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Diagnosis of poorly differentiated adenocarcinoma of the stomach by confocal laser endomicroscopy:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1481-1486页

作者： Jia-Xin lou Yong Wu Muren Huhe Jing-Jie Zhang Dong-Wu Jia Zhen-Yu Jiang Department of Gastroenterology The Second Affiliated Hospital of Baotou Medical CollegeInner Mongolia University of Science and TechnologyBaotou 014030Inner Mongolia Autonomous RegionChina Medical Innovation Center The Fourth Military Medical UniversityXi'an 710000Shaanxi ProvinceChina

BACKGROUND In recent years,confocal laser endomicroscopy(CLE)has become a new endoscopic imaging technology at the microscopic level,which is extensively performed for real-time in vivo histological *** can be performed to distinguish benign from malignant *** this study,we diagnosed using CLE an asymptomatic patient with poorly differentiated gastric *** SUMMARY A 63-year-old woman was diagnosed with gastric mucosal lesions,which may be gastric cancer,in the small curvature of the stomach by *** consented to undergo CLE for morphological observation of the gastric *** the combination of CLE diagnosis and postoperative pathology,the intraoperative CLE diagnosis was considered to be *** to our experience,CLE can be performed as the first choice for the diagnosis of gastric *** CLE has several advantages over pathological *** believe that CLE has great potential in the diagnosis of benign and malignant gastric lesions.

关键词： Confocal laser endomicroscopy Poorly differentiated gastric adenocarcinoma Diagnosis Early stage Case report

Rational design multi-color-emissive chemiluminescent carbon nanodots in a single solvothermal reaction

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Nano Research 2024年第6期17卷 4651-4660页

作者： Guang-Song Zheng Cheng-Long Shen Yuan Deng Kai-Kai Liu Jin-Hao Zang Lin Dong Qing lou Chong-Xin Shan Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Materials PhysicsMinistry of Educationand School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China

Recently,the chemiluminescence(CL)induced by carbon nanodots(CDs)has intrigued researchers’extensive interests in various applications due to its special light emission ***,the difficulty of synthesizing chemiluminescent CDs with full-spectrum emission severely hinders the further regulation of the CL emission ***,the multi-color-emissive chemiluminescent CDs are rational designed and further synthesized by regulating the sp2-hybrid core and sp3-hybrid surface from the citrate-ammonia molecular in a single solvothermal *** experimental characterizations and density functional theory calculations reveal that the higher temperature can promote the crosslinking polymerization/carbonization of carbon core and the higher protonation of solvent can determine the core size of final CDs,resulting in the variant CL emission from molecular-,crosslinking-and ***,the CL emission of the CDs can be further synthesized by tuning the luminescence chromophores in the formation process via regulating the temperature and solvent,enabling the applications of the CL CDs in illumination and information *** study paves a new technology to understand the luminescence of CDs and affords an industry translational potential over traditional chemiluminescent molecular.

关键词： carbon nanodots chemiluminescence regulation energy level alignment mechanism

Quantum circuit-based proxy blind signatures:A novel approach and experimental evaluation on the IBM quantum cloud platform

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Chinese Physics B 2024年第5期33卷 247-253页

作者：娄小平昝慧茹徐雪娇 College of Information Science and Engineering Hunan Normal UniversityChangsha 410081China

This paper presents a novel approach to proxy blind signatures in the realm of quantum circuits,aiming to enhance security while safeguarding sensitive *** main objective of this research is to introduce a quantum proxy blind signature(QPBS)protocol that utilizes quantum logical gates and quantum measurement *** QPBS protocol is constructed by the initial phase,proximal blinding message phase,remote authorization and signature phase,remote validation,and de-blinding *** innovative design ensures a secure mechanism for signing documents without revealing the content to the proxy signer,providing practical security authentication in a quantum environment under the assumption that the CNOT gates are securely *** existing approaches,our proposed QPBS protocol eliminates the need for quantum entanglement preparation,thus simplifying the implementation *** assess the effectiveness and robustness of the QPBS protocol,we conduct comprehensive simulation studies in both ideal and noisy quantum environments on the IBM quantum cloud *** results demonstrate the superior performance of the QPBS algorithm,highlighting its resilience against repudiation and forgeability,which are key security concerns in the realm of proxy blind ***,we have established authentic security thresholds(82.102%)in the presence of real noise,thereby emphasizing the practicality of our proposed solution.

关键词： proxy blind signature quantum circuits quantum computation IBM quantum cloud platform

Decompositions of the Kadomtsev-Petviashvili equation and their symmetry reductions

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Chinese Physics B 2024年第3期33卷 150-159页

作者：陈孜童贾曼郝夏芝楼森岳 School of Mathematics and Statistics Ningbo UniversityNingbo 315211China School of Physical Science and Technology Ningbo UniversityNingbo 315211China College of Science Zhejiang University of TechnologyHangzhou 310014China

Starting with a decomposition conjecture,we carefully explain the basic decompositions for the Kadomtsev-Petviashvili(KP)equation as well as the necessary calculation procedures,and it is shown that the KP equation allows the Burgers-STO(BSTO)decomposition,two types of reducible coupled BSTO decompositions and the BSTO-KdV ***,we concentrate ourselves on pointing out the main idea and result of Bäcklund transformation of the KP equation based on a special superposition principle in the particular context of the BSTO *** the framework of standard Lie point symmetry theory,these decompositions are studied and the problem of computing the corresponding symmetry constraints is treated.

关键词： Kadomtsev-Petviashvili(KP)equation decomposition Bäcklund transformation symmetry reduction

Rearranged 19-nor-7,8-seco-labdane diterpenoids and Diels-Alder cycloadducts from the Chinese liverwort Pallavicinia ambigua:Structural elucidation,photoinduced rearrangement,and cytotoxic activity

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Chinese Chemical Letters 2024年第3期35卷 415-418页

作者： Chunyang Zhang Yuelan Li Zhaojun Chu Shuangzhi Yuan Yanan Qiao Jiaozhen Zhang Lin Li Yueqing Zhang Ruifeng Tian Yajie Tang Hongxiang lou Department of Natural Products Chemistry Key Lab of Chemical Biology(MOE)School of Pharmaceutical SciencesShandong UniversityJi'nan 250012China State Key Laboratory of Microbial Technology Shandong UniversityQingdao 266237China

Two distinctive rearranged 19-nor-7,8-seco-labdane diterpenoids(1 and 2)with a novel tetracyclo[5.***.1.0^(2,5.)0^(4,10)]decane skeleton,a derivative of the open tetrahydrofuran ring(7),three dimeric compounds(8-10),and four revised homologs(3-6)were obtained from Chinese liverwort Pallavicinia *** structures were identified via combined analysis of their spectroscopic data,single-crystal X-ray diffraction patterns,and ECD *** light-driven conversion of compound 5 to compounds 1-4 demonstrated that photochemically induced postmodification involved in biosynthesis is an important way to diversify natural structures.A preliminary cytotoxicity assay revealed that compound 5 showed significant inhibition in the human prostate cancer(PC-3)cell line via an apoptotic pathway.

关键词： Liverwort Pallavicinia ambigua 19-nor-7 8-seco-Labdan diterpenoid Photoinduced rearrangement Cytotoxic activity

Functional predictability of universal gene circuits in diverse microbial hosts

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Quantitative Biology 2024年第2期12卷 129-140页

作者： Chenrui Qin Tong Xu Xuejin Zhao Yeqing Zong Haoqian M.Zhang Chunbo lou Qi Ouyang Long Qian Peking-Tsinghua Joint Center for Life Sciences Peking UniversityBeijingChina CAS Key Laboratory of Microbial Physiological and Metabolic Engineering Institute of MicrobiologyChinese Academy of SciencesBeijingChina Bluepha Co. LtdBeijingChina Center for Cell and Gene Circuit Design CAS Key Laboratory of Quantitative Engineering BiologyGuangdong Provincial Key Laboratory of Synthetic GenomicsShenzhen Key Laboratory of Synthetic GenomicsShenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenChina Center for Quantitative Biology Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijingChina

Although the principles of synthetic biology were initially established in model bacteria,microbial producers,extremophiles and gut microbes have now emerged as valuable prokaryotic chassis for biological *** the host range in which designed circuits can function reliably and predictably presents a major challenge for the concept of synthetic biology to *** this work,we systematically characterized the cross-species universality of two transcriptional regulatory modules—the T7 RNA polymerase activator module and the repressors module—in three non-model *** found striking linear relationships in circuit activities among different organisms for both *** model fitting revealed host non-specific parameters defining the universality of both ***,a genetic NOT gate and a band-pass filter circuit were constructed from these modules and tested in non-model *** models employing host non-specific parameters were successful in quantitatively predicting circuit behaviors,underscoring the potential of universal biological parts and predictive modeling in synthetic bioengineering.

关键词： circuit predictability host-independent genetic circuits host-nonspecific parameters parts characterization transcriptional regulatory modules

Mechanism of Qili Qiangxin Capsule for Heart Failure Based on miR133a-Endoplasmic Reticulum Stress

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Chinese Journal of Integrative Medicine 2024年第5期30卷 398-407页

作者： JI Xiao-di YANG Ding CUI Xi-yuan lou Li-xia NIE Bo ZHAO Jiu-li ZHAO Ming-jing WU Ai-ming Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine Key Laboratory of Chinese Internal Medicine of Ministry of Education and BeijingBeijing 100700China Department of Traditional Chinese Medicine Fuwai HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100037China

Objective:To investigate the pharmacological mechanism of Qili Qiangxin Capsule(QLQX)improvement of heart failure(HF)based on miR133a-endoplasmic reticulum stress(ERS)***:A left coronary artery ligation-induced HF after myocardial infarction model was used in this *** were randomly assigned to the sham group,the model group,the QLQX group[0.32 g/(kg·d)],and the captopril group[2.25 mg/(kg·d)],15 rats per group,followed by 4 weeks of *** function such as left ventricular ejection fraction(EF),fractional shortening(FS),left ventricular systolic pressure(LVSP),left ventricular end diastolic pressure(LVEDP),the maximal rate of increase of left ventricular pressure(+dp/dt max),and the maximal rate of decrease of left ventricular pressure(–dp/dt max)were monitored by echocardiography and *** and eosin(HE)and Masson stainings were used to visualize pathological changes in myocardial *** m RNA expression of mi R133a,glucose-regulated protein78(GRP78),inositol-requiring enzyme 1(IRE1),activating transcription factor 6(ATF6),X-box binding protein1(XBP1),C/EBP homologous protein(CHOP)and Caspase 12 were detected by *** protein expression of GRP78,p-IRE1/IRE1ratio,cleaved-ATF6,XBP1-s(the spliced form of XBP1),CHOP and Caspase 12 were detected by Western *** T-mediated d UTP nick-end labeling(TUNEL)staining was used to detect the rate of ***:QLQX significantly improved cardiac function as evidenced by increased EF,FS,LVSP,+dp/dt max,-dp/dt max,and decreased LVEDP(Pdamage to some *** staining indicated that QLQX significantly reduced collagen volume fraction in myocardial tissue(P<0.01).Results from RT-PCR and Western blot showed that QLQX significantly increased the expression of mi R133a and inhibited the m RNA expressions of GRP78,IRE1,ATF6 and XBP1,as well as decreased the protein expressions of GRP78,cleave

关键词： heart failure Qili Qiangxin Capsule miR133a endoplasmic reticulum stress apoptosis

剪切增稠幂律流体中单气泡上升动力学行为的格子Boltzmann方法研究

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物理学报 2024年第13期73卷 190-200页

作者：许鑫萌娄钦上海理工大学能源与动力工程学院上海200093

采用不可压非牛顿气液两相流格子Boltzmann方法研究了剪切增稠流体中气泡上升的动力学行为,重点分析了流变指数n、Eoυos数(Eo)和Galilei数(Ga)对气泡形变、终端速度和剪切速率的影响.数值结果表明:气泡形变程度随Eo的增大而增大,n对气... 详细信息

采用不可压非牛顿气液两相流格子Boltzmann方法研究了剪切增稠流体中气泡上升的动力学行为,重点分析了流变指数n、Eoυos数(Eo)和Galilei数(Ga)对气泡形变、终端速度和剪切速率的影响.数值结果表明:气泡形变程度随Eo的增大而增大,n对气泡形状的影响与Ga相关.另一方面,随着Ga增大,气泡终端速度随n呈非线性单调增大,且n对终端速度的影响随Ga的增大逐渐明显;当Ga固定且值较小时,气泡终端速度在较小Eo下随n的增大先增大后减小,而当Eo较大时终端速度随n的增大呈增大趋势;当Ga固定且较大时,气泡终端速度在Eo较大时较为统一地随n增大而增大.此外,气泡左右两端存在剪切速率较高的区域,该区域尺寸随Eo,Ga的增大而增大,随n的增大先增大后缩小.最后利用正交试验法得到上述三变量对剪切速率和终端速度的影响程度.对于剪切速率,参数影响程度由大到小的顺序依次为n,Ga和Eo;对于终端速度,Ga对其影响最大,n次之,Eo影响程度最小.

关键词：格子Boltzmann方法气泡动力学剪切增稠流体

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Sensitive humidity sensor based on moisture-driven energy generation

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Nano Research 2024年第6期17卷 5578-5586页

作者： Qingchao Ni Qing lou Chenglong Shen Guangsong Zheng Runwei Song Jingnan Hao Jialu Liu Jinyang Zhu Jinhao Zang Lin Dong Chong-Xin Shan Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Materials PhysicsMinistry of Educationand School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China State Centre for International Cooperation on Designer Low-Carbon&Environmental Materials and School of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China

The emergence of novel self-powered humidity sensors has attracted considerable attention in the fields of smart electronic devices and personal ***,self-powered humidity sensors have been fabricated using a moisture-driven energy generation(MEG)device based on asymmetric tubular graphitic carbon nitride(g-CN)films prepared on anodized aluminum(AAO)*** a relative humidity(RH)of 96%,the MEG device can provide an open-circuit voltage of 0.47 V and a short-circuit current of 3.51μA,with a maximum output power of 0.08μ*** inherent self-powered ability and humidity response via current variation,an extraordinary response of 1.78×106%(41%-96%RH)can be gained from the MEG *** possible power generation mechanism is that g-CN/AAO heterostructure can form ion gradient and diffusion under the action of moisture to convert chemical potential into electrical potential,evoking a connaturally sensitive response to ***-powered respiration monitoring device based on the sensor is designed to monitor human movement(sitting,warming up,and running)and sleep status(normal,snoring,and apnea),maintaining excellent stability during cumulative 12-h respiration *** self-powered humidity sensing technology has promising potential for extensive integration into smart electronic and round-the-clock health monitoring devices.

关键词： graphitic carbon nitride moisture-driven energy generation humidity sensor respiration monitoring