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Defining and tracing subtypes of patient-derived xenograft models in pancreatic ductal adenocarcinoma

Cancer Communications 2024年第8期44卷 915-920页

作者： Sangyeop Hyun Youngmin Han Jae Yun Moon Young-Ah Suh Won-Gun Yun Wooil Kwon Jong-Eun Lee daeun kim Ja-Lok Ku Jin-Young Jang Daechan Park Department of Molecular Science and Technology Ajou UniversitySuwonRepublic of Korea Department of Surgery and Cancer Research Institute Seoul National University College of MedicineSeoulRepublic of Korea Molecular Science and Technology Research Center Ajou UniversitySuwonRepublic of Korea DNA Link Inc. SeoulRepublic of Korea Korean Cell Line Bank Laboratory of Cell BiologyCancer Research InstituteSeoul National University College of MedicineSeoulRepublic of Korea

Patient-derived xenograft(PDX)models have been used to explore therapeutic opportunities for pancreatic ductal adenocarcinoma(PDAC)[1].Although original tumor characteristics are altered by cancer-stromal interactions... 详细信息

关键词： adenocarcinoma ductal xenograft

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Land Response to Atmosphere at Different Resolutions in the Common Land Model over East Asia

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Advances in Atmospheric Sciences 2016年第3期33卷 391-408页

作者： daeun kim Yoon-Jin LIM Minseok KANG Minha CHO Department of Civil and Environmental Engineering Hanyang University222 Wangsimni-roSeongdong-guSeoul 04763Republic of Korea Applied Meteorological Research Division National Institute of Meteorological ResearchKorean Meteorological Administration61 Yeouidaebang-ro16-gilDongjak-guSeoul 63568Republic of Korea National Center for AgroMeteorology Bid.#36(RM.#109)Seoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea Department of Water Resources Graduate School of Water ResourcesSungkyunkwan University2066 Seobu-roJangan-guSuwonGyeonggi-do 16419Republic of Korea

Towards a better understanding of hydrological interactions between the land surface and atmosphere, land surface mod- els are routinely used to simulate hydro-meteorological fluxes. However, there is a lack of observations available for model forcing, to estimate the hydro-meteorological fluxes in East Asia. In this study, Common Land Model （CLM） was used in offline-mode during the summer monsoon period of 2006 in East Asia, with different forcings from Asiaflux, Korea Land Data Assimilation System （KLDAS）, and Global Land Data Assimilation System （GLDAS）, at point and regional scales, separately. The CLM results were compared with observations from Asiaflux sites. The estimated net radiation showed good agreement, with r = 0.99 for the point scale and 0.85 for the regional scale. The estimated sensible and latent heat fluxes using Asiaflux and KLDAS data indicated reasonable agreement, with r = 0.70. The estimated soil moisture and soil temperature showed similar patterns to observations, although the estimated water fluxes using KLDAS showed larger discrepancies than those of Asiaflux because of scale mismatch. The spatial distribution of hydro-meteorological fluxes according to KLDAS for East Asia were compared to the CLM results with GLDAS, and the GLDAS provided online. The spatial distributions of CLM with KLDAS were analogous to CLM with GLDAS, and the standalone GLDAS data. The results indicate that KLDAS is a good potential source of high spatial resolution forcing data. Therefore, the KLDAS is a promising alternative product, capable of compensating for the lack of observations and low resolution grid data for East Asia.

关键词： Common Land Model Korea Land Data Assimilation System Global Land Data Assimilation System Asi-aflux hydro-meteorological fluxes

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A Case Study of Mesoscale Convective Band(MCB) Development and Evolution along a Quasi-stationary Front

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Advances in Atmospheric Sciences 2014年第4期31卷 901-915页

作者： daeun JEONG Ki-Hong MIN Gyuwon LEE Kyung-Eak kim Climate Research Department Asia-Pacific Economic Cooperation Climate Center Center for Atmospheric Remote Sensing Kyungpook National University Department of Astronomy and Atmospheric Sciences Kyungpook National University Department of Earth Atmospheric and Planetary Sciences Purdue University

This paper presents a case study of mesoscale convective band （MCB） development along a quasi-stationary front over the Seout metropolitan *** MCB,which initiated on 1500 UTC 20 September 2010 and ended on 1400 UTC 21 September 2010,produced a total precipitation amount of 259.5 *** MCB development occurred during a period of tropopause folding in the upper level and moisture advection with a low-level *** analyses show that the evolution of the MCB can be classified into five periods：（1） the cell-forming period,when convection initiated; （2） the frontogenetic period,when the stationary front formed over the Korean peninsula; （3） the quasi-stationary period,when the convective band remained over Seoul for 3 h; （4） the mature period,when the cloud cover was largest and the precipitation rate was greater than 90 mm h-1; and （5） the dissipating period,when the MCB diminished and *** synoptic,thermodynamic,and dynamic analyses show that the MCB maintained its longevity by a tilted updraft,which headed towards a positive PV *** was concentrated under this area,where a tilted ascending southwesterly converged with a tilted ascending northeasterly,at the axis of cyclonic *** formation of the convective cell was attributed in part by tropopause folding,which enhanced the cyclonic vorticity at the surface,and by the low-level convergence of warm moist air and upperlevel *** southwesterly flow ascended in a region with high moisture content and strong relative vorticity that maintained the development of an MCB along the quasi-stationary front.

关键词： convective band quasi-stationary front potential vorticity tropopause folding heavy precipitation

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