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Chinese Journal of Chemistry 2024年第10期42卷 1079-1083页

作者： Hui han Glen Wee zhuan Goh Yongxin Li Naohiko Yoshikai Shingo Ito Schoolof Chemistry ChemicalEngineering and BiotechnologyNanyang Technoogical University21 Nanyang LinkSingapore 637371Singapore Graduate School of Pharmaceutical Sciences Tohoku UniversitySendai 980-8578Japan

A new family of dibenzoullazine derivatives was synthesized through 1,3-dipolar cycloaddition of polycyclic aromatic azomethine ylides with alkynylbenziodoxoles followed by *** benziodoxole moiety in the resulting products was used as a versatile linchpin for the synthesis of structurally diverse functional dibenzoullazines that are difficult to access by other synthetic methods.

关键词： Cycloaddition Nitrogen heterocycles Azomethine ylides Hypervalent compounds dibenzoullazine

Phomaketals A and B,pentacyclic meroterpenoids from a eupC overexpressed mutant strain of Phoma sp.

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Chinese Chemical Letters 2024年第7期35卷 350-354页

作者： Chuan Li Yangyang han Yanan Zhai Ke Li Xingzhong Liu zhuan Zhang Cai Jia Yongsheng Che NHC Key Laboratory of Biotechnology of Antibiotics Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China State Key Laboratory of Toxicology&Medical Countermeasures Beijing Institute of Pharmacology&ToxicologyBeijing 100850China department of Microbiology College of Life SciencesNankai UniversityTianjin 300071China

Phomaketals A(1)and B(2),two tropolonic meroterpenoids with the unprecedented pentacyclic skeletons,were isolated from the solid-substrate fermentation cultures of a eupC overexpressed mutant strain of the fungus Phoma sp.,together with a biogenetically related secondary metabolite pughiinin B(3),and the known one noreupenifeldin B(4).The structures of 1–3 were elucidated primarily by nuclear magnetic resonance(NMR)*** absolute configurations of 1 and 2 were assigned by electronic circular dichroism calculations and the calculated NMR with dP4+analysis,while that of 3 was established by single-crystal X-ray diffraction analysis using Cu Kα***,phomaketals A(1)and B(2)could be derived from the hypothetical tropolonic sesquiterpene intermediates neosetophomone B(6)and 9-R-neosetophomone B(6),respectively,via different reactions *** 1 showed antiproliferative effect only against the SUPB15 cells,with an 50%inhibitory concentration(IC50)value of 4.85μmol/L,while the co-isolated known meroterpenoid 4 displayed potent effects against three tumor cell lines,SUPB15,EL4,and H9,showing IC50values of 0.36–27.08μmol/L.

关键词： Phoma sp. Tropolonic sesquiterpenes Biosynthetic pathways Hetero-diels–Alder Cytotoxicity

A comprehensive review of recent advances in chronic pancreatitis

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胰腺病学杂志(英文) 2024年第1期7卷 45-52页

作者： Mao Sheng-han Zou Wen-Bin Mao Xiao-Tong Li Zhao-Shen Liao zhuan department of Gastroenterology Changhai Hospital The Naval Medical University Shanghai China Shanghai Institute of Pancreatic diseases Shanghai China

Chronic pancreatitis (CP) is a multifaceted disorder influenced by environmental and genetic factors, with smoking and alcohol consumption being major contributors. Recent developments encompass the advent of innovative transgenic models and the identification of susceptibility genes, shedding light on the genetic aspect of CP. The pathogenesis of this disease involves a complex interplay of pancreatic acinar cell dysfunction, inflammatory reactions, and fibrosis. Current research delves into understanding these molecular mechanisms. Pain, a pivotal symptom of CP, has been increasingly studied to develop effective therapeutic interventions. diagnostic advancements, including endoscopic ultrasound, radiomics, and blood-based markers, have shown potential in enhancing early CP detection. Moreover, recent clinical trials have optimized treatment approaches, such as pancreatic stone fragmentation, stent placement, and decision-making between endoscopic and surgical procedures. Emerging therapies, including chemical pancreatectomy and gene therapy, present promising opportunities for improved CP management.

关键词： Chronic pancreatitis diagnosis Endoscopy Etiology Mechanism Surgery

Mode coupling with Fabry-Perot modes in photonic crystal slabs

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Chinese Physics B 2024年第8期33卷 90-94页

作者：秦恳胡鹏刘杰向红韩德专 department of Physics and Chongqing Key Laboratory for Strongly Coupled Physics Chongqing UniversityChongqing 401331China School of Science Chongqing Key Laboratory of New Energy Storage Materials and DevicesChongqing University of TechnologyChongqing 400054China

Fabry–Perot(FP)modes are a class of fundamental resonances in photonic crystal(PhC)*** to their low quality factors,FP modes are frequently considered as background fields with their resonance nature being ***,FP modes can play important roles in some phenomena,as exemplified by their coupling with guided resonance(GR)modes to achieve bound states in the continuum(BIC).Here,we further demonstrate the genuine resonance mode capability of FP modes PhC ***,we utilize temporal coupled-mode theory to obtain the transmittance of a PhC slab based on the FP ***,we construct exceptional points(EPs)in both momentum and parameter spaces through the coupling of FP and GR ***,we identify a Fermi arc connecting two EPs and discuss the far-field polarization *** work elucidates that the widespread FPs in PhC slabs can serve as genuine resonant modes,facilitating the realization of desired functionalities through mode coupling.

关键词： Fabry–Perot mode photonic crystal slab mode coupling exceptional point

Lactobacillus plantarum AR495 improves stress-induced irritable bowel syndrome in rats by targeting gut microbiota and Mast cell-PAR2-TRPV1 signaling pathway

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Food Science and Human Wellness 2024年第2期13卷 698-708页

作者： Hongyun Zhang Guangqiang Wang Zhiqiang Xiong zhuan Liao Yangyan Qian Xin Song Li Sui Lianzhong Ai Yongjun Xia Shanghai Engineering Research Center of Food Microbiology School of Health Science and EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China department of Gastroenterol Digestive Endoscopy CenterShanghai HospitalShanghai 200093China

Probiotics have great potential in regulating intestinal *** this study,the effects of Lactobacillus plantarum AR495 on the visceral sensitivity and gut microbiota of irritable bowel syndrome(IBS)rats were *** results showed that tryptase released after mast cell activation and degranulation plays a key role in visceral pain,and *** AR495 reduced the stimulation of colonic mast cells and the expression of protease-activated receptor 2(PAR2)and TRPV1 in dorsal root *** further showed that supplementation with *** AR495 increased the level of short-chain fatty acids(SCFAs)and enhanced the barrier function of the *** addition,the microbiota analysis of the colon indicated that *** AR495 promoted the proliferation of Bifidobacterium and inhibited the proliferation of Lachnospiraceae,which alleviated the imbalance of the intestinal microbiota caused by IBS to a certain *** total,*** AR495 might reduce visceral sensitivity through the Mast cell-PAR2-TRPV1 signaling pathway by maintaining the homeostasis of the intestinal barrier.

关键词： Lactobacillus plantarum Irritable bowel syndrome Visceral sensitivity dorsal root ganglia Tryptase Microbiota

Lactobacillus plantarum AR113 attenuates liver injury in d-galactose-induced aging mice via the inhibition of oxidative stress and endoplasmic reticulum stress

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Food Science and Human Wellness 2024年第2期13卷 885-897页

作者： Yongjun Xia Yujie Gong Xiangna Lin Yijin Yang Xin Song Guangqiang Wang Zhiqiang Xiong Yangyang Qian zhuan Liao Hui Zhang Lianzhong Ai School of Health Science and Engineering Shanghai Engineering Research Center of Food MicrobiologyUniversity of Shanghai for Science and TechnologyShanghai 200093China College of Life Sciences Linyi UniversityLinyi 276000China department of Gastroenterol. Digestive Endoscopy CenterChanghai HospitalShanghai 200082China

Probiotics could effectively eliminate excess reactive oxygen species(ROS)generated during aging or lipid metabolism disorders,but their mechanism is *** major purpose of this study was to investigate the mechanism of Lactiplantibacillus plantarun AR113 alleviating oxidative stress injury in the d-galactose induced aging *** result showed that pretreatment with *** AR113 significantly relieving H_(2)O_(2)induced cytotoxicity in HepG2 cells by maintain cell membrane integrity and increasing antioxidant enzyme *** d-galactose induced aging mice,*** AR113 could significantly attenuate liver damage and inflammatory infiltration by promoting endogenous glutathione(GSH)synthesis and activating the Nrf2/Keap1 signaling pathway in mice,and increasing the expression of regulated phaseⅡdetoxification enzymes and antioxidant *** analysis shown that gavage of *** AR113 could significantly reduce the expression of G protein-coupled receptor 78(GPR78)and C/EBP homologous protein(CHOP)proteins,and promote the restoration of endoplasmic reticulum(ER)homeostasis,thereby activating cell anti-apoptotic *** results were also confirmed in H_(2)O_(2)-treated HepG2 *** indicated that *** AR113 could inhibit d-galactose-induced liver injury through dual inhibition of ER stress and oxidative *** AR113 have good application potential in anti-aging and alleviating metabolic disorders.

关键词： Lactiplantibacillus plantarun AR113 HepG2 d-galactose Oxidative stress ER stress

From Liquid to Solid‑State Lithium Metal Batteries:Fundamental Issues and Recent developments

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Nano-Micro Letters 2024年第2期16卷 68-125页

作者： Zhao Zhang Wei‑Qiang han School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027People’s Republic of China

The widespread adoption of lithium-ion batteries has been driven by the proliferation of portable electronic devices and electric vehicles,which have increasingly stringent energy density *** metal batteries(LMBs),with their ultralow reduction potential and high theoretical capacity,are widely regarded as the most promising technical pathway for achieving high energy density *** this review,we provide a comprehensive overview of fundamental issues related to high reactivity and migrated interfaces in ***,we propose improved strategies involving interface engineering,3d current collector design,electrolyte optimization,separator modification,application of alloyed anodes,and external field regulation to address these *** utilization of solid-state electrolytes can significantly enhance the safety of LMBs and represents the only viable approach for advancing *** review also encompasses the variation in fundamental issues and design strategies for the transition from liquid to solid *** noteworthy is that the introduction of SSEs will exacerbate differences in electrochemical and mechanical properties at the interface,leading to increased interface inhomogeneity—a critical factor contributing to failure in all-solidstate lithium metal *** on recent research works,this perspective highlights the current status of research on developing high-performance LMBs.

关键词： Lithium metal batteries All-solid-state lithium metal battery Li dendrite Solid electrolyte Interface

A Generalized Blow up Criteria with One Component of Velocity for 3d Incompressible MHd System

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Chinese Annals of Mathematics,Series B 2024年第2期45卷 253-264页

作者： Bin han Xi XIONG department of Mathematics Hangzhou Dianzi UniversityHangzhou 310018China

In this paper,the authors study the global regularity of the 3d magnetohydrodynamics system in terms of one velocity *** particular,they establish a new Prodi-Serrin type regularity criterion in the framework of weak ... 详细信息

关键词： MHd Regularity Blow-up criterion

General formalism for dirty extreme-mass-ratio inspirals

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 22-29页

作者： Ye Jiang Wen-Biao han Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Shanghai Frontiers Science Center for Gravitational Wave detection Shanghai 200240China

detecting the environment around the supermassive black holes and tests of general relativity are important applications of extreme-mass-ratio inspirals(EMRIs).There is still a challenge to efficiently describe various“dirty”impacts on the inspirals,such as dark matter,gas,dipole radiation,and electromagnetic *** this study,we find the inherent linearity of the asymptotic solution of the inhomogeneous Teukolsky *** the basis of this property,we completely decouple the factors of the perturber and the background spacetime in the energy fluxes and *** the new decoupling form,the waveforms of EMRIs with non-geodesic motion in Kerr spacetime can be conveniently *** will help to resolve the environment(including gas,field,dark matter,electromagnetic interaction)around supermassive black holes and test general relativity.

关键词： gravitational wave Teukolsky equation extreme-mass-ratio inspirals

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A Graded Speed Control Method for Cyborg Rats Based on Electrical Stimulation of the Cuneiform Nucleus

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Journal of Bionic Engineering 2024年第3期21卷 1334-1346页

作者： hanyi Ling Le han Nenggan Zheng Qiushi Academy for Advanced Studies(QAAS) Zhejiang UniversityHangzhou310007China The State Key Lab of Brain-Machine Intelligence Zhejiang UniversityHangzhou310007China College of Biomedical Engineering&Instrument Science Zhejiang UniversityHangzhou310007China College of Computer Science and Technology Zhejiang UniversityHangzhou310007China CCAI by MOE and Zhejiang Provincial Government(ZJU) Hangzhou310007China

The precise movement speed regulation is a key factor to improve the control effect and efficiency of the cyborg ***,the current stimulation techniques cannot realize the graded control of the *** this study,we achieved the multi-level speed regulation of cyborg rats in the large open field and treadmill by specifically targeting the Cuneiform Nucleus(CnF)of the Mesencephalic Locomotor Region(MLR).detailed,we measured the influence of each stimulation parameter on the speed control process which included the real-time speed,accelerated speed,response time,and acceleration *** concluded that the pulse period and the pulse width were the main determinants influencing the accelerated speed of cyborg *** the amplitude of stimulation was found to affect the response time exhibited by the cyborg *** study provides valuable insights into the regulation of rat locomotion speed and highlights the potential for utilizing this approach in various experimental settings.

关键词： Cyborg rats Cuneiform nucleus Graded control Speed regulation