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Recurrence risk factors of intravitreal ranibizumab monotherapy in retinopathy of prematurity:a retrospective study at one center

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 95-101页

作者： Feng-Yue Wu Wen-Ting Yu dai-xin zhao Wei Pu Xue Zhang Chun-Liu Gai Department of Ophthalmology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Neonatology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Obstetrics and Gynecology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

AIM:To identify risk factors of recurrence of this disorder after intravitreal ranibizumab(IVR)***:Totally 33 eyes of 19 patients who underwent initial IVR treatments for type 1 retinopathy of prematurity(ROP)at our center were retrospectively reviewed between April 1,2016 and December 31,*** demographics,the side of ROP,multiple gestations,Apgar scores,zone,stage,plus disease,postmenstrual age at injection,surfactant therapy,blood transfusion therapy,hemorrhage before IVR,hemorrhage after IVR,gestational diabetes mellitus,pregnancy-induced hypertension,anemia,intraventricular hemorrhage,sepsis,respiratory distress syndrome,carbohemia,and congenital heart defects were *** hazard ratios(HRs)and 95%confidence intervals were determined after adjusting for potential confounders using multivariate proportional Cox ***:Of the 33 eyes,12(36.4%)had ROP recurrences 45.3(5.1,50.9)mo after initial IVR *** independent risk factors for ROP recurrences were zone(ⅡvsⅠ,HR:0.056,P=0.003)and gestational diabetes mellitus(no vs yes,HR:0.095,P<0.001).The mean uncorrected visual acuity for four recurrence eyes was 0.46 logMAR(0.13,0.70)at 55.0(51.0,58.9)mo after the initial IVR *** mean uncorrected visual acuity for 10 eyes without recurrence was 0.46 logMAR(0.19,0.63)at 48.0(43.8,58.4)mo after the initial IVR ***:Two independent risk factors for type 1 ROP recurrence after IVR treatment involving zoneⅠand gestational diabetes mellitus are identified,and the mean uncorrected visual acuity is 0.46 logMAR at 51.0(44.0,58.9)*** findings of this study are important for followup management and for improving the visual function of ROP patients.

关键词： retinopathy of prematurity ranibizumab recurrence visual acuity refractive error

Gradient maturation experiment on hairs implies taphonomic changes in fossil hairs

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Science China Earth Sciences 2025年第1期68卷 62-73页

作者： xin LI Yibo ZHOU Tao zhao xingjian HE Yanhong PAN State Key Laboratory for Mineral Deposits Research Center for Critical Earth Material Cycling Centre for Research and Education on Biological Evolution and Environment and Frontiers Science School of Earth Sciences and Engineering Nanjing University Institute of Palaeontology Yunnan Key Laboratory of Earth System Science Yunnan Key Laboratory for PalaeobiologyYunnan University

Mammalian hair, as a key feature related to endothermy, physical protection, and camouflage, has a long geohistorical record that dates back even to the Mesozoic. However, the limited information on the taphonomy of hair hinders the understanding of its evolutionary significance in deep time. To address this, we conducted taphonomic experiments to simulate the transformation process of black hair. The changes in the morphological structure, microscopic characteristics, and chemical composition of hair during the simulated fossilization process were documented by scanning electron microscopy, Fourier transform infrared(FTIR) spectroscopy, and Raman spectroscopy. Our results revealed that damage to the morphology of hair began at a mild temperature(150–175°C), and hair transformed into a fluid-like mass at a relatively high temperature(200°C). In addition, the morphological structure of melanosomes had relatively greater preservation potential than keratins did, and the microscopic features of melanosomes were persistently stable. The Raman and FTIR spectra indicated that the characteristic melanin and keratin peaks changed as the temperature increased. Although the chemical signals were not lost completely, the variations in the characteristic amide bands in the FTIR spectra indicate that the keratins severely degraded at high temperatures(>200°C), whereas the characteristic melanin bands in the Raman spectra suggested that melanin signals were still recognizable, even at high temperatures(>200°C). These results were confirmed by principal component analysis(PCA) and principal component analysis linear discriminant analysis(PCA–LDA). In addition, the Raman signals of all the samples in the simulated experiments were distinguished from the signals of common geological carbonaceous materials(humic acid), which suggested that Raman spectroscopy can be used to detect melanin in fossils.

关键词： Mammalian hair Melanin Keratin Fossilization Experimental taphonomy

Defect Engineering:Can it Mitigate Strong Coulomb Effect of Mg^(2+)in Cathode Materials for Rechargeable Magnesium Batteries?

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Nano-Micro Letters 2025年第1期17卷 135-159页

作者： Zhengqing Fan Ruimin Li xin Zhang Wanyu zhao Zhenghui Pan Xiaowei Yang School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024People’s Republic of China School of Materials Science and Engineering Tongji UniversityShanghai 201804People’s Republic of China

Rechargeable magnesium batteries(RMBs)have been considered a promising“post lithium-ion battery”system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage ***,the sluggish diffusion kinetics of bivalent Mg^(2+)in the host material,related to the strong Coulomb effect between Mg^(2+)and host anion lattices,hinders their further development toward practical *** engineering,regarded as an effective strategy to break through the slow migration puzzle,has been validated in various cathode materials for *** this review,we first thoroughly understand the intrinsic mechanism of Mg^(2+)diffusion in cathode materials,from which the key factors affecting ion diffusion are further ***,the positive effects of purposely introduced defects,including vacancy and doping,and the corresponding strategies for introducing various defects are *** applications of defect engineering in cathode materials for RMBs with advanced electrochemical properties are also ***,the existing challenges and future perspectives of defect engineering in cathode materials for the overall high-performance RMBs are described.

关键词： Rechargeable magnesium battery Sluggish diffusion kinetic Defect engineering Cathode materials Ion migration

城中村改造的政策及实施评价研究——以广州为例

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现代城市研究 2012年第3期27卷 53-59页

作者：廖远涛代欣召广州市城市规划勘测设计研究院

城中村形成、发展的过程,是一种具有中国特色的城镇化过程,是一种"城—乡"相互融合的渐进式演进过程。文章以回顾的视角,分析了广州城中村形成、发展的社会经济背景,重新审视广州城中村的演进历程及基本类型,以此作为理解城中村改造政... 详细信息

城中村形成、发展的过程,是一种具有中国特色的城镇化过程,是一种"城—乡"相互融合的渐进式演进过程。文章以回顾的视角,分析了广州城中村形成、发展的社会经济背景,重新审视广州城中村的演进历程及基本类型,以此作为理解城中村改造政策的基础;之后,系统梳理了广州城中村改造政策,并对其实施效果进行客观评价;最后,对城中村改造政策提出了相应的建议。

关键词：广州城中村改造政策实施评价

先天性白内障二期人工晶状体植入术后眼轴长度变化的研究

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国际眼科杂志 2011年第6期11卷 1038-1040页

作者：肖伟苗森赵岱新郑坤中国医科大学附属盛京医院眼科中国辽宁省沈阳市110004

目的:探讨婴儿出生3mo内先天性白内障摘除二期人工晶状体植入术后眼轴的变化。方法:对13例22眼(4例单眼)出生后3mo内的患儿行白内障摘除联合后囊膜连续环形撕囊及前段玻璃体切割手术,在2.5岁时行二期IOL植入手术并连续观察。分别在3,4,... 详细信息

目的:探讨婴儿出生3mo内先天性白内障摘除二期人工晶状体植入术后眼轴的变化。方法:对13例22眼(4例单眼)出生后3mo内的患儿行白内障摘除联合后囊膜连续环形撕囊及前段玻璃体切割手术,在2.5岁时行二期IOL植入手术并连续观察。分别在3,4,5岁时测量术眼眼轴长度;同时选择年龄和性别相匹配的同龄正常儿童作为对照组,比较两组之间的差异。结果:各年龄段术后患儿平均眼轴长度分别为22.41±1·75,23.16±1.42,23.73±1.37mm。与同年龄对照组进行比较,比正常儿童眼轴长,差异有统计学意义(P<0.05)。结论:婴儿早期行先天性白内障摘除并在2.5岁时植入IOL后,到5岁阶段,眼轴长度较同龄正常儿童眼轴发育快。

关键词：人工晶状体儿童眼轴长度白内障手术

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： xintian Ding Chun Chen Heng zhao Bin dai Lei Ye Tao Song Shuai Huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

Vaidya-Schwarzschild-de Sitter时空中的反作用问题

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物理学报 1992年第2期41卷 188-192页

作者：戴宪新赵峥北京师范大学物理系北京100875

本文采用一种传统的方法,对Vaidya-Schwarzschild-de Sitter时空进行研究,在考虑反作用的情况下,讨论表观视界、类时极限面和事件视界的位置,以及修正后的Hawking辐射温度。

关键词：黑洞热辐射引力场反作用时空

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球对称带电蒸发黑洞的视界与温度

物理学报 1992年第6期41卷 869-872页

作者：戴宪新赵峥北京师范大学物理系北京100875

本文从讨论视界附近的Klein-Gordon方程出发,直接准确地算出球对称带电蒸发黑洞事件视界的位置和考虑反作用后的Hawking辐射温度,而无需求助于低维能-动张量的近《似计算。

关键词：球对称带电蒸发黑洞视界温度

基于地面监测数据的2013～2015年长三角地区PM_(2.5)时空特征

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长江流域资源与环境 2016年第5期25卷 813-821页

作者：戴昭鑫张云芝胡云锋董昱中国科学院地理科学与资源研究所北京100101 中国科学院大学北京100049 内蒙古师范大学内蒙古呼和浩特010022

近年来,长三角地区灰霾天气持续增多,空气细颗粒物污染问题日益突出。基于2013年1月至2015年5月长三角地区及周边缓冲区内共214个空气质量监测站点PM_(2.5)逐时监测数据,运用普通克里金插值方法,从年、季、月尺度上分析了PM_(2.5)的空... 详细信息

近年来,长三角地区灰霾天气持续增多,空气细颗粒物污染问题日益突出。基于2013年1月至2015年5月长三角地区及周边缓冲区内共214个空气质量监测站点PM_(2.5)逐时监测数据,运用普通克里金插值方法,从年、季、月尺度上分析了PM_(2.5)的空间分布格局和时间动态变化。结果表明:(1)2 a来,长三角地区PM_(2.5)浓度空间分布明显呈现整体北部高南部低,局部地区略有突出的分布特征;长三角地区PM_(2.5)浓度年均值为57.08μg/m^3;其中,江苏省PM_(2.5)的年均值为三省市最高,为65.84μg/m^3;其次为上海市,年均值为53.87μg/m^3;浙江省PM_(2.5)的年均值较小,为51.53μg/m^3。(2)从季节尺度分析,长三角地区PM_(2.5)浓度变化表现出冬春季高,夏秋季低的变化趋势;这与区域内冬季风向来源、降水稀少、气象扩散条件差有着密切的关系;(3)长三角地区月浓度变化大致呈U形分布;12月份PM_(2.5)浓度最高;3月份以后,PM_(2.5)浓度开始呈逐步下降趋势;在5~9月份,区域PM_(2.5)处于"U"字的谷底,其中6月份夏收时期秸秆焚烧、气象等因素导致PM_(2.5)浓度有略微升高;进入10月份后迅速攀升,且11、12月份呈现持续升高态势。

关键词： PM2.5浓度地面监测空间分布时间动态变化长三角