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Micro/nano structured oleophobic agent improving the wellbore stability of shale gas wells

Petroleum Exploration and development 2022年第6期49卷 1452-1462页

作者： GENG Yuan SUN Jinsheng CHENG Rongchao QU Yuanzhi ZhanG Zhilei WANG Jianhua WANG Ren YAN Zhiyuan REN han WANG Jianlong CNPC Engineering Technology R&d Co.Ltd. Beijing 102206China School of Petroleum Engineering China University of Petroleum(East China)Qingdao 266580China

Through embedding modified nano-silica particles on the surface of polystyrene using the method of Pickering emulsion polymerization,a kind of nano/micro oleophobic agent named OL-1 was *** effects of OL-1 on the rock surface properties and its performance in inhibiting the oil phase imbibition into the rock were *** performance and mechanisms of OL-1 in improving the wellbore stability of shale gas wells were evaluated and ***-1 could absorb on the surface of the shale core to form a membrane with a micro-nano two-stage roughness,making the surface energy of the core decrease to 0.13 mN/m and the contact angle of the white oil on the core surface increase from 16.39°to 153.03°.Compared with the untreated capillary tube,when immersed into 3#white oil,the capillary tube treated by OL-1 had a reversal of capillary pressure from 273.76 Pa to-297.71 Pa,and the oil imbibition height inside the capillary tube decreased from 31 mm above the external liquid level to 33 mm below the external liquid *** amount of oil invading into the rock core modified by OL-1 decreased by 64.29%compared with the untreated *** shale core immersed into the oil-based drilling fluids with 1%OL-1 had a porosity reduction rate of only 4.5%.Compared with the core immersed in the drilling fluids without OL-1,the inherent force of the core treated by 1%OL-1 increased by 24.9%,demonstrating that OL-1 could effectively improve the rock mechanical stability by inhibiting oil phase imbibition.

关键词： shale wellbore stability oil-based drilling fluids oleophobic agent micro-nano composites wettability reversal

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Broadband electroluminescence from reverse breakdown in individual suspended carbon nanotube pn-junctions

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Nano Research 2020年第10期13卷 2857-2861页

作者： Bo Wang Sisi Yang Yu Wang Younghee Kim Ragib Ahsan Rehan K.apadia Stephen Kdoorn han Htoon Stephen B.Cronin department of Physics and Astronormy University of Southern CalforniaLos AngelesCA 90089USA Ming Hsieh department of Electrical Engineering University of Southern CaliforniaLos AngelesCA 90089USA Mork Farmily department of Chemical Engineering and Materials Science University of Southern CaliforniaLos AngelesCA 90089USA Center for Integrated Nanotechnologies Materials Physics and Applications DivisionLos Alamos National LaboratoryLos AlamosNM 87545USA

There are various mechanisms of light emission in carbon nanotubes (CNTs), which give rise to a wide range of spectral emission characteristics that provide important information regarding the underlying physical processes that lead to photon emission. Here, we report spectra obtained from individual suspended CNT dual-gate field effect transistor (FET) devices under different gate and bias conditions. By applying opposite voltages to the gate electrodes (i.e., Vg1 = –Vg2), we are able to create a pn-junction within the suspended region of the CNT. Under forward bias conditions, the spectra exhibit a peak corresponding to E11 exciton emission via thermal (i.e., blackbody) emission occurring at electrical powers around 8 μW, which corresponds to a power density of approximately 0.5 MW/cm2. On the other hand, the spectra observed under reverse bias correspond to impact ionization and avalanche emission, which occurs at electrical powers of ~ 10 nW and exhibits a featureless flat spectrum extending from 1,600 nm to shorter wavelengths up to 600 nm. Here, the hot electrons generated by the high electric fields (~ 0.5 MV/cm) are able to produce high energy photons far above the E11 (ground state) energy. It is somewhat surprising that these devices do not exhibit light emission by the annihilation of electrons and holes under forward bias, as in a light emitting diode (LEd). Possible reasons for this are discussed, including Auger recombination.

关键词： ballistic avalanche high-field band-to-band photoemission

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茶叶厌氧发酵中咖啡碱的降解途径研究

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食品安全质量检测学报 2024年第4期15卷 226-233页

作者：张欢黄友谊王成柳刘子涵周洁白颖新潍坊学院现代农学院/“十三五”山东省高等学校生物化学与分子生物学重点实验室潍坊261061 华中农业大学园艺林学学院/果蔬园艺作物种质创新与利用全国重点实验室武汉430070 泰山区农业农村局泰安271000

目的探究茶叶厌氧发酵过程中咖啡碱的降解途径。方法本研究利用高效液相色谱仪检测茶叶厌氧发酵过程中咖啡碱含量的变化,结合对发酵中代谢组和微生物群落结构的分析,获得厌氧发酵过程中咖啡碱的降解产物以及作用咖啡碱降解的微生物群。... 详细信息

目的探究茶叶厌氧发酵过程中咖啡碱的降解途径。方法本研究利用高效液相色谱仪检测茶叶厌氧发酵过程中咖啡碱含量的变化,结合对发酵中代谢组和微生物群落结构的分析,获得厌氧发酵过程中咖啡碱的降解产物以及作用咖啡碱降解的微生物群。结果经18 d发酵后,茶叶中咖啡碱含量由37.05 mg/g显著下降至5.91mg/g,腺嘌呤、次黄嘌呤、黄嘌呤、依他茶碱和羟基腺嘌呤含量显著上升,同时,92个细菌属和16个真菌属的丰度显著上升。以上结果表明咖啡碱的降解途径主要通过脱甲基化反应生成黄嘌呤,该反应的中间产物—茶碱,可能与三乙胺生成依他茶碱;细菌中芽孢杆菌(Bacillus)和赖氏菌(Leifsonia)等以及真菌赛博德林酵母菌(Cyberlindnera)、突脐蠕胞菌(Exserohilum)等可能是降解咖啡碱的关键微生物。结论厌氧发酵可以显著降低茶叶咖啡碱的含量,本研究结果可为低咖啡碱茶产品的研制提供参考。

关键词：酸茶咖啡碱黄嘌呤微生物群降解

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divergent chondro/osteogenic transduction laws of fibrocartilage stem cell drive temporomandibular joint osteoarthritis in growing mice

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International Journal of Oral Science 2023年第3期15卷 462-475页

作者： Ruiye Bi Qianli Li Haohan Li Peng Wang han Fang Xianni Yang Yiru Wang Yi Hou Binbin Ying Songsong Zhu State Key Laboratory of Oral diseases&National Center for Stomatology&National Clinical Research Center for Oral diseases&department of Orthognathic and TMJ Surgery West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral diseases&National Center for Stomatology&National Clinical Research Center for Oral diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina department of Stomatology Ningbo First HospitalNingboChina

The anterior disc displacement(Add)leads to temporomandibular joint osteoarthritis(TMJOA)and mandibular growth retardation in *** investigate the potential functional role of fibrocartilage stem cells(FCSCs)during the process,a surgical AddTMJOA mouse model was *** 1 week after model generation,Add mice exhibited aggravated mandibular growth retardation with osteoarthritis(OA)-like joint cartilage degeneration,manifesting with impaired chondrogenic differentiation and loss of subchondral bone *** tracing using Gli1^(-)CreER^(+);Tm^(fl/-)mice and Sox9-CreER^(+);Tm^(fl/-)mice showed that Add interfered with the chondrogenic capacity of Gli1+FCSCs as well as osteogenic differentiation of Sox9+lineage,mainly in the middle zone of TMJ ***,a surgically induced disc reposition(dR)mouse model was *** inhibited FCSCs capacity was significantly alleviated by dR treatment in Add *** both the Add mice and adolescent Add patients had significantly relieved OA phenotype and improved condylar growth after dR *** conclusion,Add-TMJOA leads to impaired chondrogenic progenitor capacity and osteogenesis differentiation of FCSCs lineage,resulting in cartilage degeneration and loss of subchondral bone homeostasis,finally causing TMJ growth *** at an early stage could significantly alleviate cartilage degeneration and restore TMJ cartilage growth potential.

关键词： cartilage impaired degeneration

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Effect of Wuziyanzong Pill on sperm quality and calcium ion content in oligoasthenospermia rats

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Journal of Traditional Chinese Medicine 2012年第4期32卷 631-635页

作者： Tongsheng Wang Jinling Huang deling Wu Qing Li Xiangguo Liu han Chen Lei Qiao dongdong Li Jun Li department of Pharmacology of Anhui College of Traditional Chinese Medicine College of Pharmacy of Anhui Medical University department of Chinese Medicine Chemistry of Anhui college of Traditional Chinese Medicine Central Laboratory of Anhui Provincial Hospital

OBJECTIVE： To study the effect of Wuziyanzong treatment on the sperm quality and content of cal- cium ions （Ca2＋） in oligoasthenospermia rats. METHOdS： A model of oligoasthenospermia was induced in 50 Sprague dawley rats by treatment with tripterygium glycosides at 30 mg/kg per day for 8 weeks. They were divided randomly into a model group, a positive group （Huangjingzanyu capsule, 3.01 g/kg）, and low, medium and high dose Wuziyanzong treatment groups （2.30, 4.60, 9.20 g/kg crude drug respectively） with 10 in each group. Another 10 rats were used as a control group. The rats in the control and model groups were administered distilled water, while the rats in the remaining groups were administered Wuziyan- zong for 30 d. The epididymides were removed, spermatozoa recovered and the sperm density and viability were measured. The spermatozoa were pu- rified and the contents of Ca2~ in the cytoplasm and mitochondria were detected by flow cytometry and atomic absorption spectrometry, respectively. RESULTS： After 8 weeks of treatment with tripteryg- ium glycosides, the sperm density, sperm activity and the Ca2~ content of spermatozoa in the model rats were all significantly decreased compared with the control group （all P〈O.05）. After 30 d treatment, the sperm density and activity improved and the Ca2＋ content of sperm were increased significantly in the medium and high dose Wuziyanzong treat- ment groups in comparison with the model group （all P〈O.05）. CONCLUSION： The Wuziyanzong treatment in： creased sperm density, improved sperm viability and enhanced the content of Ca2＋ in the sperm cy- toplasm and mitochondria in this rat model of oli- goasthenospermia.

关键词： Wuziyanzong Sperm count Sperm mo-tility Asthenozoospermia Oligozoospermia Calci-um ions

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绵羊源荚膜血清d型多杀性巴氏杆菌的生物学特性及2种候选疫苗的免疫效果评价

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畜牧与兽医 2024年第4期56卷 108-116页

作者：汪阳张凌金映红汪萍薛晶梁芊芊李晓卓郑启铭刘文锴韩翔舒夏俊新疆农业大学动物医学学院新疆乌鲁木齐830000 农业农村部草食动物疫病防控重点实验室(部省共建) 新疆乌鲁木齐830000 新疆畜牧科学院兽医研究所/动物临床医学研究中心新疆乌鲁木齐830000 石河子大学动物科技学院新疆石河子832061

旨在研究新疆绵羊源荚膜血清d型多杀性巴氏杆菌(Pmd)的生物学特性,探索其灭活疫苗与OmpH重组疫苗对小鼠的免疫保护效果,为防控新疆地区绵羊巴氏杆菌病提供参考。采用细菌分离鉴定、PCR鉴定、药敏试验、耐药与毒力基因检测、致病性试验... 详细信息

旨在研究新疆绵羊源荚膜血清d型多杀性巴氏杆菌(Pmd)的生物学特性,探索其灭活疫苗与OmpH重组疫苗对小鼠的免疫保护效果,为防控新疆地区绵羊巴氏杆菌病提供参考。采用细菌分离鉴定、PCR鉴定、药敏试验、耐药与毒力基因检测、致病性试验等方法初步明确Pmd的生物学特性;并通过最佳灭活条件和佐剂筛选、安全性试验、原核表达等方法制备Pmd灭活疫苗与Pmd-OmpH重组疫苗,采取小鼠攻毒保护试验评价2种疫苗的免疫效力。结果:从绵羊肺脏中分离出1株Pmd,药敏试验显示,该菌为7重耐药菌,未检测到耐药基因;毒力基因检测显示,该菌具有12种毒力基因(exbB、exbd、hgbA、tonB、fimA、Oma87、OmpH、Psl、sodA、sodC、tbpA、toxA);致病性较强,对小鼠的最小致死菌量为2.2×105 CFU;灭活疫苗和重组疫苗对相同血清型菌株攻毒的保护率分别为80%和10%;灭活疫苗对血清型A、F和未知菌株攻毒保护率分别为0、20%和0,而重组疫苗的保护率则全为0。本研究发现1株强耐药、强毒力的绵羊源Pmd,灭活疫苗对同种血清型菌株的保护性远高于重组疫苗,发病地区羊场可采用同种血清型灭活疫苗进行预防和控制绵羊巴氏杆菌病,对多价疫苗和新型疫苗的研制还有待进一步发掘。

关键词：绵羊荚膜血清d型多杀性巴氏杆菌生物学特性灭活疫苗 OmpH蛋白重组疫苗

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3d reconstruction method based on contour features

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Journal of Beijing Institute of Technology 2016年第3期25卷 301-308页

作者： han Bao-ling ZHU Ying LUO Qing-sheng XU Bo ZhanG Tian School of Mechanical Engineering Beijing Institute of Technology Beijing 100081 China School of Optoelectronics Beijing Institute of Technology Beijing 100081 China School of Mechatronical Engineering Beijing Institute of Technology Beijing 100081 China

To guarantee the accuracy and real-time of the 3d reconstruction method for outdoor scene,an algorithm based on region segmentation and matching was ***,on the basis of morphological gradient information,obtained by comparing color weight gradient images and proposing a multi-threshold segmentation,scene contour features were extracted by a watershed algorithm and a fuzzy c-means clustering ***,to reduce the search area,increase the correct matching ratio and accelerate the matching speed,the region constraint was established according to a region＇s local position,area and gray characteristics,the edge pixel constraint was established according to the epipolar constraint and the continuity ***,by using the stereo matching edge pixel pairs,their 3d coordinates were estimated according to the binocular stereo vision imaging *** results show that the proposed method can yield a high stereo matching ratio and reconstruct a 3d scene quickly and efficiently.

关键词： gradient map watershed algorithm fuzzy c-means clustering algorithm region con-straint contour matching 3d reconstruction

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Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model

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Frontiers of Medicine 2019年第5期13卷 618-625页

作者： hanyu Zhu Bo Fu Yong Wang Jing Gao Qiuxia han Wenjia Geng Xiaoli Yang Guangyan Cai Xiangmei Chen dong Zhang department of Nephrology Chinese PLA General HospitalChinese PLA Institute of NephrologyState Key Laboratory of Kidney DiseasesNational Clinical Research Center of Kidney DiseasesBeijing Key Laboratory of Kidney DiseaseBeijing 100853China department of Clinical Biochemistry Chinese PLA General HospitalBeijing 100853China department of Nephrology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

This study aimed to compare clinical features between membranous nephropathy (MN) and nonmembranous nephropathy (non-MN), to explore the clinically difTerential diagnosis of these two types, and to establish a diagnostic model of MN. After renal biopsy was obtained, 798 patients were divided into two groups based on their examination results: primary MN group (n = 248) and non-MN group (n = 550). Their data were statistically analyzed. Logistic regression analysis indicated that anti-PLA2R antibodies, IgG, and Cr were independently correlated with MN, and these three parameters were then used to establish the MN diagnostic model. A receiver operating characteristic (ROC) curve confirmed that our diagnostic model could distinguish between patients with and without MN, and their corresponding sensitivity, specificity, and AUC were 79.9%, 89.4%, and 0.917, respectively. The cutoff value for this combination in MN diagnosis was 0.34. The established diagnostic model that combined multiple factors shows a potential for broad clinical applications in differentiating primary MN from other kidney diseases and provides reliable evidence supporting the feasibility of noninvasive diagnosis of kidney diseases.

关键词： multiparameter analysis diagnosis model membranous nephropathy

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Thermodynamic favorable CO2 conversion via vicinal diols and propargylic alcohols:A metal-free catalytic method

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Chinese Chemical Letters 2020年第2期31卷 341-344页

作者： Li-Hua han Jing-Yuan Li Qing-Wen Song Kan Zhang Qian-Xia Zhang Xiao-Fang Sun Ping Liu State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China

Organocatalysis represents a promising field in chemical fixation of ***,a facile metal-free strategy was reported for the one-pot preparation of cyclic carbonates and a-hydroxy ketones from vicinal diols,propargylic alcohols and *** scope of vicinal diols and propargylic alcohols was demonstrated to be efficient under the dBU-catalyzed conditions.A plausible mechanism was proposed,which included detailed main and side reactions under the metal-free conditions.

关键词： Carbon dioxide utilization Cascade reaction Chemicals Metal-free catalysis Synthetic methods

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柴术理胃饮对功能性消化不良大鼠脑-肠轴功能及胃肠动力的影响

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河北中医 2024年第8期46卷 1305-1310页

作者：范明明常雨张艮霜林伟韩海瑞齐晶王顺黑龙江省中医药科学院老年病科黑龙江哈尔滨150000 黑龙江省中医药科学院针灸科黑龙江哈尔滨150000

目的观察柴术理胃饮对功能性消化不良(Fd)大鼠脑-肠轴功能及胃肠动力的影响。方法通过矿场实验选取SPF级雄性Sprague-dawley大鼠60只,其中50只采用郭氏夹尾刺激法+慢性疲劳+饮食失节的多重因素造模方法制备Fd肝郁脾虚模型。造模成功后... 详细信息

目的观察柴术理胃饮对功能性消化不良(Fd)大鼠脑-肠轴功能及胃肠动力的影响。方法通过矿场实验选取SPF级雄性Sprague-dawley大鼠60只,其中50只采用郭氏夹尾刺激法+慢性疲劳+饮食失节的多重因素造模方法制备Fd肝郁脾虚模型。造模成功后随机分为模型组、柴术理胃饮低、中、高剂量组和多潘立酮组,每组10只,并给予不同治疗方案,持续21 d。实验结束后观察并计算Fd大鼠进食量、糖水消耗量、体质量变化,胃排空率、小肠推进率的变化,并检测大鼠血清5-羟色胺(5-HT)、一氧化氮(NO)及一氧化氮合酶(NOS)水平。最后取胃窦组织,经苏木素-伊红(HE)染色法观察各组大鼠胃窦组织病理学改变。结果造模之初大鼠均未见异常,随着造模程序的推进,除正常组大鼠外,其余各组大鼠情绪由稳定变为烦躁、易怒、易惊,最后转化为情绪低落,并逐渐在夹尾时叫声微弱;大鼠毛发由润泽变为枯黄毛躁并散乱易掉落;大鼠饮水量、进食量、糖水消耗均减少,体质量逐渐减轻;活动量减少,嗜睡少动,扎堆,不活跃,弓背蜷缩,对外界声音不敏感;大便稀溏不成形。在3周的治疗后,各治疗组一般情况逐渐恢复造模前的状态。造模后,与正常组比较,模型组大鼠进食量、体质量及糖水消耗量均降低(Pd症状。

关键词：功能性消化不良大鼠,Sprague-dawley 动物实验中药疗法 5-羟色胺一氧化氮一氧化氮合酶

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