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Hepatitis B virus infection, infertility, and assisted reproduction

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第8期25卷 672-685页

作者： Lingjian ZHANG Fangfang ZHANG Zhiyuan MA jie jin Department of Infectious Diseases Affiliated Hangzhou First People’s HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Women’s Hospital School of MedicineZhejiang UniversityHangzhou 310003China Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310003China

Background:Hepatitis B virus(HBV)is one of the most widespread viruses worldwide and a major cause of hepatitis,cirrhosis,and hepatocellular *** studies have revealed the impacts of HBV infection on *** increasing number of infertile couples with chronic hepatitis B(CHB)virus infection choose assisted reproductive technology(ART)to meet their fertility *** the high prevalence of HBV,the effects of HBV infection on assisted reproduction treatment remain limited and ***:The aim of this study was to provide a comprehensive overview of the effect of HBV infection on fertility and discuss its effects on pregnancy outcomes,vertical transmission,pregnancy complications,and viral activity during ART ***:We conducted a literature search in PubMed for studies on HBV infection and ART published from 1996 to ***:HBV infection negatively affected fertility in both males and *** research shows that HBV infection may increase the risk of pregnancy complications in couples undergoing assisted reproduction *** impact of HBV infection on the pregnancy outcomes of ART is still *** evidence does not support that ART increases the risk of vertical transmission of HBV,while relevant studies are *** the development of ART,the risk of HBV reactivation(HBVr)is increasing,especially due to the wide application of immunosuppressive ***:Regular HBV infection screening and HBVr risk stratification and management are essential to prevent HBVr during *** determination of optimal strategy and timing of prophylactic anti-HBV therapy during ART still needs further investigation.

关键词： Assisted reproductive technology(ART) Hepatitis B virus(HBV) Immunosuppressive agent Pregnancy

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Construction of sustainable, colored and multifunctional protein silk fabric using biomass riboflavin sodium phosphate

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Frontiers of Chemical Science and Engineering 2023年第8期17卷 1131-1139页

作者： Wen-jie jin Yu Xin Xian-Wei Cheng jin-Ping Guan Guo-Qiang Chen Key Laboratory of Flame Retardancy Finishing of Textile Materials(CNTAC) College of Textile and Clothing EngineeringSoochow UniversitySuzhou 215123China

Riboflavin sodium phosphate has been confirmed as a promising biomass product derived from natural *** this paper,a novel method of dyeing and multifunctional modification of silk fabric by impregnation with riboflavin sodium phosphate was proposed,such that protein silk fabric can be endowed with bright yellow color and *** results of this paper confirmed that the pH and concentration of riboflavin sodium phosphate solution are critical factors for dyeing and multifunctional ***,the photochromic performance was one of the most distinctive features of the modified silk fabric,and the dyed silk fabric turned into fluorescent green from original yellow under 365 nm ultraviolet ***,the modified silk fabric exhibited good antibacterial properties with a high inhibition rate of 92%for Escherichia ***,the flame retardancy of silk fabric was significantly improved after *** damaged length of modified silk fabric with 40%owf riboflavin sodium phosphate was lower than 10.4 cm and passed the B1 *** revealed by the result of this paper,riboflavin sodium phosphate is sufficiently effective in serving as an eco-friendly multifunctional agent for strengthening the add-value of silk textiles.

关键词： biomass riboflavin sodium phosphate silk protein multifunctional modification flame retardant

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Prior exposure to ciprofloxacin disrupts intestinal homeostasis and predisposes ayu(Plecoglossus altivelis)to subsequent Pseudomonas plecoglossicida-induced infection

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Zoological Research 2022年第4期43卷 648-665页

作者： Xiang-Yu Wu jin-Bo Xiong Chen-jie Fei Ting dai Ting-Fang Zhu Zi-Yue Zhao jing Pan Li Nie Jiong Chen State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products Ningbo UniversityNingboZhejiang 315211China Laboratory of Biochemistry and Molecular Biology School of Marine SciencesMeishan CampusNingbo UniversityNingboZhejiang 315211China Collaborative Innovation Center for Zhejiang Marine High-Efficiency and Healthy Aquaculture School of Marine SciencesNingbo UniversityNingboZhejiang 315211China

With the rapid development of intensive farming,the aquaculture industry uses a great many antibiotics for the prevention and treatment of bacterial *** their therapeutic functions,the overuse and accumulation of antibiotics also pose a threat to aquaculture *** the present study,ayu(Plecoglossus altivelis)was used as a fish model to study the impacts of ciprofloxacin(CIP)overuse on intestinal homeostasis and immune response during subsequent Pseudomonas plecoglossicida *** on 16S rRNA gene amplification and Illumina sequencing,we found that CIP pre-exposure caused significant variation in intestinal microbiota,including increased species richness,altered microbiota composition and interaction networks,and increased metabolic ***,immunohistochemical analysis indicated that CIP pre-exposure resulted in severe mucosal layer damage,goblet cell reduction,and epithelial cell necrosis of the intestinal barrier in infected *** real-time polymerase chain reaction(qRT-PCR)showed that disruption of intestinal homeostasis impaired systemic antiinfection immune responses in the intestine,gill,spleen,and head kidney,while inhibiting IL-1β,TNF-α,and IL-10 expression and promoting TGF-β*** findings indicated that CIP administration can directly affect intestinal microbiota composition and intestinal integrity in ayu *** perturbation of intestinal homeostasis is likely responsible for the lower survival rate of hosts following subsequent infection as the capacity to mount an effective immune response is *** study also provides preliminary clues for understanding the effects of antibiotic overuse on higher vertebrates through trophic transfer.

关键词： Ciprofloxacin Microbiota Intestinal barrier Immune responses Ayu

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A biepitope,adjuvant-free,self-assembled influenza nanovaccine provides cross-protection against H3N2 and H1N1 viruses in mice

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Nano Research 2022年第9期15卷 8304-8314页

作者： Yongbo Qiao YaXin Zhang jie Chen Shenghui jin Yarning Shan National Engineering Laboratory for AIDS Vaccine School of Life SciencesJilin UniversityChangchun 130012Chin

Currently,the incorporation of multiple epitopes into vaccines is more desirable than the incorporation of a single antigen for universal influenza vaccine ***,epitopes induce poor immune *** the use of adjuvants can overcome this obstacle,it may raise new *** antigen delivery vehicles that can function as both antigen carriers and intrinsic adjuvants are highly desired for vaccine ***,we report a biepitope nanovaccine that provides complete protection in mice against H3N2 virus as well as partial protection against H1N1 *** vaccine(3MCD-f)consists of two conserved epitopes(matrix protein 2 ectodomain(M2e)and CDhelix),and these epitopes were presented on the surface of ferritin in a sequential tandem *** immunization with 3MCD-f in the absence of adjuvant induces robust humoral and cellular immune *** results provide a proof of concept for the 3MCD-f nanovaccine that might be an ideal candidate for future influenza pandemics.

关键词： influenza universal vaccine multi-epitope nanovaccine

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Biodegradable magnesium-matrix composites:A review

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International Journal of Minerals,Metallurgy and Materials 2020年第6期27卷 724-744页

作者： jin-long Su jie Teng Zi-li Xu Yuan Li College of Materials Science and Engineering Hunan UniversityChangsha 410082China The First Affiliated Hospital Hunan Normal UniversityChangsha 410006China

Biodegradable magnesium alloys as new biomedical implant materials have been extensively studied because of their notable biodegradability over traditional bio-inert ***,the extreme degradation rate of pure magnesium leads to the loss of its mechanical integrity before the tissue recovers *** solutions to this challenge are as follows:(1)purification,(2)alloying,(3)surface modification,and(4)biodegradable magnesium-matrix composites(BMMCs)*** to the tunability of mechanical properties,the adjustability of degradation rate,and the improvement of biocompatibility,BMMCs reinforced with bioactive reinforcements have promising applications as a new generation of biomedical *** this review,the processing methods,Mg matrix,and reinforcement phases of BMMCs are ***,the review comprehensively discusses various BMMCs synthesized thus far,aiming to show the governing aspects of the achieved mechanical properties,corrosion behavior,and ***,this paper also discusses the research direction and further development areas for these materials.

关键词： magnesium-matrix composites biomaterials mechanical properties corrosion behavior

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Optimal Network Partition and Edge Server Placement for Distributed State Estimation

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Journal of Modern Power Systems and Clean Energy 2022年第6期10卷 1637-1647页

作者： Lyuzerui Yuan jie Gu jinghuan Ma Honglin Wen Zhijian jin School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

This paper investigates network partition and edge server placement problem to exploit the benefit of edge computing for distributed state estimation.A constrained many-objective optimization problem is formulated to minimize the cost of edge server deployment,operation,and maintenance,avoid the difference in the partition sizes,reduce the level of coupling between connected partitions,and maximize the inner cohesion of each *** of edge server are constrained against underload and *** efficiently solve the problem,an improved non-dominated sorting genetic algorithm III(NSGA-III)is developed,with a specifically designed directed mutation operator based on topological characteristics of the partitions to accelerate *** study validates that the proposed formulations effectively characterize the practical concerns and reveal their trade-offs,and the improved algorithm outperforms existing representative ones for large-scale networks in converging to a near-optimal *** optimized result contributes significantly to real-time distributed state estimation.

关键词： Network partition edge server placement distributed state estimation edge computing non-dominated sorting genetic algorithm(NSGA)

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The texture and its optimization in magnesium alloy

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Journal of Materials Science & Technology 2020年第7期42卷 175-189页

作者： Jialin Wu Li jin jie Dong Fenghua Wang Shuai Dong National Engineering Research Center of Light Alloy Net Forming Shanghai Jiao Tong UniversityShanghai 200240China

The crystallographic orientations are generally non-random in wrought Mg alloy,which will lead to their macroscopic physical properties to be *** the texture evolution in processing of Mg alloy billets and its effect on mechanical properties is therefore an important project for all scientists and engineers in material *** paper is concerned with the description of texture,with the mechanisms of texture evolution and with the interrelationships between texture and mechanical properties in Mg *** is a full review of understanding of the basic mechanism on texture evolution,of texture altering by alloying or processing,and of the mechanism of texture ***,it provides theories necessary and available techniques to develop high-performance Mg wrought with optimized texture in the field.

关键词： Magnesium alloy Texture Rare earth(RE) Anisotropic Mechanical property

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Recent advances in metal-organic framework-based materials for anti-staphylococcus aureus infection

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Nano Research 2022年第7期15卷 6220-6242页

作者： Mei Yang jin Zhang Yinhao Wei jie Zhang Chuanmin Tao Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu 610041China College of Materials Science and Engineering Sichuan UniversityChengdu 610065China

The rapid spread of staphylococcus aureus(***)causes an increased morbidity and mortality,as well as great economic losses in the *** infection becomes a major challenge for clinicians and nursing professionals to address drug ***,it is urgent to explore high efficiency,low toxicity,and environmental-friendly methods against ***-organic frameworks(MOFs)represent great potential in treating *** infection due to the unique features of MOFs including tunable chemical constitute,open crystalline structure,and high specific surface ***,these properties endow MOF-based materials outstanding antibacterial effect,which can be mainly attributed to the continuously released active components and the exerted catalytic activity to fight bacterial ***,the structural characteristics of MOFs and evaluation method of antimicrobial activity are briefly *** we systematically give an overview on their recent progress on antibacterial mechanisms,metal ion sustained-release system,controlled delivery system,catalytic system,and energy conversion system based on MOF ***,suggestions and direction for future research to develop and mechanism understand MOF-based materials are discussed in antibacterial application.

关键词： staphylococcus aureus(S.aureus) metal-organic frameworks antimicrobial activity antibacterial mechanisms controlled drug delivery systems

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Ultra-stable Cu-based catalyst for dimethyl oxalate hydrogenation to ethylene glycol

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Chinese Journal of Chemical Engineering 2023年第8期60卷 186-193页

作者： Peipei Ai Huiqing jin jie Li Xiaodong Wang Wei Huang State Key Laboratory of Clean and Efficient Coal Utilization College of Chemical Engineering and TechnologyTaiyuan University of TechnologyTaiyuan 030024China CAS Key Laboratory of Nanophotonic Materials and Devices&Key Laboratory of Nanodevices and Applications i-LabSuzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of SciencesSuzhou 215123China

Dimethyl oxalate(DMO) hydrogenation is a crucial step in the coal to ethylene glycol(CTEG) ***, Cu catalyst supported on fibrous mesoporous silica(Cu/FMS) was synthesized via liquid phase deposition technique and applied for the DMO hydrogenation to EG. The catalyst exhibited a remarkable EG selectivity of 96.95% and maintained its activity without deactivation for 1000 h. Fibers of FMS support and liquid phase deposition technology cooperated to give high dispersion of Cu species in the Cu/FMS catalyst, resulting in a high Cu surface area. The formation of Si—O—Cu during catalyst preparation process increased the Cu^(+)/(Cu^(0)+ Cu^(+)) ratio and enhanced the thermal and valence stability of Cu *** high Cu^(+) surface area and Cu stability(thermal and valence stability) of the Cu/FMS catalyst were key factors for achieving superior EG selectivity and ultra-high stability.

关键词： Stability Cu^(+)surface area Fibrous mesoporous silica Catalyst Hydrogenation

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Thick exchange layer evaporation model with natural convection effect and evaporation experimental study for multicomponent droplet

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Chinese Journal of Aeronautics 2020年第7期33卷 1903-1918页

作者： Fang WANG Xiang GAO Yangchun XIAO Zhaoyang WU jie jin Aero-Engine Numerical Simulation Research Center School of Energy and Power EngineeringBeihang UniversityBeijing 100083China

In order to investigate the high-temperature evaporation characteristics of multicomponent liquid fuel,three kinds of blended fuel:n-heptane/n-decane/RP-3 aviation kerosene-ethanol were experimentally studied with and without forced ***,based on zerodiffusion and infinite diffusion concept,this study expanded Thick Exchange Layer evaporation model with Natural Convection effect(NC-TEL)to multicomponent liquid *** experimental results show that the droplet evaporation rate increases significantly with the increase of ambient *** temperature leads to more significant relationships between the composition ratio and the evaporation *** effect of forced convection is not obviously under the circumstance in this ***,the evaporation models were validated by experimental *** general,the new NC-TEL model behaves better than the Ranz-Marshall(R-M)model,and the prediction accuracy at high temperature is improved by 8%to 35%.In lower temperature conditions,the prediction of zero-diffusion NC-TEL model is better than the infinite diffusion NC-TEL *** high-temperature conditions,for n-heptane-ethanol droplet,the predictions of NC-TEL model are accurate,but for n-decane/RP-3 aviation kerosene-ethanol,the predictions are lower than experimental *** may be caused by the micro-explosion phenomenon and the Marangoni phenomenon.

关键词： Droplet Evaporation rate Multicomponent fuel evaporation model Natural convection Suspended droplet experiment Thick exchange layer model

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