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Identification of Potential Targets of A New anti-TMV Compound GLY-15 Containing Pyrimidine heterocycle and Moroxydine Skeleton

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Identification of Potential Targets of A New anti-TMV Compou...

Storage and redistribution of anthropogenic CO_(2) in the western North Pacific:The role of subtropical mode water transportation

中国植物病理学会2024年学术年会

作者：于淼 LIU he 安梦楠吴元华 College of Plant Protection Shenyang Agricultural University

We have previously reported that the new compound GLY-15 containing pyrimidine heterocycle and moroxydine skeleton structure has good anti-TMV activity(Yu et al.,*** Management Science).The combination of chemical molecular probes and mass spectrometry is used to identify the potential target proteins of the ***,we constructed a biotin modified active probe by covalent bonding biotin with GLY-15 using an active small molecule probe,and thereafter confirmed its e anti-TMV activity in Nicotiana *** proteins extracted from TMV infected *** plants were incubated with biotin probes P-GLY-15,and then,using the interaction between biotin and avidin,we enriched and purified the GLY-15 binding protein using an avidin coated solid phase ***,after separation by SDS-PAGE gel,we selected specific bands for LC-MS/MS mass spectrometry *** results showed that major host proteins pulled down by the XX probes include Glyceraldehyde-3-phosphate dehydrogenase(GAPDH),Fructose-bisphosphate dehydrogenase(FBA),Malate dehydrogenase(MDH),Mannose-binding lectin(MBL1),Annexin,Form dehydrogenase,mitochondrial(FDH),Cysteine synthase(CS),GDSL esterase/lipase At5 g03980-like(GELP),and Germin-like protein(GLP).Nevertheless,more precise verification of this molecular interaction between GLY-15 and viral proteins should be performed in a subsequent study using methods such as molecular dynamics simulation or Tobacco rattle virus(TRV)-based virus-induced gene silencing(VIGS).

关键词： Pyrimidine heterocycle and moroxydine skeleton tobacco mosaic virus biotinavidin LC-MS/MS

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Fundamental Research 2024年第1期4卷 103-112页

作者： Cheng-long Li Lei Han Wei-dong Zhai Di Qi Xu-chen Wang Hong-mei lin Li-wen Zheng Institute of Marine Science and Technology Shandong UniversityQingdao 266237China China-ASEAN College of Marine Science and Technology Xiamen University MalaysiaSelangorMalaysia Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519080China Polar and Marine Research Institute Jimei UniversityXiamen 361021China Key Laboratory of Marine Chemistry Theory and Technology and Frontiers Science Center for Deep Ocean Multispheres and Earth SystemMinistry of EducationOcean University of ChinaQingdao 266100China Center for Isotope Geochemistry and Geochronology Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Weihai Institute of Marine Ecology and Economy Research Weihai 264400China

Oceanic uptake and storage of anthropogenic CO_(2)(CANT)are regulated by ocean circulation and *** decipher the storage and redistribution of CANT in the western North Pacific,where a major CANT sink develops,we investigated the water column carbonate system,dissolved inorganic radiocarbon and ancillary parameters in May and August 2018,spanning the Kuroshio Extension(KE,35-39°N),Kuroshio Recirculation(KR,27-35°N)and subtropical(21-27°N)*** column CANT inventories were estimated to be 40.5±1.1 mol m^(-2) in the KR zone and 37.2±0.9 mol m^(-2) in the subtropical *** comparison with historical data obtained in 2005,relatively high rates of increase of the CANT inventory of 1.05±0.20 and 1.03±0.12 mol m^(-2) yr^(-1) in the recent decade were obtained in the KR and subtropical zones,*** water-mass-based analyses suggest that formation and transport of subtropical mode water dominate the deep penetration,storage,and redistribution of CANT in those two *** the KE zone,however,both the water column CANT inventory and the decadal CANT accumulation rate were small and uncertain owing to the dynamic hydrology,where the naturally uplifting isopycnal surfaces make CANT penetration relatively *** findings of this study improve the understanding of the spatiotemporal variations of CANT distribution,storage,and transport in the western North Pacific.

关键词： Oceanic CO_(2)uptake Anthropogenic CO_(2)storage Subtropical mode water Kuroshio extension Kuroshio recirculation Western North Pacific

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Ti–Mn系储氢合金的研究进展

硅酸盐学报 2024年第6期52卷 1873-1883页

作者：张贺林繁鑫刘勇缪国栋王振刘春荣李平曲选辉北京科技大学新材料技术研究院北京100083

Ti-Mn系储氢合金在常温下能快速可逆吸放超过1.8%(质量分数)的氢气,且具有良好的循环稳定性和较低的成本,成为最具前景的储氢合金之一,但其较高的平台压不利于大规模应用。本文综述了近年来Ti-Mn系储氢合金的研究进展,总结了取代元素的... 详细信息

Ti-Mn系储氢合金在常温下能快速可逆吸放超过1.8%(质量分数)的氢气,且具有良好的循环稳定性和较低的成本,成为最具前景的储氢合金之一,但其较高的平台压不利于大规模应用。本文综述了近年来Ti-Mn系储氢合金的研究进展,总结了取代元素的半径对Ti-Mn系储氢合金晶体结构的影响,讨论了氧含量、元素取代和制备工艺对材料储氢性能的影响,阐述了微观缺陷-循环稳定性的关联机制,并对Ti-Mn系储氢合金在储氢罐领域的突破性应用进行了综述。最后提出未来的研究重点将集中于工艺改进和机理分析。

关键词： Ti–Mn系储氢合金吸放氢反应机理储氢性能储氢罐

Single Ti atoms coupled with Ti-O clusters enable low temperature hydrogen cycling by sodium alanate

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Rare Metals 2024年第6期43卷 2671-2681页

作者： Zhuang-he Ren Xin Zhang Wen-Xuan Zhang Zhen-Guo Huang Li-Mei Yang Ya-Xiong Yang Zheng-Long Li Juan Li Wen-Ping Sun Ming-Xia Gao Hong-Ge Pan Yong-Feng Liu State Key Laboratory of Silicon and Advanced Semiconductor Materials Zhejiang UniversityHangzhou 310027China School of Materials Science and Engineering Zhejiang UniversityHangzhou 310058China School of Civil&Environmental Engineering.University of Technology Sydney Sydney2007 NSWAustralia Institute of Science and Technology for New Energy Xi'an Technological UniversityXi'an 710021China College of Materials Science and Engineering Zhejiang University of TechnologyHangzhou 310014China

Ti-based catalysts are known to improve the hydrogen storage performance of NaAlH4by facilitating the dissociation/recombination of H-H and Al-H *** catalytic activity of metallic Ti species strongly depends on its particle size and *** clusters and even single atoms are therefore highly desirable,but their controllable fabrication has been highly *** rein,we demonstrate a novel facile sonochemical synthesis of a Ti-O clusters featuring single Ti atom catalyst at room *** reducing TiCl_(4)by MgBu_(2)with ultrasound instead of heating as driving force,numerous single Ti atoms coupled with Ti-O clusters with Ti loading on graphene(Ti_(1)/Ti-O@G)up to 22.6 wt%have been successfully *** prepared Ti_(1)/Ti-O@G contributes high reactivity and superior catalytic activity,therefore enabling full dehydrogenation of NaAlH_(4)at 80℃in thermogravimetric mode and re-hydrogenation at 30℃and 10 MPa with 4.9 wt% H_(2).This fact indicates for the first time that single Ti atom catalyst with high loading is highly effective in catalyzing hydrogen cycling of NaAlH4at remarkably reduced temperatures.

关键词： Hydrogen storage Nanocatalysis Transition metals Single Ti atoms NaAlH_(4)

迈向工程科学哲学:研究进展、主要问题与研究策略

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自然辩证法研究 2024年第9期40卷 3-11,61页

作者：王大洲中国科学院大学人文学院北京100049

工程科学哲学位于工程哲学和科学哲学的交叉地带。综述了工程科学哲学研究进展,主要包括工程科学思想史、工程科学的本体论问题研究、工程科学的认识论问题研究、工程科学的方法论问题研究以及工程科学的价值论问题研究等五个方面的总... 详细信息

工程科学哲学位于工程哲学和科学哲学的交叉地带。综述了工程科学哲学研究进展,主要包括工程科学思想史、工程科学的本体论问题研究、工程科学的认识论问题研究、工程科学的方法论问题研究以及工程科学的价值论问题研究等五个方面的总体情况。在此基础上,探讨了工程科学哲学研究的基本策略和具体方法,从而为未来的工程科学哲学研究辨明了方向。

关键词：工程科学工程科学哲学工程哲学科学哲学

Chemical composition， biological activities and product development of Gastrodia elata: a review

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Food Science and Human Wellness 2024年

作者： Yuchen Jiang Liankui Wen Wenqi Wang Rongchen Zhu Jiahua Liu Yang he Fei Zheng Yuzhu Wu Department of Food Science and Engineering， Jilin Agricultural University Jilin Ginseng Academy， Changchun University of Chinese Medicine National Engineering Research Center for Wheat and Corn Deep Processing

Gastrodia elata Blume (G. elata) has a rich history of traditional Asian use. However， there is still a need for systematic analysis regarding the relationship and in-depth development between its components and functions. Through comprehensive analysis utilizing databases such as PubMed， Web of Science， and Google Scholar， the practical components， biological activities， and product development of G. elata have been investigated. It has been found that the main active components of G. elata， such as Gastrodin and Gastrodia Polysaccharides， possess functionalities in improving conditions such as epilepsy， hypertension， and osteoporosis. These active components exhibit phenolic hydroxyl groups， molecular weight， conformation， and spatial arrangement， contributing to their enhanced ability to scavenge free radicals. Additionally， G. elata is known to have organic acids and esters， which exhibit potential immune regulatory and antiviral properties. Compounds with multiple acidic functional groups exhibit even more vigorous activity. Steroidal compounds like β-sitosterol， due to their presence of alcohol and ketone groups， along with a multi-ring structure， exhibit superior cholesterol-lowering activity. G. elata has already been recognized in the Traditional Chinese Medicine and Food Homology list， showcasing its potential for development in line with the health demands of the current era. However， challenges regarding quality evaluation， peculiar odor， and the extraction process of the practical components still require immediate attention. Constructing a robust evaluation system and optimizing product processing techniques will be crucial for the future advancement of the G. elata industry.

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Broadband Antireflective Superhydrophilic Thin Films with Outstanding Mechanical Stability on Glass Substrates

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Chinese Journal of Chemistry 2014年第6期32卷 507-512页

作者： lin Yao Junhui he Functional Nanomaterials Laboratory and Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Graduate University of Chinese Academy of Sciences Beijing 100864China

A facile approach was developed to fabricate visible/near-infrared antireflective(AR),superhydrophilic and anti-fogging thin films on glass *** substrate was first etched by H_(2)SiF_(6)-based vapor and then dip-coated sequentially in a base-catalyzed 20 nm SiO_(2)nanoparticles sol and an acid-catalyzed SiO_(2)*** an-nealing,the prepared thin film(named E/BSiO_(2)/ASiO_(2))not only showed good optical and wetting properties,but also exhibited excellent mechanical *** thin film has enhanced transmittance in the spectral range of UV to *** maximum transmittance of E/BSiO_(2)/ASiO_(2)thin film coated glass substrate is 98.4%in 400-1200 nm and 96.1%in 1200-2500 nm,*** with blank glass substrate,the average transmittance increases by 5%in the wavelength range of 300-2500 ***,the film showed good anti-fogging *** and AFM were employed to characterize the morphology of the thin *** pre-pared thin film has potential application in various areas,like solar cells,windowpanes and eyeglasses,and may also find applications in membrane-based separation,selective catalysis and sensors.

关键词： etching antireflection superhydrophilicity anti-fogging mechanical properties

F?rster resonance energy transfer reveals phillygenin and swertiamarin concurrently target AKT on different binding domains to increase the anti-inflammatory effect

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Chinese Chemical Letters 2024年第5期 233-238页

作者： Xiaoyao Ma Jinling Zhang Ge Fang he Gao Jie Gao Li Fu Yuanyuan Hou Gang Bai State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University College of Life health Dalian University dalian Fusheng Pharmaceutical Co. Ltd.

The clinical benefit of combination therapy is significant, but it is not easy to define the mechanism of complexity and diversity. Previous studies illustrate that phillygenin(Phi) binds in the allosteric inhibit pocket of protein kinase B(AKT), and swertiamarin(Swe) acts on the pleckstrin homology(PH) domain of AKT. However, the combined synergistic effect of relieving the inflammatory response has yet to be elucidated. Based on high sensitivity, specificity and fast-responsibility fluorescent sensors, the F?rster resonance energy transfer(FRET) technique offers a route to provide clear insights into physiological and pathological processes. In the study, molecular docking, the fluorescent probes of Phi and Swe for FRET were designed and synthesized. FRET analysis shown that Swe and Phi concurrently acted on the PH domain and allosterically inhibited pocket of AKT, respectively. The combination of Swe and Phi significantly increased the heat stability of AKT and decreased protease-induced degeneration. In lipopolysaccharides(LPS)-induced mice and cells, the combination arrested AKT activation, nuclear factor kappa-B(NF-κB)phosphorylation, and the expression of tumor necrosis factor-α(TNF-α), interleukin(IL)-6 and IL-8. In conclusion, FRET revealed Phi and Swe concurrently targeted AKT on different domains and the combination of Phi and Swe enhanced the anti-inflammatory effect.

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面向量产的高速公路智能换道系统决策规划方法研究

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汽车工程 2024年第3期46卷 418-430页

作者：何一超寇胜杰田贺李昊芦勇联创汽车电子有限公司上海201206 清华大学车辆与运载学院北京100084

高速公路智能换道是高级辅助驾驶系统(AdaS)的重要功能,现阶段算法难以在低算力硬件资源条件下兼顾换道安全性和平顺性。为解决此问题,本文提出一种高速公路智能换道系统决策规划方法。通过分级危险区域,检测碰撞风险做出换道决策,进而... 详细信息

高速公路智能换道是高级辅助驾驶系统(AdaS)的重要功能,现阶段算法难以在低算力硬件资源条件下兼顾换道安全性和平顺性。为解决此问题,本文提出一种高速公路智能换道系统决策规划方法。通过分级危险区域,检测碰撞风险做出换道决策,进而实施横纵向解耦规划。在横向规划中,设计两阶段五次多项式换道轨迹规划,提升换道途中安全性和平顺性。在纵向规划中,巡航工况采用类PID算法,可提升规划实时性,而跟车工况采用基于同步预测时域的模型预测控制(MPC)算法,通过关联横纵向规划时间可提升换道平顺性,并设计代价函数降低求解复杂度可满足低资源占用要求。通过实车对比试验,验证了该方法在高速公路换道多场景中具有较高的安全性、平顺性和体验感。此外,算法占用的静态区存储和栈区峰值存储测试对比结果表明了该方法具有较低的硬件资源占用率,可满足低算力控制器对资源占用的要求。

关键词：智能换道系统解耦规划两阶段换道模型预测控制同步时域面向量产