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Extrahepatic metastasis of hepatocellular carcinoma to the paravertebral muscle:A case report

World Journal of Hepatology 2017年第22期9卷 973-978页

作者： Kazuhiro Takahashi Krishna G Putchakayala Mohamed Safwan Dean Y kim Transplant and Hepatobiliary Surgery Henry Ford HospitalDetroitMI 48202United States

Identification of extrahepatic metastases(EHM) of hepatocellular carcinoma(HCC) has been paradoxically increasing due to an increase in the survival of HCC patients. However, metastasis of HCC to the skeletal muscle tissue is extremely rare. We describe a unique case of HCC metastasizing to the paravertebral muscle. A 55-year-old man with a history of hepatitis B cirrhosis underwent partial liver resection with complete removal of HCC. Three months later, a computed tomography(CT) scan showed intrahepatic recurrence. The tumors were treated with yttrium-90 microspheres, transcatheter arterial chemoembolization, and sorafenib. Six months later, a CT scan showed an enhancing lesion of the left paravertebral muscle that on biopsy were consistent with metastatic HCC. The tumor was treated with stereotactic hypo-fractionated imageguided radiation therapy(SHFRT). A follow-up scan 3 mo post-radiotherapy revealed a stable appearance of the paravertebral muscle metastasis. Because of the progression in the intrahepatic tumors, the patient was treated with capecitabine, which was changed to dasatinib 6 mo later. The patient passed away three years after the primary surgical resection. Management of EHM poses an extreme challenge. This is the first case of HCC with EHM to the paravertebral muscle in which stability of disease was achieved using SHFRT. This case highlights the importance of early detection of hepatitis B viral infection and initiation of anti-viral therapy to decrease recurrence of HCC and prevent EHM.

关键词： Hepatocellular carcinoma Skeletal muscle Paravertebral muscle Extrahepatic metastasis Stereotactic hypo-fractionated image guided radiation therapy Hepatitis B virus

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Effect of music on colonoscopy performance: A propensity scorematched analysis

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World Journal of Gastrointestinal Endoscopy 2023年第5期15卷 397-406页

作者： eun Jeong Choi Sam Ryong Jee Sang Heon Lee Jun Sik Yoon Seung Jung Yu Jong Hyun Lee Han Byul Lee Sang Wook Yi Myeong Pyo kim Byung Cheol Chung Hong Sub Lee Department of Internal Medicine Inje University College of MedicineBusan Paik HospitalBusan 47392South Korea Department of Public Health Ajou University Graduate School of Public HealthSuwon 16499South Korea Department of Preventive Medicine and Public Health Catholic Kwandong University College of MedicineGangneung 25601South Korea

BACKGROUND Music has been used to reduce stress and improve task performance during medical *** To assess the effects of music on colonoscopy performance *** We retrospectively reviewed patients who underwent colonoscopy performed by four endoscopists with popular *** performance outcomes,such as insertion time,adenoma detection rate(ADR),and polyp detection rate(PDR),were compared between the music and non-music *** reduce selection bias,propensity score matching was *** After one-to-one propensity score matching,169 colonoscopies were selected from each *** significant differences in insertion time(4.97 vs 5.17 min,P=0.795)and ADR(39.1%vs 46.2%,P=0.226)were found between the two *** analysis showed that the insertion time(3.6 vs 3.8 min,P=0.852)and ADR(51.1%vs 44.7%,P=0.488)did not significantly differ between the two groups in ***,in trainees,PDR(46.9%vs 66.7%,P=0.016)and ADR(25.9%vs 47.6%,P=0.006)were significantly lower in the music than in the nonmusic *** The current study found that listening to music during colonoscopy did not affect procedure ***,it suggested that music may distract trainees from appropriately detecting adenomas and polyps.

关键词： Music Colonoscopy Performance Adenoma Colonic polyps Cecal insertion time

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Redesign of Clinical Practicum for End of Life Care with Integrated Perspectives

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Open Journal of Nursing 2017年第10期7卷 1172-1180页

作者： Sanghee kim Yonsei University College of Nursing & Mo Im kim Nursing Research Institute Seoul Korea

With the cycling of nursing research, theory, practice, education, and policy making, nursing knowledge has been developed and disseminated. A clinical practicum is a good way to deliver nursing knowledge. Also an area of end-of-life (EOL) care is a good field to integrate nursing knowledge with different perspectives and multiple ways of knowing. The purposes of this paper were 1) to describe nursing knowledge and EOL with an integrated view, 2) to critique the current phenomenon of the field of EOL, and 3) to propose a redesign of the clinical practicum in EOL care. An integrative review was performed as the method of the study. The results showed that the reflection of nursing knowledge from different perspectives regarding EOL may help the nursing discipline develop various nursing knowledge, practice, education, and research. However, this paper shows that recent education is more focused on empirical knowledge, problem-solving approaches with a totality paradigm, and didactic teaching-learning methods. For redesigning the clinical practicum, it is necessary to reestablish a caring relationship between nursing instructors and nursing students. In terms of the teaching-learning process, the human-becoming teaching-learning process is recommended over the nurse-becoming process.

关键词： Nursing Education Palliative Care Nursing Faculty Practice

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Effects of thickness of Al thermal spray coating for STS 304

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中国有色金属学会会刊：英文版 2009年第4期19卷 925-929页

作者： Min-Su HAN Yong-Bin WOO Seok-Cheol KO Young-Jae JEONG Seok-Ki JANG Seong-Jong kim Division of Marine Engineering Mokpo Maritime University Chungnam Regional Innovation Agency Jeonnam Techno Park

Thermal spray coating presents a sacrificial-anode cathodic protection method since differences between the potentials of materials are *** a base metal is exposed to seawater,due to defect in the thermal spray coating,the metal is protected by the sacrificial anodic characteristics of the coating layer because micro-cells formed by the base metal and the thermal spray coating act as cathodes and anodes,*** coating thickness has little effect on the surface morphology of the ***,the electrochemical properties with the increasing of coating thickness present good results.

关键词：涂层厚度热喷涂 STS 金属接触电化学性能保护方法牺牲阳极阳极涂层

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Effect of Korean red ginseng on blood pressure and nitric oxide production

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Acta Pharmacologica Sinica 2000年第12期 40-45页

作者： JEON Byeong Hwa,kim Cuk Seong,kim Hoe-Suk,PARK Jin-Bong,NAM Ki Yeul,CHANG Seok Jong Department of Physiology College of Medicine Chungnam National University Taejon Korea Department of Physiology College of Medicine Chungnam National University Taejon Korea Department of Physiology College of Medicine Chungnam National University Taejon Korea Department of Physiology College of Medicine Chungnam National University Taejon Korea Korea Ginseng & Tobacco Research Institute Taejon Korea Department of Physiology College of Medicine Seonam University Namwon Korea

AIM: To investigate the effect of crude saponin and non-saponin fraction of Korean red ginseng (KRG) on the blood pressure and nitric oxide (NO) production in the conscious rats and cultured endothelial cell line, ECV 304 cells. METHODS: Systolic blood pressure and heart rate were monitored in the conscious rats. Nitric oxide levels and the expression of nitric oxide synthase were measured by a spectrophotometric assay using Griess reagents and Western blotting, respectively. Nitric-oxide synthase activity was measured based on the conversion rate of [3H]arginine to [3H]citrulline. RESULTS: Systolic blood pressure was decreased by crude saponin (100 mg/kg, iv) of KRG in the conscious control and one-kidney, one-clip Goldblatt hypertensive (IK, 1C-GBH) rats. The hypotensive effect induced by crude saponin of KRG reached maximum at 2 - 4 min and slowly recovered after 20 min to the initial level in both groups. Crude saponin of KRG induced tachycardia in the conscious rats but induced bradycardia in the a

关键词： Korean red ginseng saponins saponin-free fraction nitric oxide hypertension antihy-pertensive

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Workshop design for enhancing the appropriateness of idea generation using analogical thinking

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International Journal of Innovation Studies 2017年第2期1卷 134-143页

作者： eunyoung kim Human Life Design Area School of Knowledge ScienceJapan Advanced Institute of Science and Technology1-1 AsahidaiNomiIshikawa 923Japan

As technologies advance and replace human labor in a variety of settings,we focus our attention on human creativity for generating new *** organizations,more than ever,recognize that they need employees who think creatively to maintain their competitive ***,there is a lack of research assessing new ideas and influential factors in generating innovative *** aim of this study is to identify the factors that influence the creation of innovative *** conducted two different types of workshops with 22 subjects and 23 subjects *** the first workshop,subjects were asked to generate new business ideas through analogical *** a result,half of the participants generated appropriate ideas,and three influential factors were determined:categorization skill,deliberation,and trial and *** second workshop was designed to facilitate participants to enhance these three *** a result,70%of the participants could generate appropriate *** identifying influential factors,this paper suggests a procedure for designing an innovationworkshop that enables the creation of appropriate ideas.

关键词： Analogical thinking Appropriateness in ideas generated Trial and error Categorization Deliberation

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Attractor landscape analysis of the cardiac signaling network reveals mechanism-based therapeutic strategies for heart failure

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Journal of Molecular Cell Biology 2018年第3期10卷 180-194页

作者： daebeom Park Ho-Sung Lee Jun Hyuk Kang Seon-Myeong kim Jeong-Ryeol Gong Kwang-Hyun Cho Laboratory for Systems Biology and Bio-inspired Engineering Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea Graduate School of Medical Science and Engineering KAIST Daejeon 34141 Republic of Korea

Apoptosis and hypertrophy of cardiomyocytes are the primary causes of heart failure （HF）, a global leading cause of death, and are regulated through the complicated intracellular signaling network, limiting the development of effective treatments due to its complexity. To identify effective therapeutic strategies for HF at a system level, we develop a large-scale comprehensive mathematical model of the cardiac signaling network by integrating all available experimental evidence. Attractor landscape analysis of the network model identifies distinct sets of control nodes that effectively suppress apoptosis and hypertrophy of cardiomyocytes under ischemic or pressure overload-induced HF, the two major types of HF. Intriguingly, our system-level analysis suggests that intervention of these control nodes may increase the efficacy of clinical drugs for HF and, of most importance, different combinations of control nodes are suggested as potentially effective candidate drug targets depending on the types of HF. Our study provides a systematic way of developing mechanism-based therapeutic strategies for HF.

关键词： heart failure mathematical modeling cardiac signaling network systems analysis disease mechanism mechanism-based therapeutic strategy systems biology

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Sensors-Based Ambient Assistant Living via E-Monitoring Technology

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Computers, Materials & Continua 2022年第12期73卷 4935-4952页

作者： Sadaf Hafeez Yazeed Yasin Ghadi Mohammed Alarfaj Tamara al Shloul Ahmad Jalal Shaharyar Kama Dong-Seong kim Department of Computer Science Air UniversityIslamabad44000Pakistan Department of Computer Science and Software Engineering Al Ain UniversityAl Ain15551UAE Department of Electrical Engineering King Faisal UniversityAl-Ahsa31982Saudi Arabia Department of Humanities and Social Science Al Ain UniversityAl Ain15551UAE Department of IT Convergence Engineering Kumoh National Institute of TechnologyGumiKorea

Independent human living systems require smart,intelligent,and sustainable online monitoring so that an individual can be assisted *** from ambient assisted living,the task of monitoring human activities plays an important role in different fields including virtual reality,surveillance security,and human interaction with *** systems have been developed in the past with the use of various wearable inertial sensors and depth cameras to capture the human *** this paper,we propose multiple methods such as random occupancy pattern,spatio temporal cloud,waypoint trajectory,Hilbert transform,Walsh Hadamard transform and bone pair descriptors to extract optimal features corresponding to different human *** features sets are then normalized using min-max normalization and optimized using the Fuzzy optimization ***,the Masi entropy classifier is applied for action recognition and *** have been performed on three challenging datasets,namely,UTDMHAD,50 Salad,and *** experimental evaluation,the proposed novel approach of recognizing human actions has achieved an accuracy rate of 90.1%with UTD-MHAD dataset,90.6%with 50 Salad dataset,and 89.5%with CMU-MMAC *** experimental results validated the proposed system.

关键词： Classification algorithm human action recognition motion sensors machine learning Masi entropy

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Long Short-Term Memory Recurrent Neural Network-Based Acoustic Model Using Connectionist Temporal Classification on a Large-Scale Training Corpus

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China Communications 2017年第9期14卷 23-31页

作者： Donghyun Lee Minkyu Lim Hosung Park Yoseb Kang Jeong-Sik Park Gil-Jin Jang Ji-Hwan kim Department of Computer Science and Engineering Sogang University Department of Information and Communication Engineering Yeungnam University School of Electronics Engineering Kyungpook National University

A Long Short-Term Memory(LSTM) Recurrent Neural Network(RNN) has driven tremendous improvements on an acoustic model based on Gaussian Mixture Model(GMM). However, these models based on a hybrid method require a forced aligned Hidden Markov Model(HMM) state sequence obtained from the GMM-based acoustic model. Therefore, it requires a long computation time for training both the GMM-based acoustic model and a deep learning-based acoustic model. In order to solve this problem, an acoustic model using CTC algorithm is proposed. CTC algorithm does not require the GMM-based acoustic model because it does not use the forced aligned HMM state sequence. However, previous works on a LSTM RNN-based acoustic model using CTC used a small-scale training corpus. In this paper, the LSTM RNN-based acoustic model using CTC is trained on a large-scale training corpus and its performance is evaluated. The implemented acoustic model has a performance of 6.18% and 15.01% in terms of Word Error Rate(WER) for clean speech and noisy speech, respectively. This is similar to a performance of the acoustic model based on the hybrid method.

关键词： acoustic model connectionisttemporal classification large-scale trainingcorpus long short-term memory recurrentneural network

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Financial development and the cost of equity capital:Evidence from China

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China Journal of Accounting Research 2015年第4期8卷 243-277页

作者： Jeong-Bon kim Mary L.Z.Ma Haiping Wang College of Business Administration City University of Hong Kong School of Administrative Studies York University

This study examines the relation between province-level financial development and the cost of equity in *** main findings are that(1)stock market development reduces the cost of equity in general,but the effect diminishes significantly in state-owned enterprises(SOEs)and firms with high growth potential or innovation intensity and(2)banking development only marginally lowers the cost of equity,but the effect is stronger in *** analysis reveals that stock market development substitutes for such institutional factors as accounting quality,law enforcement,stock market integration and the split-share structure reform in lowering the cost of *** also find that lack of banking competition and banking marketization and under-development of the non-state economy partially account for the weak effect of banking development on the cost of equity.

关键词： Financial development Cost of equity capital Law a

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