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Comparative efficacy and safety of Chinese patent medicines of iron deficiency anemia during pregnancy:A network meta-analysis

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World Journal of Clinical Cases 2024年第18期12卷 3515-3528页

作者： Jia-Chen Zou xian-Ling Jia hai-xia Wang Ying-Jie Su Jing-Yu Zhu School of Chinese Medicine Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Traditional Chinese Medicine Department Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina

BACKGROUND Iron deficiency anemia(Ida)is a prevalent nutritional disorder during *** studies indicate that incorporating Chinese patent medicines(CPMs)with oral iron(OI)in treating Ida in pregnancy can reduce adverse effects and improve clinical ***,the comparative efficacy of different CPMs remains *** To assess the safety and effectiveness of different CPMs for treating Ida during pregnancy using network *** We conducted a search for randomized controlled trials(RCTs)that combined CPM and OI for Ida treatment in pregnancy,spanning from 2013 to the *** analysis was performed using Rev Man 5.3 and Stata 14.0 on literature that satisfied the quality *** The analysis included 45 RCTs,encompassing 4422 pregnant patients with *** CPMs were examined,including Shengxuebao Mixture,Shengxuening Tablets(SXN),Yiqi Weixue CPMs(YQWX),Jianpi Shengxue CPMs(JPSX),Yiqi Buxue Tablets,and Compound Hongyi Buxue Oral Liquid(FFHY).Findings indicated that FFHY+OI significantly improved the clinical effective ***+OI was most effective in boosting red blood cells counts and hemoglobin ***+OI showed superior results in improving serum ferritin,and SXN+OI was most effective in increasing serum iron ***+OI was optimal in reducing adverse pregnancy outcomes,while YQBX+OI effectively minimized adverse events.A cluster analysis suggested that SXN+OI could be the potentially optimal therapeutic regimen for Ida in *** This study demonstrates that the combination of OI with CPMs offers better outcomes than OI *** on clinical efficacy and other measured outcomes,SXN+OI emerges as the most effective treatment modality for improving the health of pregnant patients with Ida.

关键词： Chinese patent medicine Network meta-analysis Shengxuebao Mixture Shengxuening Tablets Yiqi Weixue Chinese patent medicines Jianpi Shengxue Chinese patent medicines Yiqi Buxue Tablets Compound Hongyi Buxue Oral Liquid

Planning and construction of Xiong’an New Area(city of over 5 million people):Contributions of China’s geologists and urban geology

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China Geology 2024年第3期7卷 382-408页

作者： Bo Han Zhen Ma Liang-jun Lin Hong-wei Liu Yi-hang Gao Yu-bo xia hai-tao Li Xu Guo Feng Ma Yu-shan Wang Ya-long Zhou Hong-qiang Li Tianjin Center China Geological Survey(North China Center of Geoscience Innovation)Ministry of Natural ResourcesTianjin 300170China Xiong’an Urban Geological Research Center China Geological SurveyMinistry of Natural ResourcesTianjin 300170China Tianjin Key Laboratory of Coast Geological Processes and Environmental Safety Tianjin 300170China China Institute of Geo-Environment Monitoring Beijing 100081China Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Center for Hydrogeology and Environmental Geology China Geological SurveyMinistry of Natural ResourcesBaoding 071051China Institute of Geophysical&Geochemical Exploration Chinese Academy of Geological SciencesLangfang 065000China Chinese Academy of Geological Sciences Beijing 10037China

China established Xiong’an New Area in Hebei Province in 2017,which is planned to accommodate about 5 million people,aiming to relieve Beijing City of the functions non-essential to its role as China’s capital and to expedite the coordinated development of the Beijing-Tianjin-Hebei *** 2017 to 2021,the China Geological Survey(CGS)took the lead in multi-factor urban geological surveys involving space,resources,environments,and disasters according to the general requirements of“global vision,international standards,distinctive Chinese features,and future-oriented goals”in Xiong’an New Area,identifying the engineering geologic conditions and geologic environmental challenges of this *** achievements also include a 3D engineering geological structure model for the whole area,along with“one city proper and five clusters”,insights into the ecology and the background endowment of natural resources like land,geothermal resources,groundwater,and wetland of the area before engineering construction,a comprehensive monitoring network of resources and environments in the area,and the“Transparent Xiong’an”geological information platform that is open,shared,dynamically updated,and three-dimensionally ***’s geologists and urban geology have played a significant role in the urban planning and construction of Xiong’an New Area,providing whole-process geological solutions for urban planning,construction,operation and *** future urban construction of Xiong’an New Area will necessitate the theoretical and technical support of earth system science(ESS)from various aspects,and the purpose is to enhance the resilience of the new type of city and to provide support for the green,low-carbon,and sustainable development of this area.

关键词： Low Carbon New City Planning and construction Land Geothermal resources Groundwater Wetland Underground space Geologic disasters Site stability Natural resource Ecosystem Geological safety Transparent Xiong’an Resilient city Xiong’an New Area

金融集聚能有效提升县域经济韧性吗?——基于湖南省88个县(市)的空间效应分析

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湖南师范大学社会科学学报 2024年第2期53卷 88-103页

作者：谭燕芝海霞湘潭大学商学院湖南湘潭411105

面对日趋严峻的外部环境和内部新旧动能转换的冲击,县域经济韧性的提升已成为实现城乡融合可持续发展、实现乡村振兴的重要着力点。运用熵值法从抵抗力和恢复力两个方面测算了2011—2020年湖南88个县(市)的经济韧性,并采用空间杜宾模型... 详细信息

面对日趋严峻的外部环境和内部新旧动能转换的冲击,县域经济韧性的提升已成为实现城乡融合可持续发展、实现乡村振兴的重要着力点。运用熵值法从抵抗力和恢复力两个方面测算了2011—2020年湖南88个县(市)的经济韧性,并采用空间杜宾模型检验了金融集聚对县域经济韧性的影响。研究表明:县域金融资源的空间集聚对本地区的经济韧性有显著的正向直接效应,对周边地区有显著的空间溢出效应,且空间溢出效应大于直接效应;金融集聚的空间溢出效应在经济发展水平较高的县更加明显,存在显著的“效益依赖性”;金融集聚通过增加创业、激发创新提升县域经济韧性。县域金融发展应该突破区域限制,在经济发展水平较好的县设立区域性金融中心,集聚金融资源提高整体配置效率。

关键词：县域经济韧性金融集聚空间溢出效应区域差异

Half-precessional cycle revealed by environment magnetism of stalagmite in Shizhu Cave from southwestern China during the Last Glacial

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Journal of Earth Science 2024年

作者： Huihui Yang Yu-Min Chou Xiuyang Jiang Wenyue xia hai Li Yi Zhong Jingyu Zhang Yaoqi He Tsai-Luen Yu Qingsong Liu Chuan-Chou Shen College of Tourism and Air Service， Guizhou Minzu University Research Center for Future Earth， Taiwan University Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) School of Environment， Harbin Institute of Technology High-Precision Mass Spectrometry and Environment Change Laboratory (HISPEC)， Department of Geosciences， Taiwan University Key Laboratory of Humid Subtropical Eco-Geographical Processes， College of Geography Science， Fujian Normal University Center for Marine Magnetism (CM2)， Department of Ocean Science and Engineering， Southern University of Science and Technology

The environmental magnetic proxies of stalagmites hold significant potential for reconstructing regional hydroclimate changes by revealing the content and grain size of magnetic particles within stalagmites. In this study， we present the contents and grain sizes of magnetic particles within a stalagmite SZ-1， from Shizhu Cave in southwestern China from 70.4 to 22.3 thousand years ago (ka) during the last glacial period. Specifically， the parameters IRMsoft， soil-derived magnetic minerals， and ARM/SIRM (anhysteretic remanent magnetization/saturation isothermal remanent magnetization)， the ratio of fine magnetic particles to total ferrimagnetic particles preserved in stalagmite SZ-1， indicate the fluctuation of regional precipitation. Obvious half-precessional cycles are evident in these two proxies， indicating that hydroclimatic variations in southwestern China may predominantly arise from the heat and moisture transported from tropical oceans. These variations are likely influenced by shifts in the Intertropical Convergence Zone and fluctuations in the Asian summer monsoon.

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在线数据记录和扰动观测器相结合的柔性机械臂复合学习控制

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控制理论与应用 2024年第8期41卷 1417-1426页

作者：钱伟徐海钦王霞许斌河南理工大学电气工程与自动化学院河南焦作454000 西北工业大学自动化学院陕西西安710072

本文针对多输入多输出的柔性机械臂动力学模型,提出了一种基于神经网络估计和扰动观测器的复合学习控制策略.首先,通过奇异摄动分析将系统解耦为快慢子系统.然后,针对慢变刚性子系统的动力学模型,基于在线数据记录模型构造新型预测误差... 详细信息

本文针对多输入多输出的柔性机械臂动力学模型,提出了一种基于神经网络估计和扰动观测器的复合学习控制策略.首先,通过奇异摄动分析将系统解耦为快慢子系统.然后,针对慢变刚性子系统的动力学模型,基于在线数据记录模型构造新型预测误差,结合跟踪误差设计自适应控制律;针对快变柔性子系统采用滑模控制抑制弹性振动.在此基础上,构建了扰动观测器实时估计复合扰动信号,并纳入在线数据记录模型作为前馈补偿.最后,基于Lyapunov稳定性分析可证系统误差信号一致终值有界,仿真算例验证了所提策略的有效性和优越性.

关键词：柔性机械臂在线数据记录扰动观测器复合学习控制

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High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia

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Science China(Life Sciences) 2024年第8期67卷 1635-1647页

作者： Feng-Qi Liu Qing-Yuan Qu Ying Lei Qi Chen Yu-Xiu Chen Meng-Lin Li Xue-Yan Sun Ye-Jun Wu Qiu-Sha Huang hai-xia Fu Yuan Kong Yue-Ying Li Qian-Fei Wang xiao-Jun Huang xiao-Hui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Collaborative Innovation Centre of Hematology Peking UniversityBeijing 100044China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100074China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China

To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight(CyTOF).Thirtysix patients with ITP and nine healthy volunteers were enrolled in the *** soluble immunomodulatory molecules,more sCD25 and sGalectin-9 were detected in ITP *** the cell surface,co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T *** contrast,co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1 and Th17 cell *** a platelet count of 30×10^(9)L^(−1)as the cutoff value,ITP patients with high and low platelet counts showed different T cell immune ***-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions,respectively,and participate in the pathogenesis of *** conclusion,the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of *** may offer novel targets to develop personalized immunotherapies.

关键词： immune thrombocytopenia autoimmune diseases co-stimulatory co-inhibitory immune checkpoint CTLA4 Cytometry by Time of Flight bone marrow

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为有源头活水来:供应商创新的溢出效应研究

当代财经 2024年第4期 85-98页

作者：韦庆芳魏下海华侨大学经济与金融学院福建泉州362021

打造具有更强创新力的产业链供应链是“十四五”时期及未来更长时期的重要战略任务。基于上市公司供应链创新数据,从理论和经验上深入探究供应商创新对下游客户创新的影响。研究结果显示,第一,供应商在创新能力上相比下游客户具有一定... 详细信息

打造具有更强创新力的产业链供应链是“十四五”时期及未来更长时期的重要战略任务。基于上市公司供应链创新数据,从理论和经验上深入探究供应商创新对下游客户创新的影响。研究结果显示,第一,供应商在创新能力上相比下游客户具有一定的领先优势,体现为供应商的发明专利申请时间整体早于下游客户,并且在高度依赖创新驱动的行业中发明专利数量更多。第二,供应商创新具有显著的溢出效应,有效地推动了下游客户的创新产出。经过一系列内生性检验和其他稳健性检验,这一结论依然成立。第三,供应商创新有助于促进知识溢出、增加合作创新以及提升下游客户的研发效率,从而促进下游客户创新产出的增加。第四,供应商创新具有明显的经济效益,能够显著地提升下游客户的公司价值和成长性。上述研究发现有助于深化对企业创新和供应链合作的理解,同时为促进我国供应链的整合和创新能力的提升提供政策参考。

关键词：供应链创新溢出效应下游客户

Overcoming Spatial Constraints in VR:A Survey of Redirected Walking Techniques

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Journal of Computer Science & Technology 2024年第4期39卷 841-870页

作者： Jia-Hong Liu Yang-Fu Ren Qi Wen Gan Kui Huang Fiona xiao Yu Chen Er-xia Luo Khang Yeu Tang Yue-Yao Fu Cheng-Wei Fan Sen-Zhe Xu Song-hai Zhang Academy of Arts and Design Tsinghua UniversityBeijing 100084China Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China College of Computer Technology and Application Qinghai UniversityXining 810016China Zhili College Tsinghua UniversityBeijing 100084China School of Computer Beijing Information Science and Technology UniversityBeijing 100192China Department of Physics Tsinghua UniversityBeijing 100084China School of Computer and Communication Engineering University of Science and Technology BeijingBeijing 100083China

As the virtual reality(VR)technology strives to provide immersive and natural user experiences,the challenge of aligning vast virtual environments with limited physical spaces remains *** survey comprehensively explores the advancements in redirected walking(RDW)techniques aimed at overcoming spatial constraints in *** addresses this by subtly manipulating users’physical movements to allow for seamless navigation within constrained *** survey delves into gain perception mechanisms,detailing how slight discrepancies between virtual and real-world movements can be utilized without user awareness,thus extending the effective navigable *** RDW control algorithms for gain-based RDW are analyzed,highlighting their implementation and effectiveness in maintaining immersion and minimizing perceptual ***,novel methods extending beyond traditional gain-based techniques are discussed,showcasing innovative approaches that further refine VR *** practical implications of RDW in enhancing safety and reducing physical collisions in VR environments are underscored,alongside its potential to improve user experience by aligning virtual exploration more closely with natural human behavior *** a thorough review of existing literature and recent advancements,this survey provides a systematic understanding for researchers,developers,and industry *** underscores the importance of RDW in the future of VR,emphasizing RDW's role in making VR more accessible and practical across various applications,from education and training to therapy and *** paper concludes with a forward-looking perspective on the continued evolution and potential of RDW in revolutionizing virtual reality experiences.

关键词： virtual reality(VR) redirected walking(RDW) redirection gain perception

Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma

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Frontiers of Medicine 2024年第2期18卷 375-393页

作者： Fu’an Xie Yujia Niu Lanlan Lian Yue Wang Aobo Zhuang Guangting Yan Yantao Ren xiaobing Chen Mengmeng xiao Xi Li Zhe Xi Gen Zhang Dongmei Qin Kunrong Yang Zhigang Zheng Quan Zhang xiaogang xia Peng Li Lingwei Gu Ting Wu Chenghua Luo Shu-hai Lin Wengang Li Cancer Research Center Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen361102China xiamen University Research Center of Retroperitoneal Tumor Committee of Oncology Society of Chinese Medical Association Xiamen UniversityXiamen361102China Department of Laboratory Medicine Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China Department of Retroperitoneal Tumor Surgery Peking University International HospitalBeijing102206China School of Public Health Harvard UniversityBostonMA02115USA Laboratory of Biochemistry and Molecular Biology Research Department of Clinical LaboratoryFujian Medical University Cancer HospitalFuzhou350014China Surgery Department Affiliated Fuzhou First Hospital of Fujian Medical UniversityFuzhou350009China National Institute for data Science in Health and Medicine Xiamen UniversityXiamen361102China Department of Hepatobiliary Surgery Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China

Retroperitoneal liposarcoma(RLPS)is the main subtype of retroperitoneal soft sarcoma(RSTS)and has a poor prognosis and few treatment options,except for *** proteomic and metabolic profiles of RLPS have remained *** aim of our study was to reveal the metabolic profile of ***,we performed proteomic analysis(n=10),metabolomic analysis(n=51),and lipidomic analysis(n=50)of retroperitoneal dedifferentiated liposarcoma(RDDLPS)and retroperitoneal well-differentiated liposarcoma(RWDLPS)tissue and paired adjacent adipose tissue obtained during *** analysis mainly revealed that glycolysis,purine metabolism,pyrimidine metabolism and phospholipid formation were upregulated in both RDDLPS and RWDLPS tissue compared with the adjacent adipose tissue,whereas the tricarboxylic acid(TCA)cycle,lipid absorption and synthesis,fatty acid degradation and biosynthesis,as well as glycine,serine,and threonine metabolism were *** particular importance,the glycolytic inhibitor 2-deoxy-D-glucose and pentose phosphate pathway(PPP)inhibitor RRX-001 significantly promoted the antitumor effects of the MDM2 inhibitor RG7112 and CDK4 inhibitor *** study not only describes the metabolic profiles of RDDLPS and RWDLPS,but also offers potential therapeutic targets and strategies for RLPS.

关键词： RLPS proteomics metabolomics lipidomics metabolism