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Embr.onic Hyper.ension Following Exposur. to Ter.togenic Doses of 5-Fluor.-2'-Deoxyur.dine

Biomedical and Envir.nmental Sciences 1996年第4期9卷 408-417页

作者： VINU D. PATEL r.BEr. S. NOLAN NOr.AN HU EDWAr. B. CLAr.A david r. hootnick E. MAr. LEVINSOHN AND david S. PACKAr., Jr.(Depar.ments of Obstetr.cs and Gynecology, Anatomy and Cell Biotogy, and Pediatr.cs, Stale Univer.ity of New Yor. Health Science C Depar.ment of Obstetr.cs and Gynecology State University of New York Health Science Center Syracuse New York 13210 USA.

The ter.togenicity of 5-fluor.-2'-deoxyur.dine (FdU) is well established. Pr.viously, we have demonstr.ted that ter.togenic doses of FdU pr.duce hematomas and suggested that those hematomas pr.duced skeletal malfor.ations in chicken embr.os. In this study, the car.iovascular.effects of ter.togenic doses of FdU in chicken embr.os wer. studied. A dose of either.0.026 μg FdU or.0.030 μg FdU was injected into the yolk sacs of fer.ile chicken eggs containing embr.os at Hambur.er.and Hamilton stages 17-19 of development. The embr.os wer. then r.tur.ed to the incubator. Aor.ic systolic and diastolic blood pr.ssur.,blood velocity and hear. r.te wer. measur.d at stages 21, 24 or.27 using a ser.onull system and Doppler.ultr.sound. In addition, mean ar.er.al blood pr.ssur., blood flow, and str.ke volume wer. calculated fr.m these data. Similar.data wer. also r.cor.ed fr.m uninjected and saline injected contr.l embr.os. Systolic and mean ar.er.al blood pr.ssur.s wer. significantly incr.ased in FdU-tr.ated embr.os at stage 27. The other.par.meter. measur.d or.calculated wer. not significantly differ.nt fr.m contr.l embr.os. Our.study suggests that elevated systolic blood pr.ssur. in chicken embr.os tr.ated with FdU may lead to hematoma for.ation and subsequent bir.h defects

关键词： Deoxyur.dine Embr.onic Hyper.ension Following Exposur. to Ter.togenic Doses of 5-Fluor.-2

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Hematomas and Limb Skeletal Malfor.ations in Chicken Embr.os Following Exposur. to 5-Fluor.-2'-Deoxyur.dine

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Biomedical and Envir.nmental Sciences 1998年第1期11卷 15-30页

作者： r.BEr. S. NOLAN GAr.Y SCHWAr.Z SEAN FAr.UHAr.ON david r.hootnick E. MAr. LEVINSOHN MAr. MILLEr.LISA A. MANZ AND david S. PACKAr., Jr.(Depar.ments of Anatomy and Cell Biology, Or.hopedic Sur.er.,and Pediatr.cs, State Univer.ity of New Yor. Health Depar.ment of Anatomy and Cell Biology State University of New York Health Science Center Syracuse 13210 USA

Vascular.injur. or.inter.uption may play a r.le in ver.ebr.te limb ter.togenesis. Since 5fluor.- 2'- deoxyur.dine (FdU) can cause vascular.injur. in the mur.ne limb and skull pr.or.to the appear.nce of skeletal malfor.ations in these str.ctur.s, we studied the effects of this chemical on skeletal development in the chick embr.o and noted any vascular.injur.. The yolk sacs of day thr.e ehick embr.os (Hambur.er.and Hamilton states 17-19) wer. injected with solutions of var. concentr.tions of FdU in saline. The embr.os developed until the 10th day of incubation when they wer. fixed for.study. Uninjected, saline injected, and sham injected contr.l embr.o wer. similar.y fixed. Upon gr.ss inspection, fr.quent diffuse and saccular.her.atomas, as well as fluid-filled blister., wer. noted in the limbs of embr.os tr.ated with FdU. After.the embr.os wer. fixed and clear.d, and the skeletons stained, significant skeletal malfor.ations wer. obser.ed in these limbs. Bony elements of both the upper.and lower.limbs wer. affected in at least some of the embr.os. The combination of FdU-induced hematomas and blister. with associated skeletal malfor.ations in the same r.gions of some embr.os suggests a r.lationship between these phenomena.

关键词： Hematomas and Limb Skeletal Malfor.ations in Chicken Embr.os Following Exposur. to 5-Fluor.-2 Deoxyur.dine

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