic Functionality during Oxone-Mediated Oxidative Esterification

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Optimization of laser illumination configuration for directly driven inertial confinement fusion

Green and Sustainable Chemistry（绿色与可持续化学） 2022年第4期

作者： tomoko mineno yuki suzuki tomoya nobuta daiki takano hisao kansui laboratory of medicinal chemistry faculty of pharmacy takasaki university of health welfare japan

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Matter and Radiation at Extremes 2017年第2期2卷 55-68页

作者： Masakatsu Murakami daiki Nishi Institute of Laser Engineering Osaka UniversityOsaka 565-0871Japan

Optimum laser configurations are presented to achieve high illumination uniformity with directly driven inertial confinement fusion *** axisymmetric absorption pattern of individual laser beams,theoretical models are reviewed in terms of the number of laser beams,system imperfection,and laser beam *** a self-organizing system of charged particles on a sphere,a simple numerical model is provided to give an optimal configuration for an arbitrary number of laser *** a result,such new configurations as“M48”and“M60”are found to show substantially higher illumination uniformity than any other existing direct drive systems.A new polar direct-drive scheme is proposed with the laser axes keeping off the target center,which can be applied to laser configurations designed for indirectly driven inertial fusion.

关键词： Analytical model Laser illumination design Polar direct drive Inertial confinement fusion

Diffusion and collective motion of rotlets in 2D space

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Chinese Physics B 2020年第6期29卷 37-43页

作者： daiki Matsunaga Takumi Chodo Takuma Kawai Graduate School of Engineering Science Osaka University5608531 OsakaJapan

We investigate the collective motion of rotlets that are placed in a single plane. Due to the hydrodynamic interactions,the particles move through the two-dimensional(2D) plane and we analyze these diffusive motions. By analyzing the scaling of the values, we predict that the diffusion coefficient scales with φ0.5, the average velocity with φ, and relaxation time of the velocity autocorrelation function with φ-1.5, where φ is the area fraction of the particles. In this paper, we find that the predicted scaling could be seen only when the initial particle position is homogeneous. The particle collective motions are different by starting the simulation from random initial positions, and the diffusion coefficient is the largest at a minimum volume fraction of our parameter range, φ = 0.05. The deviations based on two initial positions can be explained by the frequency of the collision events. The particles collide during their movements and the inter-particle distances gradually increase. When the area fraction is large, the particles will result in relatively homogeneous configurations regardless of the initial positions because of many collision events. When the area fraction is small(φ < 0.25), on the other hand, two initial positions would fall into different local solutions because the rare collision events would not modify the inter-particle distances drastically. By starting from the homogeneous initial positions, the particles show the maximum diffusion coefficient at φ≈ 0.20. The diffusion coefficient starts to decrease from this area fraction because the particles start to collide and hinder each other from a critical fraction ~23%. We believe our current work contributes to a basic understanding of the collective motion of rotating units.

关键词： rotlet diffusion Stokes flow

Global Search of a Three-dimensional Low Solidity Circular Cascade Diffuser for Centrifugal Blowers by Meta-model Assisted Optimization

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Journal of Thermal Science 2018年第2期27卷 111-116页

作者： Daisaku Sakaguchi daiki Sakue Min Thaw Tun Nagasaki University 1-14 Bunkyo-machi Nagasaki 852-8521 Japan Yangon Technological University Insein Road East Gyogone Insein Township Yangon

A three-dimensional blade of a low solidity circular cascade diffuser in centrifugal blowers is designed by means of a multi-point optimization technique. The optimization aims at improving static pressure coefficient at a design point and at a small flow rate condition. Moreover, a clear definition of secondary flow expressed by positive radial velocity at hub side is taken into consideration in constraints. The number of design parameters for three-dimensional blade reaches to 10 in this study, such as a radial gap, a radial chord length and mean camber angle distribution of the LSD blade with five control points, control point between hub and shroud with two design freedom. Optimization results show clear Pareto front and selected optimum design shows good improvement of pressure rise in diffuser at small flow rate conditions. It is found that three-dimensional blade has advantage to stabilize the secondary flow effect with improving pressure recovery of the low solidity circular cascade diffuser.

关键词： Multi-point optimization Low solidity cascade diffuser Flow range enhancement

New Technical Trends on Adjustable Speed AC Motor Drives

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Chinese Journal of Electrical Engineering 2017年第1期3卷 1-9页

作者： Kouki Matsuse daiki Matsuhashi Meiji University TokyoJapan Meidensha Corporation TokyoJapan

Adjustable speed AC Motor drives have been used extensively in modern industry and transportation which calls for electrical and mechanical energy conversion with wide output power range *** of its modularity and scalability,the drive system can be extended to many different application *** recently,adjustable speed AC motor drive applications are spreading not only in industry applications,but also sky and the *** this paper,after summarizing the history of adjustable speed AC motor drives and applications,the main issues of AC drive technologies are reviewed and investigated in the *** issues of adjustable speed AC motor drives including its standardization are surveyed and analyzed for more ***,the paper provides the latest technical trends on adjustable speed AC motor drives technologies,and discusses the development of high speed high power PM motor.

关键词： Electric machine drive technology adjustable speed motor drive AC machine drive system Industry applications transportation application high speed PM motor