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What is the effect of Tribulus terrestris on testicular morphology and sperm production?An experimental study in the rat model

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Asian Journal of Andrology 2024年第1期26卷 67-70页

作者： Marcello Henrique Araujo Da Silva Gabriela Faria Buys-Goncalves Joao Henrique Duque Reis Estrada Francisco jose Barcellos Sampaio Diogo Benchimol de souza Urogenital Research Unit Rio de Janeiro State UniversityRio de Janeiro 20551-030RJBrazil

The objective of this study was to investigate whether treatment with Tribulus terrestris(Tt)has any impact on the testicular morphology and function in a rodent *** male rats were divided into a control group and a group receiving 100 mg kg^(-1) body weight of Tt *** 4o days of experiment,the animals were submitted to euthanasia;epididymal tail spermatozoa were collected;and spermatozoa concentration,motility,and viability were *** addition,testicles were collected and processed for histomorphometrical *** were compared using the Student's t-test and considered significant when Pdensity,seminiferous epithelium surface density,and intertubular compartment surface density were statistically similar between the ***,seminiferous epithelium height and tubular lumen surface density were augmented in animals treated with *** with Tt does not cause a major impact on testicular morphology,promoting only subtle *** difference on spermatozoa parameters was observed.

关键词： morphometry testicle Tribulus terrestris

Epidemiology and Clinical Features of Mycobacterium avium Complex Pulmonary Disease in a Brazilian Amazon Cohort

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Advances in Microbiology 2024年第6期14卷 287-302页

作者： jose Tadeu Colares Monteiro Adriana Rodrigues Barretto Ruan Seguin Azevedo Quaresma Bianca Miranda Gouveia Ismari Perini Furlaneto Victória Menezes da Costa Yan Corrêa Rodrigues Layana Rufino Ribeiro Ricardo J. de Paula souza e Guimarães Alex Brito souza Ana Roberta Fusco da Costa Karla Valéria Batista Lima Joao de Barros Barreto University Hospital Federal University of Par Belm Brazil Center for Biological and Health Sciences Ph.D. Program in Parasitic Biology in the Amazon Region (PPGBPA) State University of Par (UEPA) Belm Brazil department of Medicine Centro Universitrio do Par CESUPA Belm Brazil Bacteriology and Mycology Section Evandro Chagas Institute (SABMI/IEC) Ministry of Health Ananindeua Brazil Geoprocessing Laboratory Evandro Chagas Institute/SVSA/MS Ananineua Brazil

The incidence of Mycobacterium avium complex pulmonary disease (MACPD) has been globally increasing. The present study aims to provide a comprehensive analysis of clinical characteristics and treatment response among patients in the Amazon region of Brazil and conduct a retrospective cohort study at a prominent referral hospital in the State of Par, Brazil, from 2012 to 2020. The M. avium group represented 58.9% of cases, followed by M. intracellulare (35.7%), M. colombiense (3.6%), and M. chimaera (1.8%). The majority of patients (73.2%) were female and with an average age of 63 years. Primary clinical manifestations included persistent cough and sputum production. The Charlson comorbidity index (CCI) averaged 2.47, with 36.3% of patients having a CCI score equal to higher than 3. Notably, over 70% of patients had received treatment for pulmonary tuberculosis before initiating treatment for MAC infection. The fibrocavitary radiologic form was the most prevalent (55.4%), frequently exhibiting a bilateral distribution (53.6%). Antimicrobial susceptibility revealed a significant prevalence of MAC resistance to drugs in the therapeutic regimen. despite this, most of the patients experienced clinical improvement (50%). In conclusion, this study highlights a higher prevalence of MAC infections among middle-aged women, with a history of pulmonary tuberculosis treatment and presenting the fibrocavitary radiological form was predominant.

关键词： MACDP Nontuberculous Mycobacteria Mycobacterium avium Lung Disease

Investigation of Galactic open cluster remnants： the case of NGC 7193

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Research in Astronomy and Astrophysics 2017年第1期17卷 31-54页

作者： Mateus de souza Angelo Joao Francisco Coelho dos Santos Jr Wagner jose Barbosa Corradi Francisco Ferreira de souza Maia Andres Eduardo Piatti departamento de Fisica ICEx Universidade Federal de Minas Gerais Av. Antonio Carlos 6627 31270-901 Belo Horizonte MG Brazil Observatorio Astronomico Universidad Nacional de Cordoba Laprida 854 5000 Cordoba Argentina Consejo Nacional de Investigaciones Cientificas y Tecnicas Av. Rivadavia 1917 C1033AAJ Buenos AiresArgentina

Galactic open clusters （OCs） that survive the early gas-expulsion phase are gradually de- stroyed over time by the action of disruptive dynamical processes. Their final evolutionary stages are characterized by a poorly populated concentration of stars called an open cluster remnant （OCR）. This study is devoted to assessing the real physical nature of the OCR candidate NGC 7193. GMOS/Gemini spectroscopy of 53 stars in the inner target region were obtained to derive radial velocities and at- mospheric parameters. We also employed photometric and proper motion data. The analysis method consists of the following steps：（i） analysis of the statistical resemblance between the cluster and a set of field samples with respect to the sequences defined in color-magnitude diagrams （CMDs）; （ii） a 5-dimensional iterative exclusion routine was employed to identify outliers from kinematical and posi- tional data; （iii） isochrone fitting to thes× （J - Ks） CMD of the remaining stars and the dispersion of spectral types along empirical sequences in the （J - H） × （H - Ks） diagram were checked. A group of stars was identified for which the mean heliocentric distance is compatible with that obtained via isochrone fitting and whose metallicities are compatible with each other. Fifteen of the member stars observed spectroscopically were identified together with another 19 probable members. Our results indi- cate that NGC 7193 is a genuine OCR, of a once very populous OC, for which the following parameters were derived： d = 501±46 pc, t = 2.5±1.2 Gyr, （[Fe/H]） = -0.17±0.23 and E（B-V） = 0.05±0.05. Its luminosity and mass functions show depletion of low mass stars, confirming the OCR is in a dynam- ically evolved state.

关键词： open cluster remnants - Galactic open clusters

Integrated risk management: a Petrobras application in offshore well construction safety to minimize critical emergency disconnections

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Petroleum Science 2018年第2期15卷 421-431页

作者： Claudio Benevenuto de Campos Lima Pedro Esteves Aranha jose Francisco Tebaldi de Castro Gilson Brito Alves Lima Augusto Borella Hougaz Felipe de souza Terra Petrobras department of Production Engineering Federal Fluminense University

In order to avoid mistakes and to save a great deal of time in analysis, an innovative methodology was developed that can analyze the well operations and rig characteristics involved to define the best emergency disconnect sequence （EDS） available. A solution was developed based on the characteristics of the rigs and blowout preventers （BOPs）, and six variables were considered that directly affect the choice of EDS. All possible combinations of 64 scenarios were analyzed, and the priority of choice of the EDS was defined empirically. This paper presents an approach to EDS risk management and examples of exposure time （time without riser safety margin and shear capability） for the same well, which can be lowered from 13% to 0.1%. The impact of this reduction is related to the ability of the BOP to cut some of the heavy casings, in addition to improved availability of EDS modes. This implementation opened up many possibilities for the performance of risk exposure analysis, enabling comparison of several BOP configurations of contracted rigs and selection of the best options. This innovative approach allowed a better management of the rig schedules, prioritizing safety aspects and making it possible to allocate the fleet in a systematic way.

关键词： Well safety Safety barriers Emergency disconnect sequence (EDS) Well control Kick Well design

Liver transplant in patients with primary sclerosing cholangitis:A retrospective cohort from Northeastern Brazil

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世界肝病学杂志:英文版(电子版) 2023年第9期15卷 1033-1042页

作者： Louyse Teixeira de souza Freitas Elodie Bomfim Hyppolito Victor Leonardo Barreto Luiz Humberto JataíCastelo Júnior Bianca Carneiro de Melo Jorge Frederico César Tahim de Sousa Brasil Háteras Malthus Barbosa Marzola Clébia Azevedo Lima Raquel Mendes Celedonio Gustavo Rêgo Coelho jose Huygens Parente Garcia Liver Transplant department Walter Cantídio Teaching HospitalFortaleza 60430270CearáBrazil School of Medicine University of FortalezaFortaleza 60811905CearáBrazil Hospital São José CearáState Health DepartmentFortaleza 60455610CearáBrazil department of Surgery Federal University of CearáFortaleza 60430140CearáBrazil Surgery department São Carlos HospitalFortaleza 60130241CearáBrazil

BACKGROUND Primary sclerosing cholangitis(PSC)manifests within a broad ethnic and racial spectrum,reflecting different levels of access to health *** To evaluate the clinical profile,complications and survival rates of patients with PSC undergoing liver transplantation(LTx)at a Brazilian reference *** All patients diagnosed with PSC before or after LTx were *** medical records were reviewed for demographic and clinical variables,including outcomes and *** level of statistical significance was set at Pdel for end-stage liver *** were significantly higher in *** bowel research(IBD)was investigated by colonoscopy in 26/34(76%)and was present in most cases(18/26;69%).IBD was less common in women than in men(44.4%vs.55.6%)(P=0.692).Cholangiocarcinoma(CCA)was diagnosed in 2/34(5.9%)patients by histopathology of the explant(survival:3 years 6 mo,and 4 years 11 mo).Two patients had complications requiring a second LTx(one after 7 d due to hepatic artery thrombosis and one after 17 d due to primary graft dysfunction).Five patients(14.7%)developed biliary *** overall median post-LTx survival was 66 *** deaths occurred in the first year(infection n=2,primary liver graft dysfunction n=3,unknown cause n=1).The 1-year and 5-year survival rates of this cohort were 82.3%and 70.6%,respectively,matching the mean overall survival rates of LTx patients at our center(87.1%and 69.43%,respectively)(P=0.83).CONCLUSION Survival after 1 and 5 years was simil

关键词： Primary sclerosing cholangitis Epidemiology Liver transplantation Survivor Clinical associations Pathological features

CFD predictions for hazardous area classification

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Chinese Journal of Chemical Engineering 2019年第1期27卷 21-31页

作者： Andrey Oliveira de souza Aurélio Moreira Luiz Ant?nio Tavernard Pereira Neto Ant?nio Carlos Brandao de Araujo Heleno Bispo da Silva Sidinei Kebler da Silva jose Jailson Nicacio Alves Federal Institute of Education Science and Technology of Paraiba Petrobras-Petróleo Brasileiro S.A. Federal University of Campina Grande

This study aimed to describe a Computational Fluid Dynamics(CFD) procedure using the ANSYS CFX software 16.1 and design of Experiments for the determination of volume and extension of explosive atmospheres due to fugitive emissions of flammable *** multidimensional statistical sampling technique Latin Hypercube was used, which defined 100 simulations of random methane gas leak *** CFD model proved to be robust in predicting the extension and volume of the explosive atmosphere for orifice diameters from 0.1 to2.5 mm, pressure from 0.1 MPa to 12 MPa and temperatures from 0 ℃ to 400 ℃.It was found that the calculation domain must be parameterized 8 m in length for each millimeter of the diameter of the source of release to ensure the *** order not to lose precision for very small diameters, the mesh was parameterized with 50 elements along the orifice *** was proved that gravity does not influence the extension and volume of the explosive atmosphere at sonic *** deviation from the ideal gas behavior in the reservoir,achieved by applying the Soave–Redlich–Kwong equation of state, also has not significantly influenced the extension and volume of the explosive *** results showed that the size of the explosive atmosphere varies directly with the diameter of the source emission and reservoir pressure, and inversely with the temperature of the *** diameter of the source is the parameter that has the major effect on the extension of the explosive atmosphere, followed by the pressure and lastly the temperature of the reservoir.

关键词： Computational Fluid Dynamics Computer simulation Safety Fugitive emissions Classified area Flammable gas cloud

Clinical and environmental isolates of Burkholderia pseudomallei from Brazil: Genotyping and detection of virulence gene

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Asian Pacific Journal of Tropical Medicine 2017年第10期10卷 945-951页

作者： Tereza de Jesus Pinheiro Gomes Bandeira debora de souza Collares Maia Castelo-Branco Marcos Fabio Gadelha Rocha Rossana de Aguiar Cordeiro Crister jose Ocadaque Manoel de Araújo Neto Paiva Raimunda Samia Nogueira Brilhante jose Júlio Costa Sidrim Specialized Medical Mycology Center Postgraduate Program in Medical Microbiology Federal University of Ceará Christus School of Medicine Postgraduate Program in Veterinary Sciences State University of Ceará Federal Institute of Education Science and Technology of Ceará

Objective: To evaluate the genetic diversity of clinical and environmental isolates of Burkholderia pseudomallei(***) recovered in Ceara, Brazil, and screen these isolates for the presence of type three secretion system virulence ***: Nineteen *** isolates(9 from clinical cases and 10 from soils)were *** amplified polymorphic DNA was performed with primers OPQ-2, OPQ-4 and OPQ-16 to evaluate the genetic diversity, and type three secretion system gene was detected through polymerase chain ***: Random amplified polymorphic DNA showed a genetic relatedness of approximately 50% among the tested *** isolates, which were grouped into two clades, of which the biggest ones comprised 18/19 isolates for primer OPQ-2, and 17/19 isolates for primer *** OPQ-4 grouped the isolates into three clades comprising 1/19, 3/19 and 15/19 ***, type three secretion system gene was detected in all tested ***: This is an effort to type *** strains from Ceara, which is important for better understanding this pathogen, contributing for the epidemiological surveillance of melioidosis in this endemic region.

关键词： Burkholderia pseudomallei Melioidosis RAPD TTSS 基因

Nanocellulose-based porous materials: Regulation and pathway to commercialization in regenerative medicine

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Bioactive Materials 2023年第11期29卷 151-176页

作者： Filipe V.Ferreira Alana G.souza Rubina Ajdary Lucas P.de souza Jo˜ao H.Lopes Daniel S.Correa Gilberto Siqueira Hernane S.Barud derval dos S.Rosa Luiz H.C.Mattoso Orlando J.Rojas Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa Instrumentation-Rua XV de Novembro1452S˜ao CarlosSP13560-979Brazil Center for Engineering Modelingand Applied Social Sciences(CECS)Federal University of ABC(UFABC)Santo Andr´eBrazil department of Bioproducts and Biosystems School of Chemical EngineeringAalto UniversityP.O.Box 16300AaltoEspooFIN-00076Finland College of Engineering and Physical Sciences Aston Institute of Materials ResearchAston UniversityBirminghamUK department of Chemistry Division of Fundamental Sciences(IEF)Technological Institute of Aeronautics(ITA)S˜ao Jose dos CamposSPBrazil Laboratory for Cellulose&Wood Materials Empa-Swiss Federal Laboratories for Materials Science and TechnologyÜberlandstrasse 1298600DübendorfSwitzerland Biopolymers and Biomaterials Laboratory(BIOPOLMAT) University of Araraquara(UNIARA)Araraquar114801-340S˜ao PauloBrazil Bioproducts Institute Department of Chemical&Biological EngineeringDepartment of Chemistry andDepartment of Wood ScienceThe University of British Columbi12360 East MallVancouverBCV6T 1Z3Canada

We review the recent progress that have led to the development of porous materials based on cellulose nanostructures found in plants and other resources. In light of the properties that emerge from the chemistry, shape and structural control, we discuss some of the most promising uses of a plant-based material, nanocellulose, in regenerative medicine. Following a brief discussion about the fundamental aspects of self-assembly of nanocellulose precursors, we review the key strategies needed for material synthesis and to adjust the architecture of the materials (using three-dimensional printing, freeze-casted porous materials, and electrospinning) according to their uses in tissue engineering, artificial organs, controlled drug delivery and wound healing systems, among others. For this purpose, we map the structure-property-function relationships of nanocellulose-based porous materials and examine the course of actions that are required to translate innovation from the laboratory to industry. Such efforts require attention to regulatory aspects and market pull. Finally, the key challenges and opportunities in this nascent field are critically reviewed.

关键词： Cellulose nanofibrils Cellulose nanocrystals Regenerative medicine Biomaterial Sustainable materials Green nanomaterials

177Hf as a Competitor in the Synthesis of 177Lu-DOTAtate

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Journal of Chemistry and Chemical Engineering 2016年第5期10卷 238-240页

作者： jose de souza Caldeira Filho Centro de Tecnologia das Radiacoes. Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN/SP. Av.