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Incorporating mesopelagic fish into the evaluation of conservation areas for marine living resources under climate change scenarios

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Marine Life Science & Technology 2024年第2期6卷 68-83页

作者： Shuhao Liu Yang Liu Katharina Teschke Mark AHindell Rachel Downey Briannyn Woods Bin Kang Shuyang Ma Chi Zhang Jianchao Li Zhenjiang Ye Peng Sun Jianfeng he Yongjun Tian Research Centre for Deep Sea and Polar Fisheries and Key Laboratory of MaricultureMinistry of EducationOcean University of ChinaQingdao 266003China Frontiers Science Center for Deep Ocean Multispheres and Earth System Ocean University of ChinaQingdao 266100China Alfred Wegener Institute Helmholtz Centre for Polar and Marine ResearchAm Handelshafen 1227570 BremerhavenGermany helmholtz Institute for Functional Marine Biodiversity at the University Oldenburg Ammerländer Heerstraße 23123129 OldenburgGermany Institute for Marine and Antarctic Studies University of TasmaniaHobart 7004Australia Fenner School of Environment and Society Australian National UniversityCanberraACT 2602Australia College of Fisheries Ocean University of ChinaQingdao 266003China Polar Research Institute of China Shanghai 200136China

Mesopelagic fish(meso-fish)are central species within the Southern Ocean(SO).However,their ecosystem role and adaptive capacity to climate change are rarely integrated into protected areas *** is a pity given their importance as crucial prey and predators in food webs,coupled with the impacts of climate ***,we estimate the habitat distribution of nine meso-fish using an ensemble model approach(MAXENT,random forest,and boosted regression tree).Four climate model simulations were used to project their distribution under two representative concentration pathways(RCP4.5 and RCP8.5)for short-term(2006–2055)and long-term(2050–2099)*** addition,we assess the ecological representativeness of protected areas under climate change scenarios using meso-fish as indicator *** models show that all species shift poleward in the ***(family Myctophidae)are predicted to migrate poleward more than other families(Paralepididae,Nototheniidae,Bathylagidae,and Gonostomatidae).In comparison,lanternfishes were projected to increase habitat area in the eastern SO but lose area in the western SO;the opposite was projected for species in other *** areas(IAs)of meso-fish are mainly distributed near the Antarctic Peninsula and East *** protected area cover 23% of IAs at present and 38%of IAs in the future(RCP8.5,long-term future).Many IAs of meso-fish still need to be included in protected areas,such as the Prydz Bay and the seas around the Antarctic *** results provide a framework for evaluating protected areas incorporating climate change adaptation strategies for protected areas management.

关键词： Myctophids Mesopelagic fish Species distribution model Southern Ocean Antarctic Peninsula

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Functions and Applications of Intestinal Symbiotic Microorganisms in Insects

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Asian Agricultural Research 2024年第8期16卷 23-28页

作者： Cong CheN Junyu lin Zhaoyan lin Qianrou LI Jingyi HUANG Qijing WU Qianhua JI Institute of Pomology/College of Life Sciences Zhaoqing UniversityZhaoqing 526061China

Insects represent a diverse group of organisms on earth that carry a vast array of symbiotic microorganisms in their *** microorganisms have established a complex and intimate symbiotic relationship with their host insects over an extended period of evolutionary *** population structure of intestinal symbiotic microorganisms in insects exhibits a high degree of diversity,with notable differences among insect ***,within the same insect species,the population structure of symbiotic microorganisms in specific intestinal sites demonstrates a certain degree of stability and *** symbiotic microorganisms perform various physiological functions in the host *** biological functions encompass nutrient and material metabolism and immune and protective mechanisms,which have significant effects on host insect longevity,development,and reproductive *** microorganisms have diverse applications,including pest control,bioenergy production,the development of insect resources,*** advancements in high-throughput sequencing technology have revealed a growing diversity and biological properties of these *** application of these techniques has significantly contributed to the advancement of research in the field of insect intestinal microbial research,providing researchers with powerful tools for a deeper understanding and utilization of these symbiotic *** study reviewed the research progress of insect intestinal microorganisms in three aspects:diversity,biological functions,and *** objective was to provide useful references and insights for further research and applications of insect intestinal microorganisms.

关键词： Symbiotic microorganisms Intestinal flora Population structure Diversity High-throughput sequencing

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Research on Localized English Education for Transnational Left-behind Children in the Context of English Global Localization: A Case Study of Wenzhou Overseas Chinese Hometown

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教育技术与创新 2024年第1期6卷 36-49页

作者： Yujie Su Xueyan Li Huili Ma Shuchang Dong Ruoruo lin Lijuan Zou Qiaoqiao lin School of Foreign Studies Wenzhou UniversityChina Li'ao Overseas Chinese Primary School ZhejiangChina Wenzhou Xianyan No.2 Middle School ZhejiangChina Wenzhou High School ZhejiangChina

With the increasing development of English globalization,the trend of combining English with local cultures has become more *** research focuses on five schools in the Wenzhou overseas Chinese hometown to investigate the current status of English education from the perspectives of teachers,students,and *** aim was to propose bilingual education strategies for the education of transnational left-behind children(TLC).By examining the situation of English education in this specific context,this study sought to address the unique challenges faced by TLC and provide effective educational ***,observations,and document analysis were employed to gather data by means of questionnaire research *** findings of this study settled on the improvement of bilingual education for TLC and insights into enhancing English education in multicultural settings.

关键词： glocalization transnational left-behind children(TLC) bilingual education Wenzhou Overseas Chinese Hometown

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Altered Iron-Mediated Metabolic Homeostasis Governs the Efficacy and Toxicity of Tripterygium Glycosides Tablets Against Rheumatoid Arthritis

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Engineering 2024年第8期39卷 166-179页

作者： Zihe Ding Xiaoyue Wang Yi Zhang Jian Liu Lei Wan Tao Li lin Chen Na lin Yanqiong Zhang State Key Laboratory for Quality Ensurance and Sustainable Use of dao-di herbs Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China The First Affiliated Hospital of Anhui University of Chinese Medicine Hefei 230038China

Rheumatoid arthritis(RA),a globally increasing autoimmune disorder,is associated with increased disability rates due to the disruption of iron *** glycoside tablets(TGTs),a Tripterygium wilfordii Hook.f.(TwHF)-based therapy,exhibit satisfactory clinical efficacy for RA ***,drug-induced liver injury(DILI)remains a critical issue that hinders the clinical application of TGTs,and the molecular mechanisms underlying the efficacy and toxicity of TGTs in RA have not been fully *** address this problem,we integrated clinical multi-omics data associated with the anti-RA efficacy and DILI of TGTs with the chemical and target profiling of TGTs to perform a systematic network ***,we identified effective and toxic targets following experimental validation in a collagen-induced arthritis(CIA)mouse *** different transcriptome–protein–metabolite profiles distinguishing patients with favorable TGTs responses from those with poor outcomes were ***,the clinical efficacy and DILI of TGTs against RA were associated with metabolic homeostasis between iron and bone and between iron and lipids,***,the signal transducer and activator of transcription 3(STAT3)–hepcidin(HAMP)/lipocalin 2(LCN2)–tartrate-resis tant acid phosphatase type 5(ACP5)and STAT3–HAMP–acyl-CoA synthetase long-chain family member 4(ACSL4)–lysophosphatidylcholine acyltransferase 3(LPCAT3)axes were identified as key drivers of the efficacy and toxicity of *** play dual roles in ameliorating CIA-induced pathology and in inducing hepatic dysfunction,disruption of lipid metabolism,and hepatic lipid ***,TGTs effectively reversed“iron–bone”disruptions in the inflamed joint tissues of CIA mice by inhibiting the STAT3–HAMP/LCN2–ACP5 axis,subsequently leading to“iron–lipid”disturbances in the liver tissues via modulation of the STAT3–HAMP–ACSL4–LPCAT3 *** bidirectional validatio

关键词： Tripterygium glycosides tablets Rheumatoid arthritis Iron metabolism Clinical efficacy Drug-induced liver injury Clinical multi-omics data analysis

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Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang Zhao Yuanjie Liu Qinghua Zeng Qing Tang Zhifang Dong Guiqiong he Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

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虾活性肽微胶囊复合可食膜的制备及其保鲜作用

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食品工业科技 2024年第4期45卷 273-281页

作者：吴泽龙陈梅香何建林白锴凯余琳张怡洪碧红自然资源部第三海洋研究所海洋生物资源开发利用工程技术创新中心福建厦门361005 福建农林大学食品科学学院福建福州350002 闽台特色海洋食品加工及营养健康教育部工程研究中心福建福州350002

针对南美白对虾易腐败和黑变问题,以羟丙甲基纤维素(HPMC)、虾活性肽微胶囊为成膜原料,研发具有保鲜功能的复合可食膜。采用单因素实验,以膜的机械性能、水蒸气透过率等为指标,考察羟丙甲基纤维素添加量、甘油添加量及虾活性肽微胶囊添... 详细信息

针对南美白对虾易腐败和黑变问题,以羟丙甲基纤维素(HPMC)、虾活性肽微胶囊为成膜原料,研发具有保鲜功能的复合可食膜。采用单因素实验,以膜的机械性能、水蒸气透过率等为指标,考察羟丙甲基纤维素添加量、甘油添加量及虾活性肽微胶囊添加量对复合可食膜的成膜效果及膜性能的影响,并进一步研究虾活性肽微胶囊添加量对复合可食膜的红外光谱和自由基清除能力的影响,优化复合可食膜制备工艺;开展覆膜包装贮藏实验,以感官评分、pH、挥发性盐基氮含量、菌落总数等为指标,探究复合可食膜对南美白对虾的保鲜作用。结果表明,经单因素实验优化,复合可食膜的最佳膜材添加量为:羟丙甲基纤维素12%、甘油0.4%、微胶囊3%,此条件下,膜的综合性能佳。由膜抗氧化性能测定实验可得,当微胶囊添加量为3%及以上时,膜的抗氧化性能较好。傅里叶红外光谱显示,微胶囊添加量为3%~4%时,微胶囊与膜组分的交联作用较强。贮藏实验证实,复合可食膜可抑制虾体腐败,改善虾体感官,减缓机体pH上升、挥发性盐基氮激增和菌落总数增加等腐败现象,其贮藏期较无保护组可延长3~4 d,且总体保鲜效果优于HPMC空白膜甚至保鲜(PE)膜,展现出对南美白对虾的良好保鲜作用。

关键词：虾活性肽微胶囊可食膜南美白对虾保鲜

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Application of texture signatures based on multiparameter-magnetic resonance imaging for predicting microvascular invasion in hepatocellular carcinoma:Retrospective study

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1309-1318页

作者： Hai-Yang Nong Yong-Yi Cen Mi Qin Wen-Qi Qin You-Xiang Xie lin Li Man-Rong Liu Ke Ding Department of Radiology The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Radiology The Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Radiology The First Affiliated Hospital of Guangxi University of Traditional Chinese MedicineNanning 530031Guangxi Zhuang Autonomous RegionChina Department of hepatobiliary Surgery The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Ultrasound The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina

BACKGROUND Despite continuous changes in treatment methods,the survival rate for advanced hepatocellular carcinoma(HCC)patients remains low,highlighting the importance of diagnostic methods for *** To explore the efficacy of texture analysis based on multi-parametric magnetic resonance(MR)imaging(MRI)in predicting microvascular invasion(MVI)in preoperative *** This study included 105 patients with pathologically confirmed HCC,categorized into MVI-positive and MVI-negative *** employed Original data Analysis,Principal Component Analysis,linear Discriminant Analysis(Lda),and Non-Lda(Nda)for texture analysis using multi-parametric MR images to predict preoperative *** effectiveness of texture analysis was determined using the B11 program of the MaZda4.6 software,with results expressed as the misjudgment rate(MCR).RESULTS Texture analysis using multi-parametric MRI,particularly the MI+PA+F dimensionality reduction method combined with Nda discrimination,demonstrated the most effective prediction of MVI in *** accuracy in the pulse and equilibrium phases was 83.81%.MCRs for the combination of T2-weighted imaging(T2WI),arterial phase,portal venous phase,and equilibrium phase were 22.86%,16.19%,20.95%,and 20.95%,*** area under the curve for predicting MVI positivity was 0.844,with a sensitivity of 77.19%and specificity of 91.67%.CONCLUSION Texture analysis of arterial phase images demonstrated superior predictive efficacy for MVI in HCC compared to T2WI,portal venous,and equilibrium *** study provides an objective,non-invasive method for preoperative prediction of MVI,offering a theoretical foundation for the selection of clinical therapy.

关键词： Magnetic resonance imaging hepatocellular carcinoma Texture analysis Microvascular invasion

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逆强化学习算法、理论与应用研究综述

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自动化学报 2024年第9期50卷 1704-1723页

作者：宋莉李大字徐昕北京化工大学信息科学与技术学院北京100029 国防科技大学智能科学学院长沙410073

随着高维特征表示与逼近能力的提高,强化学习(Reinforcement learning,RL)在博弈与优化决策、智能驾驶等现实问题中的应用也取得显著进展.然而强化学习在智能体与环境的交互中存在人工设计奖励函数难的问题,因此研究者提出了逆强化学习(... 详细信息

随着高维特征表示与逼近能力的提高,强化学习(Reinforcement learning,RL)在博弈与优化决策、智能驾驶等现实问题中的应用也取得显著进展.然而强化学习在智能体与环境的交互中存在人工设计奖励函数难的问题,因此研究者提出了逆强化学习(Inverse reinforcement learning,IRL)这一研究方向.如何从专家演示中学习奖励函数和进行策略优化是一个重要的研究课题,在人工智能领域具有十分重要的研究意义.本文综合介绍了逆强化学习算法的最新进展,首先介绍了逆强化学习在理论方面的新进展,然后分析了逆强化学习面临的挑战以及未来的发展趋势,最后讨论了逆强化学习的应用进展和应用前景.

关键词：强化学习逆强化学习线性逆强化学习深度逆强化学习对抗逆强化学习

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从缔造新中国到建设新中国——中国共产党对政治话语“小米加步枪”的构建与运用

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湖北大学学报（哲学社会科学版） 2024年第4期51卷 1-9,I0002页

作者：潘大礼三峡大学马克思主义学院湖北宜昌443002

解放战争时期,“小米加步枪”经由毛泽东公开表述后,成为中国共产党的经典政治话语,它最初代表着党艰苦奋斗的政治本色和密切联系群众的优良作风,是党取得革命战争胜利的重要因素。以毛泽东为代表的中国共产党人借用日常事物形象地表达... 详细信息

解放战争时期,“小米加步枪”经由毛泽东公开表述后,成为中国共产党的经典政治话语,它最初代表着党艰苦奋斗的政治本色和密切联系群众的优良作风,是党取得革命战争胜利的重要因素。以毛泽东为代表的中国共产党人借用日常事物形象地表达抽象的政治话语,宣传党的政治主张和价值观念,实现党的意识形态在社会层面的传递和濡化。新中国成立后,“小米加步枪”形塑内政外交,成为党阐释治国理政方式的话语工具,其革命属性逐步转向建设属性。改革开放以来,“小米加步枪”不仅作为党深化军事现代化建设的话语标尺,也延伸到社会主义市场经济领域,从政治话语逐步向社会话语转变。“小米加步枪”在革命、建设、改革各时期都产生了重要影响,是党领导人民群众从缔造新中国到建设新中国历程中锻造出的政治符号,是百年来党带领中华民族从弱小不断走向强大的缩影,也是我们坚定历史自信增强历史主动的精神动力和信心源头。

关键词：中国共产党小米加步枪政治话语新中国

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政策干预对国内外粮棉价格溢出效应的影响——基于进口规模快速增长背景

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价格月刊 2024年第4期 1-12页

作者：刘大鹏中国农业发展银行博士后科研工作站北京100070

通过构建外生政策影响下的VAR-BEKK-MVGARCH-DUMMY模型,利用2000年1月至2021年12月的月度数据,分析了进口规模对玉米、棉花国内外价格溢出效应的影响,政策实施对玉米、大豆、棉花国内外价格溢出效应的影响。研究发现,进口规模扩大并未... 详细信息

通过构建外生政策影响下的VAR-BEKK-MVGARCH-DUMMY模型,利用2000年1月至2021年12月的月度数据,分析了进口规模对玉米、棉花国内外价格溢出效应的影响,政策实施对玉米、大豆、棉花国内外价格溢出效应的影响。研究发现,进口规模扩大并未对玉米、棉花国内外价格溢出效应产生显著影响;不同政策实施对国内外粮棉价格溢出效应的影响存在差异,其中,临时收储政策对粮棉价格干预最大,其影响程度较强,目标价格补贴和“市场化收购+生产者补贴”政策对粮棉价格干预较弱,其影响程度也相对较弱;政策实施对不同农产品国内外价格溢出效应的影响存在差异,大豆开放程度最高,其影响最强,棉花开放程度次之,其影响相对较弱,而玉米开放程度最低,其影响也最弱。为此,应在确定粮棉储备合理规模,打好支持保护政策“组合拳”,提高统筹利用国际国内市场、资源能力等方面着力,确保中国粮食安全和重要农产品市场稳定。

关键词：进口规模政策干预粮棉价格溢出效应

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