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Hippocampal insulin resistance and the Sirtuin 1 signaling pathway in diabetes-induced cognitive dysfunction

Neural Regeneration Research 2021年第12期16卷 2465-2474页

作者： Hui Yang Lin Tang zhan Qu Shi-Hui Lei Wei Li Yu-Hong Wang The First Hospital of Hunan University of Chinese Medicine ChangshaHunan ProvinceChina Science and Technology Innovation Center Hunan University of Chinese MedicineChangshaHunan ProvinceChina School of Nursing Health Science CenterXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina

In the peripheral nervous system,the activation of Sirtuin 1 can improve insulin resistance;however,the role played by Sirtuin 1 in the central nervous system remains *** this study,rat models of diabetes mellitus were generated by a single injection of *** 8 weeks after streptozotocin injection,the Morris water maze test and western blot assays confirmed that the diabetic model rats had learning and memory deficits,insulin resistance,and Sirtuin 1 expression could be detected in the *** and the insulin receptor inhibitor S961 were intranasally administered to investigate the regulatory effects of insulin signaling on Sirtuin *** results showed that insulin administration improved the impaired cognitive function of diabetic model rats and increased the expression levels of phosphorylated insulin receptor,phosphorylated insulin receptor substrate 1,and Sirtuin 1 in the ***,S961 administration resulted in more severe cognitive dysfunction and reduced the expression levels of phosphorylated insulin receptor,phosphorylated insulin receptor substrate 1,and Sirtuin *** Sirtuin 1 activator SRT2104 and the inhibitor Sirtinol were injected into the lateral ventricle,which revealed that the activation of Sirtuin 1 increased the expression levels of target of rapamycin complex 1,phosphorylated cAMP-response elementbinding protein,and brain-derived neurotrophic *** dendritic length and spine density also increased in response to Sirtuin 1 *** contrast,Sirtinol decreased the expression levels of target of rapamycin complex 1,phosphorylated cAMP-response elementbinding protein,and brain-derived neurotrophic factor and damaged the dendritic *** findings suggest that the Sirtuin 1 signaling pathway plays an important role in the development of insulin resistance-related cognitive deficits in diabetic *** study was approved by the Animal Ethics Welfare Committee of the First Affili

关键词： brain-derived neurotrophic factor cognitive function dendritic structure diabetes hippocampus insulin resistance Sirtuin 1 target of rapamycin complex 1

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Incorporation of nano/micron-SiC particles in Ni-based composite coatings towards enhanced mechanical and anti-corrosion properties

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International Journal of Minerals,Metallurgy and Materials 2022年第1期29卷 153-160页

作者： Bowei zhang Qiao zhang zhan zhang Kui Xiao Qiong Yao Guojia Ma Gang Sun Junsheng Wu Institute for advanced materials and technology University of Science and Technology BeijingBeijing 100083China National Materials Corrosion and Protection data Center University of Science and Technology BeijingBeijing 100083China Key Laboratory of Space Lauching Site Reliability Technology Haikou 571000China Department of Materials Application Research China Aviation Manufacturing Technology InstituteBeijing 100024China

Ni-based composite coatings incorporated with nano/micron SiC particles were fabricated via electrochemical co-deposition in Watts bath,followed by the evaluation of their mechanical and anti-corrosion *** micrographic observations suggest that the SiC particles with various sizes can be well incorporated to the Ni substrate.X-ray diffraction(XRD)patterns indicate that SiC particles with smaller sizes could weaken the preferential growth of Ni along(200)*** addition,it is found that the incorporated SiC particles with medium micron sizes(8 and 1.5μm)could significantly enhance the micro-hardness of the Ni composite ***,electrochemical measurements demonstrate that micron-sized SiC particles would weaken the corrosion resistance of Ni composite coatings ascribed to the structure defects *** contrast,the combined incorporation of nanosized(50 nm)SiC particles with medium micron(1.5μm)ones is capable of promoting the compactness of the composite coatings,which is beneficial to the long-term corrosion resistance with negligible micro-hardness loss.

关键词： Watts bath Ni coating SiC particles corrosion resistance electrodeposition

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松嫩平原齐齐哈尔地区拜泉县地表基质特征及其古环境恢复

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地质通报 2024年第9期43卷 1498-1514页

作者：邵兴坤侯红星任柄璋时凌峰詹泽东西广越李俊华曹龙宇高远中国地质调查局廊坊自然资源综合调查中心河北廊坊065000

地表基质是自然资源管理的全新概念,是支撑孕育各类自然资源的基础物质。加强地表基质沉积环境分析和古环境恢复对研究其形成机制具有重要意义。通过对松嫩平原拜泉地区50 m以浅地表基质沉积特征和沉积环境剖析,并结合全芯粘土矿物、碳... 详细信息

地表基质是自然资源管理的全新概念,是支撑孕育各类自然资源的基础物质。加强地表基质沉积环境分析和古环境恢复对研究其形成机制具有重要意义。通过对松嫩平原拜泉地区50 m以浅地表基质沉积特征和沉积环境剖析,并结合全芯粘土矿物、碳酸盐、磁化率、碳元素数据分析,认为研究区垂向上分布了16层土质基质,由深至浅呈现湖相沉积→陆域风成相→草甸相过渡沉积演化特点,深层湖相沉积具有滨湖相沉积、堤岸相沉积、滨湖相多旋回沉积特点;其中深层滨湖相和堤岸相沉积物形成于寒冷极干燥环境,中深层湖相沉积物形成于温暖湿润环境,浅表层草甸相和风成相沉积物形成于较干冷环境。综合前人资料和^(14)C、光释光、ESR测年结果,将研究区沉积演化阶段划分为早更新世晚期—中更新世早期干冷沉积阶段、中更新世中晚期温暖的湖相沉积阶段、晚更新世—早全新世风成黄土沉积阶段、中晚全新世以来黑土沉积阶段。

关键词：松嫩平原地表基质拜泉地区沉积环境古环境恢复

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Light scattering based analyses of the effects of bovine serum proteins on interactions of magnetite spherical particles with cells

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Chinese Chemical Letters 2018年第8期29卷 1291-1295页

作者： Lingling Guo Ting Wang zhan Chen Nongyue He Yaozhong Chen Tao Yuan State Key Laboratory of Bioelectronics National Demonstration Center for Experimental Biomedical Engineering Education School of Biological Science and Medical Engineering Southeast University Department of Chemistry University of Michigan Department of Orthopedic NanjingJinling Hospital

Information concerns endocytosis and autophagic effects of magnetite particles is crucial for understanding the particle-cell interactions. In this work, we investigated the effects of bovine serum proteins on the endocytosis of magnetite spherical particles（MSPs）. Autophagic effects of MSPs in breast cancer cells were studied. Light scattering based flow cytometry and microscopy were used for evaluating the uptake potential of MSPs by cells and the cellular autophagosome accumulation. Results showed bovine serum proteins significantly reduced the endocytosis of MSPs by decreasing their adsorption to cell membranes. Additionally, serum proteins had influences on the endocytic mechanisms of *** accumulation could be caused by the internalized MSPs rather than the particles associated with cell membrane. Above fundamental findings promote our understandings upon the interactions of MSPs with cells. Light scattering based methods were proved to be simple and *** present work may promote their application in studies upon endocytosis of metallic particles in the future.

关键词： Light scattering Endocytosis Autophagic effects Autophagosome Magnetite spherical particles

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ALKALINE PRETREATMENT AND AIR MIXING FOR IMPROVEMENT OF METHANE PRODUCTION FROM ANAEROBIC CO-DIGESTION OF POULTRY LITTER WITH WHEAT STRAW

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Frontiers of Agricultural Science and Engineering 2023年第3期10卷 424-436页

作者： Yuanhang zhan Jun ZHU Yiting XIAO Leland C.SCHRADER Department of Biological and Agricultural Engineering University of ArkansasFayettevilleAR 72701USA

Alkaline pretreatment(AL)and air mixing(air)both have the potential to improve anaerobic co-digestion(Co-AD)of poultry litter with wheat straw for methane *** this study,the effects of the combination of AL(pH 12 for 12 h)and air mixing(12 mL·d^(−1))on the Co-AD process were *** substrate hydrolysis was enhanced by AL,with soluble chemical oxygen demand increased by 4.59 times and volatile fatty acids increased by 5.04 *** cumulative methane yield in the group of Co-AD by AL integrated with air(Co-(AL+air)),being 287 mL·(g VS_(added))^(−1),was improved by 46.7%compared to the *** cone model was found the best in simulating the methane yield kinetics with R^(2)≥0.9979 and root mean square prediction error(rMSPE)≤***-(AL+air)had a larger hydrolysis constant k(0.14 d^(−1))and a shorter lag phaseλ(0.99 d)than the control(k=0.12 d^(−1),λ=2.06 d).The digestate improved the removal of total solids and total volatile solids by 2.0 and 2.3 times,*** facilitated substrate degradation,while air can enrich the microbial activity,together enhancing the methane *** results show that AL+air can be applied as an effective method to improve methane production from the Co-AD process.

关键词： sodium hydroxide air injection cumulative methane yield kinetic modeling analysis digestate

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MOTION VECTOR RECOVERY METHOD BASED ON MEAN SHIFT PROCEDURE

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Journal of Electronics(China) 2010年第6期27卷 830-837页

作者： zhan Xuefeng Zhu Xiuchang Image Processing and Image Communication Lab Nanjing University of Posts and Telecommunications Nanjing 210003 China

This letter presents a novel Motion Vector (MV) recovery method which is based on Mean Shift (MS) procedure. According to motion continuity, MVs in local area should be similar. If projecting MV into 2-D feature space, local MVs in the feature space tend to cluster closely. To estimate the lost MVs in local area, recovery of lost MVs is modeled as clustering operation. MS procedure is applied to enforce each lost MV in the feature space to shift to the position where dominant MVs are gathered. Meanwhile, bandwidth estimation is statistically characterized by the variation of local standard de-viations; weighted value calculation is determined by estimation of overall standard deviation. Simu-lation results demonstrate their better performance when compared with other MV recovery ap-proaches and low computation cost.

关键词： Error concealment Motion Vector (MV) recovery Mean shift K-means Bandwidth estimation

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不同应力水平对2195-T34 Al-Li合金时效行为的影响机制研究

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Journal of Central South University 2024年第1期31卷 11-24页

作者：陈非湛利华徐永谦刘春辉马博林曾泉清胡正根朱文俐鄢东洋 Light Alloy Research Institute of Central South University Changsha 410083China School of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China State Key Laboratory of High-performance Complex Manufacturing Central South UniversityChangsha 410083China Beijing Institute of Astronautical Systems Engineering Beijing 100176China

研究了不同应力水平下2195-T34 Al-Li合金的时效特性变化。当应力低于材料的高温屈服强度(YS)时,低应力时效(LSA)和无应力时效(SFA)试样的屈服强度和延伸率(EL)相近。当应力超过材料的高温屈服强度时,试样的极限拉伸强度(UTS)和伸长率... 详细信息

研究了不同应力水平下2195-T34 Al-Li合金的时效特性变化。当应力低于材料的高温屈服强度(YS)时,低应力时效(LSA)和无应力时效(SFA)试样的屈服强度和延伸率(EL)相近。当应力超过材料的高温屈服强度时,试样的极限拉伸强度(UTS)和伸长率显著下降,表明应力的增加降低了材料的抗破坏性。透射电子显微镜(TEM)和扫描电子显微镜(SEM)的观察结果表明:应力对材料时效性能的影响归因于内部析出物特征和晶界富铜析出物的共同作用。应力的增加促使铜原子在晶界发生偏析形成富铜析出物,同时促进了晶界无沉淀区(PFZ)的形成,而富铜析出物是脆性相,可作为损伤的起始位置,容易导致裂纹萌生和发展,降低材料的延展性。

关键词：铝锂合金应力水平时效力学性能

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An experiment on multibubble sonoluminescence spectra in sodium chloride solution

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Chinese Science Bulletin 2008年第10期53卷 1468-1472页

作者： CHEN zhan XU JunFeng HUANG Wei CHEN WeiZhong MIAO GuoQing Institute of Acoustics and Key Laboratory of Modern Acoustics of Ministry of Education Nanjing University Nanjing 210093 China

We investigated experimentally the spectra of MBSL in sodium chloride water solution with krypton as dissolved gas. We observed and compared the spectra of hydroxyl ion at 310 nm and that of sodium atom at 589 nm. It has been found that under the same experimental condition, the intensity of sodium atom spectra is obviously higher than that of the hydroxyl ion spectra, and is more sensitive to the experimental condition. The krypton content, the concentration of sodium chloride solution, and the driving sound pressure obviously affect the spectra intensity in certain range.

关键词：气穴现象声致发光光谱氯化钠溶液

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Efficacy of intelligent diagnosis with a dynamic uncertain causality graph model for rare disorders of sex development

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Frontiers of Medicine 2020年第4期14卷 498-505页

作者： Dongping Ning zhan zhang Kun Qiu Lin Lu Qin zhang Yan Zhu Renzhi Wang Key Laboratory of Endocrinology of National Health Commission Department of EndocrinologyPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Pediatrics Linfen Central HospitalLinfen 041000China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China Institute of Internet Industry Tsinghua UniversityBeijing 100084China Department of Neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Disorders of sex development(DSD)are a group of rare complex clinical syndromes with multiple *** the various causes of DSD is quite difficult in clinical practice,even for senior general physicians because of the similar and atypical clinical manifestations of these *** addition,DSD are difficult to diagnose because most primary doctors receive insufficient training for *** diagnoses and misdiagnoses are common for patients with DSD and lead to poor treatment and *** the basis of the principles and algorithms of dynamic uncertain causality graph(DUCG),a diagnosis model for DSD was jointly constructed by experts on DSD and engineers of artificial intelligence.“Chaining”inference algorithm and weighted logic operation mechanism were applied to guarantee the accuracy and efficiency of diagnostic reasoning under incomplete situations and uncertain *** was performed using 153 selected clinical cases involving nine common DSD-related diseases and three causes other than DSD as the differential *** model had an accuracy of 94.1%,which was significantly higher than that of interns and third-year *** conclusion,the DUCG model has broad application prospects as a computer-aided diagnostic tool for DSDrelated diseases.

关键词： disorders of sex development(DSD) intelligent diagnosis dynamic uncertain causality graph

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CDH1基因对小鼠胃类器官生长和E-caherin表达的作用机制

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世界华人消化杂志 2024年第2期32卷 141-147页

作者：邵伟余友杰夏海娜郑优优孙展杭严皓哲舟山市普陀区人民医院消化内科浙江省舟山市316100 舟山市普陀区人民医院血液肿瘤科浙江省舟山市316100 舟山市普陀区人民医院病理科浙江省舟山市316100 舟山市普陀区人民医院浙江舟山消化病防治研究所浙江省舟山市316100

背景CDH1基因编码的蛋白质E-cadherin在维持上皮组织完整性中发挥重要作用,了解CDH1基因对胃类器官生长和E-cadherin表达的作用机制对于揭示器官发育的分子基础至关重要.因此假设CDH1基因通过调控E-cadherin的表达参与调控胃类器官的发... 详细信息

背景CDH1基因编码的蛋白质E-cadherin在维持上皮组织完整性中发挥重要作用,了解CDH1基因对胃类器官生长和E-cadherin表达的作用机制对于揭示器官发育的分子基础至关重要.因此假设CDH1基因通过调控E-cadherin的表达参与调控胃类器官的发育和生长过程.目的探究钙黏蛋白1(cadherin-1,CDH1)基因对小鼠胃类器官生长和E-钙黏蛋白(E-cadherin)表达的作用机制.方法采用CRISPR/Cas9基因敲除技术获得CDH1^(-/-)C57BL/6品系小鼠10只,及野生型(WT)C57BL/6品系小鼠10只作为实验对照组.分离小鼠胃组织并培养胃类器官,免疫荧光染色观察胃类器官中E-cadherin表达,比较小鼠胃类器官数量和直径,MTT检测胃类器官细胞活力,蛋白质印迹法和RT-PCR法检测胃类器官中E-cadherin蛋白和mRNA表达.结果在光学显微镜下可见小鼠胃组织在培养基中不断生长与分裂,从第0 d开始组织在24 h内形成囊性结构,然后经历快速生长阶段.器官样细胞扩展为大的3D球形结构,到第5 d后逐渐出芽并开始形成胃类器官,提示胃类器官初步构建.免疫荧光染色结果显示,WT C57BL/6小鼠胃类器官中E-cadherin呈阳性表达,进一步提示胃类器官成功构建.和WT C57BL/6小鼠相比,CDH1^(-/-)C57BL/6小鼠胃类器官数量、胃类器官直径、吸光度值及胃类器官中E-cadherin蛋白和E-cadherin mRNA相对表达量均明显减少(P<0.05).结论CDH1基因敲除可抑制胃类器官生长形成及E-cadherin表达.

关键词： CDH1 胃类器官生长 E-cadherin

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