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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第11期15卷 1021-1034页

作者： Lei KE Guo-zheng YAN sheng YAN Zhi-wu WANG da-sheng liu Institute of Medical Precision Engineering and Intelligent Systems School of Electronic Information and Electrical EngineeringShanghai Jiao Tong University

This paper presents a set of analytical expressions used to determine the coupling coefficient between primary and secondary Litz-wire planar coils used in a transcutaneous energy transfer(TET) system. A TET system has been designed to power a novel elastic scaling artificial anal sphincter system(ES-AASS) for treating severe fecal incontinence(FI), a condition that would benefit from an optimized TET. Expressions that describe the geometrical dimension dependence of self- and mutual inductances of planar coils on a ferrite substrate are provided. The effects of ferrite substrate conductivity, relative permeability, and geometrical dimensions are also considered. To verify these expressions, mutual coupling between planar coils is computed by 3D finite element analysis(FEA), and the proposed expressions show good agreement with numerical results. Different types of planar coils are fabricated with or without ferrite substrate. Measured results for each of the cases are compared with theoretical predictions and FEA solutions. The theoretical results and FEA results are in good agreement with the experimental data.

关键词： Transcutaneous energy transfer Planar spiral inductance Mutual inductance Coupling coefficient Artificial anal sphincter Fecal incontinence

Intra-thyroid esophageal duplication cyst:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2231-2236页

作者： Hong-Guo Lin Ming liu Xue-Yang Huang da-sheng liu Department of Vascular Thyroid Surgery The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina

BACKGROUND Esophageal cysts are relatively rare in clinical practice,with most of the literature comprising case *** cysts protruding into the thyroid gland are easily misdiagnosed as thyroid *** such cases have been reported so *** SUMMARY This article reports the case of a 31-year-old adult male diagnosed with thyroid nodules before *** patient underwent left thyroidectomy and *** the surgery,esophageal cysts were identified in the esophageal muscle and thyroid *** pathology results confirmed a nodular goiter combined with esophageal ***,the patient developed a neck infection and underwent another operation and broad-spectrum antibiotic treatment for *** We report the first clinical case of an esophageal cyst located within the thyroid gland that was successfully treated *** cyst located within the thyroid gland cause difficulties in *** the present study,the contents of the esophageal cysts were calcified foci,and a small amount of fluid mixture,which were easily misdiagnosed as thyroid nodules and misled the surgical methods.

关键词： Esophageal cysts Thyroid Diagnosed Surgery Case report

Reversible Posterior Leukoencephalopathy Syndrome in Children with Nephrotic Syndrome:a Case Report

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Chinese Medical Sciences Journal 2014年第1期29卷 55-57页

作者： sheng-da liu Qing-min Shen Chun-feng Lv Department of Hyperbaric Oxygen Beijing Aerospace General Hospital

REVERSIBLE posterior leukoencephalopathy syn- drome （RPLS） is a rare neurological syndrome charac- terized by headache, altered mental status, seizures, and visual disturbance,associated with reversible white matter cnanges,- n been commonly reported in patients with severe hypertension and pre-eclampsia. Here we report a case with nephrotic syndrome complicated by RPLS.

关键词： reversible posterior leukoencephalopathy syndrome nephrotic syndrome magnetic resonance imaging

Efficiency and safety evaluation of Baimai ointment for alleviating hypermyotonia following cerebral infarction

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Neural Regeneration Research 2007年第10期2卷 607-610页

作者： sheng da liu Chu ming Jiang Dong hua Li Cui peng Xie Jian xin Yan Department of Neurology Beijing Aerospace General HospitalBeijing 100076China

Baimai ointment has Shujin and Huoluo efficiency. It has been confirmed by basic pharmacodynamic experiments that Baimai ointment has some therapeutic effects on stroke. However, the detailed evaluations of Baimai ointment on clinically treating stroke patients for function recovery are still insufficient with little reports. OBJECTIVE： To observe the efficiency and safety of Baimai ointment on alleviating hypermyotonia following cerebral infarction DESIGN： A randomized, parallel and controlled experiment. SETTING： Department of Neurology, Beijing Aerospace General Hospital. PARTICIPANTS： A total of 120 patients with acute front-cycle cerebral infarction were selected from Department of Neurology, Beijing Aerospace General Hospital from July to December 2006 and met the diagnosis criteria modified by Forth National Seminar on Cerebrovascular Disease. The experiment had got confirmed consent from local ethic committee. All 120 patients with cerebral infarction were randomly divided into experimental group （n =80; 32 in the acute phase, 32 in the recovery phase and 16 in the sequela phase） and control group （n =40; 16 in the acute phase, 16 in the recovery phase and 8 in the sequela phase）. METHODS： Within 4 weeks after the patients were enrolled in this study, no other traditional Chinese medicines containing similar components were adopted besides routine supporting therapy. The Baimai ointment being consisted of jianghuang, Roudoukou, Gansong, Yangqishi, Gancao, She, shannai, Zanghuixiang, Zangchangpu, Huajiao and dianhua was used by trial group （20 g/ampoule, Tibet Lingzhiqizheng Tibetan Drug Factory; batch number： 050403）, 2-3 times per day, the ointment was moderately coated traveling parts of Baimai. MAIN OUTCOME MEASURES： The evaluation of National Institutes of Health Stroke Scale （NIHSS）, Modified Rankin Scale and Modified Ashworth Scale were performed before administration, 2 and 4 weeks after administration. RESULTS： All 120 patients with acute front-cycle

关键词： ointments acupuncture points brain infarction muscle tonus

An Improved Heuristic Recursive Strategy Based on Genetic Algorithm for the Strip Rectangular Packing Problem

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自动化学报 2007年第9期33卷 911-916页

作者： ZHANG De-Fu CHEN sheng-da liu Yan-Juan Department of Computer Science Xiamen University Xiamen 361005 P. Ft. China

与基因算法结合的改进启发式的递归的策略在这份报纸被介绍。第一，这个方法寻找一些矩形，它有一样的长度或宽度，到没有浪费空间，形成一些层，然后，计算留下包装顺序的高度使用启发式的递归的策略并且使用基因算法的进化能力减少高... 详细信息

与基因算法结合的改进启发式的递归的策略在这份报纸被介绍。第一，这个方法寻找一些矩形，它有一样的长度或宽度，到没有浪费空间，形成一些层，然后，计算留下包装顺序的高度使用启发式的递归的策略并且使用基因算法的进化能力减少高度。基准问题的几个班上的计算结果证明了介绍算法能与已知的进化启发规则竞争。它特别为大测试问题更好表现。

关键词：改良式启发式递归策略遗传算法矩形封装

The add-on effect of a Chinese herbal formula for patients with resistant hypertension: study protocol for a pilot cohort study

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Journal of Integrative Medicine 2015年第2期13卷 122-128页

作者： Ya Yuwen Yu-qi liu Yan-ping Wang Jin-gang dai da-sheng liu Yue-xi Wang Xue-jie Han Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Experimental Research Center China Academy of Chinese Medical Sciences

BACKGROUND： Despite a recent American Heart Association （AHA） consensus statement emphasizing the importance of resistant hypertension （RH）, its control is still a challenge for conventional medicine. The Chinese herbal formula, Qutan Huayu Fang, has been used effectively to assist antihypertensive agents in blood pressure control, but its effect for RH patients is still unclear. This pilot study aims to explore the effects of taking the formula in addition to antihypertensive medication in the management of RH. METHODS/DESIGN： A prospective cohort study will be conducted in two first-class hospitals of traditional Chinese medicine （TCM）. Eligible RH patients will be classified as the experimental group （n = 100） and the control group （n = 100） based on the interventions they receive. Participants taking antihypertensive agents and the Chinese herbal formula will be in the experimental group and those taking antihypertensive agents alone will be in the control group. The whole study will last 24 weeks, including an 8-week observation and follow-up at 24 weeks. The primary outcomes, assessed against patient baseline conditions, will be the reduction of systolic blood pressure and diastolic blood pressure as well as changes in TCM symptoms and signs. These outcomes will be assessed at weeks 2, 4, 6, and 8. The reductions of blood pressure will also be assessed at week 24. Cardiac events and mortality rate will be secondary outcomes and will be assessed at weeks 8 and 24. Any adverse reactions will be recorded during the study. The causal inference method will be used to assess the effectiveness of the inclusion of TCM herbal medicine in the management of patients with RH. DISCUSSION： This study will determine whether the Chinese herbal formula is helpful for RH patients treated with antihypertensive agents and the findings will provide a basis for further confirmatory studies TRIAL REGISTRATION NUMBER： ClinicalTria/*** Identifier NCT01904695

关键词： resistant hypertension cohort study medicine, Chinese traditional Complementary therapies study protocol

Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

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Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui Ren Tian Li Xueer liu Zelin Zhang Xiaoxuan Chen Weiqiang Chen Kangsheng Li Jiangtao sheng Department of Microbiology and Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self-Powered Motion Sensing

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NANO-MICRO LETTERS 2025年第1期17卷 1-15页

作者： Wang, Yu-Ze Wang, Yu-Chang liu, Ting-Ting Zhao, Quan-Liang Li, Chen-Sha Cao, Mao-sheng Beijing Inst Technol Sch Mat Sci & Engn Beijing 100081 Peoples R China Peking Univ Sch Mat Sci & Engn Beijing 100871 Peoples R China North China Univ Technol Sch Mech & Mat Engn Beijing 100144 Peoples R China Heilongjiang Univ Minist Educ Peoples Republ China Key Lab Funct Inorgan Mat Chem Harbin 150080 Peoples R China

Polymeric microwave actuators combining tissue-like softness with programmable microwave-responsive deformation hold great promise for mobile intelligent devices and bionic soft robots. However, their application is challenged by restricted electromagnetic sensitivity and intricate sensing coupling. In this study, a sensitized polymeric microwave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx (MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique space-charge polarization and interfacial polarization, resulting in significant improvements of 230% in the dielectric loss factor and 830% in the apparent efficiency of electromagnetic energy harvest. The sensitized microwave actuation demonstrates as the shortened response time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (up to 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combines driving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of similar to 3 mV) during actuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approach for developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

不同化疗方案治疗晚期非小细胞肺癌临床分析及药物经济学评价

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临床军医杂志 2017年第7期45卷 701-705页

作者：张潇任天舒党大胜刘锋沈阳军区总医院药剂科辽宁沈阳110016 解放军第四〇三医院药械科辽宁大连116021

目的比较4种化疗方案治疗晚期非小细胞肺癌的有效性、安全性及经济性。方法选择122例原发性非小细胞肺癌患者为研究对象。将患者按治疗方案分为培美曲塞+顺铂(PP)组(n=35)、吉西他滨+顺铂(GP)组(n=29)、多西他赛+顺铂(DP)组(n=28)和紫杉... 详细信息

目的比较4种化疗方案治疗晚期非小细胞肺癌的有效性、安全性及经济性。方法选择122例原发性非小细胞肺癌患者为研究对象。将患者按治疗方案分为培美曲塞+顺铂(PP)组(n=35)、吉西他滨+顺铂(GP)组(n=29)、多西他赛+顺铂(DP)组(n=28)和紫杉醇+顺铂(TP)组(n=30)。比较4组患者的疗效、不良反应和药物经济学评价。结果 4组(PP组、GP组、DP组、TP组)化疗方案有效率分别为42.9%、41.4%、42.9%、23.3%(P>0.05);疾病控制率分别为94.3%、93.1%、92.9%、83.3%(P>0.05);骨髓抑制不良反应发生率分别为85.7%、89.6%、71.4%、76.7%(P>0.05);胃肠道反应发生率分别为82.8%、86.1%、96.4%、96.7%(P>0.05);花费成本分别为40 510.48元、5 819.44元、7 323.48元、3 490.56元。结论 4组化疗方案中,PP组的有效率和疾病控制率最佳,但4组总体的有效率和疾病控制率差异并无统计学意义(P>0.05)。PP组胃肠道反应发生率最低,DP组骨髓抑制发生率最低,但4组总体的不良反应发生率差异无统计学意义(P>0.05)。PP组花费的成本最高,TP组最低,根据最小成本分析法,TP组最为经济。

关键词：非小细胞肺癌化疗方案药物经济学最小成本分析合理用药

Estimating wheat fractional vegetation cover using a density peak k-means algorithm based on hyperspectral image data

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Journal of Integrative Agriculture 2021年第11期20卷 2880-2891页

作者： liu da-zhong YANG Fei-fei liu sheng-ping Key Laboratory of Agricultural Information Service Technology Ministry of Agriculture and Rural Affairs/Intelligent Agriculture Research OfficeAgricultural Information InstituteChinese Academy of Agricultural SciencesBeijing 100081P.R.China

Fractional vegetation cover(FVC)is an important parameter to measure crop *** studies of crop growth monitoring,it is very important to extract FVC quickly and *** the most widely used FVC extraction method,the photographic method has the advantages of simple operation and high extraction ***,when soil moisture and acquisition times vary,the extraction results are less *** accommodate various conditions of FVC extraction,this study proposes a new FVC extraction method that extracts FVC from a normalized difference vegetation index(NDVI)greyscale image of wheat by using a density peak k-means(DPK-means)*** this study,Yangfumai 4(YF4)planted in pots and Yangmai 16(Y16)planted in the field were used as the research *** a hyperspectral imaging camera mounted on a tripod,ground hyperspectral images of winter wheat under different soil conditions(dry and wet)were collected at 1 m above the potted wheat *** aerial vehicle(UAV)hyperspectral images of winter wheat at various stages were collected at 50 m above the field wheat canopy by a UAV equipped with a hyperspectral *** pixel dichotomy method and DPK-means algorithm were used to classify vegetation pixels and non-vegetation pixels in NDVI greyscale images of wheat,and the extraction effects of the two methods were compared and *** results showed that extraction by pixel dichotomy was influenced by the acquisition conditions and its error distribution was relatively scattered,while the extraction effect of the DPK-means algorithm was less affected by the acquisition conditions and its error distribution was *** absolute values of error were 0.042 and 0.044,the root mean square errors(RMSE)were 0.028 and 0.030,and the fitting accuracy R2 of the FVC was 0.87 and 0.93,under dry and wet soil conditions and under various time conditions,*** study found that the DPK-means algorithm was capable of achieving more accur

关键词： fractional vegetation cover k-means algorithm NDVI vegetation index wheat