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两样本孟德尔随机化分析循环炎症细胞因子与骨密度的因果关联

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中国组织工程研究 2025年第8期29卷 1556-1564页

作者：陈帅金杰韩化伟田宁晟李志伟南京中医药大学第二附属医院(江苏省第二中医院)骨伤科江苏省南京市210017

背景:最近许多研究表明,炎症细胞因子与骨质疏松症和骨密度之间存在密切关系,然而炎症细胞因子与骨密度之间的因果关系尚未完全揭示。目的:采用两样本孟德尔随机化方法探究炎症细胞因子与骨密度之间潜在的因果关系。方法:从全基因组关... 详细信息

背景:最近许多研究表明,炎症细胞因子与骨质疏松症和骨密度之间存在密切关系,然而炎症细胞因子与骨密度之间的因果关系尚未完全揭示。目的:采用两样本孟德尔随机化方法探究炎症细胞因子与骨密度之间潜在的因果关系。方法:从全基因组关联研究(GWAS)公开数据库中筛选出与41种循环炎症细胞因子相关的单核苷酸多态性作为工具变量。骨密度的GWAS汇总数据来自骨质疏松症遗传因素联盟(GEFOS),共涉及32735名欧洲血统的个体。逆方差加权法作为主要的分析方法来评估因果效应,加权中位数法、MR Egger回归法、简单中位数法和加权中值方法用于补充说明。利用MR-Egger Intercept和MR-PRESSO分析方法进行多效性检验,采用Cochran’s Q检验结果是否存在异质性,同时使用留一法评估结果的稳定性。另外,为了更准确地评估因果关系,采用Bonferroni校正来确定与骨密度有强因果关系的炎症细胞因子。结果与结论:①逆方差加权法分析结果显示,白细胞介素8与腰椎骨密度之间呈正向因果关系(β=0.075,95%CI:0.033-0.117,P=0.0005),白细胞介素17与腰椎骨密度之间呈负向因果关系(β=-0.083,95%CI:-0.152至-0.014,P=0.018),肿瘤坏死因子b与股骨颈骨密度之间可能存在负向因果效应(β=-0.053,95%CI:-0.088至-0.018,P=0.003),碱性成纤维细胞生长因子与股骨颈骨密度之间可能存在正向因果关系(β=0.085,95%CI:0.016-0.154,P=0.015),巨噬细胞炎症蛋白1a与全身骨密度之间可能存在负向因果效应(β=-0.056,95%CI:-0.105至-0.007,P=0.025),白细胞介素5、基质衍生因子1a、肝细胞生长因子、白细胞介素4与足跟骨密度之间存在负向因果效应(β=-0.019,95%CI:-0.031至-0.006,P=0.004;β=-0.022,95%CI:-0.038至-0.005,P=0.010;β=-0.021,95%CI:-0.041至-0.002,P=0.030;β=-0.016,95%CI:-0.032至-0.001,P=0.034),神经生长因子、粒细胞集落刺激因子与足跟骨密度之间存在正向因果关系(β=0.019,95%CI:0.002-0.036,P=0.033;β=0.011,95%CI:0.000-0.022,P=0.050);经Bonferroni校正后发现,白细胞介素8与腰椎骨密度之间有强正向因果效应(P=0.0005)。MR Egger法、加权中位数法、简单中位数法和加权中值法分析结果方向一致。②敏感性分析结果显示,循环炎症细胞因子对骨密度的因果效应没有异质性、多效性或异常值。

关键词：骨质疏松骨密度炎症细胞因子孟德尔随机化因果关系

Burnup analysis for the pebble-bed fluoride-salt-cooled high-temperature reactor based on the energy-dependent elastic scattering cross-sectional model

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Nuclear Science and Techniques 2018年第9期29卷 122-129页

作者： Zhi-Feng Li jie-jin Cai Qin Zeng Wen-jie Zeng School of Electric Power South China University of Technology School of Nuclear Engineering Purdue University School of Nuclear Science and Technology University of South China

To carry out accurate burnup calculations for a pebble-bed fluoride-salt-cooled high-temperature reactor,the energy-dependent cross-sectional model based on the Doppler broadening rejection correction method has been proposed to develop the energy-dependent elastic scattering cross-sectional model. In this study, the Monte Carlo continuous energy code PSG2/Serpent was used to examine the difference between the constant cross-sectional model and the energy-dependent cross-sectional model during burnup. For the cases analyzed in this study,numerical simulations show that the multiplication coefficient was improved by hundreds pcm and ^(239)Pu concentration was improved by approximately 1–2% during burnup when the energy-dependent elastic scattering crosssectional model is considered.

关键词： PB-FHR Doppler broadening rejection correction Resonance elastic scattering PSG2/Serpent

Modeling TCP Incast Issue in Data Center Networks and an Adaptive Application-Layer Solution

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Journal of Electronic Science and Technology 2018年第1期16卷 84-91页

作者： jin-Tang Luo jie Xu Jian Sun School of Communication and Information Engineering University of Electronic Science and Technology of ChinaChengdu 611731

In data centers, the transmission control protocol(TCP) incast causes catastrophic goodput degradation to applications with a many-to-one traffic pattern. In this paper, we intend to tame incast at the receiver-side application. Towards this goal, we first develop an analytical model that formulates the incast probability as a function of connection variables and network environment settings. We combine the model with the optimization theory and derive some insights into minimizing the incast probability through tuning connection variables related to applications. Then,enlightened by the analytical results, we propose an adaptive application-layer solution to the TCP *** solution equally allocates advertised windows to concurrent connections, and dynamically adapts the number of concurrent connections to the varying conditions. Simulation results show that our solution consistently eludes incast and achieves high goodput in various scenarios including the ones with multiple bottleneck links and background TCP traffic.

关键词： Application-layer solution data center networks modeling transmission control protocol(TCP) incast

Multifunctional anti-wax coatings for paraffin control in oil pipelines

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Petroleum Science 2019年第3期16卷 619-631页

作者： jie Bai Xu jin Jun-Tao Wu Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education School of Chemistry Beihang University Beijing 100191 People’s Republic of China PetroChina Research Institute of Petroleum Exploration and Development (RIPED) Beijing 100083 People’s Republic of China

Paraffin deposition is a severe global problem during crude oil production and *** inhibit the formation of paraffin deposits,the commonly used methods are mechanical cleaning,coating the pipe to provide a smooth surface and reduce paraffin adhesion,electric heating,ultrasonic and microbial treatments,the use of paraffin inhibitors,*** coatings not only have the advantages of simple preparation and broad applications,but also maintain a long-term efficient and stable *** recent years,important progress has been made in research on pipe coatings for mitigating and preventing paraffin *** novel superhydrophilic organogel coatings with low surface energy were successfully prepared by bionic *** paper reviews different types of coatings for inhibiting wax deposition in the petroleum *** research prospects and directions of this rapidly developing field are also briefly discussed.

关键词： Paraffin control,Coatings Surface energy Bionic design Wettability

Identification of novel antisense long non-coding RNA APMAP-AS that modulates porcine adipogenic differentiation and inflammatory responses

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Journal of Integrative Agriculture 2023年第8期22卷 2483-2499页

作者： ZHANG Lin-zhen HE Li WANG Ning AN Jia-hua ZHANG Gen CHAI jin WU Yu-jie dai Chang-jiu LI Xiao-han LIAN Ting LI Ming-zhou jin Long Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130P.R.China College of Grassland Science and Technology Sichuan Agricultural UniversityChengdu 611130P.R.China

Long non-coding RNAs(lncRNAs)are emerging as powerful regulators of adipocyte differentiation,fat metabolism and gene ***,the functional roles and mechanisms of lncRNAs in these processes remain ***,we identified a novel antisense transcript,named APMAP-AS,transcribed from adipocyte membrane-associated protein(APMAP)in the pig ***-AS and APMAP were highly expressed in retroperitoneal adipose of obese pigs,compared with that in control *** a bone mesenchymal stem cells(BMSCs)adipogenic differentiation model,we found that APMAP-AS positively regulated adipogenic ***-AS had the potential to form an RNA–RNA duplex with APMAP,and increased the stability of APMAP ***,APMAP-AS promoted lipid metabolism and inhibited the expression of inflammatory *** findings of a natural antisense transcript for a regulatory gene associated with lipid synthesis might further our understanding of lncRNAs in driving adaptive adipose tissue remodeling and preserving metabolic health.

关键词： lncRNA adipogenesis lipid metabolism inflammation RNA-RNA duplex

Experimental studies on the pore structure and mechanical properties of anhydrite rock under freeze-thaw cycles

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第3期14卷 781-797页

作者： Chao Hou Xiaoguang jin jie He Hanlin Li School of Civil Engineering Chongqing UniversityChongqing400045China Key Laboratory of New Technology for Construction of Cities in Mountain Area of the Ministry of Education Chongqing UniversityChongqing400045China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing400045China

To study the deterioration mechanisms of anhydrite rock under the freeze-thaw weathering process,the physico-mechanical characteristics and microstructure evolutions of anhydrite samples were determined by a series of laboratory ***,a descriptive-behavioral model was used to measure the integrity loss in anhydrite samples caused by cyclic ***,the freeze-thaw damage mechanisms of anhydrite rock were revealed from the macro and micro *** results show that the pore size of the anhydrite rock is mainly concentrated in the range of 0.001-10μ*** the number of freeze-thaw cycles increases,there is a growth in the proportion of macropores and ***,the proportion of micropores shows a declining *** relations of the uniaxial compressive strength,triaxial compressive strength,cohesion,and elastic modulus versus freeze-thaw cycles can be fitted by a decreasing exponential function,while the internal friction angle is basically unchanged with freezethaw *** the increase of confining pressure,the disintegration rates of the compressive strength and the elastic modulus decrease,and the corresponding half-life values increase,which reveals that the increase of confining pressures could inhibit freeze-thaw damage to ***,it has been proven that the water chemical softening mechanism plays an essential role in the freeze-thaw damage to anhydrite ***,it is concluded that the freeze-thaw weathering process significantly influences the macroscopic and microscopic damages of anhydrite rock.

关键词： Anhydrite rock Freeze-thaw cycles Physico-mechanical characteristics Microstructure evolution Deterioration mechanisms

Evaluation of Pitting Behavior on Solution Treated Duplex Stainless Steel UNS S31803

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Journal of Materials Science & Technology 2014年第2期30卷 179-183页

作者： Yiming Jiang Tao Sun jin Li jie Xu Department of Materials Science Fudan University School of Information and Electrical Engineering Zhejiang University City College

The pitting corrosion resistance of duplex stainless steels UNS S31803 annealed at different temperatures ranging from 1050 ℃ to 1200 ℃ for 24 h has been investigated by means of potentiostatic critical pitting temperature （CPT）. The microstructural evolution and pit morphologies of the specimens were studied through optical microscopy and scanning electron microscopy. The potentiostatic CPT measurements show that the CPT was elevated with the annealing temperature increased from 1050 ℃ to 1150℃ and decreased as the temperature further increased to 1200 ℃. The specimens annealed at 1150 ℃ exhibited the highest CPTand the best pitting corrosion resistance. The pit morphologies show that the pit initiation sites transfer from austenite phase to ferrite phase as the annealing temperature increases. The results were explained by the variation of pitting resistance equivalent number （PREN） of ferrite and austenite phases as the annealing temperature was varied.

关键词： Duplex stainless steel Solution treatment Pitting corrosion Critical pitting temperature Pitting resistance equivalent number

Stereoselective Synthesis of Nontethered trans-4 Bis(aziridino)[60]fullerene Derivatives

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Chinese Journal of Chemistry 2023年第18期41卷 2282-2288页

作者： jie Xiong Shuang Feng Rufang Peng Bo jin State Key Laboratory of Environment-friendly Energy Materials Southwest University of Science and TechnologyMianyangSichuan 621010China

Comprehensive Summary,The stereoselective preparation of fullerene bis-adducts through nontethered methods remains difficult due to the significant amount of regioisomers *** trans-4 aziridino[60]fullerenes,C_(60)(NC_(6)H_(4)R)n(n=1 or 2,R=OMe,OEt,OBu),were selectively synthesized even without a catalyst by reacting octabromofullerene with the corresponding *** magnetic resonance spectroscopy,UV-vis spectroscopy,and X-ray structural analysis provided convincing characterization of the compounds.A possible reaction process was proposed to clarify the synthesis of highly regioselective trans-4-bisaziridino[60]*** possible application of these aziridino[60]fullerene derivatives as propellant stabilizers was also explored.

关键词： Fullerene Regioselectivity Mechanism Nitrocellulose Stability

The SPH approach to the process of container filling based on non-linear constitutive models

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Acta Mechanica Sinica 2012年第2期28卷 407-418页

作者： Tao Jiang jie Ouyang Lin Zhang jin-Lian Ren Department of Applied Mathematics Northwestem Polytechnical University710129 Xi'anChina

In this work, the transient free surface of con- tainer filling with non-linear constitutive equation＇s fluids is numerically investigated by the smoothed particle hydrody- namics （SPH） method. Specifically, the filling process of a square container is considered for non-linear polymer fluids based on the Cross model. The validity of the presented SPH is first verified by solving the Newtonian fluid and Oldroyd- B fluid jet. Various phenomena in the filling process are shown, including the jet buckling, jet thinning, splashing or spluttering, steady filling. Moreover, a new phenomenon of vortex whirling is more evidently observed for the Cross model fluid compared with the Newtonian fluid case.

关键词： Non-linear. SPH Free surface Navier-Sto- kes Filling