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Change in expression of apoptosis genes after hyperthermia,chemotherapy and radiotherapy in human colon cancer transplanted into nude mice

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World Journal of Gastroenterology 2007年第32期13卷 4365-4371页

作者： Han Liang Hong-Jie zhan Bao-Gui Wang Yuan Pan Xi-Shan Hao Department of Gastrointestinal Oncological Surgery Tianjin Cancer Hospital Tianjin Medical University Key Laboratory of Cancer Prevention and Therapy Tianjin 300060 China

AIM:To investigate the change in expression of p53 ,Bcl-2 ,and Bax genes in human colon cancer cells transplanted into nude mice after hyperthermia,chemotherapy,radiotherapy,thermochemotherapy,thermoradiotherapy and thermochemoradiotherapy. METHODS:Human colon cancer cell line (HT29) was transplanted into the hind limbs of nude mice. Under laboratory simulated conditions of hyperthermia (43℃,60 min),the actual radiation doses and doses of mitomycin C (MMC) were calculated in reference to the clinical radiotherapy for human rectal cancer and chemotherapy prescription for colon cancer. The mice were divided into 6 groups according to the treatment approaches:hyperthermia,chemotherapy,radiotherapy,thermochemotherapy,thermoradiotherapy,and thermochemoradiotherapy. The mice were sacrificed at different time points and the tumor tissue was taken for further procedures. The morphologic changes in membrane,cytoplasm and nuclei of tumor cells of p53,Bcl-2,and Bax after treatment,were observed by immunohistochemistry staining. RESULTS:All of the six treatment modalities down-regulated the expression of p53,Bcl-2 and up-regulated the expression of Bax at different levels. The combined therapy of hyperthermia,with chemotherapy,and/or irradiation showed a greater effect on down-regulating the expression of p53 (0.208 ± 0.009 vs 0.155 ± 0.0115,P < 0.01) and Bcl-2 (0.086 ± 0.010 vs 0.026 ± 0.0170,P < 0.01) and up-regulating Bax expression (0.091 ± 0.0013 vs 0.207 ± 0.027,P < 0.01) compared with any single ***:Hyperthermia enhances the effect of radio-and chemotherapy on tumors by changing the expression of apoptosis genes,such as p53,Bcl-2 and Bax.

关键词： Hyperthermia Apoptosis p53 Bcl-2 Bax Nude mice Colon cancer Cell line

Non-commutative Chiral QCD2 Model

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Communications in Theoretical Physics 2002年第8期38卷 217-220页

作者： YANG zhan-Ying YUE Rui-Hong HOU Bo-Yu SHI Kang-Jie Institute of Modern Physics Northwest University Xi''an 710069 China Institute of Modern Physics Northwest University Xi''an 710069 China Institute of Modern Physics Northwest University Xi''an 710069 China Institute of Modern Physics Northwest University Xi''an 710069 China

The effective action of chiral QCD2 was studied in two-dimensional non-commutative space-time by usingpath integral approach. It is shown that vector boson has a mass generation and the effective Lagrangian contains a... 详细信息

关键词： chiral anomaly, non-commutative geometry, effective Lagrangian

Dislocation reconfiguration during creep deformation of an Al-Cu-Li alloy via electropulsing

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Journal of Materials Science & Technology 2022年第35期130卷 27-34页

作者： Chang Zhou Lihua zhan He Li Chunhui Liu Yongqian Xu Bolin Ma Youliang Yang Minghui Huang College of Mechanical and Electrical Engineering Central South UniversityChangsha410083China State Key Laboratory of High Performance Complex Manufacturing Central South UniversityChangsha410083China Light Alloys Research Institute Central South UniversityChangsha410083China

Creep mechanism was well-known to be mainly dominated by the dislocation sliding and climbing during creep deformation. Here we study the creep deformation of an Al-Cu-Li alloy with the assistance of electropulsing and subsequent microstructural observations. We find that creep strain increased drastically under electropulsing and was almost twelve times as much as that of the non-pulsed sample. Microstructural observations confirmed that dislocation reconfiguration happens via electropulsing, namely helical dislocations being opened rapidly. This opened dislocation structure can possess a much higher mobility than the initial helical dislocation, which mostly responsible for the greatly increased creep strain. Our results revealed a new mechanism accountable for the distinctly electroplastic creep deformation.

关键词： Dislocation reconfiguration Electroplasticity Al-Cu-Li alloy Creep deformation

A visible light-responsive iodine-doped titanium dioxide nanosphere

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Journal of Environmental Sciences 2011年第1期23卷 166-170页

作者： Zhiqiao He Liyong zhan Fangyue Hong Shuang Song Zhengying Lin Jianmeng Chen Mantong Jin College of Biological and Environmental Engineering Zhejiang University of Technology Hangzhou 310032 China Department of Chemical Engineering Hangzhou Vocational & Technical College Hangzhou 310018 China

I-doped titanium dioxide nanospheres （I-TNSs） were synthesized via a two-step hydrothermal synthesis route, their potential for the efficient utilization of visible light was evaluated. The prepared anatase-phase I-TNSs had a bimodal porous size distribution with a Brunauer-Emmett-Teller surface area of 76 m2/g, a crystallite size of approximately 14 nm calculated from X-ray diffraction data, and a remarkable absorption in the visible light region at wavelengths 〉 400 nm. The photocatalytic activity of the samples was evaluated by decoloration of Methyl Orange in aqueous solution under visible light irradiation in comparison to the iodine-doped TiO2 （I-TiO2）. The I-TNSs showed higher photocatalytic efficiency compared with I-TiO2 after irradiation for 180 rain even though the latter had a much greater surface area （115 m2/g）. It was concluded that the surface area was not the predominant factor determining photocatalytic activity, and that the good crystallization and bimodal porous nanosphere structure were favourable for photocatalysis.

关键词： I-doped titanium dioxide nanospheres Methyl Orange visible light

Comparative analysis of the ecological fitness and transcriptome between two genotypes of the brown planthopper Nilaparvata lugens

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Journal of Integrative Agriculture 2020年第6期19卷 1501-1511页

作者： LIU Kai CHEN zhan SU Qin YUE Lei CHEN Wei-wen zhanG Wen-qing State Key Laboratory of Biocontrol/School of Life Sciences Sun Yat-sen UniversityGuangzhou 510275P.R.China

Insect quantity is an important index for determining the degree of damage to *** brown planthopper(BPH),Nilaparvata lugens(Stal),is one of the most important rice pests in ***,we used two genotypes of BPH,a highfecundity genotype(HFG)and a low-fecundity genotype(LFG),to measure their ecological fitness and to explore possible causes for genotype differentiation by transcriptome *** results showed that there were significant differences in body weight,egg hatching rate and honeydew secretion between the HFG and LFG,particularly,the number of eggs laid per female was more *** analysis showed that a total of 1966 differentially expressed genes(DEGs)were mainly involved in energy metabolism,carbohydrate and lipid syn thesis,in sect horm one syn thesis and fecun dity-related ***,we found that the phosphorylation levels of AMPK,AKT and FoxO and the synthesis of ecdysone were different between the two genotypes of *** findings may partially explain the differenee in the ecological fitness between HFG and *** study is the first to compare the differences between two genotypes of BPH and to provide transcriptomic evidenee to further understand the fecundity of BPH.

关键词： Nilaparvata lugens genotype fecundity RNA-seq phosphorylation

The Feasibility Research on Reusing High Salinity Wastewater as a Plant Nutrient Medium for Plant Hydroponics in CELSS

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Space(Science & Technology) 2022年第1期2022卷 370-380页

作者： Liangchang zhang Yurong Xue You Wang Chengbo zhan Weidang Ai Xingyan Wang National Key Laboratory of Human Factors Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Environmental Science and Engineering College of Environment and ResourcesXiangtan UniversityXiangtan 411105China Space Institute of Southern China Shenzhen 518117China

The reuse of wastewater is a key problem in controlled ecological life support system(CELSS).In this study,the feasibility to reuse the treated wastewater(including sanitary wastewater and urine wastewater)as a plant hydroponic medium was *** salt-tolerant plants,apium graveolens Linn(celery)and mesembryanthemum cordifolium L.F.(cordifolium),were cultivated with the reused medium or Hoagland nutrient solution,and the characteristics of crop growth,hydroponic medium composition,and elements absorption by plants were *** results showed that the reused medium replenished with micronutrient elements could maintain the normal growth of cordifolium and celery *** biomass productivity of cordifolium cultivated by the recycled medium(121.53 g FW/strain)was higher than that cultivated by Hoagland nutrient solution(98.33 g FW/strain).The nutrient elements accumulation in plant dry mass indicated that plants could effectively utilize the recycled mineral elements in wastewater,and cordifolium exhibited better stability and adaptability to salt-induced *** absorption capacity of Na and Cl elements in cordifolium cultivated within the reused medium was the highest,which was 4.54%DW and 2.63%DW,*** study demonstrated the feasibility to directly reuse domestic wastewater as the main ingredient for plant hydroponics,which could provide insights into design and operation of plant hydroponics system and water circulation system in CELSS.

关键词： wastewater Plant utilize

Synthesis of quinoxaline derivatives catalyzed by PEG-400

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Chinese Chemical Letters 2010年第4期21卷 395-398页

作者： zhang, Xia Zhong Wang, Jin Xian Sun, Yong Jun zhan, Hong Wen NW Normal Univ Dept Chem Inst Chem Lanzhou 730070 Peoples R China

Polyethylene glycol(PEG) was found to be an effective catalyst for the condensation of 1,2-diamines with 1,2-dicarbonyl compounds to afford the corresponding quinoxaline derivatives in excellent yields under mild reac... 详细信息

关键词： PEG-400 Quinoxaline derivatives 1 2-Diamines 2-Dicarbonyl compounds

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基于稀疏自编码的多维数据去重聚类算法分析

计算机仿真 2024年第3期41卷 542-547页

作者：薛丽香高丽杰李占波郑州科技学院信息工程学院河南郑州450064 郑州大学网络管理中心河南郑州450001

随着科技信息的不断发展,数据量与数据类型与日俱增,针对数据集维度高、重复数据多导致有效信息提取复杂的问题,提出基于改进稀疏自编码器的多维数据聚类算法。算法分为数据处理与聚类分析两大部分,数据处理时首先利用S-SAE中逐层贪婪... 详细信息

随着科技信息的不断发展,数据量与数据类型与日俱增,针对数据集维度高、重复数据多导致有效信息提取复杂的问题,提出基于改进稀疏自编码器的多维数据聚类算法。算法分为数据处理与聚类分析两大部分,数据处理时首先利用S-SAE中逐层贪婪的原理将高维数据集降维至每组6维的数据集;接着采用映射值匹配机制对降维后的数据集进行重复数据清洗处理,被清洗的值用0替代;然后将处理好的数据投入到K-Means++聚类算法中进行聚类分析;最终构建出TS-SAE-K-Means++多维数据聚类模型,并通过最优化分析得出其最优化参数设置情况。通过对不同基线组合算法的仿真对比分析表明,TS-SAE-K-Means++在聚类轮廓系数S与模型特征值F1评价体系中均优于其它算法组合。这表明提出的算法在解决高维数据内有效信息提取的问题上具有一定的优越性。

关键词：改进稀疏自编码器聚类算法评级指标

Influence of(Mg_(1/3)Nb_(2/3))complex substitutions on crystal structures and microwave dielectric properties of Li2TiO3 ceramics with extreme low loss

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Journal of Materiomics 2018年第4期4卷 368-382页

作者： Huan-Huan Guo Di Zhou Li-Xia Pang Jin-zhan Su Electronic Materials Research Laboratory Key Laboratory of the Ministry of Education&International Center for Dielectric ResearchSchool of Electronic and Information EngineeringXi'an Jiaotong UniversityXi'an710049China Micro-optoelectronic Systems Laboratories Xi'an Technological UniversityXi'an710032ShaanxiChina International Research Centre for Renewable Energy State Key Laboratory of Multiphase Flow in Power EngineeringXi'an Jiaotong UniversityXi'anShaanxi710049China

A systematic investigation of the Li2Ti1-x(Mg_(1/3)Nb_(2/3))xO_(3)(0.1≤x≤0.35)solid solutions synthesized by traditional solid-state reaction method is reported in this *** the composition range of 0.1≤x≤0.25,a monoclinic rock salt structured solid solution was *** x increased to 0.3,a phase transition from monoclinic to cubic phase,along with an order-disorder phase transition,was *** x increased from 0.1 to 0.35,the microwave permittivity(εr)and temperature coefficient of resonant frequency(TCF)of the Li2Ti1-x(Mg_(1/3)Nb_(2/3))xO_(3)ceramics decreased linearly from 21.0 to 18.6,+27.1 to-19.4 ppm/℃,*** Li_(2)Ti_(0.75)(Mg_(1/3)Nb_(2/3))0.25O_(3)ceramic sintered at 1170℃shows high performance of microwave dielectric properties with aεr~19.6,a Qf(Q=quality factor=1/dielectric loss;f=resonant frequency)~109,770 GHz(at 7.7 GHz)and a near zero TCF~t 1.2 ppm/℃.Moreover,the burying sintering process can reduce the volatilization of lithium so that the porosity of Li_(2)Ti_(0.75)(Mg_(1/3)Nb_(2/3))0.25O_(3)ceramic was reduced effectively,which made Li_(2)Ti_(0.75)(Mg_(1/3)Nb_(2/3))0.25O_(3)ceramic promising for future *** area electron diffraction patterns,high-resolution transmission electron microscopy,Raman and far-infrared spectra were employed to study the relation between crystal structure and microwave dielectric properties in detail.

关键词： Microwave dielectric properties Phase evolution Crystal structure High quality