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Science China(Information Sciences) 2025年

作者： Shengzhe YAN Zhaori CONG Zi WANG Zhuoyu dai Zeyu GUO Zhihang QIAN Xufan LI Xu ZHENG Chuanke CHEN Nianduan LU Chunmeng DOU Guanhua YANG Xiaoxin XU Di GENG Jinshan YUE Lingfei WANG Ling LI Ming LIU Institute of Microelectronics of the Chinese Academy of Sciences University of Chinese Academy of Sciences

Abstract Compute-in-memory (CIM) based on various devices such as static random access memory (SRAM) and resistive random access memory (RRAM) and other emerging devices such as indium-gallium-zinc-oxide (IGZO) transistor, magnetoresistive RAM (MRAM), and ferroelectric RAM (FeRAM) has been explored for better performance and energy efficiency on neural networks applications. However, CIM based on a single-type device suffers a variety of non-ideal metrics to reach the simultaneous optimal accuracy, density, and energy efficiency. This work presents equivalent-ideal CIM (Eq-CIM), a monolithic 3D(M3D) IGZO-RRAM-SRAM integrated architecture for robust and efficient compute-in-memory enabling equivalent-ideal device metrics. To overcome the non-ideality (variation, endurance, temperature, etc.) of the single-type devices, system-technology co-optimization (STCO) is performed. This work highlights the non-ideality-aware functionality breakdown for robust high accuracy and simultaneous high density/efficiency, by utilizing 2T0C IGZO for temporal activation storage, RRAM for high-density weight storage, and SRAM for accurate CIM. Device-to-algorithm variation transfer is applied to analyze the system-level accuracy. We benchmark Eq-CIM architecture on CIFAR-10/ImageNet, with 5.06×storage density and 5.05×/2.45×area/energy efficiency compared with single-type-device-based CIM, and high robustness (<0.27%accuracy loss) from-40℃ to 120℃.

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Skeletal muscle-specific Bambi deletion induces hypertrophy and oxidative switching coupling with adipocyte thermogenesis against metabolic disorders

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Science China Life Sciences 2025年

作者： Xiangping Yao Xudong Mai Ye Tian Yifan Liu Guanghui Jin Ze Li Shujie Chen Xiaoshuang dai Liujing Huang Zijing Fan Guihua Pan Xiaohan Pan Xiangmin Li Michael C Yu Jia Sun Jingxing Ou Hong Chen Liwei Xie College of Life and Health Sciences Guangdong Industry Polytechnic Department of Endocrinology and Metabolism Zhujiang Hospital Southern Medical University State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Open Laboratory of Applied MicrobiologyInstitute of Microbiology Guangdong Academy of Sciences Institute of Aging Research Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics School of Medical Technology Guangdong Medical University Department of Hepatic Surgery and Liver transplantation Center of the Third Affiliated Hospital Organ Transplantation Institute Sun Yat-sen University Organ Transplantation Research Center of Guangdong ProvinceGuangdong province engineering laboratory for transplantation medicine Guangdong Provincial Key Laboratory of Liver Disease Research School of Public Health Xinxiang Medical University BGI Institute of Applied Agriculture BGI-Shenzhen Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Department of Biological Sciences State University of New York at Buffalo Department of Internal Medicine Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan) Guangdong Medical University

Skeletal muscle plays a significant role in both local and systemic energy metabolism. The current investigation aims to explore the role of the Bambi gene in skeletal muscle, focusing on its implications for muscle hypertrophy and systemic metabolism. We hypothesize that skeletal muscle-specific deletion of Bambi induces muscle hypertrophy, improves metabolic performance, and activates thermogenic adipocytes via the reprogramming of progenitor of i WAT, offering potential therapeutic strategies for metabolic syndromes. Leveraging the Chromatin immunoprecipitation(ChIP)-seq and bioinformatics analysis, Bambi gene is shown to be a direct target of HIF2α, which is further confirmed by ChIP-qPCR and promoter luciferase assay. Skeletal muscle-specific Bambi deletion led to significant muscle hypertrophy and improved metabolic parameters, even under high-fat diet conditions. This deletion induced metabolic reprogramming of stromal vascular fractions(SVFs) into thermogenic adipocytes, contributing to systemic metabolic improvements, potentially through the secretory ***, mice with skeletal muscle-specific Bambi deletion demonstrate resistance to high-fat diet-induced metabolic disorders, highlighting a potential therapeutic pathway for metabolic syndrome management. Thus, skeletal muscle-specific deletion of Bambi triggers muscle growth, enhances metabolic performance, and activates thermogenic adipocytes. These findings suggest Bambi as a novel therapeutic target for metabolic syndromes, providing new insights into the interaction between muscle hypertrophy and systemic metabolic improvement. The study underscores the potential of manipulating muscle physiology to regulate whole-body metabolism, offering a novel perspective on treating metabolic disorders.

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Synthesis of 2,5-diformylfuran from renewable carbohydrates and its applications: A review

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Green Energy & Environment 2021年第1期6卷 22-32页

作者： Jinhang dai College of Environment and Resources Chongqing Technology and Business UniversityChongqing400067China

The synthesis of fine chemicals and fuel candidates from renewable biomass-based feedstocks has attracted much attention due to declining fossil *** value-added furan derivatives,such as 5-hydroxymethylfurfural(HMF),2,5-diformyfuran(DFF)and 2,5-furandicarboxylic acid,have been successfully produced from *** these,DFF,the aerobic oxidation product of HMF,is a key chemical and can be used in organic synthesis and functional polymer *** this review,different catalytic systems for the synthesis of DFF from monosaccharide,disaccharide and polysaccharide were summarized,while reaction pathways and catalyst stability were also ***,the applications of DFF were introduced in ***,prospects of more effective methods to DFF production and application were discussed.

关键词： 2,5-Diformyfuran Oxidation HMF Carbohydrate Biomass

Beam dynamics design of an SP-FEL compact THz source

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Nuclear Science and Techniques 2010年第5期21卷 266-270页

作者： dai Dongdong dai Zhimin Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China Graduate School Chinese Academy of Sciences Beijing 100049 China

In recent years,people are looking for a new compact THz source with high emission power,one potential choice is to build small accelerator with Smith-Purcell *** main difficulty is how to obtain high quality electron *** this paper,the beam dynamics design of a compact THz source is *** electron beam is produced by an electron gun and compressed by permanent *** electron gun is similar to the Shanghai EBIT,but permanent magnets are used,instead of the superconducting magnets in Shanghai *** this design,we can reduce the size and cost of the whole ***/Pandira was employed to simulate and optimize the magnetic *** was used to simulate the beam trajectories from the electron gun to the *** 2 centimeters around the center of longitudinal magnetic field,the calculation showed that the beam satisfies to our design aim.

关键词：动力学设计太赫兹紧凑型 FEL SP 束流永久磁铁 EBIT

槟榔干燥动力学模型及微观结构、代谢物变化规律研究

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热带作物学报 2025年第1期46卷 222-235页

作者：张晶代佳慧王世萍代文婷康效宁吉建邦胡玉娟海南省农业科学院三亚研究院海南三亚572000 海南省农业科学院农产品加工设计研究所海南海口570100 海口市槟榔加工研究重点实验室海南海口570100

干燥是槟榔加工的第1步,干燥过程直接影响槟榔的品质和货架期。为了明确槟榔热风干燥过程的水分变化、纤维微观结构及代谢物的变化规律,以期对槟榔干燥时间进行精准调控。本研究以槟榔鲜果和槟榔杀青果为研究对象,利用5种模型对不同温... 详细信息

干燥是槟榔加工的第1步,干燥过程直接影响槟榔的品质和货架期。为了明确槟榔热风干燥过程的水分变化、纤维微观结构及代谢物的变化规律,以期对槟榔干燥时间进行精准调控。本研究以槟榔鲜果和槟榔杀青果为研究对象,利用5种模型对不同温度下槟榔热风干燥曲线进行拟合,建立槟榔干燥动力学模型,同时利用扫描电子显微镜、LC-MS等探讨干燥过程中槟榔微观结构、代谢物的变化规律。结果表明:槟榔干燥曲线呈指数下降,干燥速率曲线分为加速和降速2个阶段,温度对干燥速率有显著影响;Page模型对槟榔热风干燥曲线拟合较好,模型决定系数(R^(2))在0.98以上,均方差(mean square deviation,RMSE)在0.02~0.06范围内,模型预测值和真实值差异不显著,可以较好地反映槟榔干燥过程中的水分变化规律。微观结构分析表明,随着干燥时间的增加槟榔纤维层变得致密、紧实,杀青处理导致槟榔纤维结构松散。质构结果表明,随着干燥时间的增加,槟榔硬度和咀嚼度增加,弹性降低。差异代谢物结果显示,干燥过程通过影响氨基酸代谢通路、中心碳代谢通路、亚油酸代谢通路、黄酮类生物合成、苯丙烷类生物合成进而影响有机酸、脂质和类脂分子等发生变化。研究结果为丰富槟榔加工基础研究,以及为槟榔热风干燥时间的选择提供理论依据。

关键词：槟榔干燥动力学模型微观结构代谢物质构

AN ITERATIVE HYBRIDIZED MIXED FINITE ELEMENT METHOD FOR ELLIPTIC INTERFACE PROBLEMS WITH STRONGLY DISCONTINUOUS COEFFICIENTS

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Journal of Computational Mathematics 2003年第3期21卷 257-276页

作者： dai-quYang JenniferZhao DepartmentofMathematics WayneStateUniversityDetroitMI48202USA DepartmentofMathematicsandStatistics UniversityofMichigan-DearbornDearbornMI48128USA

An iterative algorithm is proposed and analyzed based on a hybridized mixed finite element method for numerically solving two-phase generalized Stefan interface problems with strongly discontinuous solutions, conormal derivatives, and coefficients. This algorithm iteratively solves small problems for each single phase with good accuracy and exchange information at the interface to advance the iteration until convergence, following the idea of Schwarz Alternating Methods. Error estimates are derived to show that this algorithm always converges provided that relaxation parameters are suitably chosen. Numeric experiments with matching and non-matching grids at the interface from different phases are performed to show the accuracy of the method for capturing discontinuities in the solutions and coefficients. In contrast to standard numerical methods, the accuracy of our method does not seem to deteriorate as the coefficient discontinuity increases.

关键词： Mixed finite element method Interface problems Discontinuous solutions.

带拼接板螺栓连接耗能梁段的可恢复功能钢框筒结构抗震性能研究

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铜基催化剂在乙炔氢氯化反应中的工业应用评估

工程力学 2025年第1期42卷 83-102页

作者：连鸣戴子琳程倩倩西安建筑科技大学土木工程学院西安710055 西安建筑科技大学结构工程与抗震教育部重点实验室西安710055 中国建筑西北设计研究院有限公司西安710018

为了提升传统钢框筒结构的延性和耗能能力，提出采用拼接板螺栓连接的可恢复功能剪切耗能型钢框筒结构(FTS-SRSL)，该结构结合了可更换剪切型耗能梁段和钢框筒结构具有良好的抗震性能。该文对一个2/3缩尺的单层单跨FTS-SRSL子结构试件... 详细信息

为了提升传统钢框筒结构的延性和耗能能力，提出采用拼接板螺栓连接的可恢复功能剪切耗能型钢框筒结构(FTS-SRSL)，该结构结合了可更换剪切型耗能梁段和钢框筒结构具有良好的抗震性能。该文对一个2/3缩尺的单层单跨FTS-SRSL子结构试件进行了往复加载试验，试验结果表明，FTS-SRSL子结构试件具有良好的抗震性能，结构损伤集中于耗能梁段，且耗能梁段可实现更换。在试验的基础上，以耗能梁段长度比、耗能梁段腹板加劲肋间距、螺栓直径、翼缘拼接板和腹板拼接板厚度为参数，利用ABAQUS建立了15个足尺的单层单跨FTS-SRSL有限元模型，探究各模型的抗震性能，包括承载力、刚度、耗能以及塑性变形能力。有限元分析结果表明：改变拼接板螺栓连接的剪切型耗能梁段长度比会显著影响结构的承载力、刚度及耗能，建议FTS-SRSL中的拼接板螺栓连接剪切型耗能梁段长度比取0.73~1.09;改变耗能梁段腹板加劲肋间距对结构的承载力、刚度和耗能影响较小，基于该文的分析结果，建议FTS-SRSL中的拼接板螺栓连接剪切型耗能梁段腹板加劲肋间距取e/4~e/3(e为耗能梁段长度)，且间距应满足我国抗规的规定;改变翼缘拼接板和腹板拼接板厚度对结构的承载力、刚度及耗能基本无影响;改变螺栓直径对结构承载力、刚度及耗能影响较小。

关键词：可更换耗能梁段拼接板螺栓连接钢框筒结构抗震性能参数分析

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现代化工 2025年第1期45卷 72-76页

作者：代元元杨京林牛强内蒙古鄂尔多斯电力冶金集团股份有限公司内蒙古鄂尔多斯016064

概述了近年来国内外铜催化剂在乙炔氢氯化反应中的研究进展,综述了铜催化剂的几种改性手段,探讨了催化剂的工业应用情况,分析了铜催化剂工业应用的安全风险问题。研究表明,经过适当改性,铜催化剂具备工业应用潜力,且在实际工业生产中通... 详细信息

概述了近年来国内外铜催化剂在乙炔氢氯化反应中的研究进展,综述了铜催化剂的几种改性手段,探讨了催化剂的工业应用情况,分析了铜催化剂工业应用的安全风险问题。研究表明,经过适当改性,铜催化剂具备工业应用潜力,且在实际工业生产中通过严格控制工艺指标可避免铜工业应用的安全风险问题。

关键词：乙炔氢氯化铜催化剂工业化应用安全性

Reconfigurable Intelligent Surfaces for 6G:Nine Fundamental Issues and One Critical Problem

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Tsinghua Science and Technology 2023年第5期28卷 929-939页

作者： Zijian Zhang Linglong dai Department of Electronic Engineering Tsinghua Universityand also with Beijing National Research Center for Information Science and Technology(BNRist)Beijing 100084China

Thanks to the recent advances in metamaterials,Reconfigurable Intelligent Surface(RIS)has emergedas a promising technology for future 6G wireless *** from its high array gain,low cost,and low power consumption,RISs are expected to greatly enlarge signal coverage,improve system capacity,andincrease energy *** this article,we systematically overview the emerging RIS technology with the focuson its key basics,nine fundamental issues,and one critical ***,we first explain the RIS basics,including its working principles,hardware structures,and potential benefits for *** on thesebasics,nine fundamental issues of RISs,such as“What’s the differences between RISs and massive MIMO?”and“Is RIS really intelligent?”,are explicitly addressed to elaborate its technical features,distinguish it from existingtechnologies,and clarify some misunderstandings in the ***,one critical problem of RISs is revealedthat,due to the“multiplicative fading”effect,existing passive RISs can hardly achieve visible performance gains inmany communication scenarios with strong direct *** address this critical problem,a potential solution calledactive RISs is introduced,and its effectiveness is demonstrated by numerical simulations.

关键词： Reconfigurable Intelligent Surface(RIS) sixth generation mobile system(6G) wireless communications

Adaptive ordering and filament polymerization of cell cytoskeleton by tunable nanoarrays

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Nano Research 2021年第3期14卷 620-627页

作者： Jing dai Yuan Yao School of Physical Science and Technology ShanghaiTech UniversityShanghai201210China

Matrix adaptation reconstructs the architecture of cell,and has important implication in proper biological ***,how the network of cytoskeleton filament undergoes reconstruction,reordering,and surface adaptation,requires a systematic ***,we show that surface sensing and adaptation occur correspondingly with related reorganization of cytoskeleton filaments(actin,tubulin,and vimentin).The microstructure of filament network is built by adaptive change of chemical polymerization on cytoskeleton *** transition of cellular morphology,from spheroidal architecture on nanoarray to extending structure with stress fibers on flat surface,involves spatial reorganization and polymerization modulation of *** dimension of filaments(diameter,orientation,and density)are changed accordingly to spatiotemporal distribution of cytoskeleton *** addition,our findings elucidate how cell can tune their architecture at nanoscale by matrix adaptation,and provide a novel information on interplay between cytoskeleton and pathophysiology.

关键词： adaptation cytoskeleton polymerization reordering