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Predictive value of serum alpha-fetoprotein for tumor regression after preoperative chemotherapy for rectal cancer

World Journal of Gastrointestinal Oncology 2022年第2期14卷 525-532页

作者： Da-kui Zhang Jun Qiao Shao-Xuan Chen Zhi-Yong Hou Jian-Zheng Jie Department of General Surgery China-Japan Friendship HospitalBeijing 100029China Department of General Surgery Inner Mongolia International Mongolian HospitalHohhot 010020Inner Mongolia Autonomous RegionChina

BACKGROUND Preoperative therapy is widely used in locally advanced rectal *** can improve local control of rectal ***,there are few indicators that can predict the effect of preoperative chemotherapy *** To investigate whether the increase in serumα-fetoprotein(AFP)can predict better efficacy of preoperative *** This was a retrospective *** analyzed 125 patients admitted between 2017 and 2019 with locally advanced rectal *** patients received six cycles of preoperative chemotherapy(mFOLFOX6 every 2 wk).Serum AFP of 26 patients rose slightly after three or four cycles of chemotherapy,and fell to normal again within 2 *** other 99 patients had a normal level of serum AFP during *** were divided into two groups(AFP risen and AFP normal).According to postoperative pathology,we compared tumor regression and complete response rate between the two *** primary outcome measure was the tumor regression grade(TRG)after *** difference in pathological complete response between the two groups was also *** There were no tumor progression and distant metastasis in both groups during preoperative *** in the AFP risen group achieved better TRG 0/1 than those in the AFP normal group(61.5%vs 39.4%).The increase in AFP was a significant predictor for better tumor regression[χ2=4.144,odds ratio(OR)=2.666,P=0.04].In the AFP risen group,the complete response rate was 30.8%,which was higher than in the AFP normal group(30.8%vs 12.1%,χ2=4.542,OR=3.251,P=0.03).CONCLUSION Patients with a slight increase in serum AFP can achieve better tumor regression during preoperative chemotherapy,and are more likely to achieve pathological complete response.

关键词： Rectal cancer Preoperative chemotherapy Alpha-fetoprotein Predictive value Tumor

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考虑剪切变形旋转运动复合材料薄壁梁的动力学特性

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工程力学 2014年第7期31卷 215-222页

作者：任勇生代其义山东科技大学机械电子工程学院青岛266590

研究考虑横向剪切的旋转运动复合材料薄壁梁的动力学特性。采用变分渐进法描述位移和应变并且引入横向剪切变形的影响,由Hamilton原理推导出Timoshenko梁的动力学模型,采用Galerkin法对薄壁梁进行自由振动分析,并且将计算结果与现有的... 详细信息

研究考虑横向剪切的旋转运动复合材料薄壁梁的动力学特性。采用变分渐进法描述位移和应变并且引入横向剪切变形的影响,由Hamilton原理推导出Timoshenko梁的动力学模型,采用Galerkin法对薄壁梁进行自由振动分析,并且将计算结果与现有的有限元计算结果进行对比,验证了该文动力学模型的有效性。进一步针对周向均匀刚度配置(CUS)的箱型和翼型薄壁梁进行固有频率的计算,揭示了纤维铺层角、转速和结构参数对薄壁梁动力学特性的影响。

关键词：旋转梁自由振动复合材料薄壁梁伽辽金法

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Isobaric Tags for Relative and Absolute Quantificationbased Comparative Proteomics Reveals the Features of Plasma Membrane-Associated Proteomes of Pollen Grains and Pollen Tubes from Lilium davidii

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Journal of Integrative Plant Biology 2010年第12期52卷 1043-1058页

作者： Bing Han Sixue Chen Shaojun dai Ning Yang Tai Wang Research Center for Molecular & Developmental Biology Key Laboratory of Photosynthesis & Environmental Molecular Physiology Institute of Botany Chinese Academy of Sciences and National Center for Plant Gene Research Beijing 100093 China Department of Biology Genetics Institute and Interdisciplinary Center for Biotechnology Research University of Florida GaJnesville Florida 32610 USA Key Laboratory of Saline-alkali Vegetation Ecology Restoration in Oil Field Ministry of Education Northeast Forestry University Harbin 150040 China Graduate University of the Chinese Academy of Sciences Beijing 10049 China

Mature pollen grains （PGs） from most plant species are metabolically quiescent. However, once pollinated onto stigma, they quickly hydrate and germinate. A PG can give rise to a vegetative cell-derived polarized pollen tube （PT）, which represents a specialized polar cell. The polarized PT grows by the tip and requires interaction of different signaling molecules localized in the apical plasma membrane and active membrane trafficking. The mechanisms underlying the interaction and membrane trafficking are not well understood. In this work, we purified PG and PT plasma-membrane vesicles from Lilium davidii Duch. using the aqueous two-phase partition technique, then enriched plasma membrane proteins by using Brij58 and KCl to remove loosely bound contaminants. We identified 223 integral and membrane-associated proteins in the plasma membrane of PGs and PTs by using isobaric tags for relative and absolute quantification （iTRAQ） and 2-D high-performance liquid chromatography-tandem mass spectrometry. More than 68% of the proteins have putative transmembrane domains and/or lipid-modified motifs. Proteins involved in signal transduction, membrane trafficking and transport are predominant in the plasma-membrane proteome. We revealed most components of the clathrin-dependent endocytosis pathway. Statistical analysis revealed 14 proteins differentially expressed in the two development stages： in PTs, six upregulated and eight downregulated are mainly involved in signaling, transport and membrane trafficking. These results provide novel insights into polarized PT growth.

关键词： LILIES PROTEOMICS COMPARATIVE studies PLANT cell membranes PLANT physiology POLLEN tube PLANT species PLANT metabolism

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Fabrication and characterization of Ge-Ga-Sb-S glass microsphere lasers operating at ～1.9 μm

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Chinese Physics B 2018年第11期27卷 586-590页

作者： Kun Yang Shixun dai Yuehao Wu Qiuhua Nie Advanced Technology Research Institute Laboratory of Infrared Materials and Devices Ningbo University Ningbo 315211 China Key Laboratory of Photoelectric Materials and Devices of Zhejiang Province Ningbo 315211 China

We report the fabrication and characterization of germanium gallium antimony sulfide（Ge–Ga–Sb–S or 2 S2 G, doped with Tm^（3＋）ions） microsphere lasers operating at ～1.9-μm spectral band. Compared to the chalcogenide glasses that are used in previous microsphere lasers, this 2 S2 G glass has a lower transition temperature and a higher characteristic temperature. This implies that 2 S2 G microspheres can be fabricated at lower temperatures and the crystallization problem in the sphere-forming process can be alleviated. We show that hundreds of high-quality microspheres（quality factors higher than 105） of various diameters can be produced simultaneously via a droplet sphere-forming method. Microspheres are coupled with silica fiber tapers for optical characterizations. We demonstrate that Whispering Gallery mode（WGM）patterns in the 1.7–2.0 μm band can be conveniently obtained and that once the pump power exceeds a threshold, single-and multi-mode microsphere lasers can be generated. For a typical microsphere whose diameter is 258.64 μm, we demonstrate its laser threshold is 0.383 mW, the laser wavelength is 1907.38 nm, and the thermal sensitivity of the microsphere laser is29.56 pm/？C.

关键词： chalcogenides microspheres laser whispering gallery modes

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An Upper Bound for the Adjacent Vertex Distinguishing Acyclic Edge Chromatic Number of a Graph

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Acta Mathematicae Applicatae Sinica 2009年第1期25卷 137-140页

作者： Xin-sheng Liu Ming-qiang An Yang Gao College of Mathematics and Information Science Northwest Normal University Lanzhou 730070 China Tianjin University of Science and Technology Tianjin 300222 China

A proper k-edge coloring of a graph G is called adjacent vertex distinguishing acyclic edge coloring if there is no 2-colored cycle in G and the color set of edges incident to u is not equal to the color set of edges incident to v, where uv ∈E（G）. The adjacent vertex distinguishing acyclic edge chromatic number of G, denoted by χ＇αα（G）, is the minimal number of colors in an adjacent vertex distinguishing acyclic edge coloring of G. In this paper we prove that if G（V, E） is a graph with no isolated edges, then χ＇αα（G）≤32△.

关键词： Adjacent strong edge coloring adjacent vertex distinguishing acyclic edge coloring adjacent vertexdistinguishing acyclic edge chromatic number the LovNsz local lemma

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Hybrid data-driven and physics-based modeling for viscosity prediction of ionic liquids

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Green Energy & Environment 2024年第12期9卷 1878-1890页

作者： Jing Fan Zhengxing dai Jian Cao Liwen Mu Xiaoyan Ji Xiaohua Lu State Key Laboratory of Materials-Oriented and Chemical Engineering Nanjing Tech UniversityNanjing211816China Energy Engineering Division of Energy ScienceLulea University of TechnologyLulea97187Sweden

Viscosity is one of the most important fundamental properties of ***,accurate acquisition of viscosity for ionic liquids(ILs)remains a critical *** this study,an approach integrating prior physical knowledge into the machine learning(ML)model was proposed to predict the viscosity *** method was based on 16 quantum chemical descriptors determined from the first principles calculations and used as the input of the ML models to represent the size,structure,and interactions of the *** strategies based on the residuals of the COSMO-RS model were created as the output of ML,where the strategy directly using experimental data was also studied for *** performance of six ML algorithms was compared in all strategies,and the CatBoost model was identified as the optimal *** strategies employing the relative deviations were superior to that using the absolute deviation,and the relative ratio revealed the systematic prediction error of the COSMO-RS *** CatBoost model based on the relative ratio achieved the highest prediction accuracy on the test set(R^(2)=0.9999,MAE=0.0325),reducing the average absolute relative deviation(AARD)in modeling from 52.45% to 1.54%.Features importance analysis indicated the average energy correction,solvation-free energy,and polarity moment were the key influencing the systematic deviation.

关键词： Viscosity Fundamental property Ionic liquids COSMO-RS Machine learning

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土石坝沥青混凝土心墙力学参数反演分析

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岩土力学 2009年第3期30卷 635-639,644页

作者：朱晟张美英戴会超河海大学水文水资源与水利工程科学国家重点实验室南京210098 河海大学水电工程学院南京210098 中国长江三峡工程开发总公司宜昌443002

沥青混凝土的本构模型参数与试件成型方法、试验条件密切相关,具有较大的离散性,难以准确确定。利用基于免疫学原理的遗传算法与有限元计算理论,建立了土石坝力学特性参数的反演分析方法,并编写了相应的计算程序。结合三峡茅坪溪沥青混... 详细信息

沥青混凝土的本构模型参数与试件成型方法、试验条件密切相关,具有较大的离散性,难以准确确定。利用基于免疫学原理的遗传算法与有限元计算理论,建立了土石坝力学特性参数的反演分析方法,并编写了相应的计算程序。结合三峡茅坪溪沥青混凝土心墙堆石坝工程,利用竣工期坝体填筑现场原型监测资料,对心墙沥青混凝土的Duncan模型参数进行了反演计算。利用139m水位的原型监测资料验证了反演成果的合理性,对沥青混凝土力学参数的合理确定提供了一条有效途径。

关键词：土石坝沥青混凝土本构模型参数免疫遗传算法反分析

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Ni-Fe合金磁致伸缩波导丝特性研究

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功能材料 2009年第11期40卷 1791-1793页

作者：卢云申蓉冯哲圣曹奎电子科技大学电子薄膜与集成器件国家重点实验室四川成都610054

化学成分对磁致伸缩波导丝的性能产生重要影响。中频感应熔炼技术制备出Ni-Fe磁致伸缩合金铸锭,研究了Ni、Fe含量对合金磁性能、相结构以及合金金相的影响,并分析产生变化的原因。研究表明,提高Ni含量为43%时,合金的磁致伸缩系数最高、... 详细信息

化学成分对磁致伸缩波导丝的性能产生重要影响。中频感应熔炼技术制备出Ni-Fe磁致伸缩合金铸锭,研究了Ni、Fe含量对合金磁性能、相结构以及合金金相的影响,并分析产生变化的原因。研究表明,提高Ni含量为43%时,合金的磁致伸缩系数最高、磁性γ相强度增强,而矫顽力变化不明显。

关键词：磁致伸缩材料 Ni—Fe合金磁性能

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Synthesis of multifunctional monomers from rosin for the properties enhancement of soybean-oil based thermosets

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Science China(Technological Sciences) 2017年第9期60卷 1332-1338页

作者： LIU Yuan LI Chao dai JinYue JIANG YanHua LIU XiaoQing ZHU Jin Ningbo Institute of Material Technology and Engineering Chinese Academy of Sciences Ningbo 315201 China Engineering Research Center for Materials Protection of Wear and Corrosion of Guizhou Province Guiyang University Guiyang 550005 China University of Chinese Academy of Sciences Beijing 100049 China

Two kinds of rosin derivatives, （2-hydroxy-3-（methacryloyloxy）propyl 7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,4b,5,6,10,10a- decahydrophenanthrene-1-carboxylate）（HMPIDDC） and （（（7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenan- thren-1-yl）methyl）azanediyl）bis（2-hydroxypropane-3,1-diyl）bis（2-methylacrylate）（IDOMAHM） were synthesized under mild and easy to implement conditions. The two derivatives were employed as the rigid monomers to copolymerize with acrylated epoxidized soybean oil （AESO）, as so to improve the performance of the cured resins. The chemical structures of HMPIDDC and IDOMAHM were confirmed by nuclear magnetic resonance （NMR） and Fourier Transform Infrared （FT-IR） before copolymerization. The curing behaviors of pristine AESO, AESO/HMPIDDC blend, and AESO/IDOMAHM blend were monitored by differential scanning calorimetry （DSC）. Moreover, the thermal and mechanical properties of the cured resins were evaluated by universal mechanical testing, dynamic mechanical analysis （DMA） and thermogravimetric analysis （TGA）. The results demonstrated that after the introduction of HMPIDDC and IDOMAHM, the glass transition temperature and mechanical properties of the copolymerized resin were significantly increased. In one word, HMPIDDC and IDOMAHM showed dramatic potential to be used as bio-based compounds to improve the properties of soybean-oil based thermosets.

关键词： rosin derivatives bio-based compound rigid monomer thermosets

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Mitofusion 2 Overexpression Decreased Proliferation of Human Embryonic Lung Fibroblasts in Acute Respiratory Distress Syndrome through Inhibiting RAS-RAF-1-ERK1/2 Pathway

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Current Medical Science 2020年第6期40卷 1092-1098页

作者： Juan LI Mei-xia XU Zhong dai Tao XU Department of Critical Care Medicine Wuhan Fourth Hospital(Puai Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Acute respiratory distress syndrome(ARDS)is one of the most fatal diseases *** fibrosis occurs early in ARDS,and its severity plays a crucial role in ARDS mortality *** studies suggested that fibroproliferation is an essential mechanism in ***2(Mfn2)overexpression plays a role in inhibiting cell ***,the role and potential mechanism of Mfn2 on the proliferation of fibroblasts is still *** this study,we aimed at exploring the effect of Mfn2 on the human embryonic lung fibroblasts(HELF)and discussed its related *** HELF were treated with the Mfn2 overexpressing lentivirus(adv-Mfn2).The cell cycle was detected by flow ***,PCR and Western blotting were used to investigate the effect of Mfn2 on the proliferation of the HELF,collagen expression,the RAS-RAF-1-ERK1/2 pathway and the expression of cycle-related proteins(p21,p27,Rb,Raf-1,p-Raf-1,Erk1/2 and p-Erk1/2).The co-immunoprecipitation assay was used to explore the interaction between Mfn2 and *** results showed that the overexpression of Mfn2 inhibited the proliferation of the HELF and induced the cell cycle arrest at the G0/G1 ***,Mfn2 also inhibited the expression of collagen I,p-Erk and *** addition,an interaction between Mfn2 and Ras existed in the *** study suggests that the overexpression of Mfn2 can decrease the proliferation of HELF in ARDS,which was associated with the inhibition of the RAS-RAF-1-ERK1/2 *** results may offer a potential therapeutic intervention for patients with ARDS.

关键词： Mitofusion2 human embryonic lung fibroblasts acute respiratory distress syndrome RAS-RAF-1-ERK1/2 pathway

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