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OIP5 Interacts with NCK2 to Mediate Human Spermatogonial Stem Cell Self-Renewal and Apoptosis through Cell Cyclins and Cycle Progression and Its Abnormality Is Correlated with Male Infertility

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Research 2024年第1期2023卷 455-469页

作者： Yinghong cui Wei Chen li Du Zuping He The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province The Research Center of Reproduction and Translational Medicine of Hunan ProvinceHunan Normal University School of MedicineChangsha 410013HunanChina

Spermatogonial stem cells(SSCs)have important applications in both reproduction and regenerative ***,specific genes and signaling transduction pathways in mediating fate decisions of human SSCs remain ***,we have demonstrated for the first time that OIP5(Opa interacting protein 5)controlled the self-renewal and apoptosis of human *** sequencing identified that NCK2 was a target for OIP5 in human SSCs,and interestingly,OIP5 could interact with NCK2 as shown by Co-IP(co-immunoprecipitation),IP-MS(mass spectrometry),and GST pulldown ***2 silencing decreased human SSC proliferation and DNA synthesis but enhanced their ***,NCK2 knockdown reversed the influence of OIP5 overexpression on human ***,OIP5 inhibition decreased the numbers of human SSCs at S and G2/M phases,while the levels of numerous cell cycle proteins,including cyclins A2,B1,D1,E1 and H,especially cyclin D1,were remarkably ***,whole-exome sequencing of 777 patients with nonobstructive azoospermia(NOA)revealed 54 singlenucleotide polymorphism mutations of the OIP5 gene(6.95%),while the level of OIP5 protein was obviously lower in testes of NOA patients compared to fertile ***,these results implicate that OIP5 interacts with NCK2 to modulate human SSC self-renewal and apoptosis via cell cyclins and cell cycle progression and that its mutation and/or lower expression is correlated with *** such,this study offers novel insights into molecular mechanisms underlying the fate determinations of human SSCs and the pathogenesis of NOA,and it provides new targets for treating male infertility.

关键词： OIP5 Apoptosis reversed

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Distributed user pairing and effective computation offloading in aerial edge networks

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Chinese Journal of Aeronautics 2024年第4期37卷 378-390页

作者： Wei liANG Shuhui WEN lixin li Jingjing cui School of Electronics and Information Northwestern Polytechnical UniversityXi’an CN710072China The State Key Laboratory of Integrated Services Networks Xidian UniversityXi’an CN710126China School of Electronics and Computer Science University of SouthamptonSouthampton SO167NSUK

Future Sixth-Generation (6G) mobile communication networks extremely require the global connectivity and the ground Base Stations (BSs) are difficult to develop in some specific areas,such as mountainous ***,the aerial networks are the key framework for the future communications,in which the aerial vehicle could act as the access ***,Mobile Edge Computing (MEC) is also essential to enhance the data processing capabilities of aerial *** this paper,we study a comprehensive communication-computation resource management problem for jointly optimizing user pairing,power and time allocation in the MEC aided Cognitive Radio (CR) aerial networks,namely CR-MEC aerial ***,this multilevel optimization problem could be decomposed into the user pairing and power allocation as well as time allocation *** the conceived CR-MEC aerial networks,we propose a User Pairing and Computation Offloading Management Algorithm (UPCOMA) based on three-sided matching theory,aiming to minimize the system’s energy *** the first step of UPCOMA,multiple Primary Users (PUs) and Cognitive Users (CUs) on the ground negotiate to each other with the suitable power allocation coefficients and construct the stable user ***,the stable user pairs would match to a high altitude platform who act as the base station,which is for appropriately allocating Transmission Time Slots (TSs) at the second step of ***,a hybrid offloading mode is proposed in our conceived networks in order to support ground users to offload their tasks adaptively according to their individual ***,the simulation results reveal that the relative performance of UPCOMA is close to that of the Brute-Force Search Algorithm (BFSA) with low ***,the hybrid offloading mode with less energy consumption supports much more ground user pairs to offload tasks compared to the binary mode.

关键词： Aerial edge computing Binary offloading Cognitive radio Hybrid offloading Resource management

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Experimental investigation of spectral evolution in flash radiation by hypervelocity impact on aluminum plates

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Defence Technology（防务技术） 2024年第7期37卷 96-110页

作者： Xing Chen Yonggang Lu Zhiwen li Zhonghua cui Institute of Systems Engineering China Academy of Engineering PhysicsMianyang 621900SichuanChina Chongqing Qianwei Technology Group Co. LtdChongqing 401121China

In this study,a series of hypervelocity impact tests were carried out based on a two-stage light gas gun,and the sequence spectrum and radiation evolution data of the impact products under different impact conditions were *** diameter of the projectile is 3-5 mm,the impact velocity is 3.13-6.58 km/s,and the chamber pressure is 0.56-990 *** spectrum of ejected debris cloud in the 250-310 nm band were obtained using a transient spectral measurement system and a multi-channel radiometer measurement *** test results reveal that the flash radiation intensity increases as a power function with the kinetic energy of the ***,the peak value of the line spectrum decreases as the chamber vacuum degree increases,while the radiation width gradually *** line spectrum in the spectral characterization curve corresponds to the ejected debris clouds splitting phase,which does not produce significant line spectrum during material fragmentation and is dominated by the continuum spectrum produced by blackbody *** will appear one or three characteristic peaks in the flash radiation time curve,the first and second peaks correspond to the penetration phase and the third peak corresponds to the expansion phase of the ejected debris clouds on the time scale,the first and second peaks are more sensitive to the chamber vacuum degree,and when the pressure is higher than 99 Pa,the first and second characteristic peaks will *** radiant heat attenuation of the flash under different impact conditions is significantly different,the attenuation exponent has a power function relationship with the impact velocity and the chamber vacuum degree,while the attenuation exponent has a linear relationship with the diameter of the projectile,the specific expression of the attenuation exponent is obtained by *** findings from this research can serve as a valuable reference for remote diagnostic technologies based on flash radiation characte

关键词： Hypervelocity impact Flash radiation Evolution Spectral characteristics damage evaluation

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Discriminatively Constrained Semi-Supervised Multi-View Nonnegative Matrix Factorization with Graph Regularization

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Big data Mining and Analytics 2024年第1期7卷 55-74页

作者： Guosheng cui Ye li Jianzhong li Jianping Fan Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China Joint Engineering Research Center for Health Big data Intelligent Analysis Technology Shenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China School of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Nonnegative Matrix Factorization(NMF)is one of the most popular feature learning technologies in the field of machine learning and pattern *** has been widely used and studied in the multi-view clustering tasks because of its *** study proposes a general semi-supervised multi-view nonnegative matrix factorization *** algorithm incorporates discriminative and geometric information on data to learn a better-fused representation,and adopts a feature normalizing strategy to align the different *** specific implementations of this algorithm are developed to validate the effectiveness of the proposed framework:Graph regularization based Discriminatively Constrained Multi-View Nonnegative Matrix Factorization(GDCMVNMF)and Extended Multi-View Constrained Nonnegative Matrix Factorization(ExMVCNMF).The intrinsic connection between these two specific implementations is discussed,and the optimization based on multiply update rules is *** on six datasets show that the effectiveness of GDCMVNMF and ExMVCNMF outperforms several representative unsupervised and semi-supervised multi-view NMF approaches.

关键词： multi-view semi-supervised clustering discriminative information geometric information feature normalizing strategy

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Low-temperature graphitization of lignin via Co-assisted electrolysis in molten salt

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Green Energy & Environment 2024年第9期9卷 1449-1458页

作者： Shijie li Wei-li Song Xue Han Qingqing cui Yan-li Zhu Shuqiang Jiao Institute of Advanced Structure Technology Beijing Institute of Technology State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing State Key Laboratory of Explosion Science and Technology Beijing Institute of Technology

The ever-growing energy demand and environmental issues have stimulated the development of sustainable energy ***,an efficient and environmentally friendly electrochemical transformation technology was proposed to prepare highly graphitized carbon materials from an abundant natural resource-lignin （LG）.The preparation process mainly includes pyrolytic carbonization of raw LG material and electrochemical conversion of amorphous carbon ***,with the assistance of Co catalyst,the graphitization degree of the products was significantly improved,in which the mechanism was the removal of heteroatoms in LG and the rearrangement of carbon atoms into graphite ***,tunable microstructures （nanoflakes） under catalytic effects could also be observed by controlling the electrolytic *** with the products CN1 （without catalyst） and CN5 （with 10%catalyst）,the specific surface area are 158.957 and202.246 m2g-1,*** used as the electrode material for lithium-ion batteries,CN5 delivered a competitive specific capacity of～350 m Ah g-1（0.5 C） compared with commercial *** strategy proposed in this work provides an effective way to extract value-added graphite materials from lignin and can be extended to the graphitization conversion of any other amorphous carbon precursor materials.

关键词： lignin Graphitic carbon Electrochemical conversion lithium-ion batteries

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Additives strategies to improving cycling stability of li metal batteries by modifying electrode electrolyte interphases

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Progress in Natural Science:Materials International 2024年第2期34卷 338-344页

作者： Yuan li Pengfei Huang Chunyu cui Xiaoyuan Ma li Chen Zekun li linhai li Yuhong Tian School of Biological and Chemical Engineering Guangxi University of Science and Technology School of College of Chemistry and Chemical Engineering Hunan University Isky Future Energy Institute

li metal batteries（LMBs） have attracted much attention due to the ultra-high theoretical capacity of the li metal anode（LMA）.However,the uncontrollable dendrites growth and low coulombic efficiency hinder their practical ***,we explore 3,5-difluoropyridine（2F-BD） as a novel electrolyte additive to enable highperformance *** 2F-BD additive participates in and modifies the solvation structure of li ions by reducing the coordinated number of PF6-at the electrode surface,leading to the formation of a liF and li3N-rich solid electrolyte interphase（SEI）.The liF component increases the robustness of SEI and suppresses the formation of li dendrites,while the li3N component facilitates the transportation and reaction kinetics of li *** a result,the li‖li symmetric cell presents a stable cycling performance of up to 500 h at a current density of 1 mA *** coupling with liFePO4cathode,the obtained full cell achieves high specific capacities of 106.06 mA h g-1and 84.98 mA h g-1at 2.55 mA cm-2and 5.10 mA cm-2,respectively,and maintains a high capacity retention of84.0% after 1000 cycles at 0.13 mA cm-2,with an average cycling CE of 99.58%.

关键词： Electrolyte additive li dendrites li metal batteries liF and li3N-Rich electrode-electrolyte interphase liFePO4 cathode

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Transcriptomics integrated with metabolomics reveals the mechanism of CaCl_(2)-HCl electrolyzed water-induced glucosinolate biosynthesis in broccoli sprouts

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Food Science and Human Wellness 2024年第2期13卷 801-812页

作者： cui li Shuhui Song Yanan He Haijie liu College of Food Science and Nutritional Engineering China Agricultural UniversityBeijing 100083China Institute of Agri-food Processing and Nutrition Beijing Academy of Agriculture and Forestry SciencesBeijing 100097China

Glucosinolates are important phytochemicals in *** investigated the effect of CaCl_(2)-HCl electrolyzed water(CHEW)on glucosinolates biosynthesis in broccoli *** results showed that CHEW treatment significantly decreased reactive oxygen species(ROS)and malondialdeh yde(Mda)contents in broccoli *** the the 8^(th)day,compared to tap water treatment,the the total glucosinolate content of broccoli sprouts with CHEW treatment increased by 10.6%and calcium content was dramatically enhanced from 14.4 mg/g DW to 22.7 mg/g *** transcriptome and metabolome analyses revealed that CHEW treatment activated ROS and calcium signaling transduction pathways in broccoli sprouts and they interacted through MAPK ***,CHEW treatment not only promoted the biosynthesis of amino acids,but also enhanced the expression of structural genes in glucosinolate synthesis through transcription factors(MYBs,bHLHs,WRKYs,etc.).The results of this study provided new insights into the regulatory network of glucosinolates biosynthesis in broccoli sprouts under CHEW treatment.

关键词： Broccoli sprouts CaCl_(2)-HCl electrolyzed water Glucosinolates Transcriptomics Metabolomics

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Acute Effects of Low Temperatures and Cold Waves on Elderly Infectious Pneumonia Mortality—Jinan City,Shandong Province,China,2014-2022

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China CDC weekly 2024年第5期6卷 77-82,I0002-I0005页

作者： Huiyun Chang Mingjun li Ying Wang liangliang cui Tiantian li Jinan Municipal Center for Disease Control and Prevention Jinan Municipal Center for Disease Control and Prevention Affiliated to Shandong UniversityJinan CityShandong ProvinceChina Chinese Filed Epidemiology Training Program Chinese Center for Disease Control and PreventionBeijingChina China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?The mortality rate due to pneumonia varies depending on the infectious agents present in a low-temperature *** is added by this report?This study aimed to examine the relationship between low temperatures and cold waves and the risk of mortality from infectious pneumonia in the *** findings indicate a significant increase in the risk of infectious pneumonia.

关键词： environment Shandong finding

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Experimental study on the size effect on the equation of state of concretes under shock loading

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Defence Technology（防务技术） 2024年第3期33卷 160-167页

作者： Mei li Jian cui Yanchao Shi Baijian Tang Xin Chen Key Laboratory of Coast Civil Structural Safety of the Ministry of Education Tianjin UniversityTianjin 300072China School of Civil Engineering Suzhou University of Science and Technology1701 Binhe RoadSuzhou 215011JiangsuChina School of Civil Engineering Tianjin UniversityTianjin 300072China

Adopting the classical theory of hydrocodes,the constitutive relations of concretes are separated into an equation of state(EoS)which describes the volumetric behavior of concrete material and a strength model which depicts the shear properties of *** experiments on the EoS of concrete is always challenging due to the technical difficulties and equipment limitations,especially for the specimen size effect on the *** some researchers investigate the shock properties of concretes by fly-plate impact tests,the specimens used in their tests are usually in one *** this paper,the fly-plate impact tests on concrete specimens with different sizes are performed to investigate the size effect on the shock properties of concrete *** mechanical background of the size effect on the shock properties are revealed,which is related to the lateral rarefaction effect and the deviatoric stress produced in the *** to the tests results,the modified EoS considering the size effect on the shock properties of concrete are proposed,which the bulk modulus of concrete is unpredicted by up to 20% if size effects are not accounted for.

关键词： Concrete Equation of state Size effect Shock wave Fly-plate impact test

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Corrosion Behavior of Pre-oxidized GH4169 Alloy with Solid NaCI Deposited in a Wet Oxygen Flow at 600 ℃

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1249-1264页

作者： Weidong Zhang Yu cui li liu Wenquan Wang Wenzheng Chen Rui li Fuhui Wang Shenyang National Laboratory for Materials Science Northeastern UniversityShenyang110819China Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016China

The corrosion behavior of the pre-oxidized GH4169 alloy was studied after 20 h of exposure under a solid NaCl deposit film in a wet O_(2) environment at 600℃ by mass-gain measurements,X-ray diffraction,scanning electron microscopy,transmission electron microscopy *** results indicate that the pre-oxidized GH4169 alloy undergoes serious corrosion in the corrosive *** preformed Cr_(2)O_(3) layer is gradually destroyed by deposit NaCl,and the inner Nb2O5 layer beneath the complete outer Cr_(2)O_(3) layer also reacts with NaCl to form NaNbO_(3).The electrochemical test results testified the existence of electrochemical reactions during this corrosion *** corrosion behavior of pre-oxidized GH4169 under a solid NaCl deposit film in a wet O_(2) environment at 600℃has been discussed in detail.

关键词： Pre-oxidation Solid NaCl Wet O2 Electrochemical corrosion

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