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Effect of hyperthermia on calbindin-D 28k immunoreactivity in the hippocampal formation following transient global cerebral ischemia in gerbils

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Neural Regeneration Research 2017年第9期12卷 1458-1464页

作者： Jae-Chul Lee Jeong-Hwi Cho Tae-Kyeong Lee In Hye kim Moo-Ho Won Geum-Sil Cho Bich-Na Shin In Koo Hwang Joon Ha Park Ji Hyeon Ahn Il Jun Kang Young Joo Lee Yang Hee kim Department of Neurobiology School of Medicine Kangwon National University Department of Pharmacology & Toxicology Shinpoong Pharmaceutical Co. Ltd. Department of Physiology College of Medicine Hallym University Department of Anatomy and Cell Biology College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University Department of Biomedical Science Research Institute of Bioscience and Biotechnology Hallym University Department of Food Science and Nutrition Hallym University Department of Emergency Medicine Seoul Hospital College of Medicine Sooncheonhyang University Department of Surgery School of Medicine Kangwon National University

Calbindin D-28K （CB）, a Ca2＋-binding protein, maintains Ca2＋ homeostasis and protects neurons against various insults. Hyperthermia can exacerbate brain damage produced by ischemic insults. However, little is reported about the role of CB in the brain under hyperthermic condition during ischemic insults. We inves- tigated the effects of transient global cerebral ischemia on CB immunoreactivity as well as neuronal damage in the hippocampal formation under hyperthermic condition using immunohistochemistry for neuronal nuclei （Neun） and CB, and Fluoro-Jade B histofluorescence staining in gerbils. Hyperthermia （39.5 ＋ 0.2~C） was induced for 30 minutes before and during transient ischemia. Hyperthermic ischemia resulted in neu- ronal damage/death in the pyramidal layer of CA1-3 area and in the polymorphic layer of the dentate gyrus at 1, 2, 5 days after ischemia. In addition, hyperthermic ischemia significantly decreaced CB immunoreac- tivity in damaged or dying neurons at 1, 2, 5 days after ischemia. In brief, hyperthermic condition produced more extensive and severer neuronal damage/death, and reduced CB immunoreactivity in the hippocampus following transient global cerebral ischemia. Present findings indicate that the degree of reduced CB immu- noreactivity might be related with various neuronal damage/death overtime and corresponding areas after ischemic insults.

关键词： nerve regeneration hyperthermic condition ischemia/reperfusion injury subregions of hippocampus delayed neuronal death calbindin D-28k neural regeneration

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Effect of botulinum toxin type A on the cervical sympathetic trunk in chronic relapsing inflammatory optic neuropathy

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Chinese Medical Journal 2021年第22期134卷 2771-2772页

作者： Ji Yeong kim Yong Ho Lee Young Hoon kim Department of Anesthesiology and Pain Medicine Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoulRepublic of Korea

To the Editor:Optic neuritis(ON)usually ends with one episode,but recurs in 3%to 5%of *** recurrent patients,those that emerge negative from multiple sclerosis or neuromyelitis optica(NMO)workup are diagnosed with chronic relapsing inflammatory optic neuropathy(CRION).This disease group,first named by Kidd et al,[1]refers to a clinical situation in which inflammatory optic nerve inflammation on both sides occurs repeatedly and worsens when steroids or immu-nosuppressants are *** diagnosis is important in this group because the risk of blindness is significant,and as such,treatment is focused on preserving ***,because a significant number of CRION patients suffer from ocular pain,alleviation of pain should not be overlooked.

关键词： neuropathy diagnosis inflammation

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Apalutamide for patients with metastatic castrationsensitive prostate cancer in East Asia:a subgroup analysis of the TITAN trial

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Asian Journal of Andrology 2022年第2期24卷 161-166页

作者： Byung Ha Chung Jian Huang Zhang-Qun Ye Da-Lin He Hirotsugu Uemura Gaku Arai Choung Soo kim Yuan-Yuan Zhang Yusoke Koroki SuYeon Jeong Suneel Mundle Spyros Triantos Sharon McCarthy kim N Chi Ding-Wei Ye Department of Urology Gangnam Severance HospitalYonsei University College of Medicine211 Eonju-roGangnam-guSeoul 135-271Korea Sun Yat-Sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510120China Wuhan Tongji Hospital Tongji Medical CollegeWuhan 430030China First Affiliated Hospital of Xi’an Jiaotong University Xi’an 719054China Kindai University Hospital Ōsakasayama 589-8511Japan Dokkyo Medical University Saitama Medical Center Saitama 2-1-50Japan Asian Medical Center University of UlsanSeoul 138-040Korea Janssen Medical Affairs Department Beijing 100025China Janssen Medical Affairs Department Tokyo 101-0065Japan Janssen Medical Affairs Department Seoul 140-012Korea Janssen Global Medical Affairs Department HorshamPA 08869USA Janssen Research and Development Spring HousePA 19477USA Janssen Research and Development RaritanNJ 08869USA BC Cancer and Vancouver Prostate Centre VancouverBC V5Z 1G1Canada Fudan University Shanghai Cancer Center Shanghai 200032China

Ethnicity might be associated with treatment outcomes in advanced prostate *** study aimed to evaluate the efficacy and safety of androgen deprivation therapy(ADT)combined with apalutamide in East Asians with metastatic castration-sensitive prostate cancer(mCSPC).The original phase 3 Targeted Investigational Treatment Analysis of Novel Anti-androgen(TITAN)trial was conducted at 260 sites in 23 *** subgroup analysis included patients enrolled in 62 participating centers in China,Japan,and *** progression-free survival(PFS),time to prostate-specific antigen(PSA)progression,and PSA changes from baseline were compared between groups in the East Asian *** intent-to-treat East Asian population included 111 and 110 participants in the apalutamide and placebo groups,*** 24-month radiographic PFS rates were 76.1%and 52.3%in the apalutamide and placebo groups,respectively(apalutamide vs placebo:hazard ratio[HR]=0.506;95%confidence interval[CI],0.302–0.849;P=0.009).Median time to PSA progression was more favorable with apalutamide than placebo(HR=0.210;95%CI,0.124–0.357;P<0.001).Median maximum percentages of PSA decline from baseline were 99.0%and 73.9%in the apalutamide and placebo groups,*** most common adverse event(AE)was rash in the apalutamide group,with a higher rate than that in the placebo group(37.3%vs 9.1%).The most common grade 3 or 4 AEs were rash(12[10.9%])and hypertension(12[10.9%])for *** efficacy and safety of apalutamide in the East Asian subgroup of the TITAN trial are consistent with the global results.

关键词： apalutamide East Asia metastasis prostatic neoplasm survival

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Antipoisoning catalysts for the selective oxygen reduction reaction at the interface between metal nanoparticles and the electrolyte

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Carbon Energy 2023年第7期5卷 57-69页

作者： Sourabh S.Chougule A.Anto Jeffery Sreya Roy Chowdhury Jiho Min Yunjin kim Keonwoo Ko Bathinapatla Sravani Namgee Jung Graduate School of Energy Science and Technology(GEST) Chungnam National UniversityYuseong-guDaejeonRepublic of Korea

One of the primary challenges in relation to phosphoric acid fuel cells is catalyst poisoning by phosphate anions that occurs at the interface between metal nanoparticles and the *** strong adsorption of phosphate anions on the catalyst surface limits the active sites for the oxygen reduction reaction(ORR),significantly deteriorating fuel cell ***,antipoisoning catalysts consisting of Pt-based nanoparticles encapsulated in an ultrathin carbon shell that can be used as a molecular sieve layer are rationally *** pore structure of the carbon shells is systematically regulated at the atomic level by high-temperature gas treatment,allowing O_(2) molecules to selectively react on the active sites of the metal nanoparticles through the molecular ***,the carbon shell,as a protective layer,effectively prevents metal dissolution from the catalyst during a long-term ***,the defect-controlled carbon shell leads to outstanding ORR activity and durability of the hybrid catalyst even in phosphoric acid electrolytes.

关键词： carbon shell catalyst poisoning effect molecular sieve effect oxygen reduction reaction phosphate anions phosphoric acid fuel cells

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Efficacy of hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第26期18卷 3426-3434页

作者： Yang Hyun Baek Kyoung Tae kim Sung Wook Lee Jin Sook Jeong Byeong Ho Park Kyung Jin Nam Jin Han Cho Young Hoon kim Young Hoon Roh Hyung Sik Lee Young Min Choi Sang Young Han Department of Internal Medicine Dong-A University College of MedicineBusan 602-103South Korea Department of Pathology Dong-A University College of MedicineBusan 602-103South Korea Department of Radiology Dong-A University College of MedicineBusan 602-103South Korea Department of Surgery Dong-A University College of MedicineBusan 602-103South Korea Department of Radiation Oncology Dong-A University College of MedicineBusan 602-103South Korea

AIM:To investigate the efficacy of hepatic arterial infusion chemotherapy(HAIC) using floxuridine(FUDR) in patients with advanced hepatocellular carcinoma(HCC) confined to the ***:Thirty-four patients who had advanced HCC with unresectability or unsuccessful previous therapy in the absence of extrahepatic metastasis were treated with intra-arterial FUDR chemotherapy at ourhospital between March 2005 and May *** the 34 patients,9 patients were classified as Child class C,and 18 patients had portal vein tumor thrombus(PVTT).One course of chemotherapy consisted of continuous infusion of FUDR(0.3 mg/kg during day 1-14) and dexamethasone(10 mg on day 1,4,7 and 11),and this treatment was repeated every 28 ***:Two patients(5.9%) displayed a complete response,and 12 patients(35.3%) had a partial *** tumor control rate was 61.8%.The median overall survival times were 15.3 mo,12.4 mo and 4.3 mo for the patients who were classified as Child class A,Child class B and Child class C,respectively(P = 0.0392).The progression-free survival was 12.9 mo,7.7 mo and 2.6 mo for the patients who were classified as Child class A,Child class B and Child class C,respectively(P = 0.0443).The cumulative survival differed significantly according to the Child-Pugh classification and the presence of *** addition to hepatic reserve capacity and PVTT,the extent of HCC was an independent factor in determining a poor *** most common adverse reactions to HAIC were mucositis,diarrhea and peptic ulcer disease,but most of these complications were improved by medical treatment and/or a delay of ***:The present study demonstrates that intra-arterial FUDR chemotherapy is a safe and effective treatment for advanced HCC that is recalcitrant to other therapeutic modalities,even in patients with advanced cirrhosis.

关键词： Hepatic arterial infusion chemotherapy Floxuridine Advanced hepatocellular carcinoma Child-Pugh classification Portal vein tumor thrombus

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Compensating the impurities on the Cu surface by MOFs for enhanced hydrocarbon production in the electrochemical reduction of carbon dioxide

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Journal of Energy Chemistry 2022年第3期31卷 68-73,I0003页

作者： Shin Joon Kang Jong Ho Won Hansaem Choi Woohyeong Sim Mun Kyoung kim Siraj Sultan Youngkook Kwon Hyung Mo Jeong School of Mechanical Engineering and Department of Smart Fab.Technology Sungkyunkwan University2066 Seobu-roJangan-guSuwon 16419Republic of Korea Department of Chemistry Kookmin University77 Jeongneung-roSeongbuk-guSeoul 02707Republic of Korea School of Energy and Chemical Engineering Emergent Hydrogen Technology R&D CenterUlsan National Institute of Science and Technology50 UNIST-gilUlsan 44919Republic of Korea

Copper(Cu)provides a cost-effective means of producing value-added fuels through the electrochemical reduction of carbon dioxide(CO_(2)RR).However,we observed the production of hydrocarbons via CO_(2)RR on commercial Cu films is less efficient because of the surface impurities,i.e.,*** monoxide(CO),a reaction intermediate of CO_(2)RR to hydrocarbons,binds strongly to the Fe sites and interrupts the production of hydrocarbons,resulting in an active hydrogen evolution reaction(HER).Herein,we report a method of blocking the effect of Fe impurities on the Cu surface through the preferential growth of nano-sized metal-organic frameworks(MOFs)on Fe *** zirconium(Zr)-based MOFs(UiO-66)forms a compensating layer on Cu film via the terephthalic acid(TPA)-Fe coordination bond,the Ui O-66 coated Cu film(UiO-66@Cu)presents significantly improved hydrocarbon Faradaic efficiency(FE)of 37.59%compared to 14.68%FE on commercial Cu film(99.9%purity)by suppressing *** to X-ray photoelectron spectroscopy(XPS)analysis,the UiO-66 ligand binds to entire metallic Fe site on the Cu surface,while metallic Cu is ***,UiO-66@Cu provides active sites of Cu for CO_(2)RR and leads to highly efficient and selective production of hydrocarbons.

关键词： Impurity on Cu film Zr-based MOFs Electrocatalysts CO_(2)reduction Hydrocarbon

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Computer graphics for metaverse

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Virtual Reality & Intelligent Hardware 2022年第5期4卷 I0002-I0004页

作者： Nadia Magnenat THALMANN Jinman kim George PAPAGIANNAKIS Daniel THALMANN Bin SHENG University of Geneva Switzerland The University of Sydney Australia University of Crete Greece EPFL Switzerland Shanghai Jiao Tong University China

CGI is one of the oldest international conferences in Computer Graphics in the *** is the official conference of the Computer Graphics Society(CGS),a long-standing international computer graphics *** conference has been held annually in many different countries across the world and has gained a reputation as one of the key conferences for researchers and practitioners to share their achievements and discover the latest advances in Computer Graphics.

关键词： graphics CGI Graphics

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Reevaluation of the expanded indications in undifferentiated early gastric cancer for endoscopic submucosal dissection

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World Journal of Gastroenterology 2022年第15期28卷 1548-1562页

作者： Jiyoung Yoon Seung-Yeon Yoo Young Soo Park Kee Don Choi Beom Su kim Moon-Won Yoo In Seob Lee Jeong Hwan Yook Ga Hee kim Hee Kyong Na Ji Yong Ahn Jeong Hoon Lee Kee Wook Jung Do Hoon kim Ho June Song Gin Hyug Lee Hwoon-Yong Jung Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Pathology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Surgery Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Although the criteria for the indication of endoscopic submucosal dissection(ESD)for undifferentiated early gastric cancer(UD-EGC)have been recently proposed,accumulating reports on the non-negligible rate of lymph node metastasis(LNM)after indicated ESD raise questions on the reliability of the current *** To investigate the prevalence and risk factors of LNM in UD-EGC cases meeting the expanded indication for *** We retrospectively reviewed 4780 UD-EGC cases that underwent surgical resection between January 2008 and February 2019 at Asan Medical Center,a tertiary university hospital in *** identify the risk factors of LNM of UDEGC meeting the expanded criteria for ESD,we performed a case-control study by matching the cases with LNM to those without at a ratio of 1:*** reviewed the clinical,endoscopic,and histologic features of the cases to identify features with a significant difference according to the presence of *** and multivariate logistic regression analyses were performed to estimate the odds ratios(ORs).RESULTS Of the 4780 UD-EGC cases,1240(25.9%)were identified to meet the expanded indication for *** the 1240 cases,14(1.1%)cases had *** the various clinical,endoscopic,and histopathological features that were evaluated,mixed histology(tumors consisting of 10%-90%of signet ring cells)had a marginally significant association(P=0.059)with the risk of ***,diffuse blurring of the muscularis mucosae(MM)underneath the tumorous epithelium,a previously unrecognized histologic feature,had a significant association with the absence of LNM(P=0.028).Multivariate logistic regression analysis showed that the blurring of MM was the only explanatory variable significantly associated with a reduced risk of LNM(OR:0.12,95%CI:0.02-0.95;P=0.045).CONCLUSION The risk of LNM is higher than expected when using the current expanded indication for *** evaluation could provide useful clues for reducing the

关键词： Gastric cancer Undifferentiated carcinoma Endoscopic submucosal dissection Lymph node metastasis

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作者：金·巴克 kim·Barker编剧

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Sensitive Resource and Traffic Density Risk Analysis of Marine Spill Accidents Using Automated Identification System Big Data

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Journal of Marine Science and Application 2020年第2期19卷 173-181页

作者： eunlak kim Hyungmin Cho Namgyun kim eunjin kim Jewan Ryu Heekyung Park Department of Civil and Environmental Engineering KAISTDaejeonSouth Korea

This study developed a new methodology for analyzing the risk level of marine spill accidents from two perspectives,namely,marine traffic density and sensitive *** a case study conducted in Busan,South Korea,detailed procedures of the methodology were proposed and its scalability was *** analyze the risk from a more detailed and microscopic viewpoint,vessel routes as hazard sources were delineated on the basis of automated identification system(AIS)big *** outliers and errors of AIS big data were removed using the density-based spatial clustering of applications with noise algorithm,and a marine traffic density map was evaluated by combining all of the gridded *** of marine environment was identified on the basis of the sensitive resource map constructed by the Korea Coast Guard in a similar manner to the National Oceanic and Atmospheric Administration environmental sensitivity index *** this study,aquaculture sites,water intake facilities of power plants,and beach/resort areas were selected as representative indicators for each *** vulnerability values of neighboring cells decreased according to the Euclidean distance from the resource *** resulting maps were aggregated to construct a final sensitive resource and traffic density(SRTD)risk analysis map of the Busan–Ulsan sea *** confirmed the effectiveness of SRTD risk analysis by comparing it with the actual marine spill accident *** show that all of the marine spill accidents in 2018 occurred within 2 km of high-risk cells(level 6 and above).Thus,if accident management and monitoring capabilities are concentrated on high-risk cells,which account for only 6.45%of the total study area,then it is expected that it will be possible to cope with most marine spill accidents effectively.

关键词： SRTD risk analysis AIS big data Sensitive resource Marine spill accidents Marine traffic Traffic density Marine oil spill

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