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Numerical Investigation on Inclined Hydraulic Transport of Large Particles for Deepsea Mining

China Ocean Engineering 2023年第3期37卷 420-432页

作者： LIU Lei LI Xin TIAN Xin-liang zhanG Xian-tao XU Li-xin zhanG Xiu-zhan State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Sanya Yazhou Bay Institution of Deep-sea Sci-Tech Shanghai Jiao Tong UniversitySanya 572000China China Merchants Marine And Offshore Research Institute Co. Ltd.Shenzhen 518067China China Merchants Deepsea Research Institute(Sanya)Co. Ltd.Sanya 572000China

Hydraulic transport in pipelines is the most promising conveying method for large ore particles in deepsea *** dynamic performances of particles during transportation in vertical,inclined and horizontal pipelines are significant for the design of hydraulic transport *** the present study,we focus on the statistical characteristics and flow regimes of the mixture composed of ore particles and seawater in the *** simulations are conducted by using Computational Fluid Dynamics(CFD)and Discrete Element Method(DEM).The influences of inclination angle and particle diameter are evaluated through two sets of numerical *** regulation of the inclined transport is totally different from that of the vertical transport,whereas the dynamics of the mixtures in inclined and horizontal pipes are similar.A number of particles accumulate on the pipe wall even with a small inclination *** hydraulic gradient and local concentration would occur when the inclination angle of the pipe is in the range of30°-60°.With the decrease of particle diameter,the particle flow becomes uniform,reflected by the almost uniform particle distribution in the vertical pipe and the clear interface between the suspended load and the bed-load in the inclined ***,small particles will introduce larger local concentrations and hydraulic gradients in the inclined pipe,which is not conducive to particle transport.

关键词： deepsea mining hydraulic transport inclined pipe numerical simulation

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Hypoxia-degradable and long-circulating zwitterionic phosphorylcholine-based nanogel for enhanced tumor drug delivery

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Acta Pharmaceutica Sinica B 2021年第2期11卷 560-571页

作者： Shaojun Peng Boshu Ouyang Yongjie Xin Wei Zhao Shun Shen Meixiao zhan Ligong Lu Zhuhai Precision Medical Center Zhuhai Interventional Medical CenterZhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 519000China The Institute for Translational Nanomedicine Shanghai East HospitalTongji University School of MedicineShanghai 200120China Zhejiang Cancer Hospital Institute of Cancer ResearchHangzhou 310012China Central Laboratory First Affiliated HospitalInstitute(College)of Integrative MedicineDalian Medical UniversityDalian 116021China

Tumor microenvironment has been widely utilized for advanced drug delivery in recent years,among which hypoxia-responsive drug delivery systems have become the research *** hypoxia-responsive micelles or polymersomes have been successfully developed,a type of hypoxia-degradable nanogel has rarely been reported and the advantages of hypoxia-degradable nanogel over other kinds of degradable nanogels in tumor drug delivery remain ***,we reported the synthesis of a novel hypoxia-responsive crosslinker and the fabrication of a hypoxia-degradable zwitterionic poly(phosphorylcholine)-based(HPMPC)nanogel for tumor drug *** obtained HPMPC nanogel showed ultra-long blood circulation and desirable immune compatibility,which leads to high and long-lasting accumulation in tumor ***,HPMPC nanogel could rapidly degrade into oligomers of low molecule weight owing to the degradation of azo bond in hypoxic environment,which leads to the effective release of the loaded ***,HPMPC nanogel showed superior tumor inhibition effect both in vitro and in vivo compared to the reduction-responsive phosphorylcholine-based nanogel,owing to the more complete drug ***,the drug-loaded HPMPC nanogel exhibits a pronounced tumor inhibition effect in a humanized subcutaneous liver cancer model with negligible side effects,which showed great potential as nanocarrier for advanced tumor drug delivery.

关键词： Hypoxia-degradable Zwitterionic nanogel Long blood circulation Drug release Drug delivery

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Claudin-15 overexpression inhibits proliferation and promotes apoptosis of Schwann cells in vitro

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Neural Regeneration Research 2020年第1期15卷 169-177页

作者： Jian-Nan Li zhan zhang Guang-Zhi Wu Deng-Bing Yao Shu-Sen Cui China-Japan Union Hospital of Jilin University ChangchunJilin ProvinceChina School of Life Sciences Jiangsu Key Laboratory of NeuroregenerationCo-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina

Our previous experiments have discovered that Claudin-15 was up-regulated in Schwann cells of the distal nerve stumps of rat models of sciatic nerve ***,how Claudin-15 affects Schwann cell function is still *** study aimed to identify the effects of Claudin-15 on proliferation and apoptosis of Schwann cells cultured in vitro and explore the underlying *** Schwann cells were obtained from ***-15 in Schwann cells was knocked down using siRNA(siRNA-1 group)compared with the negative control siRNA transfection group(negative control group).Claudin-15 in Schwann cells was overexpressed using pGV230-Claudin-15 plasmid(pGV230-Claudin-15 group).The pGV230 transfection group(pGV230 group)acted as the control of the pGV230-Claudin-15 *** proliferation was analyzed with EdU *** apoptosis was analyzed with flow cytometric *** migration was analyzed with Transwell *** mRNA and protein expressions were analyzed with quantitative polymerase chain reaction assay and western blot *** results showed that compared with the negative control group,cell proliferation rate was up-regulated;p-AKT/AKT ratio,apoptotic rate,p-c-Jun/c-Jun ratio,mRNA expression of protein kinase C alpha,Bcl-2 and Bax were down-regulated;and mRNA expression of neurotrophins basic fibroblast growth factor and neurotrophin-3 were increased in the siRNA-1 *** significant difference was found in cell migration between the negative control and siRNA-1 *** with the pGV230 group,the cell proliferation rate was down-regulated;apoptotic rate,p-c-Jun/c-Jun ratio and c-Fos protein expression increased;mRNA expression of protein kinase C alpha and Bax decreased;and mRNA expressions of neurotrophins basic fibroblast growth factor and neurotrophin-3 were up-regulated in the pGV230-Claudin-15 *** above results demonstrated that overexpression of Claudin-15 inhibited Schwann cell proliferation and promoted Schwann cell apopt

关键词： apoptosis Bax cell proliferation c-Jun Claudin-15 nerve regeneration peripheral nerve injury protein kinase C alpha Schwann cells Wallerian degeneration

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An efficient electrocatalytic system composed of nickel oxide and nitroxyl radical for the oxidation of bio-platform molecules to dicarboxylic acids

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Journal of Energy Chemistry 2023年第5期80卷 58-67,I0003页

作者： Kai zhang Zixiang zhan Minzhi Zhu Haiwei Lai Xiangyang He Weiping Deng Qinghong zhang Ye Wang State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsInnovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM)College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005FujianChina

Selective oxidation of biomass and its derivatives to dicarboxylic acids represents a promising route for biomass ***,the co-presence of multiple functional groups in biomass molecules makes the selective oxidation of particular functional a challenging ***,we demonstrate an efficient electrocatalytic system consisting of nickel oxide(NiO)and a nitroxyl radical,i.e.,2,2,6,6-tetrame thylpiperidine-1-oxyl(TEMPO)or 4-acetamido-TEMPO(ACT),for the selective oxidation of key bioplatform molecules including glucose,xylose and 5-hydroxymethylfurfural(HMF)into corresponding dicarboxylic acids,i.e.,glucaric acid,xylaric acid,and 2,5-furandicarboxylic acid(FDCA).NiO is clarified as the active catalyst for the oxidation of aldehyde in bio-platform molecules to carboxylic acid,while TEMPO or ACT is responsible for the oxidation of primary alcohol to *** combination of NiO and TEMPO or ACT significantly accelerated the tandem oxidation of aldehyde and hydroxyl groups in glucose,xylose and HMF,thus achieving excellent yields(83%-99%)of dicarboxylic ***,the combination catalyst enables the selective oxidation of glucose and xylose with high concentrations(e.g.,20 wt%),which offers a promising strategy for biomass valorization.

关键词： Biomass Electrocatalysis Nio Nitroxyl radical Dicarboxylic acid

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Hardware Implementation and Simulations of Joint Coding and Modulation Diversity MIMO-OFDM Scheme

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Journal of Harbin Institute of Technology(New Series) 2013年第3期20卷 27-34页

作者： Xiang Gao zhan-Ji Wu Long-Fei Hua Jun-Peng Liu School of Information and Communication Engineering Beijing University of Posts and Telecommunications

This paper presents an efficient Joint Coding and Modulation Diversity ( JCMD ) scheme. The proposed scheme applied modulation diversity technique to MIMO-OFDM system which can effectively use time, frequency and space diversity combined with channel coding. In fading channel,the proposed scheme not only achieves high spectral efficiency,but also greatly enhances the reliability of wireless transmission. The self- developed hardware prototype system proves that the proposed scheme can be realized and has high reliability. Compared with traditional MIMO-OFDM scheme based on bit-interleaved coded modulation ( BICM) ,software and hardware simulation results show that the proposed scheme with the optimal rotational angle can obtain a significant performance advantage both for precoded and non-precoded system in the condition of non-perfect channel knowledge and non-ideal synchronization.

关键词： multiple input multiple output ( MIMO) orthogonal frequency division multiplexing ( OFDM) modulation diversity channel estimation

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经典名方中乳香的本草考证

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中国实验方剂学杂志 2024年第4期30卷 55-66页

作者：周海燕王青青张奇肖苏萍陈蒙周建新张业达贾丹阳詹志来中国中药有限公司北京102600 北京城市学院北京100094 众花南药有限公司槟城乔治14100 中国中医科学院中药资源中心北京100700

通过查阅历代本草、医籍、方书和近现代文献资料,笔者对经典名方中所用乳香药材从名称、基原、学名、产地、品质评价、采收加工、炮制历史沿革及变迁等方面进行了系统梳理与考证,以期为包含乳香的经典名方开发提供依据。经考证可知,乳... 详细信息

通过查阅历代本草、医籍、方书和近现代文献资料,笔者对经典名方中所用乳香药材从名称、基原、学名、产地、品质评价、采收加工、炮制历史沿革及变迁等方面进行了系统梳理与考证,以期为包含乳香的经典名方开发提供依据。经考证可知,乳香以薰陆香为名始载于《名医别录》,直至唐代《本草拾遗》首次以“乳香”为正名,此后历代本草均延续此名;历代主流基原为橄榄科植物乳香树Boswellia carterii;古代著录的产地主要有古印度和阿拉伯地区,现主产于索马里、埃塞俄比亚及阿拉伯半岛南部;古今乳香药用部位均为树皮渗出的树脂,以春夏两季为主进行采收;近代以来乳香品质以淡黄色、颗粒状、半透明、无砂石和树皮等杂质、粉末粘手、气芳香者为佳。古代炮制方法较多,有净制(水飞、去杂质)、研制(酒研、灯心研)、炒制(清炒、灯心炒、酒炒)、去油、醋制、煎膏等,近现代炮制方法日趋简化,沿用的炮制方法主要为净制、清炒、醋制。现今常用的炮制规格有生乳香、炒乳香、醋乳香,其中生乳香为净制后的生品,炒乳香为清炒法炮制品,醋乳香为净乳香加醋拌炒的炮制品。基于考证结果,建议蠲痹汤等含乳香的经典名方选择乳香树***树皮渗出的树脂,原方注明炮制要求的按要求操作,未注明炮制要求的建议以净制后的生品入药。

关键词：经典名方乳香基原中药炮制本草考证醋制品蠲痹汤

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补片形式对蒙皮复合材料孔边裂纹修复效果的影响

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兵器材料科学与工程 2024年第5期47卷 65-70页

作者：朱洪伟赵千惠田飞翔高奇玉王磊磊占小红中国直升机设计研究所天津300000 南京航空航天大学材料科学与技术学院江苏南京210016

针对蒙皮复合材料孔边裂纹,提出了共固化补片修复和预固化补片修复两种修复方式,并设计了与之适配的修复方案,研究了修复方式对试样抗拉强度恢复效果的影响,阐明了完好试样和各类修复试样的断裂失效机制。结果表明:相同补片尺寸下,预固... 详细信息

针对蒙皮复合材料孔边裂纹,提出了共固化补片修复和预固化补片修复两种修复方式,并设计了与之适配的修复方案,研究了修复方式对试样抗拉强度恢复效果的影响,阐明了完好试样和各类修复试样的断裂失效机制。结果表明:相同补片尺寸下,预固化补片修复试样的强度恢复率均高于共固化补片修复试样,预固化补片修复试样强度恢复率最高为81.9%,且试样断口平齐,补片与复合材料层压板之间的断裂机制为纤维纵向拉断;共固化补片修复试样强度恢复率最高为78.6%,主要断裂机制为复合材料层压板分层。证明了相比于共固化补片修复,预固化补片修复试样能够恢复更高的抗拉强度,为蒙皮复合材料修复提供了具体的工艺方案和理论基础。

关键词：复合材料裂纹修复强度恢复孔边裂纹

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Growth and Common Prosperity in China

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China & World Economy 2022年第1期30卷 28-57页

作者： Nanak Kahwani Xiaobing Wang Ning Xue Peng zhan School of Economics Renmin University of ChinaChina School of Economics University of New South WalesAustralia Department of Economics University of ManchesterUK Department of Economics and Related Studies University of YorkUK Institute for Common Prosperity and Development Zhejiang UniversityChina

This paper introduces a decomposition method that quantifies the contributions to common prosperity of labor market performance and social policies and extends the idea of shared prosperity to a new measure of inequity in *** resulting common prosperity indices and opportunity equality indices are then applied to five waves of the Chinese Household Income Project data from 1988 to *** paper shows that the labor market performance and social policies have been improving over the last 30 years and have helped China move towards common prosperity for *** indices developed in this paper allow us to quantify the extent of shared prosperity that a country has achieved and to carry out empirical studies on which policy is working and which is *** can also help us identify the fundamental causes of inequality and aid us in achieving equality in opportunity among all members of society.

关键词： common prosperity income growth inequity in opportunity labor market social policies

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Monomer reactivity ratios for fluoroacrylate and butyl methacrylate in miniemulsion copolymerizations initiated by potassium persulphate

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Chinese Chemical Letters 2009年第4期20卷 478-482页

作者： Qing Hua zhang Zhen Huan Luo Xiao Li zhan Feng Qiu Chen College of Materials Science and Chemical Engineering Zhejiang University Hangzhou 310027 China

Miniemulsion copolymerization of butyl mathacrylate （BMA） with fluoroacrylate （HFMA, TFMA） was carried out at 70 ℃ by employing potassium persulphate （KPS） as initiator. Copolymer compositions at low conversion levels were determined by ^1H NMR spectra techniques. The reactivity ratios were evaluated by employing Kellen-Tudos （K-T） methods, which yields the apparent reactivity ratios, rBMA = 0.74, rHFMA = 0.87 and rBMA = 0.73, rTFMA = 0.75, respectively, and Q- and e-values of HFMA and TFMA were calculated by the Alfrey-Price method. The results show that HFMA and TFMA are more active than BMA, and the cross-propagation rate constant is greater than the self-propagation one in these two copolymerizations.

关键词： Fluoroacrylate Reactivity ratios Miniemulsion Copolymerization

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A long-term record(1995-2019)of the dynamics of land desertification in the middle reaches of Yarlung Zangbo River basin derived from Landsat data

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Geography and Sustainability 2021年第1期2卷 12-21页

作者： Qiqi zhan Wei Zhao Mengjiao Yang Donghong Xiong Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 10049China Kathmandu Center for Research and Education Chinese Academy of Sciences-Tribhuvan UniversityBeijing 100101China

Widespread desertification in the middle part of the Yarlung Zangbo River(YZR)basin is threatening the sustain-able development of this *** capture this process,a method was proposed for large-scale desertification monitoring by using Landsat images from 1995 to *** method used an integrated classification method combined with a hierarchical decision tree and nearest neighbor *** spatio-temporal dynamics of the desertification pattern were analyzed to assist in the detection of possible driving *** validation samples collected from Google Earth high-resolution images and field investigations,the overall accuracy of the classification in 2019 was 92.3%with a Kappa coefficient of *** major results were:(1)total sandy land area in 2019 was 734.1 km^(2),which accounted for 3.7%of the study area,prominently distributed along the wide river valleys and inlets of tributaries with a strip and discontinuous *** land tends to be distributed in the southern aspect regions with lower elevations and that are closer to rivers;(2)sandy land areas showed two temporal stages:a gradual increase of 102.4 km^(2)from 1995 to 2015 and a large decrease of 106.8 km^(2)from 2015 to 2019;(3)newly increased sandy land was distributed in the YZR Valley,while the revegetation on sandy land occurred mainly in the Lhasa River basin and some regions in the YZR Valley;and(4)increased sandy land area of 142.1 km^(2)was mainly distributed in the southern band of the two ***,revegetation on sandy land was more effective on the northern banks of the river *** findings provide guidance for implementing vegetation recovery on sandy lands and provide important insights for maintaining sustainable development.

关键词： Desertification Landsat Spatial-temporal dynamics Yarlung Zangbo River Basin Qingzang Plateau

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