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Breather Interaction Properties Induced by Self-Steepening and Space-Time Correction

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Chinese Physics Letters 2020年第4期37卷 9-13页

作者： Yu-Han Wu Chong Liu zhan-Ying Yang Wen-Li Yang School of Physics Northwest UniversityXi'an 710127 Shaanxi Key Laboratory for Theoretical Physics Frontiers Xi'an 710127 NSFC-SPTP Peng Huanwu Center for Fundamental Theory Xi'an 710127 Institute of Modern Physics Northwest UniversityXi7an 710127

We study the properties of breather interactions in nonlinear Kerr media with self-steepening and space-time correction and with either self-focusing or self-defocusing nonlinearity,and present a new family of exact breather solutions via the darboux transformation with a special-designed quadratic spectral *** contrast to the previous results of the nonlinear Schrodinger equation(NLSE)hierarchy,we show that the relative phase of colliding breathers has a significant effect on the collision *** particular,only the out-of-phase interactions can generate small amplitude waves at the collision center,which are analogous to the NLSE superregular *** results will deepen our understanding of the properties of breather interactions and they will offer the possibility of experimental observations of super-regular breather dynamics in systems with self-steepening and space-time correction.

关键词： parameter. collision nonlinear

Deregulated expression and subcellular localization of CPSF6,a circRNA-binding protein,promote malignant development of esophageal squamous cell carcinoma

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Chinese Journal of Cancer Research 2022年第1期34卷 11-27页

作者： Shichao Guo Guangchao Wang Zitong Zhao dan Li Yongmei Song Qimin zhan State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital&InstituteBeijing 100142China

Objective:Cleavage and polyadenylation specific factor 6(CPSF6)has been documented as an oncoprotein in different types of ***,functions of CPSF6 have not been investigated yet in esophageal squamous cell carcinoma(ESCC).Here,we aimed to investigate the potential clinical values and biological functions of CPSF6 in ***:For determining the expression level of CPSF6 in ESCC patients,we analyzed published data,performed quantitative real-time polymerase chain reaction(RT-qPCR)and immunohistochemistry ***-Meier curves and log-rank tests were used for survival *** and KEGG analyses were done for CPSF6-related *** proliferation,colony formation and xenograft assays were conducted to verify the effects of CPSF6 on *** addition,cell cycle and apoptosis assays were also performed to manifest the functions of CPSF6 and *** pulldown and radioimmunoprecipitation(RIP)assays were used for confirming the interaction between circCPSF6(hsa_circ_0000417)and CPSF6 *** regulatory relationship between CPSF6 protein and circCPSF6 was determined by ***:We found that CPSF6 was upregulated in ESCC tissues and overexpression of cytoplasmic CPSF6 was associated with poor *** and KEGG analyses suggested that CPSF6 could mainly affect cell division in *** experiments manifested that CPSF6 promoted cell proliferation and colony formation in *** assay showed that knockdown of CPSF6 significantly decreased tumor growth rate in ***,we verified that depletion of CPSF6 led to cell cycle arrest and ***,we validated that CPSF6,as a circRNA-binding protein,interacted with and regulated its circular isoform circCPSF6(hsa_circ_0000417),of which depletion also resulted in cell cycle arrest and cell apoptosis in ***:These findings gave us insight that overexpression of cytoplasmic CPSF6 protein is associated with poor prognosis in ESCC and CPSF6 may function a

关键词： CPSF6 esophageal squamous cell carcinoma prognosis cell proliferation circRNA-binding protein circCPSF6

Pollen Extract of Populus deltoides Stimulates Lung Inflammation in a Mouse Model

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Biomedical and Environmental Sciences 2022年第2期35卷 161-164页

作者： GUO Wei JIANG Yu Xin zhan Xiao Dong JIANG Feng XI Yi Long School of Ecology and Environment Anhui Normal UniversityWuhu 241002AnhuiChina School of Basic Medicine Wannan Medical CollegeWuhu 241002AnhuiChina Department of Pathogenic Biology and Immunology Jiaxing University College of MedicineJiaxing 314001ZhejiangChina

Allergic asthma is an inflammatory disease of the airways characterized by recurrent episodes of wheezing,bronchoconstriction,and airway hyperresponsiveness(AHR)[1].In recent years,allergic asthma has become a heated public health problem because of the highly increased incidence and prevalence[2].The main pathogenesis of asthma is airway inflammation and *** is caused by an imbalance of Th1/Th2 cells with predominance to Th2,whereas airway inflammation is caused by increased levels of Th2 cytokine[3].Major effects of pathological changes in the respiratory include eosinophil infiltration,bronchial epithelial cell damage,obstruction of the mucus plug,and thickening of the submucosal muscle layer[4,5].

关键词： Th1/Th2 Th2 inflammation

Features and influencing mechanisms of gaseous elemental mercury over the equatorial Pacific and their differences with the Southern Ocean

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Advances in Polar Science 2022年第1期33卷 86-101页

作者： WANG Jiancheng YUE Fange zhan Haicong KANG Hui XIE Zhouqing Institute of Polar Environment&Anhui Key Laboratory of Polar Environment and Global Change Department of Environmental Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China Center for Excellence in Urban Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China

Due to the harmful impacts on the ecosystem and even human health,mercury(Hg)compounds in the environment deserve serious *** mobilization and exchange at the air-sea interface are important processes in biogeochemical cycling of *** on the 30th(2013/2014),31st(2014/2015),and 33rd(2016/2017)Chinese National Antarctic Research Expedition aboard R/V Xuelong,we found significant rising gaseous elemental mercury(GEM)concentrations over the equatorial Central Indo-Pacific *** the contribution of anthropogenic,volcanic and biomass burning emissions,the enhanced GEM in marine boundary layer was likely due to the combined actions of two driving factors drove by the Inter-Tropical Conversion Zone(ITCZ):(1)intense wet deposition of Hg,followed by subsequent rapid photoreduction and vast evasion from the surface sea;and(2)the regional low-level convergence of airflow that caused the mass accumulation of GEM in *** addition,apparently higher GEM concentration level in the equatorial Central Indo-Pacific than in the Southern Ocean was observed in one *** investigation suggests that apart from the ITCZ corresponded mechanisms,the effects of spatial differences in anthropogenic emissions and more significant GEM oxidation in Antarctic sea should play roles in this phenomenon.

关键词： mercury equatorial seas Southern Ocean rainfall air-sea exchange low-level convergence

Expression and prognosis of inducible T-cell co-stimulator and its ligand in Chinese stage I–III lung adenocarcinoma patients

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Animal Models and Experimental Medicine 2023年第5期6卷 464-473页

作者： Xiao-Kai zhan Xi-Kun Liu Sen zhang Hong Chen Division of Oncology and Hematology Beijing Chao-Yang HospitalCapital Medical UniversityBeijingP.R.China State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Pathology Department Beijing Chao-Yang HospitalCapital Medical UniversityBeijingP.R.China

Background:Immunotherapy has become the fastest-adopting treatment paradigm for lung cancer with improved *** binding with its ligand(inducible T-cell costimulator and its ligand[ICOSL]),an inducible T-cell co-stimulator(ICOS)could contribute to reversing immunosuppression and improving immune response and thus be a potential target for cancer ***:We selected 54 formalin-fixed,paraffin-embedded tumor tissues from cases with stage I–III lung adenocarcinoma *** expression of ICOS and ICOSL was *** correlation with clinical parameters in Chinese patients was also compared with TCGA ***:The positive rates of ICOS and ICOSL were 68%and 81.5%,respectively,in lung tumor *** these,9 cases had a low expression of ICOS,and 22 cases had a high expression of ICOS;ICOSL expression was low in 20 cases and high in 24 *** to the International Association for the Study of Lung Cancer(8th edition),phase I lesions were detected in 21 cases,phase II lesions in 15 cases,and phase III lesions in 18 *** median survival time of all patients was 44.5 months,and the median disease-free survival was 32 *** analysis showed that the factors significantly associated with overall survival were tumor size,regional lymph node involvement,stage,and expression level of ICOS/*** analysis using log-rank test indicated that the lower ICOS+cell infiltration may predict poor prognosis,whereas lower ICOSL protein expression may be associated with better prognosis,but ICOSL data need further validation in larger samples due to inconsistency in TCGA mRNA ***:ICOS/ICOSL might be associated with prognosis of lung cancer,and ICOS and its ligand may be potential therapeutic targets in non-small cell lung cancer.

关键词： Chinese patients ICOS ICOSL lung adenocarcinoma prognostic factor

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飞机实验室动态运行下的飞机性能验证技术

环境技术 2024年第2期42卷 83-89页

作者：张惠吴敬涛田培强任战鹏中国飞机强度研究所强度与结构完整性全国重点实验室西安710065

气候环境适应性是飞机的重要质量特性之一,实验室飞机气候环境实验是验证飞机气候环境适应性的重要手段。在飞机的试飞或取证进程中,需要考核发动机及其交联系统(如APU、气源系统、燃油系统等)之间的匹配性,验证飞机整机对复杂气候环境... 详细信息

气候环境适应性是飞机的重要质量特性之一,实验室飞机气候环境实验是验证飞机气候环境适应性的重要手段。在飞机的试飞或取证进程中,需要考核发动机及其交联系统(如APU、气源系统、燃油系统等)之间的匹配性,验证飞机整机对复杂气候环境的适应性。构建动力系统与飞机其他系统间的交联矩阵,在气候环境实验室实现发动机运行状态下的飞机系统成功验证。以实验验证案例为基础,分析复杂气候环境下发动机启动中的飞机主要系统运行特性,为后续飞机的故障定位、诊断和分析提供依据。

关键词：发动机 APU 环境适应性动态运行气候响应

Exosomal miRNA in early-stage hepatocellular carcinoma

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World Journal of Clinical Cases 2023年第3期11卷 528-533页

作者： Zhi-Qiang Wu Yi-Xin Zhu Yun Jin Yin-Chu zhan Department of Surgery The Second People's Hosptal of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Surgery The Second Affiliated HospitalZhejiang UniversitySchool of MedicineHangzhou 310009Zhejiang ProvinceChina

The incidence and mortality of hepatic carcinoma(HCC)remain high,and early diagnosis of HCC is seen as a key approach in improving clinical ***,the sensitivity and specificity of current early screening methods for HCC are not *** recent years,research around exosomal miRNA has gradually increased,and these molecules have emerged as attractive candidates for early diagnosis and treatment of *** review summarizes the feasibility of using miRNAs in peripheral blood exosomes as early diagnostic tools for HCC.

关键词： Hepatic carcinoma Early diagnosis Exosomal miRNA Biomarker

肾下型腹主动脉瘤瘤体最大径与患者年龄比值对不同手术方法远期效果的影响

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中华外科杂志 2024年第6期62卷 598-605页

作者：林任占松彪钱结胜贺海朋招扬吕俊兵彭嘉欣张义博陈惠宁殷恒讳中山大学附属第三医院血管外科广州510630

目的探讨瘤体最大径与患者年龄的比值(R)对肾下型腹主动脉瘤(IAAA)患者接受血管腔内修复术(EVAR)与开放手术修复(OSR)远期疗效的影响。方法本研究为回顾性队列研究。回顾性收集2016年1月至2022年10月于中山大学附属第三医院血管外科接... 详细信息

目的探讨瘤体最大径与患者年龄的比值(R)对肾下型腹主动脉瘤(IAAA)患者接受血管腔内修复术(EVAR)与开放手术修复(OSR)远期疗效的影响。方法本研究为回顾性队列研究。回顾性收集2016年1月至2022年10月于中山大学附属第三医院血管外科接受手术治疗的317例IAAA患者的临床资料。男性266例,女性51例,年龄(69.7±8.3)岁(范围:37~87岁)。计算所有患者的R值,并利用受试者工作特征(ROC)曲线建立模型,计算最佳截断值。根据手术方式不同将患者分为EVAR组和OSR组。采用倾向性评分匹配法对EVAR组和OSR组患者的基线资料进行3∶1匹配(卡钳值为0.05),并根据R的截断值对患者进行分层,分析患者术后疗效及生存情况。主要研究终点为全因病死率,次要研究终点包括术后并发症发生率及再干预率。分类变量的组间比较采用χ^(2)检验或Fisher确切概率法,定量资料的比较采用独立样本t检验或Wilcoxon秩和检验;生存曲线使用Kaplan-Meier法描述,生存差异的比较采用Log-rank检验。结果倾向性评分匹配后EVAR组198例,OSR组66例。ROC曲线建立模型得出R值的最佳截断值为0.90,将两组病例分为R<0.90、R≥0.90两层。其中R<0.90的患者112例(EVAR 84例,OSR 28例);R≥0.90的患者152例(EVAR 114例,OSR 38例);随访时间为(23.6±1.6)个月(范围:1~70个月)。在R≥0.90分层中,EVAR组在全因病死率(26.3%比5.3%,χ^(2)=7.600,P=0.006)、并发症发生率(44.7%比26.3%,χ^(2)=4.025,P=0.045)、二次干预率(31.6%比13.2%,χ^(2)=4.910,P=0.027)均高于OSR组。而在R<0.90分层中,两组全因病死率(13.1%比10.7%,χ^(2)=0.109,P=0.741)、并发症发生率(28.6%比35.7%,χ^(2)=0.507,P=0.477)及二次干预率(14.3%比21.4%,χ^(2)=0.353,P=0.552)的差异无统计学意义。结论对于R≥0.90的IAAA患者,OSR的术后生存率、并发症发生率和二次干预率较EVAR可能更优;对于R<0.90的IAAA患者,两种手术方式的生存率、并发症发生率和二次干预率未见差异。

关键词：主动脉瘤,腹治疗结果肾下型腹主动脉瘤开放手术修复血管腔内修复术年龄瘤体最大径

In Situ Formation of LiF-Rich Carbon Interphase on Silicon Particles for Cycle-Stable Battery Anodes

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Transactions of Tianjin University 2023年第2期29卷 101-109页

作者： Yang Ni Shuibin Tu Renmin zhan Zhao Cai Xiaohong Wang Yongming Sun Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China China-EU Institute for Clean and Renewable Energy Huazhong University of Science and TechnologyWuhan 430074China State Key Laboratory of Material Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China Faculty of Materials Science and Chemistry China University of Geosciences(Wuhan)Wuhan 430074China

Silicon(Si)is a potential high-capacity anode material for the next-generation lithium-ion battery with high energy ***,Si anodes suff er from severe interfacial chemistry issues,such as side reactions at the electrode/electrolyte interface,leading to poor electrochemical cycling ***,we demonstrate the fabrication of a conformal fl uorine-containing carbon(FC)layer on Si particles(Si-FC)and its in situ electrochemical conversion into a LiF-rich carbon layer above 1.5 V(***^(+)/Li).The as-formed LiF-rich carbon layer not only isolates the active Si and electrolytes,leading to the suppression of side reactions,but also induces the formation of a robust solid-electrolyte interface(SEI),leading to the stable interfacial chemistry of as-designed Si-FC *** Si-FC electrode has a high initial Coulombic effi ciency(CE)of 84.8%and a high reversible capacity of 1450 mAh/g at 0.4 C(1000 mA/g)for 300 *** addition,a hybrid electrode consisting of 85 wt%graphite and 15 wt%Si-FC,and mass 2.3 mg/cm^(2) loading delivers a high areal capacity of 2.0 mAh/cm^(2) and a high-capacity retention of 93.2%after 100 cycles,showing the prospects for practical use.

关键词： Lithium-ion batteries Silicon anode LiF-rich carbon interphase Capacity Cycling stability