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针药联合运动康复训练对冠心病心力衰竭患者的影响

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实用中西医结合临床 2022年第8期22卷 14-16,20页

作者：于大印河南省开封市通许第一医院心内科通许475400

目的:探讨针药联合运动康复训练对冠心病心力衰竭患者的疗效。方法:选取医院心血管内科2017年6月至2019年10月收治的冠心病心力衰竭患者100例,采用双盲法分为对照组(50例)与观察组(50例)。对照组给予药物联合运动康复训练干预,观察组采... 详细信息

目的:探讨针药联合运动康复训练对冠心病心力衰竭患者的疗效。方法:选取医院心血管内科2017年6月至2019年10月收治的冠心病心力衰竭患者100例,采用双盲法分为对照组(50例)与观察组(50例)。对照组给予药物联合运动康复训练干预,观察组采用针药联合运动康复训练治疗。两组均治疗4周。对比两组治疗前、治疗4周后中医证候评分、心功能指标[左房内径(LAd)、左室射血分数(LVEF)、左室舒张末期内径(LVEDd)、左室收缩末期内径(LVESd)]及6 min步行距离。结果:治疗4周后,两组中医证候评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗4周后,两组LVEF均上升,LVEDd、LAd及LVESd均下降,且观察组LVEF高于对照组,LVEDd、LAd及LVESd均低于对照组,差异有统计学意义(P<0.05);治疗4周后,两组6 min步行距离均大于治疗前,且观察组大于对照组,差异有统计学意义(P<0.05)。结论:冠心病心力衰竭患者采用针药联合运动康复训练治疗可促进心功能恢复,提高运动耐量,改善临床症状。

关键词：冠心病心力衰竭针灸运动康复训练心功能

硝苯地平与氨氯地平治疗72例原发性高血压的临床疗效对比评价

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医药论坛杂志 2016年第10期37卷 68-69,72页

作者：于大印开封东原心血管病医院心血管内二科河南开封475400

目的对比评价硝苯地平与氨氯地平治疗72例原发性高血压的临床疗效。方法将72例原发性高血压患者纳入本次研究,以随机的方式分为两组,观察组36例采取氨氯地平治疗,对照组36例采取硝苯地平治疗,对比两组患者治疗前后血压变化情况、临床疗... 详细信息

目的对比评价硝苯地平与氨氯地平治疗72例原发性高血压的临床疗效。方法将72例原发性高血压患者纳入本次研究,以随机的方式分为两组,观察组36例采取氨氯地平治疗,对照组36例采取硝苯地平治疗,对比两组患者治疗前后血压变化情况、临床疗效以及不良反应发生情况。结果 1与治疗前相比,两组血压(包括舒张压与收缩压)均有明显改善(P0.05)。2在治疗总有效率方面,观察组与对照组分别为94.44%、80.56%;观察组治疗总有效率明显高于对照组(P<0.05)。3在不良反应发生率方面,观察组与对照组分别为5.56%、16.67%;观察组不良反应发生率明显低于对照组(P<0.05)。结论虽然硝苯地平与氨氯地平均能够使原发性高血压患者血压得到有效控制;但在临床疗效方面,采取氨氯地平治疗更高,在不良反应发生率则更低;因此,值得采纳应用。

关键词：硝苯地平氨氯地平原发性高血压

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑yuan yu Jing Wu Guang yin Fan‑Zhen Jiao Zhong‑Zhen yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin yin Yalan Xu Jie Mu yu Leng Lei Ma yu Zheng Ruizhi Li yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

Towards the full realization of the RIBLL2 beam line at the HIRFL-CSR complex

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Science Bulletin 2018年第2期63卷 78-80页

作者： Bao-Hua Sun Jian-Wei Zhao Xue-Heng Zhang Li-Na Sheng Zhi-yu Sun Isao Tanihata Satoru Terashima Yong Zheng Li-Hua Zhu Li-Min Duan Liu-Chun He Rong-Jiang Hu Guang-Shuai Li Wen-Jian Lin Wei-Ping Lin Chuan-Ye Liu Zhong Liu Chen-Gui Lu Xin-Wen Ma Li-Jun Mao Yi Tian Feng Wang Meng Wang Shi-Tao Wang Jia-Wen Xia Xiao-Dong Xu Hu-Shan Xu Zhi-Guo Xu Jian-Cheng Yang da-yu yin You-Jin yuan Wen-Long Zhan yu-Hu Zhang Xiao-Hong Zhou School of Physics and Nuclear Energy Engineering Beihang University Beijing 100191 China International Research Center for Nuclei and Particles in the Cosmos Beijing 100191 China Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China

More than 99%of the mass in the visible universe—the material that makes up ourselves,our planet,stars—is in the atomic *** the matter has existed for billions of years,only over the past few decades have we had the tools and the knowledge necessary to get a basic understanding of the structure and dynamic of *** physicists around the world have made tremendous strides by initiating a broad range of key

关键词： HIRFL-CSR 横梁建筑群排队原子核物理学家试验性世界

Enhancement of electron–ion recombination rates at low energy range in the heavy ion storage ring CSRm

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Chinese Physics B 2020年第3期29卷 169-175页

作者： Nadir Khan Zhong-Kui Huang Wei-Qiang Wen Shu-Xing Wang Han-Bing Wang Wan-Lu Ma Xiao-Long Zhu Dong-Mei Zhao Li-Jun Mao Jie Li Xiao-Ming Ma Mei-Tang Tang da-yu yin Wei-Qing Yang Jian-Cheng Yang You-Jin yuan Lin-Fan Zhu Xin-Wen Ma Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Hefei National Laboratory for Physical Sciences at Micro-scale Department of Modern PhysicsUniversity of Science and Technology of ChinaHefei 230026China

Recombination of Ar^(14+), Ar^(15+), Ca^(16+), and Ni^(19+) ions with electrons has been investigated at low energy range based on the merged-beam method at the main cooler storage ring CSRm in the Institute of Modern Physics, Lanzhou,China. For each ion, the absolute recombination rate coefficients have been measured with electron–ion collision energies from 0 meV to 1000 meV which include the radiative recombination(RR) and also dielectronic recombination(DR)processes. In order to interpret the measured results, RR cross sections were obtained from a modified version of the semiclassical Bethe and Salpeter formula for hydrogenic ions. DR cross sections were calculated by a relativistic configuration interaction method using the flexible atomic code(FAC) and AUTOSTRUCTURE code in this energy range. The calculated RR + DR rate coefficients show a good agreement with the measured value at the collision energy above 100 ***, large discrepancies have been found at low energy range especially below 10 meV, and the experimental results show a strong enhancement relative to the theoretical RR rate coefficients. For the electron–ion collision energy below 1 meV, it was found that the experimentally observed recombination rates are higher than the theoretically predicted and fitted rates by a factor of 1.5 to 3.9. The strong dependence of RR rate coefficient enhancement on the charge state of the ions has been found with the scaling rule of q^(3.0), reproducing the low-energy recombination enhancement effects found in other previous experiments.

关键词： storage ring electron cooler highly charged ions radiative recombination enhancement

Low energy range dielectronic recombination of Fluorine-like Fe^17+at the CSRm

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Chinese Physics C 2018年第6期42卷 53-58页

作者： Nadir Khan Zhong-Kui Huang Wei-Qiang Wen Sultan Mahmood Li-Jun Dou Shu-Xing Wang Xin Xu Han-Bing Wang Chong-Yang Chen Xiao-Ya Chuai Xiao-Long Zhu Dong-Mei Zhao Li-Jun Mao Jie Li da-yu yin Jian-Cheng Yang You-Jin yuan Lin-Fan Zhu Xin-Wen Ma Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China University of Chinese Academy of Sciences Beijing 100049 China Hefei National Laboratory for Physical Sciences at Micro Scale Department of Modern Physics University of Science and Technology of China Hefei 230026 China Shanghai EBIT Laboratory Key Laboratory of Nuclear Physics and Ion-beam Application Institute of Modern Physics Department of Nuclear Science and Technology Fudan University Shanghai 200433 China

The accuracy of dielectronic recombination （DR） data for astrophysics related ions plays a key role in astrophysical plasma modeling. The absolute DR rate coefficient of Fe^17＋ ions was measured at the main cooler storage ring at the Institute of Modern Physics, Lanzhou, China. The experimental electron-ion collision energy range covers the first Rydberg series up to n = 24 for the DR resonances associated with the 2p1/2 →^2 p3/2△n= 0 core excitations. A theoretical calculation was performed by using FAC code and compared with the measured DR rate coefficient. Overall reasonable agreement was found between the experimental results and calculations. Moreover, the plasma rate coefficient was deduced from the experimental DR rate coefficient and compared with the available results from the literature. At the low energy range, significant discrepancies were found, and the measured resonances challenge state-of-the-art theory at low collision energies.

关键词： storage ring electron cooler electron-ion recombination plasma rate coefficient

Flexible Strain Sensors with Ultra-High Sensitivity and Wide Range Enabled by Crack-Modulated Electrical Pathways

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NANO-MICRO LETTERS 2025年第1期17卷 1-19页

作者： Bai, yunzhao Zhou, yunlei Wu, Xuanyu yin, Mengfei yin, Liting Qu, Shiyuan Zhang, Fan Li, Kan Huang, Yongan Huazhong Univ Sci & Technol State Key Lab Intelligent Mfg Equipment & Technol Wuhan 430074 Peoples R China Huazhong Univ Sci & Technol Flexible Elect Res Ctr Wuhan 430074 Peoples R China Xidian Univ Hangzhou Inst Technol Hangzhou 311200 Peoples R China Xidian Univ Sch Mechanoelect Engn Xian 710071 Peoples R China Univ Southern Calif Dept Aerosp & Mech Engn Los Angeles CA 90089 USA

This study presents a breakthrough in flexible strain sensor technology with the development of an ultra-high sensitivity and wide-range sensor, addressing the critical challenge of reconciling sensitivity with measurement range. Inspired by the structure of bamboo slips, we introduce a novel approach that utilises liquid metal to modulate the electrical pathways within a cracked platinum fabric electrode. The resulting sensor demonstrates a gauge factor greater than 108 and a strain measurement capability exceeding 100%. The integration of patterned liquid metal enables customisable tuning of the sensor's response, while the porous fabric structure ensures superior comfort and air permeability for the wearer. Our design not only optimises the sensor's performance but also enhances the electrical stability that is essential for practical applications. Through systematic investigation, we reveal the intrinsic mechanisms governing the sensor's response, offering valuable insights for the design of wearable strain sensors. The sensor's exceptional performance across a spectrum of applications, from micro-strain to large-strain detection, highlights its potential for a wide range of real-world uses, demonstrating a significant advancement in the field of flexible electronics.

关键词： Flexible strain sensor Fabric Crack Response regulation Epidermal device

Investigations of the dielectronic recombination of phosphorus-like tin at CSRm

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Chinese Physics B 2018年第6期27卷 268-273页

作者： Xin Xu Shu-Xing Wang Zhong-Kui Huang Wei-Qiang Wen Han-Bing Wang Tian-Heng Xu Xiao-Ya Chuai Li-Jun Dou Wei-Qing Xu Chong-Yang Chen Chuan-ying Li Jian-Guo Wang ying-Long Shi Chen-Zhong Dong Li-Jun Mao da-yu yin Jie Li Jian-Cheng Yang You-Jin yuan Xin-Wen Ma and Lin-Fan Zhu Hefei National Laboratory for Physical Sciences at Microscale and Department of Modern Physics University of Science and Technology of China Hefei 230026 China Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China Hefei 230026 China Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China School of Physical Sciences University of the Chinese Academy of Sciences Beijing 100049 China Shanghai EBIT Laboratory Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application （MOE） Fudan University Shanghai 200433 China National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230026 China 7 The Key Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics Beijing 100088 China 8Institute for Fundamental Physics Tianshui Normal University Tianshui 741000 China 9 Key Laboratory of Atomic and Molecular Physics and Functional Materials of Gansu Province College of Physics and Electronic Engineering Northwest Normal University Lanzhou 730070 China

The electron–ion recombination for phosphorus-like^（112） Sn^（35＋）has been measured at the main cooler storage ring of the Heavy Ion Research Facility in Lanzhou, China, employing an electron–ion merged-beams technique. The absolute total recombination rate coefficients for electron–ion collision energies from 0 e V–14 e V are presented. Theoretical calculations of recombination rate coefficients were performed using the Flexible Atomic Code to compare with the experimental results. The contributions of dielectronic recombination and trielectronic recombination on the experimental rate coefficients have been identified with the help of the theoretical calculation. The present results show that the trielectronic recombination has a substantial contribution to the measured electron–ion recombination spectrum of^（112）Sn^（35＋）. Although a reasonable agreement is found between the experimental and theoretical results the precise calculation of the electron–ion recombination rate coefficients for M-shell ions is still challengeable for the current theory.

关键词： dielectronic recombination trielectronic recombination storage ring electron cooling