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Food Science and Human Wellness 2024年第2期13卷 1065-1078页

作者： dai cheng Qianqian Yu Kexin Zhu Dingdong Bu Zijian Wu State Key Laboratory of Food Nutrition and Safety Tianjin University of Science&TechnologyTianjin 300457China School of Biotechnology and Food Science Tianjin University of CommerceTianjin 300134China

Epicatechin(EC)was used in this study to antagonize the cognitive dysfunction caused by lead(Pb)exposure in ***-week-old male Kunming mice were treated with PbCl_(2)(20 mg/kg)and/or EC(50 mg/kg)by gavage administration for 4 *** water maze test showed that EC could improve memory dysfunction induced by *** antagonized Ca^(2+)overload,activated Nrf2 signaling pathway and reduced the accumulation of Pb in the brain and serum,which suggested that EC might alter Pb distribution in *** vitro,spectroscopic analysis,potentiometric titration and docking studies were applied to inquiry into the interaction between bovine serum albumin(BSA)and Pb^(2+)in presence or absence of *** was proved to chelate Pb^(2+)and reduced the interaction between BSA and Pb^(2+).In summary,EC might protect Pb-induced cognitive impairment by activating Nrf2 signaling pathway,and suppressing Pb accumulation via interference on the binding of Pb to albumin.

关键词： Lead Epicatechin Bovine serum albumin Interaction Oxidative stress

Fracture network types revealed by well test curves for shale reservoirs in the Sichuan Basin,China

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Energy Geoscience 2024年第1期5卷 264-274页

作者： Yanyan Wang Hua Liu Xiaohu Hu cheng dai Sidong Fang State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development Petroleum Exploration and Development Research InstituteSinopecBeijing100083China

Pressure buildup testing can be used to analyze fracture network characteristics and conduct quantitative interpretation of relevant parameters for shale gas wells,thus providing bases for assessing the well productivity and formulating proper development *** study establishes a new well test interpretation model for fractured horizontal wells based on seepage mechanisms of shale reservoirs and proposes a method for identifying fracturing patterns based on the characteristic slopes of pressure buildup curves and curve combination *** pressure buildup curve patterns are identified to represent three types of shale reservoirs in the Sichuan Basin,namely the moderately deep shale reservoirs with high pressure,deep shale reservoirs with ultra-high pressure,and moderately deep shale reservoirs with normal *** on this,the relationship between the typical pressure buildup curve patterns and the fracture network types are put *** effects of three types of shale gas reservoir are compared and *** results show that typical flow patterns of shale reservoirs include bilinear flow in primary and secondary fractures,linear flow in secondary fractures,bilinear flow in secondary fractures and matrix,and linear flow in *** fracture network characteristics can be determined using the characteristic slopes of pressure buildup curves and curve *** linear flow in early secondary fractures is increasingly distinct with an increase in primary fracture ***,the bilinear flow in secondary fractures and matrix and the subsequent linear flow in the matrix occur as the propping and density of secondary fractures *** increase in the burial depth,in-situ stress,and stress difference corresponds to a decrease in the propping of primary fractures that expand along different directions in the shale gas wells in the Sichuan *** pressure buildup curve patterns exist in the Sichuan Basin and it

关键词： Shale gas Fractured horizontal well Well testing interpretation Flow pattern characterization Parameter inversion Fracture network characteristics Sichuan basin

CO_(2)flooding in shale oil reservoir with radial borehole fracturing for CO_(2)storage and enhanced oil recovery

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Petroleum Science 2024年第1期21卷 519-534页

作者： Jia-cheng dai Tian-Yu Wang Jin-Tao Weng Kang-Jian Tian Li-Ying Zhu Gen-Sheng Li State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China China National Oil and Gas Exploration and Development Company Limited Beijing100034China

This study introduces a novel method integrating CO_(2)flooding with radial borehole fracturing for enhanced oil recovery and CO_(2)underground storage,a solution to the limited vertical stimulation reservoir volume in horizontal well fracturing.A numerical model is established to investigate the production rate,reservoir pressure field,and CO_(2)saturation distribution corresponding to changing time of CO_(2)flooding with radial borehole fracturing.A sensitivity analysis on the influence of CO_(2)injection location,layer spacing,pressure difference,borehole number,and hydraulic fractures on oil production and CO_(2)storage is *** CO_(2)flooding process is divided into four *** in layer spacing will significantly improve oil production rate and gas storage ***,serious gas channeling can occur when the spacing is lower than 20 *** the pressure difference between the producer and injector,the borehole number,the hydraulic fracture height,and the fracture width can also increase the oil production rate and gas storage *** analysis shows that layer spacing and fracture height greatly influence gas storage and oil *** outcomes are expected to provide a theoretical basis for the efficient development of shale oil reservoirs in the vertical direction.

关键词： Shale oil Radial borehole fracturing Embedded discrete fracture model Enhanced oil recovery Carbon storage

Quantitative characterizations of anisotropic dynamic properties in organic-rich shale with different kerogen content

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Petroleum Science 2024年第2期21卷 855-865页

作者： Jian-Yong Xie Yan-Ping Fang Xing-Hua Wu Jian'er Zhao Jun-cheng dai Jun-Xing Cao Ji-Xin Deng State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengdu610059SichuanChina Key Lab of Earth Exploration&Information Techniques of Ministry of Education Geophysical InstituteChengdu University of TechnologyChengdu610059SichuanChina PetroChina Southwest Oil&Gasfield Company Chengdu610017SichuanChina

Understanding the quantitative responses of anisotropic dynamic properties in organic-rich shale with different kerogen content(KC)is of great significance in hydrocarbon exploration and *** controlled experiments with a single variable is challenging for natural shales due to their high variations in components,diagenesis conditions,or pore *** employed the hot-pressing technique to construct 11 well-controlled artificial shale with varying *** artificial shale samples were successive machined into prismatic shape for ultrasonic measurements along different *** revealed bedding perpendicular P-wave velocities are more sensitive to the increasing KC than bedding paralleling velocities due to the preferential alignments of *** elastic stiffnesses except C_(13)are generally decreasing with the increasing KC,the variation of C_(1) and C_(33)on kerogen content are more sensitive than those of C_(44)and C_(66).Apparent dynamic mechanical parameters(v and E)were found to have linear correlation with the true ones from complete anisotropic equations independent of KC,which hold value towards the interpretation of well logs consistently across formations,Anisotropic mechanical parameters(ΔE and brittlenessΔB)tend to decrease with the reducing KC,withΔB showing great sensitivity to KC *** the range of low KC(10%)shale,compilation of data from natural organic rich-shales globally verified the similar systematic relationships that can be empirically used to predict the fraction of KC in shales.

关键词： Elastic properties Organic shale Anisotropy Kerogen content Physical modeling

Perforated gastric ulcer causing mediastinal emphysema: A case report

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World Journal of Clinical Cases 2024年第4期12卷 859-864页

作者： Zhi-cheng dai Xun-Wu Gui Feng-He Yang Hao-Yuan Zhang Wen-Feng Zhang Department of General Surgery Mengcheng County First People's HospitalMengcheng 233500Anhui ProvinceChina Department of Medical Imaging Mengcheng County First People's HospitalMengcheng 233500Anhui ProvinceChina

BACKGROUND Mediastinal emphysema is a condition in which air enters the mediastinum between the connective tissue spaces within the pleura for a variety of *** can be spontaneous or secondary to chest trauma,esophageal perforation,medi-cally induced factors,*** common symptoms are chest pain,tightness in the chest,and respiratory *** mediastinal emphysema patients have mild symptoms,but severe mediastinal emphysema can cause respiratory and circulatory failure,resulting in serious *** SUMMARY A 75-year-old man,living alone,presented with sudden onset of severe epigastric pain with chest tightness after drinking *** to the remoteness of his residence and lack of neighbors,the patient was found by his nephew and brought to the hospital the next morning after the disease *** tomography(CT)showed free gas in the abdominal cavity,mediastinal emph-ysema,and subcutaneous *** gastrointestinal angiography showed that the esophageal mucosa was intact and the gastric antrum was ***,we chose to perform open gastric perforation repair on the patient under thoracic epidural anesthesia combined with intravenous *** operative incision of the muscle layer of the patient's abdominal wall was made,and a large amount of subperitoneal gas was *** a continued incision of the peritoneum revealed the presence of a perforation of approx-imately 0.5 cm in the gastric antrum,which we repaired after pathological ***,the patient received high-flow oxygen and cough *** CT was performed on the first and sixth postoperative days,and the mediastinal and subcutaneous gas was gradually *** After gastric perforation,a large amount of free gas in the abdominal cavity can reach the mediastinum through the loose connective tissue at the esophageal hiatus of the diaphragm,and upper gastrointestinal angiography can clarify the site of *** pat

关键词： Gastric ulcer Perforated Mediastinal emphysema Case report

Identification of marker genes associated with N6-methyladenosine and autophagy in ulcerative colitis

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World Journal of Clinical Cases 2024年第10期12卷 1750-1765页

作者： Xiao-Yan Liu Dan Qiao Ya-Li Zhang Zi-Xuan Liu You-Lan Chen Ren-Ye Que Hong-Yan Cao Yan-cheng dai Department of Gastroenterology Shanghai Traditional Chinese Medicine-Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai 200082China Institute of Digestive Diseases Long Hua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Gastroenterology Shu Guang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China

BACKGROUND Both N6-methyladenosine(m6A)methylation and autophagy are considered relevant to the pathogenesis of ulcerative colitis(UC).However,a systematic exploration of the role of the com-bination of m6A methylation and autophagy in UC remains to be *** To elucidate the autophagy-related genes of m6A with a diagnostic value for *** The correlation between m6A-related genes and autophagy-related genes(ARGs)was ***,gene set enrichment analysis(GSEA)was performed on the characteristic ***,the expression levels of four characteristic genes were verified in dextran sulfate sodium(DSS)-induced colitis in *** GSEA indicated that BAG3,P4HB and TP53INP2 were involved in the inflammatory response and TNF-αsignalling via nuclear factor ***,polymerase chain reaction results showed significantly higher mRNA levels of BAG3 and P4HB and lower mRNA levels of FMR1 and TP53INP2 in the DSS group compared to the control *** This study identified four m6A-ARGs that predict the occurrence of UC,thus providing a scientific reference for further studies on the pathogenesis of UC.

关键词： Ulcerative colitis m6A Autophagy Characteristic genes Immune infiltration

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公理化的矩阵半张量积

控制理论与应用 2024年第7期41卷 1172-1180页

作者：程代展赵荣冯俊娥中国科学院数学与系统科学研究院系统科学研究所北京100190 山东大学数学学院山东济南250100

本文给出矩阵半张量积的一个公理化框架,它包括矩阵–矩阵半张量积、矩阵–向量半张量积和向量–向量半张量积.首先,对目前通用的各类矩阵半张量积的基本性质与应用做一个综述性的回顾.然后,介绍一种新近出现的矩阵半张量积,即保维数矩... 详细信息

本文给出矩阵半张量积的一个公理化框架,它包括矩阵–矩阵半张量积、矩阵–向量半张量积和向量–向量半张量积.首先,对目前通用的各类矩阵半张量积的基本性质与应用做一个综述性的回顾.然后,介绍一种新近出现的矩阵半张量积,即保维数矩阵半张量积.跟普通矩阵乘法一样,它是多功能的,即它可同时实现矩阵–矩阵乘积、矩阵–向量乘积和向量–向量乘积这3种功能.最后,本文介绍保维数矩阵半张量积的一些代数性质,包括非方矩阵的Cayley-Hamilton定理,非方矩阵的特征值、特征向量等.

关键词：公理化的矩阵半张量积超矩阵保维数矩阵半张量积非方矩阵的Cayley-Hamilton定理

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2017—2022年扬州市江都区手足口病流行病学特征分析

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中国初级卫生保健 2024年第4期38卷 67-69页

作者：戴澄扬州市江都区疾病预防控制中心江苏扬州225200

目的:探讨2017—2022年扬州市江都区手足口病流行病学特点,为当地手足口病疫情的预防和控制提供依据。方法:从中国疾病预防控制信息系统中筛选2017—2022年江都区手足口病上报病例,采用描述性流行病学方法进行统计分析,运用WPS 2019及SP... 详细信息

目的:探讨2017—2022年扬州市江都区手足口病流行病学特点,为当地手足口病疫情的预防和控制提供依据。方法:从中国疾病预防控制信息系统中筛选2017—2022年江都区手足口病上报病例,采用描述性流行病学方法进行统计分析,运用WPS 2019及SPSS 23.0软件对数据进行整理和统计分析。结果:2017—2022年江都区手足口病病例报告2586例,死亡0例,年平均发病率为41.75/10万,发病率变化总体呈波动性,差异有统计学意义(χ^(2)=1701.890,P<0.05)。发病主要集中于每年的5—7月及11月—次年1月,表现为冬、春2个季节的双峰。发病地区主要集中在中心城区。发病人群主要为0~5岁患儿(2494例,占96.44%)。结论:2017—2022年江都区手足口病发病率呈波动变化趋势,具有明显季节性,表现为双峰状,其中<5岁组的患儿患病情况尤为明显。要加强手足口疫苗的接种和手足口疾病宣教,减少手足口病发病率,控制手足口病流行。

关键词：手足口病流行病学特征发病率儿童

Functional genomics of Brassica napus:Progresses,challenges,and perspectives

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Journal of Integrative Plant Biology 2024年第3期66卷 484-509页

作者： Zengdong Tan Xu Han cheng dai Shaoping Lu Hanzi He Xuan Yao Peng Chen Chao Yang Lun Zhao Qing-Yong Yang Jun Zou Jing Wen Dengfeng Hong Chao Liu Xianhong Ge Chuchuan Fan Bing Yi Chunyu Zhang Chaozhi Ma Kede Liu Jinxiong Shen Jinxing Tu Guangsheng Yang Tingdong Fu Liang Guo Hu Zhao National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China Yazhouwan National Laboratory Sanya 572025China

Brassica napus,commonly known as rapeseed or canola,is a major oil crop contributing over 13%to the stable supply of edible vegetable oil *** and understanding the gene functions in the *** genome is crucial for genomic breeding.A group of genes controlling agronomic traits have been successfully cloned through functional genomics studies in *** this review,we present an overview of the progress made in the functional genomics of ***,including the availability of germplasm resources,omics databases and cloned functional *** on the current progress,we also highlight the main challenges and perspectives in this *** advances in the functional genomics of *** contribute to a better understanding of the genetic basis underlying the complex agronomic traits in *** and will expedite the breeding of high quality,high resistance and high yield in *** varieties.

关键词： accelerate breeding Brassica napus functional genomics high resistance high yield

耐亚磷酸盐除草剂转基因油菜的创建和抗性评价

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作物学报 2024年第5期50卷 1158-1171页

作者：钟元朱天宇戴成马朝芝华中农业大学作物遗传改良全国重点实验室/国家油菜工程技术研究中心/洪山实验室湖北武汉430070

在油菜的生产过程中,大量伴生的杂草严重影响了其产量和品质。由于近年来田间抗除草剂杂草数量的增加,除草剂的选择正在迅速减少,这影响了未来农业的可持续发展。植物可以通过正磷酸盐(Pi)转运蛋白吸收亚磷酸盐(Phi),但Phi不能被代谢为... 详细信息

在油菜的生产过程中,大量伴生的杂草严重影响了其产量和品质。由于近年来田间抗除草剂杂草数量的增加,除草剂的选择正在迅速减少,这影响了未来农业的可持续发展。植物可以通过正磷酸盐(Pi)转运蛋白吸收亚磷酸盐(Phi),但Phi不能被代谢为作物的磷肥料,导致植物生长受到抑制。此前,从罗尔斯通菌属(Raltsonia *** 4506)中分离出了ptxD(phosphite dehydrogenase)基因,其139位的酪氨酸突变为谷氨酰胺(Y139Q)的突变蛋白ptxD_(Q)催化Phi转化为Pi的活性显著提高。为了评价ptxD_(Q)/Phi系统对甘蓝型油菜杂草的防治效果,本研究获得了带有密码子优化的ptxD(Y139Q,ptxD_(Q))基因的转基因甘蓝型油菜。在以Phi为单一磷元素的条件下,ptxD_(Q)转基因油菜可以正常生长,体内Pi含量显著提高,且Pi饥饿响应基因(PT21和PT24等)的表达水平被显著抑制,说明ptxD_(Q)在油菜体内可以促使Phi转化为Pi。此外,ptxD_(Q)转基因油菜具有比野生型油菜和单子叶杂草(狗尾草)更强的生长竞争优势。综上所述,ptxD_(Q)/Phi是一种有效的油菜磷利用和杂草控制系统,既可以抑制杂草的生长,又可以为作物提供充足的Pi营养,从而提高了农业的可持续性。

关键词：甘蓝型油菜除草剂亚磷酸盐 ptxD_(Q)