检索结果-南通市图书馆

Overview of the immunological mechanisms in hepatitis B virus reactivation:Implications for disease progression and management strategies

引用

World Journal of Gastroenterology 2024年第10期30卷 1295-1312页

作者： Hui Ma Qing-Zhu Yan Jing-Ru Ma dong-fu li Jun-ling Yang Department of Clinical Laboratory The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Ultrasound Medicine The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Digestive Diseases Center Department of Hepatopancreatobiliary MedicineThe Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Respiratory and Critical Care Medicine The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina

Hepatitis B virus(HBV)reactivation is a clinically significant challenge in disease *** review explores the immunological mechanisms underlying HBV reactivation,emphasizing disease progression and *** delves into host immune responses and reactivation’s delicate balance,spanning innate and adaptive *** factors’disruption of this balance,as are interac-tions between viral antigens,immune cells,cytokine networks,and immune checkpoint pathways,are ***,the roles of T cells,natural killer cells,and antigen-presenting cells are discussed,highlighting their influence on disease *** reactivation’s impact on disease severity,hepatic flares,liver fibrosis progression,and hepatocellular carcinoma is *** strategies,including anti-viral and immunomodulatory approaches,are critically *** role of prophylactic anti-viral therapy during immunosuppressive treatments is explored alongside novel immunotherapeutic interventions to restore immune control and prevent *** conclusion,this compre-hensive review furnishes a holistic view of the immunological mechanisms that propel HBV *** a dedicated focus on understanding its implic-ations for disease progression and the prospects of efficient management stra-tegies,this article contributes significantly to the knowledge *** more profound insights into the intricate interactions between viral elements and the immune system will inform evidence-based approaches,ultimately enhancing disease management and elevating patient *** dynamic landscape of management strategies is critically scrutinized,spanning anti-viral and immunomodulatory *** role of prophylactic anti-viral therapy in preventing reactivation during immunosuppressive treatments and the potential of innovative immunotherapeutic interventions to restore immune control and proactively deter reactivation.

关键词： Hepatitis B virus reactivation Immunological mechanisms Disease progression Management strategies Immune response

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Single-cell omics: experimental workflow, data analyses and applications

引用

Science China life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan li dongqing Sun Shaliu fu Lei Gu Xin Shao Qinqin Wang Xin dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-dong J.Han Qi liu Xiaohui Fan Chen li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of life Science Chinese Academy of Sciences Peking-Tsinghua Center for life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

引用

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou Zhang Shuo li fu Tang Jingkai Zhang Yuetong Kang Hean Zhang lidong li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

创业期科技型中小企业人力资源管理困境分析

引用

人口学刊 2009年第6期31卷 56-59页

作者：陈莉李东福长春工业大学政治与行政学院吉林长春130012

创业期科技型中小企业由于规模小、进入市场时间短,对如何充分发挥人力资源的作用缺乏研究和认识,造成人员大量、频繁地流动,使企业在管理、研发、创新等方面缺乏持续的人力资源来源。创业期科技型中小企业的人力资源管理问题已经越来... 详细信息

创业期科技型中小企业由于规模小、进入市场时间短,对如何充分发挥人力资源的作用缺乏研究和认识,造成人员大量、频繁地流动,使企业在管理、研发、创新等方面缺乏持续的人力资源来源。创业期科技型中小企业的人力资源管理问题已经越来越成为制约其发展的瓶颈。对此提出转变人力资源管理观念;有意识地培养企业文化和团队精神;灵活运用物质激励与精神激励措施;形成切实可行的培训体系等对策。

关键词：科技型中小企业创业期人力资源管理

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of lamellarization on the microstructure and mechanical properties of marine 10Ni5CrMoV steel

引用

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 402-413页

作者： Tao Zou Yanwu dong Zhouhua Jiang Shuyang Du Yushuo li School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Key Laboratory for Ecological Metallurgy of Multimetallic Ores(Ministry of Education) Northeastern UniversityShenyang 110819China

Multistage heat treatment involving quenching(Q),lamellarizing(L),and tempering(T)is applied to marine 10Ni5CrMoV *** microstructure and mechanical properties were studied by multiscale characterizations,and the kinetics of reverse austenite transformation,strain hardening behavior,and toughening mechanism were further *** lamellarized specimens possess low yield strength but high toughness,especially cryogenic *** leads to the development of film-like reversed austenite at the martensite block and lath boundaries,refining the martensite structure and lowering the equivalent grain *** analysis of austenite reversion based on the JMAK model shows that the isothermal transformation is dominated by the growth of reversed austenite,and the maximum transformation of reversed austenite is reached at the peak temperature(750℃).The strain hardening behavior based on the modified Crussard-Jaoul analysis indicates that the reversed austenite obtained from lamellarization reduces the proportion of martensite,significantly hindering crack propagation via martensitic transformation during the *** a consequence,the QLT specimens exhibit high machinability and low yield *** with the QT specimen,the ductile-brittle transition temperature of the QLT specimens decreases from-116 to-130℃due to the low equivalent grain size and reversed austenite,which increases the cleavage force required for crack propagation and absorbs the energy of external load,*** work provides an idea to improve the cryogenic toughness of marine 10Ni5CrMoV steel and lays a theoretical foundation for its industrial application and comprehensive performance improvement.

关键词： 10Ni5CrMoV steel lamellarizing reversed austenite cryogenic toughness ductile-brittle transition temperature

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microstructural evolution during the progressive transformation-induced plasticity effect in a Fe-0.1C-5Mnmedium manganese steel

引用

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 369-379页

作者： Mei Zhang Wenhao li Yangfei Chen Yang Jiang Xiaofei Guo Han dong School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile ***-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation *** findings were discussed with the local strain measurements via digital image *** results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of *** small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier *** volume fraction of RA gradually decreased from 26.8%to 8.2%prior to *** the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.

关键词： medium-Mn steel retained austenite progressive transformation-induced plasticity effect local strain fracture initiation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于多尺度小波分解和时间序列法的风电场风速预测

引用

华北电力大学学报（自然科学版） 2012年第2期39卷 43-48页

作者：李东福董雷礼晓飞廖毅华北电力大学电气与电子工程学院北京102206 中国南方电网超高压输电公司广州局广东广州510663

针对目前风电场风速预测精度较低的问题,提出一种基于多尺度小波分解和时间序列法的混合风速预测模型,通过小波分解将风速非平稳时间序列分解为不同尺度坐标上的平稳时间序列,然后把分解后的各层序列重构回原尺度,再应用自回归滑动平均... 详细信息

针对目前风电场风速预测精度较低的问题,提出一种基于多尺度小波分解和时间序列法的混合风速预测模型,通过小波分解将风速非平稳时间序列分解为不同尺度坐标上的平稳时间序列,然后把分解后的各层序列重构回原尺度,再应用自回归滑动平均模型对平稳时间序列进行预测,最后通过叠加合成得出原始风速序列的预测值。同时在验证时间序列模型有效性与模型选优过程中,采用基于贝叶斯理论的SBC定阶准则,改善了以往模型定阶准则的收敛特性。在算例分析中分别利用本文方法和常规预测法对实际风速分布特性进行预测分析,结果表明,本文方法对不平稳风速序列的预测具有更高的预测精度和更强的适应性。

关键词：风速预测小波分解时间序列法定阶准则预测精度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

低碳钢在湿热工业海洋大气中的腐蚀特征

引用

工程科学学报 2017年第5期39卷 739-746页

作者：李东亮付贵勤朱苗勇东北大学冶金学院沈阳110819

以0.1 mol·L^(-1)NaCl+0.01 mol·L^(-1)NaHSO_3溶液为腐蚀介质,采用干/湿周浸加速腐蚀实验、腐蚀失重、X射线衍射、扫描电镜和能谱分析等方法,研究了湿热工业海洋大气中低碳钢的腐蚀行为.结果表明:实验钢的腐蚀过程均遵循幂函数d=At^... 详细信息

以0.1 mol·L^(-1)NaCl+0.01 mol·L^(-1)NaHSO_3溶液为腐蚀介质,采用干/湿周浸加速腐蚀实验、腐蚀失重、X射线衍射、扫描电镜和能谱分析等方法,研究了湿热工业海洋大气中低碳钢的腐蚀行为.结果表明:实验钢的腐蚀过程均遵循幂函数d=At^n分布规律,钢种不同,常系数A、n的值不同;腐蚀产物主要由非晶物质和少量Fe_3O_4、α-FeOOH、β-FeOOH、γ-FeOOH晶体组成.所得锈层可分为主体锈层和界面疏松带两部分,由内至外锈层中Fe、O含量梯度变化很小.Cl^-、SO_2与水分的长期协同作用会导致内锈层结构变差,而添加稳定性或耐蚀性较高的元素可以改善锈层质量,进而增强钢材的耐腐蚀性能.

关键词：低碳钢大气腐蚀工业海洋大气湿热环境锈层

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The principle of optimization of binary mobile phase composition of multi-step linear gradient elution

引用

Acta Chimica Sinica English Edition 1989年第6期7卷 511-519页

作者： ZOU Han-Fa ZHANG Yu-Kui dong li-fu BAO Mian-Sheng LU Pei-Zhang Dalian Institute of Chemical Physics Academia SinicaDalian Chromatographic R&D Center of ChinaDalian

The basic principle of optimal method called “moving overlapping resolution mapping Method” to select the optimal binary mobile phase composition of multi-step linear gradient liquid chromatography is discussed with simultaneously considering effects of position of solute inside the column and mobile phase composition on peak resolution and retention value, then a BASIC program based on this principle is developed in IBM-PC computer. The validities of both principle of optimization and BASIC program are confirmed by separation of samples Containing bile acids and PAHs in RP-HPLC.

关键词： time length The principle of optimization of binary mobile phase composition of multi-step linear gradient elution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

抗原提呈相关转运体基因多态性与慢性HBV感染研究进展

引用

国际免疫学杂志 2010年第2期33卷 102-105,109页

作者：邱冰李东复吉林大学第二医院消化内科长春130041

抗原提呈相关转运体（TAP）在内源性抗原提呈过程中有重要作用，负责内源性抗原从胞浆到内质网腔的转运。TAP是由TAP1基因和TAP2基因编码的TAP1和TAP2组成的异二聚体。TAP基因具有多态性。乙型肝炎病毒（HBV）作为细胞内抗原，主要是经... 详细信息

抗原提呈相关转运体（TAP）在内源性抗原提呈过程中有重要作用，负责内源性抗原从胞浆到内质网腔的转运。TAP是由TAP1基因和TAP2基因编码的TAP1和TAP2组成的异二聚体。TAP基因具有多态性。乙型肝炎病毒（HBV）作为细胞内抗原，主要是经过内源性抗原加工和提呈途径而启动免疫应答的，TAP1／TAP2基因多态性的改变造成了分子结构异常，则会出现抗原呈递的功能障碍，抗原提呈不能有效进行，HBV抗原肽不能被细胞毒细胞识别而清除，则形成HBV的慢性持续感染。

关键词：抗原提呈相关转运体多态性乙型肝炎病毒慢性感染

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：