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Phenolic profile and biological potential of Endopleura uchi extracts

Asian Pacific Journal of Tropical Medicine 2015年第11期8卷 870-878页

作者： Luis R.silva Rafaela Teixeira CICS-UBI-Centro de Investigacao em Ciencias da Saude.Universidale da Beira Interior Av.Infante D.Henrique.6201-506.Corilha.Portugal Instituto Politecnico de Castelo Branco Escola Superior de Saude Dr Lopes DiasArenido do EmpresarioCampus da Talagueira6000-767Castelo BrancaPortugal LEPABE Departamento de Engenharia QuimicaFaculdade de Engenharia.Universidade do PortoRua Dr.Roberto Friass/n4200-465 PortoPortugal REQUIMTE/Laboratorio de Farmacognosia Departamento de QuimicaFaculdade de FarmaciaUniversidade do Porto.Rua de Jorge Viterbo Ferreira228.4050-313 PortoPortugal

Objective:To improve the knowledge on the metabolite composition of Endopleura uchi bark,concerning phenolic compounds,and to evaluate some of its biological capacities for further possible exploitation in food and pharmaceutical industries associated to their healthpromoting ***:Two different extracts(infusion and hydroethanolic) were studied concerning phenolic composition and biological ***:Five compounds were determined by HPLC-DAD,being bergenin the major *** general way,infusion presents a greater richness in these *** antioxidant,***,α-glucosidase and antibacterial activity were checked by in vitro assays.A dose-dependent response was noticed against DPPH,superoxide and nitric oxide radicals,acetylcholinesterase,butyrylcholinesterase and against α-glucosidase inhibitory *** capacity of both extracts was investigated against Gram-positive and Gramnegative bacteria,being more effective against the first *** concentrations of infusion extract tested here revealed that is non-toxic for intestinal(Caco-2) cells ***:The results suggest that the extracts of Endopleura uchi may be interesting for incorporating in pharmaceutical preparations for human health,since it can suppress hyperglycaemia and inhibit cholinesteases,and or as food additive due to its antiradical and antibacterial activities.

关键词： Endopleura uchi Bark Phenolic compounds Anti-diabe

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Care Measures and Health Outcomes in a Pediatric Intensive Care Unit in Brazil

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Open Journal of Pediatrics 2023年第5期13卷 697-706页

作者： Arnildo Linck Junior Flávia lopes Gabani Edmarlon Girotto Ana Maria Rigo silva Selma Maffei Andrade Department of Pediatrics and Pediatric Surgery Universidade Estadual de Londrina Londrina Brazil

Introduction: In low- and middle-income countries, including Brazil, conditions that favor mortality in the PICU remain significant. Compared to developed countries, there is a shortage of skilled human resources, lower availability of technological resources, greater difficulty of access and a higher incidence of infections, including both those acquired prior to admission and those resulting from treatment and hospitalization (i.e., healthcare-associated infections (HAIs)). HAIs in the PICU include ventilator-associated pneumonia and catheter-related bloodstream infections. Actions for the prevention of HAIs can minimize the occurrence of negative outcomes. Materials and Methods: This is an epidemiological study comparing admissions at the PICU of a high-complexity hospital in South Brazil over two three-year periods: 2012-2014 (before the measures were adopted) and 2015-2017 (after the measures). The care measures were adopted mainly at the beginning of 2015 and consisted of expansion of physical therapy care, adoption of care protocols, acquisition of new materials and equipment (transparent dressings for central catheters, high-tech mechanical ventilators and multiparametric monitors) and multidisciplinary team training. The frequency of the outcomes mortality, length of PICU stay, diagnosis of catheter-related bloodstream infection, need for and duration of ventilatory support and diagnosis of ventilator-associated pneumonia were compared between the two trienniums using logistic regression with adjustment for age in months and need of vasoactive drugs. Results: A total of 1140 admissions were analyzed (470 in the first triennium and 670 in the second), representing an increase in the admission rate of 42.6% after the adoption of the measures. After adjustments, significant reductions in the frequency of mortality (adjusted OR [adjOR] = 0.54;CI 95%: 0.34 - 0.84), length of PICU stay > 7 days (adjOR = 0.75;CI 95%: 0.57 - 0.97) and duration of ventilatory suppor

关键词： Pediatric Intensive Care Units Outcomes Assessment In-Hospital Mortality Hospital Stay Mechanical Ventilation Catheter-Related Infections

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Porcine Circovirus 2:Immunopathogenesis and Recent Developments in Vaccines

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World Journal of Vaccines 2012年第2期2卷 96-104页

作者： Abelardo silva Junior Otavio Valerio de Carvalho Luiz Henrique silva Bulos Juliana lopes Rangel Fietto Mauro Pires Moraes Marcia Rogeria de Almeida Animal Virology Laboratory Veterinary DepartmentFederal University of VicosaVicosaBrazil Molecular Animal Infectology Laboratory Applied Biotechnology Institute(BIOAGRO)Federal University of VicosaVicosaBrazil Plum Island Animal Dis-ease Center New YorkUSA

Porcine circovirus 2 (PCV2) is currently considered an important etiologic agent of swine and its infection has potentially serious economic impact on the swine industry worldwide. This virus is frequently associated with postweaning multisystemic wasting syndrome (PMWS), and also with other clinical conditions such as porcine dermatitis and nephropathy syndrome (PDNS), late-term abortions, reproductive failure in sows, proliferative and necrotizing pneumonia and congenital tremors. The term porcine circovirus-associated disease (PCVAD) is currently used to refer to any of these diseases when they are associated with PCV2 infection. The PCV2 was recognized as a pathogen in 1997, and many questions regarding its biology and pathogenesis remain unanswered. Currently, some studies have shown the production of new vaccine candidates and field efficacy testing of commercial vaccines. This review discusses some major points concerned with immunopathogenesis and vaccines for PCV2 infection.

关键词： Porcine circovirus 2 Vaccine Immunopathogenesis

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Yield, Water Use Efficiency and Physiological Characteristic of “Tommy Atkins” Mango under Partial Rootzone Drying Irrigation System

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Journal of Water Resource and Protection 2015年第13期7卷 1029-1037页

作者： Marcelo Rocha dos Santos Breno Rosa Neves Bismarc lopes da silva Sérgio Luiz Rodrigues Donato Instituto Federal de Educa ç o Ciência e Tecnologia Baiano Campus Guanambi Bahia Brazil

This study was conducted to evaluate the yield, water use efficiency and physiologic characteristics of “Tommy Atkins” mango under partial rootzone drying. The experiment was carried out in an orchard of mango in the irrigated perimeter of Ceraíma, BA. Five treatments and six repetitions were used with one tree per experimental plot: 01—Full Irrigation, 100% of ETc, 02—100% of ETc with frequency of alternance (FA) of 15 days, 03—80% ETc with FA of 15 days, 04—60% of ETc with FA of 15 days, 05—40% ETc with FA of 15 days. The treatments were conductedfrom the beginning of flowering to the harvest of mango in an orchard irrigated by drip. There was no significant reduction in productivity of “Tommy Atkins” mango under PRD up to 40% of ETc and PRD with 40% ETc resulted in greater water use efficiency. There was no significant difference among the averages of photosynthetically active radiation, Qleaf;leaf temperature, Tl;internal CO2 concentration, Ci;transpiration, E;stomatal conductance, gs;photosynthesis, A;carboxylation efficiency, A/Ci;quantum efficiency of photosynthesis, A/Qleaf and instantaneous water use efficiency, A/E between full irrigation and PRD with different water depth. The increase in leaf temperature causes reduction in A/Qleaf and A/E, however, it increases the transpiration. Increased gs results in higher rates of E, A and A/Ci. The use of the PRD with 40% of ETc causes no interference in gas exchange, maintains the yield and increases water use efficiency in “Tommy Atkins” mango tree.

关键词： Irrigation Strategy Mangifera Regulated Deficit Irrigation

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Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis

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World Journal of Hepatology 2018年第1期10卷 105-115页

作者： Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida lopes Ricardo Oliveira silva Postgraduate Program in Tropical Medicine Center for Health SciencesUniversidade Federal de PernambucoRecifePernambuco 50670-901Brazil Department of Gastroenterology and Hepatology Hospital das ClínicasUniversidade Federal de PernambucoRecifePernambuco 50670-901Brazil Department of Fundamental Chemistry Center for Exact and Nature SciencesUniversidade Federal de PernambucoRecifePernambuco 50670-901Brazil Intensive Care Unit Hospital das ClínicasUniversidade Federal de PernambucoRecifePernambuco 50670-901Brazil Department of Pathology Hospital das ClínicasUniversidade Federal de PernambucoRecifePernambuco 50670-901Brazi

AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy.

关键词： Metabolomics Nuclear magnetic resonance spectroscopy Chronic hepatitis C Liver fibrosis Surrogate markers

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Stability Analysis of Tubular Steel Shores

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Journal of Civil Engineering and Architecture 2016年第5期10卷 563-567页

作者： Febio Andre Frutuoso lopes Femando Artur Nogueira silva Romilde Almeida de Oliveira Romildo Alves Berenguer Department of Civil Engineering Catholic University of Pernambuco Recife 51110-200 Brazil

The design of tubular steel scaffold-type shoring is usually performed by calculating the load capacity of the elements, taking into account their axial strength, mainly. Geometric stiffness effects and changes in the stiffness of connections are seldom considered. This paper assesses the stability of tubular steel shores using experimental and numerical approaches that take into account geometric nonlinearities as well as the features of the elements used to make the link between the steel tubes （pressed double coupler--right angle）. The increase in overall stiffness generated by diagonal bars used in the analyzed models was examined. The results obtained show the importance of using P-delta analyses in this kind of structure in order to evaluate structure＇s overall stability even when compressive stresses are within acceptable ranges of code limits.

关键词： Tubular steel shores global stability semi-rigid connections P-delta analyses.

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Proliferative verrucous leukoplakia may initially mimic lichenoid reactions

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World Journal of Clinical Cases 2015年第10期3卷 861-863页

作者： Marcio Ajudarte lopes Patricia Feio Alan Roger Santos-silva Pablo Agustin Vargas Oral Diagnosis Department Semiology and Oral PathologyPiracicaba Dental SchoolState University of Campinas(UNICAMP)PiracicabaSao Paulo 13083-970Brazil

Proliferative verrucous leukoplakia is an intriguing disease, which occurs particularly in women aged greater than 60 years, is not associated with tobacco and alcohol, and has a high risk of recurrence and malignant transformation. Although it is well known that the typical presentation is characterized by multifocal and verrucous white lesions, there is no description that its initial clinical presentation may simulate a lichenoid reaction.

关键词： Proliferative verrucous leukoplakia Lichenoid reactions Diagnosis

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Tuberculosis Presenting as Multiple Vein Thrombosis in a Hospitalized Man

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Journal of Tuberculosis Research 2020年第3期8卷 177-180页

作者： Neuza Soares Mariana Pacheco João Rocha Diogo José M. lopes Rodrigo Correia Inês silva Internal Medicine Department Centro Hospitalar Universitário de Sa&#227 oJoaã o Porto Portugal Clinical Pharmacology Unit Centro Hospitalar Universitário de Sa&#227 oJoaã o Porto Portugal Physical Medicine and Rehabilitation Deparment Centro Hospitalar Vila Nova de Gaia/Espinho Gaia Portugal

Tuberculosis (TB) remains an infectious disease with a high prevalence worldwide and represents a major public health issue. Although venous thromboembolism (VTE) is a rare complication of this disease, it may be a potentially life-threatening event. A 58-year-old man was admitted due to hematemesis due to inflammation at the anastomosis site after a gastrectomy years ago. After 3 days in-hospital, he showed a peroneal deep vein thrombosis and superficial thrombosis of left cephalic vein. Although reduced mobility and lack of prophylactic heparin could explain vein thrombosis, a simple etiologic workup was performed and active tuberculosis was diagnosed. This case illustrates a rare and unusual presentation form of tuberculosis, a condition that remains now-a-days one of the leading infectious causes of death worldwide. The association between tuberculosis and VTE is rare, but it should be systematically investigated.

关键词： Pulmonary Tuberculosis Thrombosis Hypercoagulable State

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Carbon-13 Solid State NMR Techniques to Evaluate the Morphology of PP/TiO₂ Composites

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Materials Sciences and Applications 2016年第1期7卷 20-25页

作者： Igor lopes Soares Maria Inês Bruno Tavares André Luis B. B. e silva Antonio Gabriel Malagueta Feio Instituto de Macromoléculas Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Instituto Federal do Mato Grosso IFMT Mato Grosso Brazil CENIMAT/I3N Departamento de Ciência dos Materiais Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa Caparica Portugal

Solid state NMR was successfully used to determine the proton spin-lattice relaxation time in the rotating frame (T1ρH) for systems based on polypropylene (PP) and PP with titanium dioxide (TiO2) organically modified or unmodified incorporated, in order to understand the molecular behavior of these systems. These techniques were employed in the samples organically modified and unmodified TiO2 to investigate the effect of organic modification on the dispersion and distribution of the particles in the PP matrix. The results were analyzed in terms of the effect of the particles organic modified or not according to the intermolecular interaction in the composites. According to the T1ρH values, all composites showed at least two domains: the short values were related to the rigid part, which included the crystalline and amorphous phase constricted in it, while the longer times were attributed to the amorphous region, which had higher molecular mobility compared to the rigid region of the materials. The increase in the relaxation time parameter in the composites compared to the pure PP was associated to the strong interaction between titanium dioxide particles and the polymer chains. This effect was more pronounced for the systems containing organically modified TiO2. According to the results, it could be inferred that intermolecular interaction occurred in the CH2 and CH groups, being more intense with CH2 groups. Finally, the solid state NMR techniques were able to evaluate the molecular dynamics of those systems.

关键词： NMR PP TiO2 Composites

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Histological analysis and transcription profiles on somatic embryogenesis in interspecific hybrids of <i>Elaeis guineensis ×E. oleifera</i>

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Agricultural Sciences 2013年第11期4卷 1-11页

作者： Paula Cristina da silva Angelo Douglas André Steinmacher Ricardo lopes Raimundo Nonato Vieira da Cunha Miguel Pedro Guerra Embrapa Western Amazon Manaus Brazil UFSC Federal University of Santa Catarina—CCA Graduate Program in Plant Genetic Resources Physiology of Development and Plant Genetics Laboratory Florianópolis Brazil Brazilian Council for Technological Development—CNPq Brazil

Elaeis guineensis (African oil palm) and E. oleifera (American oil palm) are bred to attain high oil yields, disease resistances, and decelerated shoot elongation. We cultivated immature zygotic embryos from backcrossed and F1 interspecific progenies on media containing 110, 150, or 200 mg·l-1 2,4-diclorophenoxyacetic acid (2,4-D) to obtain embryogenic cultures. These were set to multiply on medium containing 8 mg·l-1 2,4-D or lower concentrations of auxins and finally we induced plantlets regeneration, from each zygotic embryo, independently, in order to have the clones organized according to their respective origins. Reductions in auxins induced cultures to revert from highly embryogenic into competent for embryogenesis and finally to organogenic degenerated callus lines. Histology and the expression of SOMATIC EMBRYOGENESIS RECEPTOR KINASE, DEHYDRIN, DEFENSIN, TRANSPOSASE, and LIPID TRANSFER PROTEIN were analyzed on four callus lines representative of morphological aspects consistently observed. The highest number of embryogenic cultures was obtained on 150 mg·l-1 2,4-D. Maturation and multiplication of somatic embryos through secondary embryogenesis occurred simultaneously on 8 mg·l-1 2,4-D. LIPID TRANSFER PROTEIN expression was detected in one of the embryogenic cultures and correlated with protoderm onset. Three six-week cycles on induction medium yielded 1.5 shoots above 6 cm per poly-embryogenic complex, which performed better than embryoids individualized mechanically. Rooting was observed for 77% and 82% of shoots from these two types of explants, respectively. Rooted plantlets ready for acclimatization were obtained nine months after shoot

关键词： Amazon Arecaceae Dendê Caiaué Gene Expression

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