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Laparoscopic liver resections for hepatocellular carcinoma:Current role and limitations

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World Journal of Gastroenterology 2014年第17期20卷 4892-4899页

作者： Martin Gaillard Hadrien Tranchart ibrahim dagher Department of Minimally invasive Digestive Surgery Antoine Béclère HospitalAP-HPParis-Sud University92141 Clamart cedexFrance

Liver resection for hepatocellular carcinoma(HCC)is currently known to be a safer procedure than it was before because of technical advances and improvement in postoperative patient management and remains the first-line treatment for HCC in compensated *** aim of this review is to assess current indications,advantages and limits of laparoscopic surgery for HCC *** also discussed the possible evolution of this surgical approach in parallel with new technologies.

关键词： Hepatocellular carcinoma Laparoscopic liver resection Hepatectomy Minimally invasive Review Laparoscopic resection of gastrointestinal

Facial expression recognition using threestage support vector machines

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Visual Computing for industry,Biomedicine,and Art 2019年第1期2卷 236-244页

作者： issam dagher Elio Dahdah Morshed Al Shakik Computer Engineering Department University of BalamandTripoli P.O.BOX 100Lebanon

Herein,a three-stage support vector machine(SVM)for facial expression recognition is *** first stage comprises 21 SVMs,which are all the binary combinations of seven *** one expression is dominant,then the first stage will suffice;if two are dominant,then the second stage is used;and,if three are dominant,the third stage is *** multilevel stages help reduce the possibility of experiencing an error as much as *** image preprocessing stages are used to ensure that the features attained from the face detected have a meaningful and proper contribution to the classification *** expressions are created as a result of muscle movements on the *** subtle movements are detected by the histogram-oriented gradient feature,because it is sensitive to the shapes of *** features attained are then used to train the three-stage *** different validation methods were used:the leave-one-out and K-fold *** results on three databases(Japanese Female Facial Expression,Extended Cohn-Kanade Dataset,and Radboud Faces Database)show that the proposed system is competitive and has better performance compared with other works.

关键词： Facial expression recognition Support vector machine Histogram of oriented gradients Viola-Jones Validation

Prostate-specific antigen doubling time and response to cabazitaxel in a hormone-resistant metastatic prostate cancer patient

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The Journal of Biomedical Research 2015年第5期29卷 420-422页

作者： Marwan Ghosn Alain dagher Fadi El-Karak Hematology-Oncology Department Faculty of MedicineSaint-Joseph University

We report a case of metastatic castration-resistant prostate cancer, who received prior treatment with docetaxel and was then given cabazitaxel as salvage therapy. The patient was monitored by prostate-specific antigen doubling time and prostate-specific antigen absolute value. The prostate-specific antigen doubling time was found to be a good response predictor in the patient.

关键词： prostate-specific antigen doubling time prostate cancer cabazitaxel docetaxel

Janus:Toward preventing counterfeits in supply chains utilizing a multi-quorum blockchain

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Blockchain(Research and Applications) 2023年第4期4卷 75-85页

作者： Vika Crossland Connor Dellwo Golam Bashar Gaby G.dagher Computer Science Central Washington UniversityWA 98926United States Computer Science Washington State UniversityWA 99163United States Computer Science Boise State UniversityID 83725United States

The modern pharmaceutical supply chain lacks transparency and traceability,resulting in alarming rates of counterfeit products entering the *** illegitimate products cause harm to end users and wreak havoc on the supply chain itself,costing billions of dollars in profit *** this paper,in response to the Drug Supply Chain Security Act(DSCSA),we introduce Janus,a novel pharmaceutical track-and-trace system that utilizes blockchain and cloning-resistant hologram tags to prevent counterfeits from entering the pharmaceutical supply *** design a multi-quorum consensus protocol that achieves load balancing across the *** perform a security analysis to show robustness against various threats and *** implementation of Janus proves that the system is fair,scalable,and resilient.

关键词： Blockchain Pharmaceutical supply chain Consensus protocol

Comparing the demographic data and outcomes of septic shock patients presenting to teaching or non-teaching metropolitan hospitals in the United States

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World Journal of Emergency Medicine 2022年第6期13卷 433-440页

作者： Ralph Bou Chebl Nadim Kattouf Mohamad Assaf Saadeddine Haidar Gilbert Abou dagher Sarah Abdul Nabi Rana Bachir Mazen El Sayed Department of Emergency Medicine American University of BeirutBeirut 11072020Lebanon

BACKGROUND:Studies looking at the effect of hospital teaching status on septic shock related in-hospital mortality are *** aim of this study was to examine the effect of hospital teaching status on mortality in septic shock patients in the United ***:This was a retrospective observational study,using the Nationwide Emergency Department Sample Database(released in 2018).All patients with septic shock were *** sample logistic regression was performed to assess the impact of hospital teaching status on patient ***:A total of 388,552 septic shock patients were included in the *** average age was 66.93 years and 51.7%were *** of the patients presented to metropolitan teaching hospitals(68.2%)and 31.8%presented to metropolitan non-teaching *** shock patients presenting to teaching hospitals were found to have a higher percentage of medical comorbidities,were more likely to be intubated and placed on mechanical ventilation(50.5%vs.46.9%)and had a longer average length of hospital stay(12.47 d vs.10.20 d).Septic shock patients presenting to teaching hospitals had greater odds of in-hospital mortality compared to those presenting to metropolitan non-teaching hospitals(adjusted odd ratio[OR]=1.295,95%confidence interval[Ci]:1.256-1.335).CONCLUSiON:Septic shock patients presenting to metropolitan teaching hospitals had significantly higher risks of mortality than those presenting to metropolitan non-teaching *** also had higher rates of intubation and mechanical ventilation as well as longer lengths of hospital stay than those in non-teaching hospitals.

关键词： Sepsis Septic shock in-hospital mortality Hospital teaching status United States Epidemiology Outcome

Lifesaving transarterial embolization using absorbable gelatin sponge particles for massive bleeding of ruptured metastatic hepatic melanoma

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Hepatobiliary & Pancreatic Diseases international 2020年第2期19卷 194-196页

作者： Panagiotis Lainas Giorgia Amy Rodda George Rafek Maude Millereux Carmelisa Dammaro Pierre Trouiller Sophie Maitre ibrahim dagher Department of Minimally invasive Digestive Surgery Antoine-Beclere HospitalAP-HPClamart F-92140France Paris-Saclay University Orsay F-91405France Department of Radiology Antoine-Beclere HospitalAP-HPClamart F-92140France Department of intensive Care Unit Antoine-Beclere HospitalAP-HPClamart F-92140France

To the Editor:Melanoma is an aggressive malignant tumor that arises from melanocytic cells. it usually originates from the epithelial tissues of the skin, retina and anorectal canal. Melanoma is characterized by early metastases, even from thin primary tumors. The most common sites of distant metastasis are: skin, lung, brain, liver, bone and intestine. Liver involvement occurs in 14% to 20% of cases [1] , but the diagnosis is usually performed incidentally on imaging studies, since these lesions are seldom symptomatic. Rarely, metastatic hepatic melanoma can manifest as an acute condition of massive bleeding due to spontaneous rupture of one or more hepatic lesions, with disastrous outcomes for patients in most cases. in the current literature, very few cases of spontaneous rupture of metastatic hepatic melanoma have been reported, all with fatal outcomes [2–5] . indeed, when such a condition occurs, prompt management and bleeding control strategies are essential for long-term survival of these patients.

关键词： hepatic melanoma involvement

Hepatopulmonary Syndrome and Liver Transplantation:A Recent Review of the Literature

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Journal of Clinical and Translational Hepatology 2016年第1期4卷 47-53页

作者： Caglar Cosarderelioglu Arif M.Cosar Merve Gurakar Nabil N.dagher Ahmet Gurakar Johns Hopkins University School of Medicine Department of Gastroenterology/Hepatology Baltimore MD USA Virginia Commonwealth University School of Medicine Richmond VA USA Johns Hopkins University School of Medicine Department of Surgery/Liver Transplant Baltimore MD USA

A severe and common pulmonary vascular complication of liver disease is hepatopulmonary syndrome (HPS).it is a triad of liver dysfunction and/or portal hypertension,intrapulmonary vascular dilatations,and increased alveolar-arterial oxygen *** varies according to various study groups from 4%-47%.While the most common presenting symptom of HPS is dyspnea,it is usually asymptomatic,and thus all liver transplant candidates should be screened for its *** oximetry is a useful screening method,but arterial blood gas examination is the gold *** there is an abnormal P (A-a)O2 gradient,microbubble transthoracic echocardiography should be done for *** is unpredictable,and there is currently no effective medical *** only effective therapy is considered to be liver *** resolution of HPS after liver transplantation is seen within a year in most HPS patients.

关键词： Hepatopulmonary syndrome Pulmonary complications of cirrhosis Liver transplantation

The Emergency Department Crash Cart: A systematic review and suggested contents

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World Journal of Emergency Medicine 2018年第2期9卷 93-98页

作者： Gabrielle A.Jacquet Bachar Hamade Karim A.Diab Rasha Sawaya Gilbert Abou dagher Eveline Hitti Jamil D.Bayram Department of Emergency Medicine Boston University School of Medicine Center for Global Health and Development Boston University School of Public Health Department of Critical Care Medicine University of Pittsburgh Medical Center Department of Pediatrics Rush University Medical Center Department of Emergency Medicine American University of Beirut Medical Center

BACKGROUND: As the field of Emergency Medicine grows worldwide, the importance of an Emergency Department Crash Cart(EDCC) has long been recognized. Yet, there is paucity of relevant peer-reviewed literature specifically discussing EDCCs or proposing detailed features for an EDCC suitable for both adult and pediatric patients. METHODS: The authors performed a systematic review of EDCC-specific literature indexed in Pubmed and Embase on December 20, 2016. in addition, the authors reviewed the 2015 American Heart Association(AHA) guidelines for cardiopulmonary resuscitation and emergency cardiovascular care, the 2015 European Resuscitation Council(ERC) guidelines for resuscitation, and the 2013 American College of Surgeons(ACS) Advanced Trauma Life Support(ATLS) 9 th ***: There were a total of 277 results, with 192 unique results and 85 duplicates. After careful review by two independent reviewers, all but four references were excluded. None of the four included articles described comprehensive contents of equipment and medications for both the adult and pediatric populations. This article describes in detail the final four articles specific to EDCC, and proposes a set of suggested contents for the EDCC. CONCLUSiON: Our systematic review shows the striking paucity of such a high impact indispensable item in the ED. We hope that our EDCC content suggestions help enhance the level of response of EDs in the resuscitation of adult and pediatric populations, and encourage the implementation of and adherence to the latest evidence-based resuscitation guidelines.

关键词： Resuscitation Crash cart Emergency department

Current strategies to induce liver remnant hypertrophy before major liver resection

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World Journal of Hepatology 2021年第11期13卷 1629-1641页

作者： Celeste Del Basso Martin Gaillard Panagiotis Lainas Stella Zervaki Gabriel Perlemuter Pierre Chagué Laurence Rocher Cosmin Sebastian Voican ibrahim dagher Hadrien Tranchart Department of Minimally invasive Digestive Surgery Antoine Béclère HospitalClamart 92140France Department of Hepato-Gastroenterology and Nutrition Antoine Béclère HospitalClamart 92140France Department of Radiology Antoine Béclère HospitalClamart 92140France

Hepatic resection is the gold standard for patients affected by primary or metastatic liver tumors but is hampered by the risk of post-hepatectomy liver *** recent impro-vements,liver surgery still requires excellent clinical judgement in selecting patients for surgery and,above all,efficient pre-operative strategies to provide adequate future liver *** aim of this article is to review the literature on the rational,the preliminary assessment,the advantages as well as the limits of each existing technique for preparing the liver for major hepatectomy.

关键词： Liver regeneration Major hepatectomy Liver insufficiency Future liver remnant Portal vein embolization