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Real-Time In Vivo Dose Verification for Serial Tomotherapy of Head and Neck Patients

Real-Time In Vivo Dose Verification for Serial Tomotherapy o...

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中华医学会放射肿瘤治疗学分会六届二次暨中国抗癌协会肿瘤放疗专业委员会二届二次学术会议

作者： Zhen-Yu Qi,Xiao-Wu Deng,Shao-Min Huang,Xiao-Yan Huang,Zhi-Chun He,Almon S Shiu,Michael Lerch,Peter Metcalfe,Anatoly Rosenfeld,Tomas Kron a Department of Radiation Oncology,Sun Yat-Sen University cancer Center and State Key Laboratory of Oncology in Southern China,Guangzhou 510060,China b centre for Medical Radiation Physics, University of Wollongong,Wollongong,NSW 2522,australia cRadiation Physics Department,The University of Texas,M.D.Anderson cancer Center,Houston,Texas 77030,USA dpeter maccallum cancer centre,melbourne,vic 3002,australia

Purpose:The complexity of intensity-modulated radiation therapy(IMRT) has enhanced the need for a rigorous quality assurance program to ensure accurate treatment delivery. Methods and Materials:In this work,a recently designed metal-oxide-semiconductor field effect transistor(MOSFET) dosimetry system that can enable the real-time monitoring of the delivered doses to the patients during serial tomotherapy treatment has been *** key factors that may affect the accuracy of MOSFET measurements such as source-surface distance(SSD),field size,beam incident angles and radiation energy spectrum are *** feasibility of this dosimetry system in IMRT dose verification is evaluated with comparison to ionization chamber measurements in an IMRT QA phantom. Results:The initial results of the real-time in vivo measurements with MOSFTEs during serial tomotherapy treatment of head and neck cancer patients are *** MOSFET sensitivity did not change with *** photon field sizes less than 20×20 cm,the MOFET sensitivity varied with field size within 1.0%.The detector angular response was isotropic within 2%over full 360°,and the observed sensitivity variation with depth due to changes in the radiation energy spectrum waa negligible in high energy photon *** MOSFET measurements agreed with the ionization chamber results in IMRT phantom plan verification at all points to within±5%.The overall deviation of in vivo measurements for head and neck cancer patients undergoing serial tomotherapy treatment was on average 3.33%ranging from -2.20%to 7.89%,compared with doses predicted by a commercial treatment planning system (TPS).Less than 5%deviation from the planned dose was measured in 92%of all cases. Conclusion:The developed real-time in vivo MOSFET dosimetry system has proven to be a useful tool both in evaluating the actual dose within individual patients and in avoiding misadministration in the delivery of serial IMRT treatment.

关键词： MOSFET in vivo dosimetry real time dosimetry intensity modulated radiation therapy quality assurance

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