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Contribution to the Study of the Incidence of Post-Streptococcal Complications in Republic Central African Republic from 2015 to 2018

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Open Journal of Epidemiology 2024年第1期14卷 110-121页

作者： Zéphirin dalengat Vogbia Ernest Lango Yaya Jean De Dieu Longo augustin Balekouzou Gaspard Tekpa Christian Maucler Pamaticka Stéphanie Judith N’Yetobouko Maurel Anicet Adonis Ouoko Fatigbia Christian Diamant Mossoro Kpindet Gérard Gresenguet Epidemiology and Research Service National Reference Center for Sexually Transmitted Infections and Anti-Retroviral Therapy Ministry of Health Bangui Central African Republic Direction of National Laboratory of Clinical Biology and Public Health Ministry of Health Bangui Central African Republic Training Project Manager and Heald of Public Departement Ministry of Health Bangui Central African Republic Faculty of Health Sciences Doctoral School of Human and Veterinary Health Sciences University of Bangui Bangui Central African Republic National Committee for the Fight against AIDS Primature Bangui Central African Republic Infectious Disease Department The Sino Central African Friendship University Hospital Center Bangui Central African Republic Epidemiology Department Bangui National University Hospital Center Bangui Central African Republic

Introduction: Acute rheumatic fever (AAR) is a non-suppurative complication of late infection by group A. Infections due to streptococci remain a public health problem in the Central African Republic. The present study aims to determine the incidence rate of AAR cases and its complications. Methodology: This was a retrospective and analytical study over a period of 4 years (from January 2015 to December 2018) at the National Laboratory of Clinical Biology and Public Health (LNBCSP) in Bangui. It focused on samples concerning the diagnosis of AAR and patient files seen in consultation in the capital’s reference health establishments. Laboratory registers and patient consultation files were used to collect data. They were entered into Excel 2010 to be analyzed with Epi Info 7. A univariate analysis by logistic regression, Ficher’s exact test, and chi2 at the 5% threshold (p Results: We analyzed 94 cases meeting Jones’s criteria. The ages of the patients ranged from 18 to 85 years (mean age 52 years and mode 45 years). The incidence rate of AAR for the female sex was higher than that of the male sex during the study period (p > 0.05). It went from 166.6 in 2015 to 200 in 2016 and 2018 cases of AAR per 1000 people per year. The average incidence rate was 296.18 cases of AAR per 1000 people per year. The average incidence rate was 223.5 cases of AAR per 1000 people per year for joint damage. Joint damage represented 80.85% (RR = 0.62;Chi2 = 4.88;95% CI [0.39-0.97];p Conclusion: The study allowed data on the impact rate and complications of the AAR in Bangui. Special attention to data management will help produce a complete result on the problem. Joint complications predominated. Sustaining an effective surveillance system and preventing infection would help reduce the risk of AAR occurrence.

关键词： Incidence Acute Joint Rheumatism Central African Republic

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Ultrafast laser-driven topological spin textures on a 2D magnet

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npj Computational Materials 2022年第1期8卷 1630-1635页

作者： Mara Strungaru Mathias augustin Elton J.G.Santos Institute for Condensed Matter Physics and Complex Systems School of Physics and AstronomyThe University of EdinburghEdinburghEH93FDUK Donostia International Physics Center(DIPC) 20018Donostia-San SebastiánBasque CountrySpain Higgs Centre for Theoretical Physics The University of EdinburghEdinburghEH93FDUK

Ultrafast laser excitations provide an efficient and low-power consumption alternative since different magnetic properties and topological spin states can be triggered and manipulated at the femtosecond(fs)***,it is largely unknown whether laser excitations already used in data information platforms can manipulate the magnetic properties of recently discovered two-dimensional(2D)van der Waals(vdW)*** we show that ultrashort laser pulses(30−85 fs)can not only manipulate magnetic domains of 2D-XY CrCl_(3)ferromagnets,but also induce the formation and control of topological nontrivial meron and antimeron spin *** observed that these spin quasiparticles are created within~100 ps after the excitation displaying rich dynamics through motion,collision and annihilation with emission of spin waves throughout the *** findings highlight substantial opportunities of using photonic driving forces for the exploration of spin textures on 2D magnetic materials towards magneto-optical topological applications.

关键词： laser excitation topological

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Prevalence, Maternal and Perinatal Prognosis of Breech Delivery Compared to That of the Vertex in 242 Cases for 484 Controls at Ségou Hospital in Malti

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Open Journal of Obstetrics and Gynecology 2024年第9期14卷 1414-1421页

作者： Tidiani Traoré Famakan kané Abdoulaye kassogué Seydou Traoré Seydou Z. dao Balilé Harber Sabré Koné kassoum Sidibé Brahima Donigolo Babou Traoré Adama Coulibaly Abdrhamane Diarisso Alima Sidibé Mamadou Sima augustin Théra Youssouf Traoré Ibrahima Teguété Niani Mounkoro Ministry of Health in Bamako Nianakoro Fomba Hospital Segou Mali Regional Health Department of Segou District Hospital Bla Mali Regional Health Department of Koutiala Reference Health Center Koutiala Mali Regional Health Department of Bamako Reference Health Center Commune II Bamako Mali Ministry of Health in Bamako Fousseyni Daou Hospital Kayes Mali Ministry of Health in Bamako Point G University Hospital Center Bamako Mali Ministry of Health in Bamako Gabriel Toure University Hospital Center Bamako Mali

Introduction: Breech birth has always been a subject of great interest because of its risks of perinatal morbidity and mortality. Aim: The aim of our study was to compare the maternal and perinatal prognosis of breech delivery with that of vertex delivery. Patients and Method: This was a retrospective case-control analytical study carried out in the obstetrics and gynaecology department of Ségou hospital over a 2-year period from 1 January 2020 to 31 December 2021, involving 242 breech deliveries compared with 484 top deliveries with a live single foetus without foetal malformation of gestational age ≥ 35 SA. The statistical tests used were: chi² (p Results: The frequency of breech delivery was 3.3%, with a predominance of caesarean section for breech presentation (64.88%) compared with 32.85% for vertex (P: 0.00;CI: (0.191 - 0.367). The perinatal prognosis of fetuses with breech presentations was marked by a higher rate of neonatal asphyxia (Apgar score Conclusion: Breech birth is relatively rare in our department. It carries a higher risk of maternal morbidity and neonatal morbidity than breech delivery. However, the vital prognosis for the mother was identical in both groups.

关键词： Delivery Breech Vertex Prognosis Mali

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Hysterectomies for Gynaecological Pathology: 56 Cases at the Segou Regional Hospital in Mali

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Open Journal of Obstetrics and Gynecology 2024年第9期14卷 1363-1373页

作者： Tidiani Traoré Famakan kané Abdoulaye kassogué Seydou Traoré Seydou Z. dao Balilé Harber Sory Diallo kassoun Sidibé Brahima Donigolo Babou Traoré Adama Coulibaly Abdrahamane Diarisso Alima Sidibé Mamadou Sima augustin Théra Youssouf Traoré Ibrahima Teguété Niani Mounkoro Ministry of Health in Bamako Nianakoro Fomba Hospital Segou Mali Regional Health Department of Segou District Hospital Bla Mali Regional Health Department of Koutiala Reference Health Center Koutiala Mali Regional Health Department of Bamako Reference Health Center Commune II Bamako Mali Ministry of Health in Bamako Fousseyni Daou Hospital Kayes Mali Ministry of Health in Bamako Point G University Hospital Center Bamako Mali Ministry of Health in Bamako Gabriel Toure University Hospital Center Bamako Mali

Introduction: Hysterectomy is a surgical procedure involving partial or total removal of the uterus. It is the most common gynaecological surgery in the world. Objective: To describe the epidemio-clinical and prognostic aspects of gynaecological hysterectomies. Patients and methods: This was an 18-month retrospective prospective descriptive study with a six-month follow-up period from 1 December 2020 to 31 May 2022 carried out in the gynaecology department of the Segou regional hospital. Results: Fifty-six (56) hysterectomies were performed out of 118 gynaecological surgical procedures (47.45%). The mean age was 47 ± 11.77 years. Large multiparous women were the most common (50%), with an average parity of 4.58. The main indications were uterine fibroids (30.4%), precancerous lesions of the cervix (17.85%) and uterine prolapse (17.85%). The abdominal route was the most commonly used surgical route (82.14%). Hysterectomy was total in 100% of cases and associated with bilateral adnexectomy in 48.2% of cases. The intra- and post-operative prognosis was satisfactory in 94.6% of cases. No deaths were recorded. The average length of stay was 3.28 days, irrespective of the surgical approach. Three cases of dyspareunia were noted among those who had resumed sexual activity.

关键词： Hysterectomy Gynaecological Pathology Mali

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Assessing global Sentinel-2 coverage dynamics and data availability for operational Earth observation(EO)applications using the EO-Compass

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International Journal of Digital Earth 2020年第7期13卷 768-784页

作者： Martin Sudmanns Dirk Tiede Hannah augustin Stefan Lang Department of Geoinformatics University of SalzburgSalzburgAustria

Sentinel-2 scenes are increasingly being used in operational Earth observation(EO)applications at regional,continental and global scales,in near-real time applications,and with multi-temporal *** a broader scale,they are therefore one of the most important facilitators of the Digital ***,the data quality and availability are not spatially and temporally homogeneous due to effects related to cloudiness,the position on the Earth or the acquisition *** spatiotemporal inhomogeneity of the underlying data may therefore affect any big remote sensing analysis and is important to *** study presents an assessment of the metadata for all accessible Sentinel-2 Level-1C scenes acquired in 2017,enabling the spatio-temporal coverage and availability to be quantified,including scene availability and *** exploratory analysis of the global,multi-temporal metadata also reveals that higher acquisition frequencies do not necessarily yield more cloud-free scenes and exposes metadata quality issues,*** incorrect cloud cover estimation in high,nonvegetated *** continuously updated datasets and analysis results are accessible as a Web application called *** contributes to a better understanding and selection of Sentinel-2 scenes,and improves the planning and interpretation of remote sensing analyses.

关键词： Sentinel-2 metadata cloud cover scene coverage global analysis big Earth data digital earth

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Contribution of Bone Scintigraphy in the Diagnosis of a Case of SAPHO in the Nuclear Medicine Department of Idrissa Pouye General Hospital (dakar, Senegal)

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Open Journal of Medical Imaging 2024年第1期14卷 1-9页

作者： El Hadji Amadou Lamine Bathily kalidou Gueye Serigne Moussa Badiane Mamoudou Salif Djigo Gora Thiaw Ousseynou Diop Olatounde Herbert Fachinan Papa Mady Sy Alfonse Rodrigue Djiboune Kokou Fofo Toussaint Adambounou Louis augustin Diaga Diouf Boucar Ndong Gora Mbaye Omar Ndoye Mounibé Diarra Mamadou Mbodj Nuclear Medicine Department Idrissa Pouye General Hospital (HOGIP) Dakar Senegal Biophysical Laboratory FMPO Cheikh Anta Diop University (UCAD) Dakar Senegal Biophysical Laboratory UFR2S Gaston Berger University (UGB) Saint-Louis Senegal Nuclear Medicine Department Hospital Dalal Jamm Dakar Senegal Laboratory of Physical and Pharmaceutical Biophysics FMPO Cheikh Anta Diop University Dakar Senegal Biophysical Laboratory University of Lome Lome Togo

Introduction: The acronym SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis) is a syndrome combining osteoarticular and cutaneous manifestations. It occurs mainly between the ages of 30 and 50. Sternocostoclavicular hyperostosis is one of the main distinguishing features. We report a case of SAPHO in dakar diagnosed by bone scintigraphy. Observation: 28-year-old Senegalese women presented with left shoulder pain and relative functional impotence for over 2 years. Examination revealed right sternoclavicular hyperostosis and left shoulder pain on palpation. Questioning revealed a history of acne and hyperostosis of the right first toe. Bone scintigraphy, performed after injection of 630 MBq of 99mTc-HMDP, revealed: hyperfixation of the bilateral (right++) manubrio-sternal and sternoclavicular junction, producing the classic bull’s horn image;hyperfixation of the left shoulder with an inflammatory appearance;hyperfixation of the sacroiliac joints suggestive of bilateral sacroiliitis;hyperfixation of the right first toe;two mandibular hyper fixations probably related to dental damage. This scintigraphic appearance in one was strongly suggestive of SAPHO syndrome. Conclusion: SAPHO syndrome, related to spondyloarthropathy, associates cutaneous and osteoarticular signs. It is characterized by frequent delays in diagnosis due to poor recognition. Soy is an invaluable diagnostic tool, enabling us to assess the extent of the disease and its evolution.

关键词： SAPHO Bone Scintigraphy Young Woman Senegalese

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Iodine 131 Treatment in Graves’ Disease in a West African Country: Preliminary Study about 25 Cases in Senegal

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Open Journal of Biophysics 2024年第1期14卷 56-72页

作者： El Hadji Amadou Lamine Bathily Serigne Moussa Badiane Mamoudou Salif Djigo Gora Thiaw kalidou Gueye Ousseynou Diop Boucar Ndong Kokou Fofo Toussaint Adambounou Alphonse Rodrigue Djiboune Papa Mady Sy Mamadou Soumbounou Mohamed Chekhma Louis augustin Diaga Diouf Gora Mbaye Omar Ndoye Mounibé Diarra Mamadou Mbodj Nuclear Medicine Department General Hospital of Idrissa Pouye (HOGIP) Dakar Senegal Biophysical Laboratory Cheikh Anta Diop University (UCAD) Dakar Senegal Biophysical Laboratory Gaston Berger University (UGB) Saint-Louis Nuclear Medicine Department Hospital Dalal Jamm Dakar Senegal Biophysical Laboratory University of Lome Lome Togo Laboratory of Physical and Pharmaceutical Biophysics Cheikh Anta Diop University Dakar Senegal

Introduction: Graves’ disease is the most common cause of hyperthyroidism. Its treatment uses synthetic antithyroid drugs but the use of aggressive radical therapy such as surgery or non-aggressive therapy such as iodine-131 is not uncommon. Treatment of Graves’ disease with radioactive iodine or iratherapy is a simple, inexpensive, well-tolerated treatment. It was introduced in Senegal in 2016. We report through this work the preliminary assessment of the only nuclear medicine service in Senegal in the management of Graves’ disease by iodine-131. Patients and Methods: Retrospective study of the first cases of Graves’ disease treated with iratherapy in Senegal. Socio-demographic, clinical, paraclinical, therapeutic and evolutionary aspects were studied. Radiation protection rules have been implemented and contraception has been effective for six months in women of childbearing age. Results: 25 patients were collected with a mean age of 45 years, twenty women (80%), a family goiter in 24% and a psycho-affective context in 64% of cases. Thyrotoxicosis syndrome was associated with goiter in 68% of patients and exophthalmos in 64%. Thyroid ultrasound performed in 20 patients showed vascular goiter in 80% and thyroid scintigraphy in 3 patients, homogeneous and diffuse hyperfixation. TRAK dosed in 8 patients was still positive. All patients had received first-line medical treatment. The average duration of this treatment was more than 18 months in 92%. The empirically used iodine-131 activity averaged 15.35 mCi. Oral corticosteroid therapy was prescribed in 7 patients for the prevention of malignant orbitopathy. No early side effects were noted. The remission rate at 3 months was 52% and at 6 months was 88% to 92%. Conclusion: The effectiveness of radioactive iodine, in particular ablative doses in the treatment of hyperthyroidism, is no longer to be demonstrated. Taking into account our socioeconomic context, iratherapy should be a treatment of choice for hyperthyroidism

关键词： Graves’ Disease Iratherapy Iodine-131 Senegal

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Longitudinal Variability of the Vertical Drift Velocity Inferred from Ground-Based Magnetometers and C/NOFS Observations in Africa

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International Journal of Geosciences 2022年第8期13卷 657-680页

作者： Messanga Etoundi Honoré Paul Obiakara Amaechi augustin daïka Diaby kassamba Abdel Aziz Mohamed kaab César Biouele Mbané Zouhair Benkhaldoun Department of Geomatics Higher Technical Teacher Training College of Ebolowa University of Ebolowa Ebolowa Cameroon Applied Biotechnology and Engineering Laboratory Higher Technical Teacher Training College of Ebolowa Ebolowa Cameroon Laboratory of Earth’s Atmosphere Physics Faculty of Science University of Yaoundé 1 Yaoundé Cameroon Cardiff School of Education & Social Policy Cardiff Metropolitan University Cyncoed Campus Cardiff UK Department of Meteorology and Climatology National Advanced School of Engineering University of Maroua Maroua Cameroon Laboratoire de Physique de l’Atmosphère UFR-SSMT Université Félix Houphou&#235 t Boigny Abidjan C&#244 te d’Ivoire Oukaimeden Observatory LPHEA FSSM Cadi Ayyad University Marrakech Morrocco National School of Applied Sciences of Beni Mellal Sultan Moulay Sliman University Beni Mellal Morocco

This study aims at discussing longitudinal effects on the variability of the vertical E × B drift velocity at low latitudes, specifically over African sector. To this effect, observations from ground-based magnetometers and the Ion Velocity Meter experiment onboard C/NOFS satellite are analyzed in conjunction with equatorial electric field and neutral wind model estimates under geomagnetically quiet conditions in the years 2012-2013. Notwithstanding the limitation in data over Africa, the combination of ground-based and in-situ observations confirmed the existence of longitudinal differences in the E × B between the Atlantic, Western and Eastern African sectors. This was well reproduced by the equatorial electric field model (EEFM) which showed that during noon, the peak of the equatorial electric field (EEF) was the lowest in the Atlantic sector, with an increasing trend towards the Eastern longitude. The Horizontal Wind Model 14 (HWM14) showed that the eastward zonal (poleward meridional) wind velocity was the lowest (highest) in the Eastern sector. Furthermore, the zonal (meridional) wind increased (decreased) from the Eastern to the Atlantic sector. These results highlight the contribution of the neutral wind velocity in driving the longitudinal difference in the vertical drift velocity over Africa.

关键词： Equatorial Electrojet Vertical Drift Velocity (E × B) Longitudinal Variability African Sector

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Suture granuloma of the abdominal wall with intra-abdominal extension 12 years after open appendectomy

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World Journal of Gastroenterology 2009年第32期15卷 4083-4086页

作者： Goran augustin Dragan Korolija Mate Skegro Jasminka Jakic-Razumovic Department of Surgery Division of Abdominal SurgeryUniversity Hospital Center ZagrebKipatieva 1210000 ZagrebCroatia Department of Pathology University Hospital Center Zagreb Kipatieva 1210000 ZagrebCroatia

Most complications after appendectomy occur within ten days; however, we report the unusual case of a suture granuloma 12 years after open appendectomy. The afebrile 75-year-old woman presented with a slightly painful palpable mass in the right lower abdomen. There was no nausea or vomiting and bowel movements were normal. She lost 10 kg during the 3 mo before presentation. The patient had undergone an appendectomy 12 years previously. Physical examination revealed a tender mass, 10 cm in diameter, under the appendectomy scar. The preoperative laboratory findings, tumor markers and plain abdominal radiographs were normal. Multi-slice computed tomography scanning showed an inhomo-genous abdominal mass with minimal vascularization in the right lower abdomen 8.6cm×8cm×9 cm in size which communicated with the abdominal wall. The abdominal wall was thickened, weak and bulging. The abdominal wall mass did not communicate with the cecum or the ascending colon. Complete excision of the abdominal wall mass was performed via median laparotomy. Histopathological examination revealed a granuloma with a central abscess. This case report demonstrates that a preoperative diagnosis of abdominal wall mass after open appendectomy warrants the use of a wide spectrum of diagnostic modalities and consequently different treatment options.

关键词： Appendectomy Differential diagnosis Postoperative complication Suture granuloma

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Intestinal bile acid physiology and pathophysiology

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World Journal of Gastroenterology 2008年第37期14卷 5630-5640页

作者： Olga Martínez-augustin Fermín Sánchez de Medina Department of Biochemistry and Molecular Biology II School of Pharmacy University of Granada Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y DigestivasGranada 18071 Spain Department of Pharmacology School of Pharmacy University of Granada Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y DigestivasGranada 18071 Spain

Bile acids (BAs) have a long established role in fat digestion in the intestine by acting as tensioactives, due to their amphipatic characteristics. BAs are reabsorbed very efficiently by the intestinal epithelium and recycled back to the liver via transport mechanisms that have been largely elucidated. The transport and synthesis of BAs are tightly regulated in part by specific plasma membrane receptors and nuclear receptors. In addition to their primary effect, BAs have been claimed to play a role in gastrointestinal cancer, intestinal inflammation and intestinal ionic transport. BAs are not equivalent in any of these biological activities, and structural requirements have been generally identified. In particular, some BAs may be useful for cancer chemoprevention and perhaps in inflammatory bowel disease, although further research is necessary in this field. This review covers the most recent developments in these aspects of BA intestinal biology.

关键词： Colitis Bile acid absorption Colon cancer

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