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Pretreated Glehnia littoralis Extract Prevents Neuronal Death Following Transient Global Cerebral Ischemia through Increases of Superoxide Dismutase 1 and Brain-derived Neurotrophic Factor Expressions in the Gerbil Hippocampal Cornu Ammonis 1 Area

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Chinese Medical Journal 2017年第15期130卷 1796-1803页

作者： Joon Ha Park Tae-Kveono Lee Bing-Chun Yan Bich-Na Shin Ji hyeon Ahn In hye Kim jeong Hwi Cho Jae-Chul Lee In Koo Hwang Jong dai Kim Seongkweon Hong Young Joo Lee Moo-Ho Woll Il Jun Kang Department of Biomedical Science Research Institute of Bioscience and Biotechnology Hallym University Chuncheon 24252 Korea Department of Neurobiology School of Medicine Kangwon National University Chuncheon 24341 Korea Department of Traditional Chinese and Western Medicine Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou Jiangsu 225001 China Department of Physiology College of Medicine Hallym University Chuncheon 24252 Korea Department of Anatomy and Cell Biology College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University Seoul08826 Korea Division of Food Biotechnology School of Biotechnology Kangwon National University Chuncheon 24341 Korea Department of Surgery School of Medicine Kangwon National University Chuncheon 24341 Korea Department of Emergency Medicine Seoul Hospital College of Medicine Sooncheonhyang University Seoul 04401 Korea Department of Food Science and Nutrition Hallym University Chuncheon 24252 Korea

Background：Glehnia littoralis,as a traditional herbal medicine to heal various health ailments in East Asia,displays various therapeutic properties including antioxidant ***,neuroprotective effects of *** against cerebral ischemic insults have not yet been ***,in this study,we first examined its neuroprotective effects in the hippocampus using a gerbil model of transient global cerebral ischemia （TGCI）.Methods：Gerbils were subjected to TGCI for 5 *** extract （GLE;100 and 200 mg/kg） was administrated orally once daily for 7 days before ischemic *** was examined by neuronal nuclear antigen immunohistochemistry and Fluoro-Jade B histofluorescence *** was observed by immunohistochemistry for glial fibrillary acidic protein and ionized calcium-binding adapter molecule *** neuroprotective mechanisms,immunohistochemistry for superoxide dismutase （SOD） 1 and brain-derived neurotrophic factor （BDNF） was ***：Pretreatment with 200 mg/kg of GLE protected pyramidal neurons in the cornu ammonis 1 （CA1） area from ischemic insult area （F=29.770,P 〈 0.05） and significantly inhibited activationsof astrocytes （F =22.959,P 〈 0.05） and microglia （F =44.135,P 〈 0.05） in the ischemic CA1 *** addition,pretreatment with GLE significantly increased expressions of SOD1 （F =28.561,P 〈 0.05） and BDNF （F =55.298,P 〈 0.05） in CA1 pyramidal neurons of the sham-and ischemia-operated ***：Our findings indicate that pretreatment with GLE can protect neurons from ischemic insults,and we suggest that its neuroprotective mechanism may be closely associated with increases of SOD 1 and BDNF expressions as well as attenuation ofglial activation.

关键词： Antioxidant Gtial Activation Neurotrophic Factor Neuroprotection Pyramidal Neurons

Hippophae rhamnoides *** extract enhances cell proliferation and neuroblast differentiation through upregulation of intrinsic factors in the dentate gyrus of the aged gerbil

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Chinese Medical Journal 2014年第23期127卷 4006-4011页

作者： Ji hyeon Ahn Bai Hui Chen Joon Ha Park In hye Kim jeong-Hwi Cho Jae-Chul Lee Bing Chun Yan Jung Hoon Choi In Koo Hwang Ju-Hee Park Sang-No Han Yun Lyul Lee Myong Jo Kim Moo-Ho Won Department of Neurobiology School of Medicine Kangwon National University Chuncheon 200-701 South Korea Department of Physiology College of Medicine Hallym University Chuncheon 200-702 South Korea Institute of Integrative Traditional & Western Medicine Medical College Yangzhou University Yangzhou Jiangsu 225001 China Department of Anatomy College of Veterinary Medicine Kangwon NationaL University Chuncheon 200-701 South Korea Department of Anatomy and Cell Biology College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University Seoul 151-742 South Korea Samsung Herb Medicine Company Limitedl 304 BIO-ldong ChunCheon Biotechnology Innovation Center Chuncheon 200-957 South Korea Oriental Bio-herb Research Institute Kangwon National University Chuncheon 200-701 South Korea

Background Hippophae rhamnoides L.（HL） exerts antioxidant activities against various oxidative stress *** this study,we investigated effects of extract from HL leaves （HLE） on cell proliferation and neuroblast differentiation in the subgranular zone （SGZ） of the dentate gyrus （DG） of aged *** Aged gerbils （24 months） were divided into vehicle （saline）-treated-and *** vehicle and HLE were orally administered with 200 mg/kg once a day for 20 days before *** proliferation and neurobiast differentiation were examined in the DG using Ki67 and doublecortin （DCX）,*** also observed changes in immunoreactivities of superoxide dismutase 1 （SOD1） and superoxide dismutase 2 （SOD2）,brain-derived neurotrophic factor （BDNF）,and phospho-glycogen synthase kinase-3-beta （p-GSK-3β） to examine their relation with neurogenesis using *** The administration of HLE significantly increased the number of Ki67-positive cells and DCX-positive neuroblasts with well-developed processes in the SGZ of the DG of the *** addition,immunoreactivities of SOD1,SOD2,BDNF,and p-GSK-3β were significantly increased in granule and polymorphic cells of the DG in the HLE-treated-group compared with those in the *** HLE treatment significantly increased cell proliferation and neuroblast differentiation,showing that immunoreactivities of SOD1,SOD2,BDNF,and p-GSK-3β were significantly increased in the *** indicate that increased neuroblast differentiation neurogenesis may be closely related to upregulation of SOD1,SOD2,BDNF,and p-GSK-3β in aged gerbils.

关键词： aging antioxidants dentate gyrus hippophae rhamnoides extract neurogenesis neurotrophic factors

Effect of Oenanthe Javanica Extract on Antioxidant Enzyme in the Rat Liver

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Chinese Medical Journal 2015年第12期128卷 1649-1654页

作者： Choong-Hyun Lee Joon-Ha Park jeong-Hwi Cho In-hye Kim Ji-hyeon Ahn Jae-Chul Lee Bai Hui Chen Bich-Na Shin Hyun-Jin Tae Eun Joo Bae II-Jun Kang Moo-Ho Won Jong-dai Kim Department of Pharmacy College of Pharmacy Dankook University Cheonan 330-714 South Korea Department of Neurobiology School of Medicine Kangwon National University Chuncheon 200-701 South Korea Department of Physiology College of Medicine Hallym University Chuncheon 200-702 South Korea Department of Biomedical Science Research Institute for Bioscience and Biotechnology Hallym University Chunchon 200-702 South Korea Department of Pediatrics Chuncheon Sacred Heart Hospital College of Medicine Hallym University Chuncheon 200-701 South Korea Department of Food Science and Nutrition Hallym University Chuncheon 200-702 South Korea Division of Food Biotechnology School of Biotechnology Kangwon National University Chuncheon 200-701 South Korea

Background：Oenanthe javanica （***） has been known to have high antioxidant properties via scavenging reactive oxygen *** examined the effect of *** extract （OJE） on antioxidant enzymes in the rat ***：We examined the effect of the OJE on copper,zinc-superoxide dismutase （SOD1）,manganese superoxide dismutase （SOD2）,catalase （CAT）,and glutathione peroxidase （GPx） in the rat liver using immunohistochemistry and western blot ***-dawley rats were randomly assigned to three groups;（1） normal diet fed group （normal-group）,（2） diet containing ascorbic acid （AA）-fed group （AA-group） as a positive control,（3） diet containing OJE-fed group （OJE-group）.Results：In this study,no histopathological finding in the rat liver was found in all the experimental *** of SOD1,SOD2,CAT,and GPx immunoreactive cells and their protein levels were significantly increased in the AA-fed group compared with those in the *** the other hand,in the OJE-group,numbers of SOD1,SOD2,CAT,and GPx immunoreactive cells in the liver were significantly increased by about 190%,478%,685%,and 346%,respectively,compared with those in the *** addition,protein levels of SOD 1,SOD2,CAT,and GPx in the OJE-group were also significantly much higher than those in the ***：OJE significantly increased expressions of SOD 1 and SOD2,CAT,and GPx in the liver cells of the rat,and these suggests that significant enhancements of endogenous enzymatic antioxidants by OJE might be a legitimate strategy for decreasing oxidative stresses in the liver.

关键词： Antioxidant Enzymes Immunohistochemistry Liver Oenanthe Javanica Extract Western Blotting

Sandwich-structure transferable free-form OLEDs for wearable and disposable skin wound photomedicine

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Light(Science & Applications) 2019年第1期8卷 96-110页

作者： Yongmin Jeon hye-Ryung Choi jeong Hyun Kwon Seungyeop Choi Kyung Mi Nam Kyoung-Chan Park Kyung Cheol Choi School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Department of Dermatology Seoul National University Bundang Hospital(SNUBH)Seongnam 13620Republic of Korea

Free-form optoelectronic devices can provide hyper-connectivity over space and ***,most conformable optoelectronic devices can only be fabricated on flat polymeric materials using low-temperature processes,limiting their application and *** paper presents free-form optoelectronic devices that are not dependent on the shape or *** medical applications,the transferable OLED(10μm)is formed in a sandwich structure with an ultra-thin transferable barrier(4.8μm).The results showed that the fabricated sandwich-structure transferable OLED(STOLED)exhibit the same high-efficiency performance on cylindricalshaped materials and on materials such as textile and *** the neutral axis is freely adjustable using the sandwich structure,the textile-based OLED achieved both folding reliability and washing reliability,as well as a long operating life(>150 h).When keratinocytes were irradiated with red STOLED light,cell proliferation and cell migration increased by 26 and 32%,*** the skin equivalent model,the epidermis thickness was increased by 39%;additionally,in organ culture,not only was the skin area increased by 14%,but also,reepithelialization was highly *** on the results,the STOLED is expected to be applicable in various wearable and disposable photomedical devices.

关键词： optoelectronic structure transfer

High Resolution Regional and Coastal Operational Storm Surges/Tide Forecasting System in Korea

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Journal of Environmental Science and Engineering(B) 2012年第3期1卷 324-335页

作者： Sung Hyup You Woo jeong Lee Ji hye Kwun Jang-Won Seo and Sang Boom Ryoo Marine Meteorology Division Observation Infrastructure Bureau KMA Seoul 156720 Korea Global Environment System Research Laboratory National Institute of Meteorological Research KMA Seoul 156720 Korea

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韩国标签印刷行业发展趋势分析

标签技术 2011年第1期01卷 16-17页

作者： hye—jeong Ahn 韩国《GRAPHICS WORLD》

目前，韩国从事标签印刷的企业共计2500多家，有65％的标签印刷企业位于首尔地区，35％的企业分布在首尔以外的地区，如图1所示。

关键词：标签印刷发展趋势印刷行业韩国印刷企业首尔

Monocarboxylate transporter 4 plays a significant role in the neuroprotective mechanism of ischemic preconditioning in transient cerebral ischemia

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Neural Regeneration Research 2015年第10期10卷 1604-1611页

作者： Seongkweon Hong Ji Yun Ahn Geum-Sil Cho In hye Kim jeong Hwi Cho Ji hyeon Ahn Joon Ha Park Moo-Ho Won Bai Hui Chen Bich-Na Shin Hyun-Jin Tae Seung Min Park Jun Hwi Cho Soo Young Choi Jae-Chul Lee Department of Surgery School of Medicine Kangwon National University Department of Emergency Medicine Sacred Heart Hospital College of Medicine Hallym University Department of Emergency Medicine School of Medicine Kangwon National University Department of Neuroscience College of Medicine Korea University Department of Neurobiology School of Medicine Kangwon National University Department of Physiology College of Medicine Hallym University Department of Biomedical Science Research Institute of Bioscience and Biotechnology Hallym University

Monocarboxylate transporters（MCTs）, which carry monocarboxylates such as lactate across biological membranes, have been associated with cerebral ischemia/reperfusion process. In this study, we studied the effect of ischemic preconditioning（IPC） on MCT4 immunoreactivity after 5 minutes of transient cerebral ischemia in the gerbil. Animals were randomly designated to four groups（sham-operated group, ischemia only group, IPC ＋ sham-operated group and IPC ＋ ischemia group）. A serious loss of neuron was found in the stratum pyramidale of the hippocampal CA1 region（CA1）, not CA2/3, of the ischemia-only group at 5 days post-ischemia; however, in the IPC ＋ ischemia groups, neurons in the stratum pyramidale of the CA1 were well protected. Weak MCT4 immunoreactivity was found in the stratum pyramidale of the CA1 in the sham-operated group. MCT4 immunoreactivity in the stratum pyramidale began to decrease at 2 days post-ischemia and was hardly detected at 5 days post-ischemia; at this time point, MCT4 immunoreactivity was newly expressed in astrocytes. In the IPC ＋ sham-operated group, MCT4 immunoreactivity in the stratum pyramidale of the CA1 was increased compared with the sham-operated group, and, in the IPC ＋ ischemia group, MCT4 immunoreactivity was also increased in the stratum pyramidale compared with the ischemia only group. Briefly, present findings show that IPC apparently protected CA1 pyramidal neurons and increased or maintained MCT4 expression in the stratum pyramidale of the CA1 after transient cerebral ischemia. Our findings suggest that MCT4 appears to play a significant role in the neuroprotective mechanism of IPC in the gerbil with transient cerebral ischemia.

关键词： nerve regeneration monocarboxylate transporters ischemic preconditioning ischemia/ reperfusion injury hippocampus CA1 pyramidal neurons neural regeneration

Delayed hippocampal neuronal death in young gerbil following transient global cerebral ischemia is related to higher and longer-term expression of p63 in the ischemic hippocampus

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Neural Regeneration Research 2015年第6期10卷 944-950页

作者： Eun Joo Bae Bai Hui Chen Bing Chun Yan Bich Na Shin jeong Hwi Cho In hye Kim Ji hyeon Ahn Jae Chul Lee Hyun-Jin Tae Seongkweon Hong Dong Won Kim Jun Hwi Cho Yun Lyul Lee Moo-Ho Won Joon Ha Park Department of Pediatrics Chuncheon Sacred Heart HospitalCollege of MedicineHallym University Department of Physiology College of MedicineInstitute of Neurodegeneration and NeuroregenerationHallym University Institute of Integrative Traditional & Western Medicine Medical CollegeYangzhou University Department of Neurobiology School of MedicineKangwon National University Department of Biomedical Science and Research Institute for Bioscience and Biotechnology Hallym University Department of Surgery School of MedicineKangwon National University Department of Emergency Medicine Chuncheon Sacred Heart HospitalCollege of MedicineHallym University Department of Emergency Medicine School of MedicineKangwon National University

The tumor suppressor p63 is one of p53 family members and plays a vital role as a regulator of neuronal apoptosis in the development of the nervous system. However, the role of p63 in mature neuronal death has not been addressed yet. In this study, we first compared ischemia-induced effects on p63 expression in the hippocampal regions （CA1-3） between the young and adult gerbils subjected to 5 minutes of transient global cerebral ischemia. Neuronal death in the hippocampal CA1 region of young gerbils was significantly slow compared with that in the adult gerbils after transient global cerebral ischemia, p63 immunoreactivity in the hippocampal CA1 pyramidal neurons in the sham-operated young group was significantly low compared with that in the sham-operated adult group, p63 immunoreactivity was apparently changed in ischemic hippocampal CA1 pyramidal neurons in both ischemia-operated young and adult groups. In the ischemia-operated adult groups, p63 immunoreactivity in the hippocampal CA1 pyramidal neurons was significantly decreased at 4 days post-ischemia; however, p63 immunoreactivity in the ischemia-operated young group was significantly higher than that in the ischemia-operated adult group. At 7 days post-ischemia, p63 immunoreactivity was decreased in the hippocampal CA1 pyramidal neurons in both ischemia-operated young and adult groups. Change patterns of p63 level in the hippocampal CA1 region of adult and young gerbils after ischemic damage were similar to those observed in the immunohistochemical results. These findings indicate that higher and longer-term expression of p63 in the hippocampal CA1 region of the young gerbils after ischemia/reperfusion may be related to more delayed neuronal death compared to that in the adults.

关键词： p53 tumor suppressor gene family cerebral ischemia/reperfusion pyramidal neurons CA1 region delayed neuronal death immunohistochemistry western blotting neural regeneration

Dipsacussaponin C from <i>Dipsacus asper</i>Reduces the Risk of Gastritis and Gastric Ulcer in Rats

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Food and Nutrition Sciences 2012年第7期3卷 931-941页

作者： Seon A. Hwang In Young Hwang Joohee Jung hye Kyung Kang Kun Ho Son Choon Sik jeong College of Pharmacy Duksung Women’s University Seoul 132-714 South Korea College of Pharmacy Duksung Women’s University Seoul Korea Department of Food Science and Nutrition Andong National University Gyeongbuk 760-749 South Korea

The roots of Dipsacus asper (da) have been used as a tonic and analgesic agent in traditional Chinese medicine for the treatment of osteoporosis, low back pain, knee pain, and as an anti-inflammatory agent. Few studies have reported pharmacological gastric activities. In this study, we investigated the effects of dipsacussaponin C (DSC) and 70% ethanol and water extracts of da on gastritis and gastric ulcer in rat. First, we examined the free radical scavenging effect by the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay. Second, we examined the Helicobacter pylori (H. pylori) colonization inhibitory effect and found that DSC has a mild anti-H. pylori effect. Third, the cytotoxicity was assessed by measuring the cell viability of human gastric cancer cells (SNU638 and AGS). Also, we observed the acid-neutralizing capacity by measuring NaOH consumption volume and found that DSC is effective as an antacid agent. For these reasons, we observed the effect of DSC on HCl?ethanol-induced gastritis and indomethacin-induced gastric ulcer in rat. In pylorus-ligated rats, DSC (200 mg/kg) also decreased the volume of gastric secretion (approximately 2.2 mL) and gastric acid output (0.16 mEq/4 hrs). From these results, we suggest that DSC isolated from da may be useful for the treatment and/or protection of gastritis and gastric ulcer.

关键词： Dipsacussaponin C Dipsacusasper Antioxidants Gastritis Gastric Ulcer